Tnfrsf1a | tumor necrosis factor receptor superfamily, member 1a

GeneMGI:1314884Synonyms: TNF-alphaR1, CD120a, +13 more

Physiological systems

22 / 24 physiological systems tested

7 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Integument Growth/size/body region Hematopoietic system Behavior/neurological Cardiovascular system

15 No significant impact

2 Not tested

Gene metrics:16Significant phenotypes
4Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues

Phenotypes

decreased circulating calcium level1 supporting datasetTnfrsf1atm2b(EUCOMM)WtsihomozygoteLate adult7.71x10-5 
increased grip strength2 supporting datasetsTnfrsf1atm2b(EUCOMM)WtsihomozygoteLate adult2.75x10-5 
increased basophil cell number1 supporting datasetTnfrsf1atm2b(EUCOMM)WtsihomozygoteLate adult1.56x10-7 
decreased neutrophil cell number1 supporting datasetTnfrsf1atm2b(EUCOMM)WtsihomozygoteLate adult2.83x10-5 
abnormal heart morphology1 supporting datasetTnfrsf1aem1(IMPC)CcpczhomozygoteEarly adultN/A * 
increased lymphocyte cell number3 supporting datasetsTnfrsf1atm2b(EUCOMM)WtsihomozygoteLate adult1.51x10-10 
increased neutrophil cell number2 supporting datasetsTnfrsf1aem1(IMPC)CcpczhomozygoteEarly adult2.18x10-5 
increased basophil cell number1 supporting datasetTnfrsf1atm2b(EUCOMM)WtsihomozygoteEarly adult9.68x10-6 
increased large unstained cell number1 supporting datasetTnfrsf1atm2b(EUCOMM)WtsihomozygoteLate adult5.49x10-5 
increased effector memory CD8-positive, alpha-beta T cell number1 supporting datasetTnfrsf1aem1(IMPC)CcpczhomozygoteEarly adult2.46x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Tnfrsf1aem1(IMPC)CcpczIntra-exon deletionmouse
Tnfrsf1atm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Tnfrsf1atm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Tnfrsf1atm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell
Tnfrsf1atm2a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Tnfrsf1atm2b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Tnfrsf1atm2e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell

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