Gene: Trex1

Order

Name three prime repair exonuclease 1

Status ES CellsMice
tm1
phenotype data available

Links MGI:1328317    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Trex1

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Trex1 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
decreased effector memory CD4-positive, alpha-beta T cell number Trex1tm1(KOMP)Wtsi HOM Female Male postnatal 2.52E-14
decreased NK cell number Trex1tm1(KOMP)Wtsi HOM Female Male postnatal 3.3E-6

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/2)
Aorta 2 No (1/562)
Blood vessel 2 No (2/2)
Bone 2 No (1/539)
Brain 2 No (6/562) (2/2)
Brainstem 2 No (4/562)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/562) (2/2)
Cerebellum 2 No (4/562)
Cerebral cortex 2 No (5/562)
Eye 2 No (1/562)
Gall bladder 2 No (2/2)
Heart 2 No (3/562) (2/2)
Hippocampus 2 No (5/562)
Hypothalamus 2 No (4/562)
Kidney 2 No (20/562) (2/2)
Large intestine 2 No (12/562) (2/2)
Liver 2 No
Lower urinary tract 2 No (3/562) (2/2)
Lung 2 No (3/562) (2/2)
Lymph node 2 No (1/562) (2/2)
Mammary gland 2 No
Esophagus 2 No
Olfactory lobe 2 No
Ovary 2 No (1/562) (1/2)
Oviduct 2 No (2/562) (1/2)
Pancreas 2 No (6/562)
Parathyroid gland 2 No (2/540)
Peripheral nervous system 2 No (3/562) (2/2)
Peyer's patch 2 No
Pituitary gland 2 No (1/562)
Prostate gland 2 No (5/562)
Skeletal muscle tissue 2 No
Skin 2 No (1/562)
Small intestine 2 No (11/562)
Spinal cord 2 No (3/562) (2/2)
Spleen 2 No (4/562) (2/2)
Stomach 2 No (9/562)
Striatum 2 No (4/562)
Testis 2 No (4/562) (1/2)
Thymus 2 No
Thyroid gland 2 No (16/562)
Trachea 2 No (3/562)
Uterus 2 No (2/562) (1/2)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system postnatal mouse respiratory system digestive system cardiovascular system nervous system set of connective tissues reproductive system immune system trunk urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
trunk (12)
  • Trex1tm1(KOMP)Wtsi
    HEART, HET, Female, WTSI
  • Trex1tm1(KOMP)Wtsi
    LUNG, HET, Female, WTSI
  • Trex1tm1(KOMP)Wtsi
    UTERUS, OVIDUCT, OVARY, HET, Female, WTSI
  • Trex1tm1(KOMP)Wtsi
    LARGE INTESTINE, HET, Female, WTSI
  • Trex1tm1(KOMP)Wtsi
    GALL BLADDER, HET, Female, WTSI

show all 12 images

immune system (4)
  • Trex1tm1(KOMP)Wtsi
    MESENTERIC LYMPH NODE, LYMPH NODE, HET, Female, WTSI
  • Trex1tm1(KOMP)Wtsi
    LYMPH NODE, HET, Female, WTSI
  • Trex1tm1(KOMP)Wtsi
    SPLEEN, HET, Female, WTSI
  • Trex1tm1(KOMP)Wtsi
    SPLEEN, HET, Female, WTSI
nervous system (3)
  • Trex1tm1(KOMP)Wtsi
    BRAIN, HET, Female, WTSI
  • Trex1tm1(KOMP)Wtsi
    BRAIN, HET, Female, WTSI
  • Trex1tm1(KOMP)Wtsi
    SPINAL CORD, HET, Female, WTSI
cardiovascular system (2)
  • Trex1tm1(KOMP)Wtsi
    HEART, HET, Female, WTSI
  • Trex1tm1(KOMP)Wtsi
    BLOOD VESSEL, CARTILAGE TISSUE, HET, Female, WTSI
digestive system (2)
  • Trex1tm1(KOMP)Wtsi
    LARGE INTESTINE, HET, Female, WTSI
  • Trex1tm1(KOMP)Wtsi
    GALL BLADDER, HET, Female, WTSI
reproductive system (2)
  • Trex1tm1(KOMP)Wtsi
    UTERUS, OVIDUCT, OVARY, HET, Female, WTSI
  • Trex1tm1(KOMP)Wtsi
    TESTIS, HET, Male, WTSI
set of connective tissues (2)
  • Trex1tm1(KOMP)Wtsi
    CARTILAGE TISSUE, HET, Female, WTSI
  • Trex1tm1(KOMP)Wtsi
    BLOOD VESSEL, CARTILAGE TISSUE, HET, Female, WTSI
urinary system (2)
  • Trex1tm1(KOMP)Wtsi
    URINARY BLADDER, LOWER URINARY TRACT, HET, Female, WTSI
  • Trex1tm1(KOMP)Wtsi
    KIDNEY, HET, Female, WTSI
endocrine system (1)
  • Trex1tm1(KOMP)Wtsi
    ADRENAL GLAND, HET, Female, WTSI
respiratory system (1)
  • Trex1tm1(KOMP)Wtsi
    LUNG, HET, Female, WTSI

Associated Images

Legacy Phenotype Associated Images
Xray (103)
  • Trex1tm1(KOMP)Wtsi
    LOWER ARM, HET, Female, WTSI
  • Trex1tm1(KOMP)Wtsi
    TRUNK, HET, Female, WTSI
  • Trex1tm1(KOMP)Wtsi
    TRUNK, HET, Female, WTSI
  • Trex1tm1(KOMP)Wtsi
    HEAD, HET, Female, WTSI
  • Trex1tm1(KOMP)Wtsi
    HEAD, HET, Female, WTSI

show all 103 images

Skin Histopathology (2)
  • Trex1tm1(KOMP)Wtsi
    FOOT DIGIT 4, HET, Female, WTSI
  • Trex1tm1(KOMP)Wtsi
    FOOT DIGIT 4, HET, Female, WTSI
Eye Morphology (1)
  • Trex1tm1(KOMP)Wtsi
    EYE, corneal opacity, fused cornea and lens, HET, Female, WTSI

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Trex1tm1(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette)
Vector
Gene