Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

vesicle-associated membrane protein 1
VAMP-1,  Syb-1,  Syb1,  lew

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Vamp1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Vamp1 by orthology or direct annotation.

Disease Similarity of
Matching phenotypes Source
Spastic Ataxia 1, Autosomal Dominant
Spastic ataxia, Gait disturbance, Dystonia OMIM:108600
Autosomal Dominant Spastic Ataxia Type 1
Dystonia, Tremor, Spastic ataxia, Limb ataxia, Difficulty walking, Spastic gait, Impaired vibrati... ORPHA:251282
Presynaptic Congenital Myasthenic Syndromes
Difficulty walking, Waddling gait, Toe walking, Ataxia ORPHA:98914
Myasthenic Syndrome, Congenital, 25, Presynaptic

The table below shows human diseases predicted to be associated to Vamp1 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Parkinson Disease 17
Tremor, Resting tremor, Akinesia, Bradykinesia OMIM:614203
Spinocerebellar Ataxia Type 27
Tremor, Gait ataxia, Truncal ataxia, Akinesia, Difficulty walking, Limb ataxia, Gait disturbance,... ORPHA:98764
Striatal Degeneration, Autosomal Dominant 1
Dysdiadochokinesis, Gait disturbance, Bradykinesia, Hypokinesia OMIM:609161
Progressive Supranuclear Palsy-Pure Akinesia With Gait Freezing Syndrome
Akinesia, Loss of ability to walk, Blepharospasm, Unsteady gait, Falls, Short stepped shuffling g... ORPHA:240094
Atypical Juvenile Parkinsonism
Inability to walk, Dystonia, Gait ataxia, Akinesia, Resting tremor, Bradykinesia, Short stepped s... ORPHA:391411
Corticobasal Syndrome
Dystonia, Tremor, Akinesia, Gait disturbance, Bradykinesia, Somatic sensory dysfunction, Limb dys... ORPHA:454887
Spinocerebellar Ataxia Type 21
Progressive cerebellar ataxia, Tremor, Gait ataxia, Akinesia ORPHA:98773
Spinocerebellar Ataxia Type 12
Postural tremor, Limb dysmetria, Gait disturbance, Ataxia, Bradykinesia, Hypokinesia, Action trem... ORPHA:98762
Segawa Syndrome, Autosomal Recessive
Hypokinesia, Tremor, Gait ataxia, Limb dystonia OMIM:605407
Spinocerebellar Ataxia 21
Postural tremor, Dystonia, Gait ataxia, Akinesia, Limb ataxia, Ataxia, Progressive cerebellar ata... OMIM:607454
Kufor-Rakeb Syndrome
Dystonia, Tremor, Akinesia, Gait disturbance, Ataxia, Bradykinesia, Hypokinesia, Torticollis, Dis... OMIM:606693
Arthrogryposis Multiplex Congenita 6
Neonatal death, Akinesia OMIM:619334
Classic Progressive Supranuclear Palsy Syndrome
Dystonia, Axial dystonia, Tremor, Akinesia, Blepharospasm, Bradykinesia, Falls, Gait imbalance ORPHA:240071
Neuropathy, Congenital Hypomyelinating, 2
Inability to walk, Hypokinesia OMIM:618184
Manganese Poisoning
Postural tremor, Dystonia, Akinesia, Gait disturbance, Bradykinesia ORPHA:306682
Autosomal Recessive Dopa-Responsive Dystonia
Postural tremor, Lethargy, Gait ataxia, Ataxia, Bradykinesia, Hypokinesia, Oculogyric crisis, Gen... ORPHA:101150
Sporadic Adult-Onset Ataxia Of Unknown Etiology
Dysdiadochokinesis, Gait ataxia, Akinesia, Abnormal vestibulo-ocular reflex, Resting tremor, Atax... ORPHA:247234
Postencephalitic Parkinsonism
Paresthesia, Akinesia, Resting tremor, Bradykinesia, Oculogyric crisis, Tremor by anatomical site... ORPHA:97349
Perry Syndrome
Dystonia, Tremor, Akinesia, Bradykinesia, Short stepped shuffling gait OMIM:168605
Autosomal Dominant Cerebellar Ataxia
Postural tremor, Dystonia, Tremor, Impaired vibratory sensation, Akinesia, Chorea, Gait disturban... ORPHA:99
