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Gene: Vamp1 MGI:1313276

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
vesicle-associated membrane protein 1
Synonyms:
lew,  Syb1,  VAMP-1,  Syb-1

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Vamp1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Vamp1 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Spastic Ataxia 1, Autosomal Dominant
Spastic ataxia, Gait disturbance, Dystonia OMIM:108600
Autosomal Dominant Spastic Ataxia Type 1
Spastic ataxia, Tremor, Impaired vibration sensation in the lower limbs, Impaired proprioception,... ORPHA:251282
Presynaptic Congenital Myasthenic Syndromes
Waddling gait, Tip-toe gait, Ataxia, Difficulty walking ORPHA:98914
Myasthenic Syndrome, Congenital, 25, Presynaptic
OMIM:618323

The table below shows human diseases predicted to be associated to Vamp1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Dystonia 31
Generalized dystonia, Writer's cramp, Leg dystonia, Arm dystonia, Difficulty walking, Abnormal po... OMIM:619565
Spinocerebellar Ataxia Type 27
Akinesia, Tremor, Limb ataxia, Gait ataxia, Hand tremor, Gait disturbance, Difficulty walking, Tr... ORPHA:98764
Parkinson Disease 17
Tremor, Resting tremor, Akinesia OMIM:614203
Spinocerebellar Ataxia Type 21
Tremor, Progressive cerebellar ataxia, Akinesia, Gait ataxia ORPHA:98773
Progressive Supranuclear Palsy-Pure Akinesia With Gait Freezing Syndrome
Freezing of gait, Akinesia, Tremor, Unsteady gait, Blepharospasm, Falls, Gait imbalance, Loss of ... ORPHA:240094
Atypical Juvenile Parkinsonism
Resting tremor, Akinesia, Inability to walk, Gait ataxia, Shuffling gait, Dystonia, Short stepped... ORPHA:391411
Intellectual Developmental Disorder With Language Impairment And Early-Onset Dopa-Responsive Dystonia-Parkinsonism
Resting tremor, Postural tremor, Akinesia, Dystonia, Freezing of gait OMIM:619911
Corticobasal Syndrome
Somatic sensory dysfunction, Dystonia, Akinesia, Tremor, Gait disturbance, Limb dystonia ORPHA:454887
Segawa Syndrome, Autosomal Recessive
Tremor, Limb dystonia, Hypokinesia, Gait ataxia OMIM:605407
Striatal Degeneration, Autosomal Dominant 1
Dysdiadochokinesis, Gait disturbance, Hypokinesia OMIM:609161
Spinocerebellar Ataxia 21
Ataxia, Postural tremor, Akinesia, Limb ataxia, Gait ataxia, Progressive cerebellar ataxia, Dysto... OMIM:607454
Spinocerebellar Ataxia Type 12
Ataxia, Postural tremor, Action tremor, Unsteady gait, Gait disturbance, Limb dysmetria, Tremor b... ORPHA:98762
Kufor-Rakeb Syndrome
Torticollis, Ataxia, Akinesia, Tremor, Distal sensory impairment, Gait disturbance, Dystonia, Hyp... OMIM:606693
Fetal Akinesia Syndrome, X-Linked
Stillbirth, Hypokinesia OMIM:300073
Arthrogryposis Multiplex Congenita 6
Neonatal death, Akinesia OMIM:619334
Sporadic Adult-Onset Ataxia Of Unknown Etiology
Resting tremor, Ataxia, Akinesia, Gait ataxia, Dysdiadochokinesis, Shuffling gait, Abnormal vesti... ORPHA:247234
Neurodegeneration With Brain Iron Accumulation 5
Tremor, Akinesia, Dystonia OMIM:300894
Neuropathy, Congenital Hypomyelinating, 2
Inability to walk, Hypokinesia, Sensory ataxia OMIM:618184
Perry Syndrome
Tremor, Short stepped shuffling gait, Akinesia, Dystonia OMIM:168605
Classic Progressive Supranuclear Palsy Syndrome
Axial dystonia, Akinesia, Tremor, Blepharospasm, Falls, Gait imbalance, Dystonia ORPHA:240071
Congenital Myopathy 9A
Akinesia OMIM:618822
Manganese Poisoning
Postural tremor, Gait disturbance, Akinesia, Dystonia ORPHA:306682
Postencephalitic Parkinsonism
Resting tremor, Oculogyric crisis, Akinesia, Diminished movement, Paresthesia, Tremor by anatomic... ORPHA:97349
Intellectual Developmental Disorder With Muscle Tone Abnormalities And Distal Skeletal Defects
