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Gene: Itm2b MGI:1309517

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
integral membrane protein 2B
Synonyms:
Bri2,  D14Sel6,  Bricd2b

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Itm2b mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Itm2b by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Cerebral Amyloid Angiopathy, Itm2B-Related, 1
Dementia, Progressive neurologic deterioration OMIM:176500
Cerebral Amyloid Angiopathy, Itm2B-Related, 2
Dementia OMIM:117300
Retinal Dystrophy With Inner Retinal Dysfunction And Ganglion Cell Abnormalities
OMIM:616079

The table below shows human diseases predicted to be associated to Itm2b by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Specific Language Impairment 2
Deficit in phonologic short-term memory OMIM:606712
Specific Language Impairment 1
Deficit in phonologic short-term memory OMIM:606711
Presenile Dementia, Kraepelin Type
Dementia OMIM:176600
7q11.23 duplication syndrome
Short attention span DECIPHER:43
Monoamine Oxidase A Deficiency
Cognitive impairment ORPHA:3057
Microangiopathy And Leukoencephalopathy, Pontine, Autosomal Dominant
Dementia, Cognitive impairment OMIM:618564
Schizophrenia 19
Cognitive impairment OMIM:617629
Cerebral Amyloid Angiopathy, Itm2B-Related, 1
Dementia, Progressive neurologic deterioration OMIM:176500
Cerebral Amyloid Angiopathy, Itm2B-Related, 2
Dementia OMIM:117300
Retinal Dystrophy With Inner Retinal Dysfunction And Ganglion Cell Abnormalities
OMIM:616079

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Itm2b

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Itm2b.

No publications found that use IMPC mice or data for Itm2b.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Itm2btm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Itm2btm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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