Myopathy, Congenital, With Respiratory Insufficiency And Bone Fractures
Akinesia OMIM:618822
Dystonia 1, Torsion, Autosomal Dominant
Torsion dystonia, Tremor, Abnormal posturing, Blepharospasm, Writer's cramp, Torticollis OMIM:128100
Lissencephaly Type Iii And Bone Dysplasia
Akinesia OMIM:601160
Dystonia, Gait ataxia, Tremor, Akinesia, Limb ataxia, Chorea, Blepharospasm, Craniofacial dystoni... ORPHA:48818
Muscular Hypertonia, Lethal
Hypokinesia OMIM:254120
Parkinson Disease 23, Autosomal Recessive Early-Onset
Limb dystonia, Resting tremor, Akinesia OMIM:616840
Progressive Supranuclear Palsy-Corticobasal Syndrome
Tremor, Bradykinesia, Somatic sensory dysfunction, Focal dystonia, Diminished movement ORPHA:240103
Mohr-Tranebjaerg Syndrome
Dystonia, Tremor, Abnormal posturing OMIM:304700
Huntington Disease-Like 1
Gait ataxia, Abnormal posturing, Chorea, Gait disturbance, Bradykinesia, Hypokinesia, Dysmetria ORPHA:157941
Classic Pantothenate Kinase-Associated Neurodegeneration
Inability to walk, Abnormal posturing, Gait disturbance, Toe walking, Opisthotonus, Generalized d... ORPHA:216866
Lethal Congenital Contracture Syndrome 2
Akinesia OMIM:607598
Infantile Dystonia-Parkinsonism
Dystonia, Chorea, Bradykinesia, Hypokinesia, Oculogyric crisis ORPHA:238455
Fetal Akinesia Syndrome, X-Linked
Hypokinesia, Stillbirth OMIM:300073
Proliferative Vasculopathy And Hydranencephaly-Hydrocephaly Syndrome
Akinesia OMIM:225790
Mitochondrial Complex Iv Deficiency, Nuclear Type 19
Hypokinesia, Bradykinesia OMIM:619063
Myopathy, Congenital, Compton-North
Akinesia OMIM:612540
Dopa-Responsive Dystonia
Inability to walk, Dystonia, Lethargy, Tremor, Difficulty walking, Gait disturbance, Hypokinesia,... ORPHA:255
Fetal Akinesia Deformation Sequence
Hypokinesia, Akinesia ORPHA:994
Supranuclear Palsy, Progressive, 1
Tremor, Axial dystonia, Akinesia, Bradykinesia, Falls, Limb dystonia, Gait imbalance, Retrocollis OMIM:601104
Mercaptolactate-Cysteine Disulfiduria
Hypokinesia OMIM:249650
German Syndrome
Hypokinesia OMIM:231080
Hereditary Late-Onset Parkinson Disease
Dystonia, Akinesia, Resting tremor, Bradykinesia, Shuffling gait ORPHA:411602
Developmental And Epileptic Encephalopathy 28
Hypokinesia OMIM:616211
Combined Oxidative Phosphorylation Deficiency 6
Hypokinesia OMIM:300816
Supranuclear Palsy, Progressive, 2
Postural tremor, Axial dystonia, Akinesia, Bradykinesia, Falls, Gait imbalance, Retrocollis OMIM:609454
Sporadic Infantile Bilateral Striatal Necrosis
Dystonia, Gait ataxia, Abnormal posturing, Chorea, Gait disturbance, Resting tremor, Bradykinesia... ORPHA:225147
Combined Oxidative Phosphorylation Deficiency 2
Hypokinesia, Lethargy OMIM:610498
Multiple Pterygium Syndrome, Lethal Type
Akinesia OMIM:253290
Brown-Vialetto-Van Laere Syndrome 2
Hypokinesia, Ataxia OMIM:614707
Neurodegeneration With Brain Iron Accumulation 1
Dystonia, Tremor, Akinesia, Gait disturbance, Blepharospasm, Ataxia, Bradykinesia, Hyperactivity,... OMIM:234200
Gaucher Disease, Perinatal Lethal
Hypokinesia, Opisthotonus, Akinesia OMIM:608013
Severe X-Linked Mitochondrial Encephalomyopathy
Hypokinesia ORPHA:238329
Huntington Disease
Inability to walk, Dystonia, Difficulty walking, Chorea, Gait disturbance, Bradykinesia, Hypokine... ORPHA:399
Aromatic L-Amino Acid Decarboxylase Deficiency
Lethargy, Blepharospasm, Limb tremor, Oculogyric crisis, Torticollis, Exaggerated startle respons... OMIM:608643
