Genes Phenotypes

Gene: Slc40a1

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Name
solute carrier family 40 (iron-regulated transporter), member 1
MGI ID
MGI:1315204
Synonyms
Pcm Dusg Slc11a3 metal transporting protein 1 FPN1 Ol5 ferroportin1 MTP1 IREG1
Viability
Homozygous - Lethal
Embryo viewer
N/A
Other links
MGI   Ensembl  
Significant phenotypes (8) Measurements chart (244) All data table (558)
Expression & images (67) Disease models (0) Order (2)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
long tibia Slc40a1tm1b(EUCOMM)Hmgu HET Early adult 6.60×10-11
decreased bone mineral content Slc40a1tm1b(EUCOMM)Hmgu HET Early adult 6.32×10-08
decreased lean body mass Slc40a1tm1b(EUCOMM)Hmgu HET Early adult 2.82×10-05
embryonic lethality prior to tooth bud stage Slc40a1tm1b(EUCOMM)Hmgu HOM E12.5 0.00
increased circulating triglyceride level Slc40a1tm1b(EUCOMM)Hmgu HET Early adult 3.06×10-07
preweaning lethality, complete penetrance Slc40a1tm1b(EUCOMM)Hmgu HOM Early adult 0.00
abnormal bone structure Slc40a1tm1b(EUCOMM)Hmgu HET Early adult 2.66×10-06
decreased bone mineral density Slc40a1tm1b(EUCOMM)Hmgu HET Early adult 2.55×10-06

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Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No N/A
Bone 2 No N/A
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (2/2)  Wholemount images
Cerebellum 2 No N/A
Cerebral cortex 2 No  (2/2)  Wholemount images
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No N/A
Hippocampus 2 No  (2/2)  Wholemount images
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (2/2)  Wholemount images
Large intestine 2 No  (10/584)  (2/2)  Wholemount images
Liver 2 No  (2/2)  Wholemount images
Lower urinary tract 2 No  (2/2)  Wholemount images
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/2) N/A
Oral epithelium 2 No N/A
Ovary 2 No  (1/584) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No  (2/2)  Wholemount images
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (2/2)  Wholemount images
Small intestine 2 No  (9/584)  (2/2)  Wholemount images
Spinal cord 2 No N/A
Spleen 2 No  (2/584)  (2/2)  Wholemount images
Stomach 2 No  (12/584)  (2/2)  Wholemount images
Striatum 2 No N/A
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No  (2/2)  Wholemount images
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No  (1/2) N/A
Uterus 2 No  (1/2)  Wholemount images
Vascular system 2 No N/A
White adipose tissue 2 No N/A
LacZ Wholemount Images
digestive system (4)
Large Intestine expression
MA:0000333
endocrine system (1)
Parathyroid gland expression
MA:0000128
immune system (2)
Spleen expression
MA:0000141
integumental system (1)
Skin expression
MA:0000151
nervous system (1)
Cerebral Cortex expression
Hippocampus expression
Brain expression
MA:0000185
MA:0000191
MA:0000168
postnatal mouse (15)
Cartilage tissue expression
MA:0000104
reproductive system (2)
Testis expression
MA:0000411
set of connective tissues (2)
Cartilage tissue expression
MA:0000104
trunk (9)
Kidney expression
MA:0000368
urinary system (2)
Kidney expression
MA:0000368
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/504)  (1/2) N/A
Ear 2  (1/504) N/A
Embryo 2  (1/505)  (2/2) N/A
Eye 2  (1/504) N/A
Foot 2  (1/504) Image Only N/A
Forebrain 2  (1/504) N/A
Forelimb 2  (1/504) N/A
Hand 2  (1/503) Image Only N/A
Head 2  (5/504)  (1/2) N/A
Heart 2  (1/504) Image Only N/A
Hindbrain 2  (6/504)  (1/2) N/A
Hindlimb 2  (1/503) N/A
Liver 2  (1/504) N/A
Lung 2  (1/500)  (1/2) N/A
Mandibular process 2  (1/504) N/A
Maxillary process 2  (1/504) N/A
Midbrain 2  (1/504)  (1/2) N/A
Oral cavity 2  (1/504) N/A
Skin 2  (1/504)  (1/2) N/A
Tail 2  (1/504) N/A
Tail somite 2  (1/504) N/A

 Associated Images

Echo: M-Mode Images
28 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images
X-ray: XRay Images Whole Body Dorso Ventral
12 Images
X-ray: XRay Images Whole Body Lateral Orientation
12 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
12 Images
Embryo LacZ: LacZ images wholemount
4 Images
Adult LacZ: LacZ Images Wholemount
15 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Slc40a1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Slc40a1tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice

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