Ataxia, Hypokinesia OMIM:620007
Parkinson Disease 23, Autosomal Recessive Early-Onset
Resting tremor, Akinesia, Limb dystonia OMIM:616840
Developmental And Epileptic Encephalopathy 37
Choreoathetosis, Chorea, Gait disturbance, Hypokinesia OMIM:616981
Aceruloplasminemia
Torticollis, Ataxia, Akinesia, Tremor, Chorea, Limb ataxia, Gait ataxia, Blepharospasm, Dystonia,... ORPHA:48818
Dystonia 1, Torsion, Autosomal Dominant
Torticollis, Generalized dystonia, Writer's cramp, Tremor, Inability to walk, Torsion dystonia, B... OMIM:128100
Mitochondrial Complex I Deficiency, Nuclear Type 28
Choreoathetosis, Akinesia, Truncal ataxia OMIM:618249
Lethal Congenital Contracture Syndrome 2
Akinesia OMIM:607598
Autosomal Recessive Dopa-Responsive Dystonia
Generalized dystonia, Ataxia, Postural tremor, Oculogyric crisis, Focal dystonia, Gait ataxia, Li... ORPHA:101150
Fetal Akinesia Deformation Sequence
Hypokinesia, Akinesia ORPHA:994
Spinocerebellar Ataxia 29
Broad-based gait, Truncal titubation, Limb ataxia, Impaired tandem gait, Dysmetria, Gait ataxia, ... OMIM:117360
Huntington Disease-Like 1
Chorea, Dysmetria, Gait ataxia, Gait disturbance, Abnormal posturing, Hypokinesia ORPHA:157941
Classic Pantothenate Kinase-Associated Neurodegeneration
Generalized dystonia, Inability to walk, Opisthotonus, Tip-toe gait, Gait disturbance, Abnormal p... ORPHA:216866
Muscular Hypertonia, Lethal
Hypokinesia OMIM:254120
Mohr-Tranebjaerg Syndrome
Tremor, Abnormal posturing, Dystonia OMIM:304700
Progressive Supranuclear Palsy-Corticobasal Syndrome
Tremor, Somatic sensory dysfunction, Diminished movement, Focal dystonia ORPHA:240103
Infantile Dystonia-Parkinsonism
Chorea, Oculogyric crisis, Hypokinesia, Dystonia ORPHA:238455
Gaucher Disease, Perinatal Lethal
Neonatal death, Hypokinesia, Akinesia, Opisthotonus OMIM:608013
Congenital Myopathy 12
Akinesia OMIM:612540
Combined Oxidative Phosphorylation Deficiency 6
Hypokinesia OMIM:300816
Hereditary Late-Onset Parkinson Disease
Resting tremor, Shuffling gait, Akinesia, Dystonia ORPHA:411602
Multiple Pterygium Syndrome, Lethal Type
Akinesia OMIM:253290
Sporadic Infantile Bilateral Striatal Necrosis
Resting tremor, Chorea, Gait ataxia, Titubation, Gait disturbance, Dystonia, Abnormal posturing ORPHA:225147
Mercaptolactate-Cysteine Disulfiduria
Hypokinesia OMIM:249650
Proliferative Vasculopathy And Hydranencephaly-Hydrocephaly Syndrome
Akinesia OMIM:225790
Spinocerebellar Ataxia, Autosomal Recessive 30
Ataxia, Tremor, Unsteady gait, Dysmetria, Titubation OMIM:619405
Supranuclear Palsy, Progressive, 2
Axial dystonia, Postural tremor, Akinesia, Falls, Gait imbalance, Retrocollis OMIM:609454
Severe X-Linked Mitochondrial Encephalomyopathy
Hypokinesia ORPHA:238329
Leukoencephalopathy, Progressive, Infantile-Onset, With Or Without Deafness
Akinesia OMIM:619147
Supranuclear Palsy, Progressive, 1
Axial dystonia, Akinesia, Tremor, Falls, Gait imbalance, Retrocollis, Limb dystonia OMIM:601104
Spinocerebellar Ataxia Type 18
Somatic sensory dysfunction, Dysmetria, Gait ataxia, Titubation, Head tremor ORPHA:98771
Hypermanganesemia With Dystonia 2
Generalized dystonia, Dystonia, Tremor, Inability to walk, Scissor gait, Opisthotonus, Tip-toe ga... OMIM:617013
Brown-Vialetto-Van Laere Syndrome 2
Ataxia, Hypokinesia OMIM:614707
Spinocerebellar Ataxia, Autosomal Recessive 7
Impaired vibratory sensation, Ataxia, Postural tremor, Truncal titubation, Unsteady gait, Dysmetr... OMIM:609270
Combined Oxidative Phosphorylation Deficiency 2
Neonatal death, Hypokinesia OMIM:610498
Neurodegeneration With Brain Iron Accumulation 1
Ataxia, Akinesia, Tremor, Choreoathetosis, Blepharospasm, Gait disturbance, Dystonia OMIM:234200