Leukoencephalopathy, Progressive, Infantile-Onset, With Or Without Deafness
Akinesia OMIM:619147
Parkinson Disease 1, Autosomal Dominant
Dystonia, Gait disturbance, Resting tremor, Bradykinesia, Hypokinesia, Shuffling gait OMIM:168601
Spinocerebellar Ataxia Type 18
Gait ataxia, Head tremor, Somatic sensory dysfunction, Titubation, Dysmetria ORPHA:98771
Intermediate Nemaline Myopathy
Difficulty walking, Hypokinesia ORPHA:171433
Arthrogryposis Multiplex Congenita 5
Dystonia, Hand tremor, Akinesia OMIM:618947
Combined Oxidative Phosphorylation Deficiency 1
Hypokinesia OMIM:609060
Methylmalonic Aciduria And Homocystinuria, Cblj Type
Lethargy, Abnormal posturing OMIM:614857
Pelizaeus-Merzbacher Disease, Classic Form
Dystonia, Difficulty walking, Head tremor, Ataxia, Titubation, Athetosis, Dystonic gait ORPHA:280219
Hyperekplexia 1
Hypokinesia, Exaggerated startle response OMIM:149400
Autosomal Spastic Paraplegia Type 58
Tremor, Gait ataxia, Spastic ataxia, Chorea, Unsteady gait, Torticollis, Titubation, Dysmetria, I... ORPHA:397946
Congenital Disorder Of Glycosylation, Type Iu
Hypokinesia OMIM:615042
African Trypanosomiasis
Tremor, Paresthesia, Akinesia, Difficulty walking, Gait disturbance, Somatic sensory dysfunction,... ORPHA:3385
Sandifer Syndrome
Torticollis, Abnormal posturing ORPHA:71272
Spinocerebellar Ataxia Type 13
Gait ataxia, Difficulty walking, Limb ataxia, Bradykinesia, Torticollis, Impaired distal vibratio... ORPHA:98768
Autosomal Recessive Spastic Paraplegia Type 75
Titubation, Impaired vibratory sensation, Dysmetria ORPHA:459056
Hypokinesia, Opisthotonus, Ataxia ORPHA:280071
German Syndrome
Hypokinesia ORPHA:2077
Spastic Ataxia 1, Autosomal Dominant
Spastic ataxia, Gait disturbance, Dystonia OMIM:108600
Typical Nemaline Myopathy
Hypokinesia, Gait disturbance, Waddling gait ORPHA:171436
Autosomal Dominant Spastic Ataxia Type 1
Dystonia, Tremor, Spastic ataxia, Limb ataxia, Difficulty walking, Spastic gait, Impaired vibrati... ORPHA:251282
Myopathy, Centronuclear, X-Linked
Hypokinesia OMIM:310400
Spondylometaphyseal Dysplasia, Megarbane-Dagher-Melki Type
Hypokinesia OMIM:613320
Inability to walk, Paresthesia, Diminished movement ORPHA:2912
Autosomal Dominant Progressive External Ophthalmoplegia
Tremor, Lethargy, Gait ataxia, Gait disturbance, Resting tremor, Bradykinesia, Ataxia, Hypokinesia ORPHA:254892
Severe Congenital Nemaline Myopathy
Hypokinesia ORPHA:171430
Danon Disease
Hypokinesia OMIM:300257
Vici Syndrome
Abnormal posturing OMIM:242840
Laminin Subunit Alpha 2-Related Congenital Muscular Dystrophy
Inability to walk, Hypokinesia ORPHA:258
Rat-Bite Fever
Diminished movement ORPHA:31205
Posterior Meningocele
Difficulty walking, Hypokinesia ORPHA:268810
Unilateral Polymicrogyria
Abnormal posturing ORPHA:268943
Presynaptic Congenital Myasthenic Syndromes
Difficulty walking, Waddling gait, Toe walking, Ataxia ORPHA:98914
Myasthenic Syndrome, Congenital, 25, Presynaptic


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Vamp1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Vamp1.

No publications found that use IMPC mice or data for Vamp1.

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MGI Allele Allele Type Produced
Vamp1tm43087(L1L2_gt2) Targeting vectors
Vamp1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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