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Gene: Gpr37 MGI:1313297

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
G protein-coupled receptor 37
Synonyms:
parkin-associated endothelin B-like receptor,  Pael-R

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Gpr37 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Gpr37 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Lipomatosis, Multiple Symmetric
Lipoma OMIM:151800
Lipomatosis, Multiple
Multiple lipomas OMIM:151900
Joubert Syndrome 27
Ataxia, Molar tooth sign on MRI OMIM:617120
Joubert Syndrome 33
Ataxia, Molar tooth sign on MRI OMIM:617767
Paragangliomas 6
Elevated circulating catecholamine level, Paraganglioma OMIM:618464
Joubert Syndrome 25
Ataxia, Molar tooth sign on MRI OMIM:616781
Joubert Syndrome 13
Molar tooth sign on MRI OMIM:614173
Joubert Syndrome 31
Molar tooth sign on MRI, Truncal ataxia OMIM:617761
Joubert Syndrome 4
Elongated superior cerebellar peduncle, Thickened superior cerebellar peduncle, Ataxia, Molar too... OMIM:609583
Meckel Syndrome 13
Ataxia, Molar tooth sign on MRI OMIM:617562
Joubert Syndrome 15
Ataxia, Molar tooth sign on MRI OMIM:614464
Joubert Syndrome 28
Ataxia, Molar tooth sign on MRI OMIM:617121
Joubert Syndrome 17
Ataxia, Molar tooth sign on MRI OMIM:614615
Adult Krabbe Disease
Broad-based gait, Abnormal pons morphology, Ataxia, Acroparesthesia, Abnormal medulla oblongata m... ORPHA:206448
Joubert Syndrome 36
Molar tooth sign on MRI OMIM:618763
Coach Syndrome 3
Ataxia, Molar tooth sign on MRI OMIM:619113
Joubert Syndrome 32
Ataxia, Molar tooth sign on MRI OMIM:617757
Joubert Syndrome 7
Ataxia, Molar tooth sign on MRI, Brainstem dysplasia, Hypoplasia of the brainstem OMIM:611560
Septopreoptic Holoprosencephaly
Precocious puberty, Hypoplasia of the pons, Anterior hypopituitarism, Abnormal midbrain morpholog... ORPHA:280195
Joubert Syndrome 6
Elongated superior cerebellar peduncle, Ataxia, Thickened superior cerebellar peduncle, Molar too... OMIM:610688
Paragangliomas 1
Glomus jugular tumor, Extraadrenal pheochromocytoma, Glomus tympanicum paraganglioma, Vagal parag... OMIM:168000
Multiple Epiphyseal Dysplasia, Al-Gazali Type
Molar tooth sign on MRI ORPHA:166024
Progressive Supranuclear Palsy
Neuronal loss in central nervous system, Cerebral cortical atrophy, Bradykinesia, Falls, Unsteady... ORPHA:683
Paragangliomas 3
Glomus jugular tumor, Extraadrenal pheochromocytoma, Elevated circulating catecholamine level, Ad... OMIM:605373
Joubert Syndrome 35
Elongated superior cerebellar peduncle, Ataxia, Molar tooth sign on MRI OMIM:618161
Joubert Syndrome 10
Molar tooth sign on MRI OMIM:300804
Joubert Syndrome 3
Elongated superior cerebellar peduncle, Ataxia, Molar tooth sign on MRI OMIM:608629
Orofaciodigital Syndrome Xvi
Ataxia, Inability to walk, Molar tooth sign on MRI OMIM:617563
Pure Autonomic Failure
Abnormality of circulating catecholamine level ORPHA:441
Orofaciodigital Syndrome Xv
Molar tooth sign on MRI OMIM:617127
Joubert Syndrome 40
Molar tooth sign on MRI OMIM:619582
Joubert Syndrome 8
Ataxia, Molar tooth sign on MRI OMIM:612291
Joubert Syndrome 18
Molar tooth sign on MRI OMIM:614815
Joubert Syndrome 20
Molar tooth sign on MRI OMIM:614970
Joubert Syndrome 16
Molar tooth sign on MRI OMIM:614465
Joubert Syndrome With Renal Defect
Gait disturbance, Abnormality of the hypothalamus-pituitary axis, Molar tooth sign on MRI, Ataxia ORPHA:220497
Slc35A2-Cdg
Precocious puberty, Inability to walk, Atrophy/Degeneration affecting the brainstem, Elevated cir... ORPHA:356961
Hydrolethalus Syndrome 2
Molar tooth sign on MRI OMIM:614120
Al-Gazali-Bakalinova Syndrome
Molar tooth sign on MRI OMIM:607131
Joubert Syndrome With Ocular Defect
Gait disturbance, Abnormality of the hypothalamus-pituitary axis, Molar tooth sign on MRI, Ataxia ORPHA:220493
Joubert Syndrome With Oculorenal Defect
Abnormality of the hypothalamus-pituitary axis, Molar tooth sign on MRI, Ataxia ORPHA:2318