Arthrogryposis Multiplex Congenita 5
Dystonia, Akinesia, Hand tremor OMIM:618947
Huntington Disease
Inability to walk, Chorea, Gait disturbance, Gait imbalance, Difficulty walking, Dystonia, Hypoki... ORPHA:399
Aromatic L-Amino Acid Decarboxylase Deficiency
Torticollis, Exaggerated startle response, Oculogyric crisis, Diminished movement, Limb tremor, C... OMIM:608643
Parkinson Disease 1, Autosomal Dominant
Resting tremor, Gait disturbance, Shuffling gait, Dystonia, Loss of ambulation, Hypokinesia OMIM:168601
Mitochondrial Complex Iv Deficiency, Nuclear Type 19
Hypokinesia OMIM:619063
Intellectual Developmental Disorder, Autosomal Dominant 56
Broad-based gait, Ataxia, Inability to walk, Dystonia, Hypokinesia OMIM:617854
Intermediate Nemaline Myopathy
Hypokinesia, Difficulty walking ORPHA:171433
Pelizaeus-Merzbacher Disease, Classic Form
Dystonia, Ataxia, Dystonic gait, Titubation, Athetosis, Difficulty walking, Head tremor ORPHA:280219
Combined Oxidative Phosphorylation Deficiency 1
Hypokinesia OMIM:609060
Autosomal Spastic Paraplegia Type 58
Spastic ataxia, Torticollis, Tremor, Chorea, Unsteady gait, Dysmetria, Gait ataxia, Titubation, T... ORPHA:397946
Dpagt1-Cdg
Tremor, Inability to walk, Ataxia, Akinesia ORPHA:86309
Hyperekplexia 1
Exaggerated startle response, Hypokinesia OMIM:149400
Congenital Disorder Of Glycosylation, Type Iu
Hypokinesia OMIM:615042
African Trypanosomiasis
Somatic sensory dysfunction, Akinesia, Tremor, Impaired proprioception, Choreoathetosis, Paresthe... ORPHA:3385
Developmental And Epileptic Encephalopathy 28
Hypokinesia OMIM:616211
Methylmalonic Aciduria And Homocystinuria, Cblj Type
Abnormal posturing OMIM:614857
Sandifer Syndrome
Abnormal posturing, Torticollis ORPHA:71272
Spastic Ataxia 1, Autosomal Dominant
Spastic ataxia, Gait disturbance, Dystonia OMIM:108600
Alg11-Cdg
Ataxia, Hypokinesia, Opisthotonus ORPHA:280071
Typical Nemaline Myopathy
Waddling gait, Gait disturbance, Hypokinesia ORPHA:171436
German Syndrome
Hypokinesia ORPHA:2077
Poliomyelitis
Diminished movement, Inability to walk, Paresthesia ORPHA:2912
Spondylometaphyseal Dysplasia, Megarbane-Dagher-Melki Type
Hypokinesia OMIM:613320
Autosomal Dominant Spastic Ataxia Type 1
Spastic ataxia, Tremor, Impaired vibration sensation in the lower limbs, Impaired proprioception,... ORPHA:251282
Myopathy, Centronuclear, X-Linked
Hypokinesia OMIM:310400
Severe Congenital Nemaline Myopathy
Hypokinesia ORPHA:171430
Autosomal Dominant Progressive External Ophthalmoplegia
Resting tremor, Ataxia, Tremor, Gait ataxia, Gait disturbance, Hypokinesia ORPHA:254892
Wilson Disease
Limb dystonia, Tremor, Hypoesthesia, Hand tremor, Dystonia, Hypokinesia OMIM:277900
Vici Syndrome
Abnormal posturing OMIM:242840
Laminin Subunit Alpha 2-Related Congenital Muscular Dystrophy
Inability to walk, Hypokinesia ORPHA:258
Isolated Posterior Meningocele
Hypokinesia, Difficulty walking ORPHA:268810
Danon Disease
Hypokinesia OMIM:300257
Unilateral Polymicrogyria
Abnormal posturing ORPHA:268943
Rat-Bite Fever
Diminished movement ORPHA:31205
Presynaptic Congenital Myasthenic Syndromes
Waddling gait, Tip-toe gait, Ataxia, Difficulty walking ORPHA:98914
Myasthenic Syndrome, Congenital, 25, Presynaptic
OMIM:618323

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Vamp1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Vamp1.

No publications found that use IMPC mice or data for Vamp1.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Vamp1tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Vamp1tm43087(L1L2_gt2) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Vamp1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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