Gene: Lhx6

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Phenotype System Allele Zyg Sex Life Stage P Value
hypoactivity Lhx6tm1b(KOMP)Wtsi HET Early adult 1.99×10-06
preweaning lethality, incomplete penetrance Lhx6tm1b(KOMP)Wtsi HOM Early adult 0.00
abnormal behavior Lhx6tm1b(KOMP)Wtsi HET Early adult 1.88×10-06

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Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 3 No  (2/584)  (1/3)  Section images
Aorta 3 No N/A
Blood 1 No N/A
Bone marrow 1 No N/A
Brain 3 No  (2/3)  Section images
Brainstem 3 No N/A
Brown adipose tissue 1 No N/A
Cartilage tissue 3 No N/A
Cecum 2 No  (12/379)  (1/2) N/A
Cerebellum 3 No N/A
Cerebral cortex 3 No  (2/3) N/A
Chest bone 1 No N/A
Colon 1 No  (12/127) N/A
Diaphragm 1 No N/A
Duodenum 1 No  (2/127) N/A
Epididymis 1 No  (18/134)  (1/1)  Section images
Esophagus 3 No  (7/415) N/A
Eye 3 No N/A
Gall bladder 1 No N/A
Gonadal fat pad 1 No N/A
Harderian gland 1 No N/A
Heart 3 No N/A
Hindlimb 1 No N/A
Hippocampus 3 No N/A
Hypothalamus 3 No  (2/3) N/A
Ileum 1 No  (14/127)  (1/1)  Section images
Jejunum 1 No  (6/127) N/A
Kidney 3 No  (18/584)  (2/3) N/A
Large intestine 3 No  (10/584) N/A
Liver 3 No N/A
Lower urinary tract 3 No N/A
Lung 3 No N/A
Lymph node 3 No N/A
Mammary gland 3 No N/A
Mesenteric adipose tissue 1 No  (1/1)  Section images
Mesenteric lymph node 1 No N/A
Midbrain 1 No  (1/1)  Section images
Olfactory lobe 3 No N/A
Ovary 3 No  (1/584)  (1/3) N/A
Oviduct 3 No N/A
Pancreas 3 No  (5/584) N/A
Parathyroid gland 1 No N/A
Parotid gland 1 No N/A
Penis 1 No N/A
Peripheral nervous system 3 No N/A
Peyer's patch 3 No N/A
Pituitary gland 3 No N/A
Prostate gland 3 No  (12/584)  (1/3) N/A
Quadriceps 1 No  (1/1)  Section images
Sciatic nerve 1 No N/A
Skeletal muscle 3 No N/A
Skin 3 No N/A
Small intestine 3 No  (9/584)  (1/3) N/A
Spinal cord 3 No N/A
Spleen 3 No  (2/584) N/A
Stomach 3 No  (12/584) N/A
Stomach pyloric region 1 No N/A
Striatum 3 No  (2/3) N/A
Sublingual gland 1 No N/A
Submandibular gland 1 No  (2/132) N/A
Testis 3 No  (2/584)  (2/3)  Section images
Thymus 3 No N/A
Thyroid gland 3 No  (15/584)  (1/3) N/A
Tongue 3 No  (5/127)  (3/3)  Section images
Trachea 3 No  (1/3)  Section images
Trigeminal V nerve 1 No N/A
Urinary bladder 1 No N/A
Uterus 3 No N/A
Vagina 1 No N/A
Vas deferens 1 No  (15/388)  (1/1)  Section images
Vascular system 3 No N/A
Vesicular gland 1 No N/A
White adipose tissue 3 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 2  (1/61) N/A
Brain 3  (6/504) N/A
Central nervous system ganglion 2  (1/70)  (2/2) N/A
Ear 3  (1/504)  (2/5) N/A
Embryo 3  (1/505)  (2/5) N/A
Eye 3  (1/504)  (2/5) N/A
Foot 3  (1/504) N/A
Forebrain 3  (1/504) N/A
Forelimb 3  (1/504) N/A
Gut 2  (1/56) N/A
Hand 3  (1/503) N/A
Head 3  (5/504)  (2/5) N/A
Heart 3  (1/504) N/A
Hindbrain 3  (6/504) N/A
Hindlimb 3  (1/503) N/A
Liver 3  (1/504) N/A
Lung 3  (1/500) N/A
Mandibular process 3  (1/504)  (2/5) N/A
Maxillary process 3  (1/504)  (2/5) N/A
Midbrain 3  (1/504) N/A
Nose 2  (1/70) N/A
Oral cavity 3  (1/504) N/A
3  (7/37)  (4/5) N/A
Skeleton 2  (1/70) N/A
Skin 3  (1/504)  (2/5) N/A
Spinal cord 2  (1/69) N/A
Tail 3  (1/504) N/A
Tail somite 3  (1/504)  (2/5) N/A
Trachea 2  (1/56) N/A
Urinary system 2  (1/56) N/A

 Associated Images

Adult LacZ: LacZ Images Section
27 Images
Embryo LacZ: LacZ images wholemount
20 Images
X-ray: XRay Images Whole Body Dorso Ventral
7 Images
X-ray: XRay Images Whole Body Lateral Orientation
7 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Lhx6tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Lhx6tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue

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