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Gene: Gpr37 MGI:1313297

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
G protein-coupled receptor 37
Synonyms:
Pael-R,  parkin-associated endothelin B-like receptor

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Gpr37 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Gpr37 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Lipomatosis, Multiple Symmetric
Lipoma OMIM:151800
Lipomatosis, Multiple
Multiple lipomas OMIM:151900
Joubert Syndrome 27
Molar tooth sign on MRI, Ataxia OMIM:617120
Joubert Syndrome 33
Molar tooth sign on MRI, Ataxia OMIM:617767
Joubert Syndrome 13
Molar tooth sign on MRI, Pachygyria OMIM:614173
Paragangliomas 6
Elevated circulating catecholamine level, Paraganglioma OMIM:618464
Joubert Syndrome 25
Molar tooth sign on MRI, Ataxia OMIM:616781
Spinocerebellar Ataxia Type 2
Dystonia, Gait ataxia, Cerebral white matter atrophy, Chorea, Olivopontocerebellar hypoplasia, Pr... ORPHA:98756
Joubert Syndrome 31
Hypoplasia of the corpus callosum, Molar tooth sign on MRI, Truncal ataxia OMIM:617761
Septopreoptic Holoprosencephaly
Abnormality of the septum pellucidum, Abnormal midbrain morphology, Megalencephaly, Abnormal corp... ORPHA:280195
Joubert Syndrome 4
Thickened superior cerebellar peduncle, Molar tooth sign on MRI, Elongated superior cerebellar pe... OMIM:609583
Meckel Syndrome 13
Molar tooth sign on MRI, Ataxia OMIM:617562
Neurodegeneration With Brain Iron Accumulation 6
Dystonia, Gait disturbance, Neurodegeneration, Toe walking, Bradykinesia, Oromandibular dystonia OMIM:615643
Joubert Syndrome 15
Molar tooth sign on MRI, Ataxia OMIM:614464
Adult Krabbe Disease
Impaired tactile sensation, Abnormal midbrain morphology, Gait disturbance, Ataxia, Acroparesthes... ORPHA:206448
Joubert Syndrome 28
Molar tooth sign on MRI, Ataxia OMIM:617121
Joubert Syndrome 17
Molar tooth sign on MRI, Ataxia OMIM:614615
Joubert Syndrome 7
Hypoplasia of the brainstem, Brainstem dysplasia, Ataxia, Abnormal corpus callosum morphology, Mo... OMIM:611560
Joubert Syndrome 32
Polymicrogyria, Molar tooth sign on MRI, Ataxia OMIM:617757
Joubert Syndrome 36
Molar tooth sign on MRI OMIM:618763
Coach Syndrome 3
Molar tooth sign on MRI, Ataxia OMIM:619113
Paragangliomas 1
Extraadrenal pheochromocytoma, Vagal paraganglioma, Adrenal pheochromocytoma, Elevated circulatin... OMIM:168000
Autosomal Dominant Dopa-Responsive Dystonia
Gait ataxia, Hypothyroidism, Ataxia, Bradykinesia, Torticollis, Impaired vibration sensation in t... ORPHA:98808
Slc35A2-Cdg
Inability to walk, Cerebral white matter atrophy, Abnormal midbrain morphology, Hypoplasia of the... ORPHA:356961
Paragangliomas 3
Extraadrenal pheochromocytoma, Adrenal pheochromocytoma, Elevated circulating catecholamine level... OMIM:605373
Joubert Syndrome 35
Molar tooth sign on MRI, Elongated superior cerebellar peduncle, Ataxia OMIM:618161
Orofaciodigital Syndrome Xv
Molar tooth sign on MRI, Agenesis of corpus callosum OMIM:617127
Hydrolethalus Syndrome 2
Molar tooth sign on MRI, Agenesis of corpus callosum, Anencephaly OMIM:614120
Joubert Syndrome 6
Thickened superior cerebellar peduncle, Molar tooth sign on MRI, Elongated superior cerebellar pe... OMIM:610688
Joubert Syndrome 3
Molar tooth sign on MRI, Elongated superior cerebellar peduncle, Ataxia OMIM:608629
Joubert Syndrome 10
Molar tooth sign on MRI OMIM:300804
Orofaciodigital Syndrome Xvi
Inability to walk, Molar tooth sign on MRI, Ataxia OMIM:617563
Pure Autonomic Failure
Abnormality of circulating catecholamine level ORPHA:441
Joubert Syndrome 18
Molar tooth sign on MRI OMIM:614815
Joubert Syndrome 2
Thickened superior cerebellar peduncle, Hypoplasia of the brainstem, Brainstem dysplasia, Ataxia,... OMIM:608091
Joubert Syndrome 22
Hypoplasia of the corpus callosum, Molar tooth sign on MRI, Temporal cortical atrophy OMIM:615665
Joubert Syndrome With Renal Defect
Abnormality of the hypothalamus-pituitary axis, Gait disturbance, Ataxia, Polymicrogyria, Molar t... ORPHA:220497