Joubert Syndrome 30
Molar tooth sign on MRI OMIM:617622
Joubert Syndrome 22
Molar tooth sign on MRI OMIM:615665
Joubert Syndrome 9
Molar tooth sign on MRI OMIM:612285
Joubert Syndrome 2
Elongated superior cerebellar peduncle, Ataxia, Thickened superior cerebellar peduncle, Molar too... OMIM:608091
Orofaciodigital Syndrome Vi
Molar tooth sign on MRI OMIM:277170
Coach Syndrome 2
Molar tooth sign on MRI OMIM:619111
Amoebiasis Due To Free-Living Amoebae
Abnormal pons morphology, Ataxia, Abnormal brainstem MRI signal intensity, Abnormality of the adr... ORPHA:68
Coach Syndrome 1
Ataxia, Molar tooth sign on MRI OMIM:216360
Joubert Syndrome 1
Elongated superior cerebellar peduncle, Ataxia, Molar tooth sign on MRI, Brainstem dysplasia, Hyp... OMIM:213300
Joubert Syndrome 38
Decreased response to growth hormone stimulation test, Small pituitary gland, Ectopic posterior p... OMIM:619476
Japanese Encephalitis
Abnormal pons morphology, Inappropriate antidiuretic hormone secretion, Abnormal substantia nigra... ORPHA:79139
Arima Syndrome
Ataxia, Molar tooth sign on MRI, Brainstem dysplasia, Hypoplasia of the brainstem OMIM:243910
Joubert Syndrome 37
Molar tooth sign on MRI OMIM:619185
Meckel Syndrome, Type 10
Molar tooth sign on MRI OMIM:614175
Orofaciodigital Syndrome Type 6
Gait disturbance, Ataxia, Molar tooth sign on MRI ORPHA:2754
Joubert Syndrome 5
Thickened superior cerebellar peduncle, Ataxia, Molar tooth sign on MRI OMIM:610188
Joubert Syndrome 39
Pain insensitivity, Molar tooth sign on MRI OMIM:619562
Cerebellar-Facial-Dental Syndrome
Hypoplasia of the pons, Abnormal midbrain morphology, Hypoplasia of the brainstem ORPHA:444072
Duplication Of The Pituitary Gland
Abnormality of the pituitary gland, Abnormal midbrain morphology ORPHA:314621
Von Hippel-Lindau Disease
Paraganglioma, Elevated circulating catecholamine level, Adrenal pheochromocytoma, Pancreatic end... ORPHA:892
Meckel Syndrome, Type 4
Molar tooth sign on MRI OMIM:611134
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Adrenocorticotropic hormone deficiency, Decreased response to growth hormone stimulation test, Ab... ORPHA:293987
Neurodevelopmental Disorder With Dysmorphic Facies And Cerebellar Hypoplasia
Molar tooth sign on MRI, Hypoplasia of the brainstem OMIM:619306
Joubert Syndrome With Jeune Asphyxiating Thoracic Dystrophy
Elongated superior cerebellar peduncle, Molar tooth sign on MRI ORPHA:397715
Wilson Disease
Hypoparathyroidism, Face of the giant panda sign, Hypoesthesia OMIM:277900
Short-Rib Thoracic Dysplasia 13 With Or Without Polydactyly
Molar tooth sign on MRI OMIM:616300
Short-Rib Thoracic Dysplasia 21 Without Polydactyly
Molar tooth sign on MRI, Small pituitary gland OMIM:619479
Short-Rib Thoracic Dysplasia 14 With Polydactyly
Molar tooth sign on MRI OMIM:616546
Meckel Syndrome, Type 1
Adrenal hypoplasia, Molar tooth sign on MRI OMIM:249000
Orofaciodigital Syndrome Type 14
Molar tooth sign on MRI ORPHA:434179
Orofaciodigital Syndrome Xiv
Molar tooth sign on MRI OMIM:615948

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Gpr37

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Gpr37.

There are 3 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Metabolic Profiling of Mice with Deletion of the Orphan G Protein-Coupled Receptor, GPR37L1. Cells (June 2022) Gpr37l1tm1d(EUCOMM)Wtsi PMC9180194
Mouse Mutants of Gpr37 and Gpr37l1 Receptor Genes: Disease Modeling Applications. International journal of molecular sciences (April 2022) Gpr37l1tm1a(EUCOMM)Wtsi Gpr37l1tm1b(EUCOMM)Wtsi Gpr37l1tm1d(EUCOMM)Wtsi PMC9025225
Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control. Biology of sex differences (April 2018) Gpr37l1tm1c(EUCOMM)Wtsi Gpr37l1tm1a(EUCOMM)Wtsi PMC5889568

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MGI Allele Allele Type Produced
Gpr37tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells

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