The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
Legacy Phenotype Associated Images
malocclusion, head, abnormal snout morphology, asymmetric snout, HET, Male, WTSI
abnormal snout morphology, asymmetric snout, malocclusion, head, HET, Male, WTSI
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Timeless by orthology or direct annotation.
The table below shows human diseases predicted to be associated to Timeless by phenotypic similarity.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Timeless.
There are 5 publications which use IMPC produced mice or data.
|Title||Journal||IMPC Allele||PubMed ID|
|A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation.||G3 (Bethesda, Md.) (June 2020)||Timelesstm1b(EUCOMM)Hmgu||PMC7263671|
|High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation.||Nature immunology (December 2019)||Timelesstm1b(EUCOMM)Hmgu||PMC7338221|
|Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis.||Nature communications (August 2019)||Timelesstm1b(EUCOMM)Hmgu||PMC6671969|
|Mouse screen reveals multiple new genes underlying mouse and human hearing loss.||PLoS biology (April 2019)||Timelesstm1b(EUCOMM)Hmgu||PMC6459510|
|Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation.||Scientific data (September 2017)||Timelesstm1b(EUCOMM)Hmgu||PMC5827107|
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|MGI Allele||Allele Type||Produced|
|Timelesstm1a(EUCOMM)Hmgu||KO first allele (reporter-tagged insertion with conditional potential)||Mice, Targeting vectors, ES Cells|
|Timelesstm1b(EUCOMM)Hmgu||Reporter-tagged deletion allele (with selection cassette)||Mice|
|Timelesstm1e(EUCOMM)Hmgu||Targeted, non-conditional allele||ES Cells|