Amoebiasis Due To Free-Living Amoebae
Abnormal brainstem MRI signal intensity, Lethargy, Abnormal hypothalamus morphology, Abnormal mid... ORPHA:68
Joubert Syndrome 8
Molar tooth sign on MRI, Ataxia OMIM:612291
Al-Gazali-Bakalinova Syndrome
Molar tooth sign on MRI, Agenesis of corpus callosum OMIM:607131
Joubert Syndrome 20
Molar tooth sign on MRI OMIM:614970
Joubert Syndrome 16
Molar tooth sign on MRI OMIM:614465
Joubert Syndrome 1
Hypoplasia of the brainstem, Brainstem dysplasia, Ataxia, Elongated superior cerebellar peduncle,... OMIM:213300
Japanese Encephalitis
Abnormality of thalamus morphology, Dystonia, Focal T2 hyperintense thalamic lesion, Abnormality ... ORPHA:79139
Joubert Syndrome With Ocular Defect
Abnormality of the hypothalamus-pituitary axis, Gait disturbance, Ataxia, Polymicrogyria, Molar t... ORPHA:220493
Meckel Syndrome, Type 10
Molar tooth sign on MRI, Anencephaly OMIM:614175
Joubert Syndrome With Oculorenal Defect
Molar tooth sign on MRI, Aplasia/Hypoplasia of the corpus callosum, Ataxia, Abnormality of the hy... ORPHA:2318
Coach Syndrome 2
Molar tooth sign on MRI, Agenesis of corpus callosum OMIM:619111
Joubert Syndrome 30
Molar tooth sign on MRI OMIM:617622
Orofaciodigital Syndrome Vi
Hypothalamic hamartoma, Molar tooth sign on MRI OMIM:277170
Joubert Syndrome 9
Molar tooth sign on MRI OMIM:612285
Coach Syndrome 1
Dystonia, Molar tooth sign on MRI, Ataxia OMIM:216360
Meckel Syndrome, Type 4
Hypoplasia of the corpus callosum, Molar tooth sign on MRI, Microcephaly, Anencephaly OMIM:611134
Duplication Of The Pituitary Gland
Abnormality of the pituitary gland, Abnormal hypothalamus morphology, Abnormal midbrain morpholog... ORPHA:314621
Arima Syndrome
Hypoplasia of the brainstem, Molar tooth sign on MRI, Ataxia, Brainstem dysplasia OMIM:243910
Joubert Syndrome 5
Thickened superior cerebellar peduncle, Molar tooth sign on MRI, Ataxia OMIM:610188
Cerebellar-Facial-Dental Syndrome
Hypoplasia of the brainstem, Abnormal midbrain morphology, Hypoplasia of the corpus callosum, Per... ORPHA:444072
Orofaciodigital Syndrome Type 6
Hypothalamic hamartoma, Aplasia/Hypoplasia of the corpus callosum, Gait disturbance, Ataxia, Mola... ORPHA:2754
Joubert Syndrome With Jeune Asphyxiating Thoracic Dystrophy
Open operculum, Absent septum pellucidum, Abnormal corpus callosum morphology, Abnormality of the... ORPHA:397715
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Abnormal midbrain morphology, Premature adrenarche, Central hypothyroidism, Decreased response to... ORPHA:293987
Neurodevelopmental Disorder With Dysmorphic Facies And Cerebellar Hypoplasia
Hypoplasia of the brainstem, Hypoplasia of the corpus callosum, Fusion of the left and right thal... OMIM:619306
Von Hippel-Lindau Disease
Pancreatic endocrine tumor, Adrenal pheochromocytoma, Paraganglioma, Elevated circulating catecho... ORPHA:892
Short-Rib Thoracic Dysplasia 14 With Polydactyly
Polymicrogyria, Molar tooth sign on MRI, Anencephaly OMIM:616546
Aprosencephaly And Cerebellar Dysgenesis
Aprosencephaly, Absent mesencephalon OMIM:601374
Short-Rib Thoracic Dysplasia 13 With Or Without Polydactyly
Molar tooth sign on MRI OMIM:616300
Orofaciodigital Syndrome Type 14
Hypoplasia of the corpus callosum, Dilated third ventricle, Molar tooth sign on MRI, Microcephaly... ORPHA:434179
Orofaciodigital Syndrome Xiv
Hypoplasia of the corpus callosum, Polymicrogyria, Simplified gyral pattern, Microcephaly, Molar ... OMIM:615948

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Gpr37

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Gpr37.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control. Biology of sex differences (April 2018) Gpr37l1tm1c(EUCOMM)Wtsi Gpr37l1tm1a(EUCOMM)Wtsi PMC5889568

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MGI Allele Allele Type Produced
Gpr37tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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