Hipk2 | homeodomain interacting protein kinase 2
Physiological systems
20 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Growth/size/body region Vision/eye Skeleton Craniofacial Cardiovascular system Mortality/aging Renal/urinary system
13 No significant impact
4 Not tested
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
abnormal tooth morphology | 3 supporting datasets | Hipk2tm2b(EUCOMM)Hmgu | homozygote | Early adult | 1.52x10-6 | ||
abnormal snout morphology | 1 supporting dataset | Hipk2tm2b(EUCOMM)Hmgu | homozygote | Early adult | 4.9x10-5 | ||
abnormal lens morphology | 1 supporting dataset | Hipk2tm2b(EUCOMM)Hmgu | homozygote | Early adult | 9.54x10-6 | ||
increased kidney weight | 1 supporting dataset | Hipk2tm2b(EUCOMM)Hmgu | heterozygote | Early adult | 1.85x10-5 | ||
preweaning lethality, incomplete penetrance | 1 supporting dataset | Hipk2tm2b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
abnormal maxilla morphology | 1 supporting dataset | Hipk2tm2b(EUCOMM)Hmgu | homozygote | Early adult | 3.08x10-5 | ||
increased heart weight | 1 supporting dataset | Hipk2tm2b(EUCOMM)Hmgu | heterozygote | Early adult | 4.5x10-5 |
| | | | | | | | | |
adrenal gland | heterozygote | n/a | 100% (4/4) | 0.7% (4/570) |
aorta | heterozygote | n/a | 100% (4/4) | 0.19% (1/533) |
bone | heterozygote | n/a | 0% (0/4) | 0% (0/394) |
brain | heterozygote | n/a | 100% (4/4) | 0.86% (5/579) |
brainstem | heterozygote | n/a | 100% (4/4) | 0.41% (2/490) |
brown adipose tissue | heterozygote | n/a | 100% (4/4) | 0% (0/588) |
cartilage tissue | heterozygote | n/a | 100% (4/4) | 0.22% (1/454) |
cerebellum | heterozygote | n/a | 100% (4/4) | 0.56% (3/532) |
cerebral cortex | heterozygote | n/a | 100% (4/4) | 0.41% (2/491) |
esophagus | heterozygote | n/a | 75% (3/4) | 1.67% (7/419) |
External links
No external links available for Hipk2.
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Hipk2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
Hipk2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
Hipk2tm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
Hipk2tm2b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
Hipk2tm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |