Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
coagulation factor II (thrombin) receptor-like 3
Synonyms:
PAR4

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by F2rl3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to F2rl3 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Von Willebrand Disease, X-Linked Form
Prolonged bleeding time, Abnormal bleeding OMIM:314560
Tatsumi Factor Deficiency
Prolonged bleeding time, Abnormal bleeding OMIM:272650
Athrombia, Essential
Abnormal bleeding, Prolonged bleeding time, Impaired platelet adhesion, Impaired platelet aggrega... OMIM:209050
Pseudo-Von Willebrand Disease
Prolonged bleeding time OMIM:177820
Bleeding Disorder, Platelet-Type, 18
Epistaxis, Prolonged bleeding time, Impaired platelet aggregation OMIM:615888
Glanzmann Thrombasthenia 2
Epistaxis, Impaired ADP-induced platelet aggregation, Bruising susceptibility, Impaired epinephri... OMIM:619267
Bleeding Disorder, Platelet-Type, 11
Bruising susceptibility, Ecchymosis, Menorrhagia, Prolonged bleeding time, Epistaxis OMIM:614201
Bleeding Disorder, Platelet-Type, 14
Bruising susceptibility, Prolonged bleeding time, Ecchymosis, Epistaxis OMIM:614158
Glanzmann Thrombasthenia 1
Bruising susceptibility, Gastrointestinal hemorrhage, Impaired platelet aggregation, Purpura, Men... OMIM:273800
Platelet Glycoprotein Iv Deficiency
Prolonged bleeding time, Abnormal bleeding OMIM:608404
Glanzmann Thrombasthenia
Bruising susceptibility, Spontaneous hematomas, Ecchymosis, Gastrointestinal hemorrhage, Purpura,... ORPHA:849
Factor V Deficiency
Bruising susceptibility, Menorrhagia, Abnormal bleeding, Prolonged prothrombin time, Prolonged bl... OMIM:227400
Bernard-Soulier Syndrome
Epistaxis, Gastrointestinal hemorrhage, Purpura, Menorrhagia, Gingival bleeding, Prolonged bleedi... OMIM:231200
Platelet Disorder, Undefined
Abnormal bleeding, Prolonged bleeding time, Impaired platelet aggregation OMIM:173420
Prothrombin Deficiency, Congenital
Bruising susceptibility, Ecchymosis, Gastrointestinal hemorrhage, Menorrhagia, Gingival bleeding,... OMIM:613679
Von Willebrand Disease, Type 3
Persistent bleeding after trauma, Bruising susceptibility, Epistaxis, Impaired platelet aggregati... OMIM:277480
Platelet Aggregation, Spontaneous
Spontaneous platelet aggregation, Abnormal platelet function OMIM:173400
Macrothrombocytopenia and progressive sensorineural deafness
Bruising susceptibility, Prolonged bleeding time, Abnormal bleeding OMIM:600208
Sebastian syndrome
Prolonged bleeding time, Epistaxis OMIM:605249
Macrothrombocytopenia And Granulocyte Inclusions With Or Without Nephritis Or Sensorineural Hearing Loss
Bruising susceptibility, Menorrhagia, Abnormal bleeding, Prolonged bleeding time, Epistaxis OMIM:155100
Bleeding Disorder, Platelet-Type, 22
Subcutaneous hemorrhage, Excessive bleeding from superficial cuts, Impaired platelet aggregation OMIM:618462
Storage Pool Platelet Disease
Prolonged bleeding time, Abnormal bleeding OMIM:185050
Hemophilia B
Delayed onset bleeding, Prolonged bleeding after dental extraction, Spontaneous, recurrent epista... ORPHA:98879
Thrombocytopenia, Paris-Trousseau Type
Prolonged bleeding time, Abnormal bleeding OMIM:188025
Von Willebrand Disease, Type 1
Persistent bleeding after trauma, Bruising susceptibility, Epistaxis, Gastrointestinal hemorrhage... OMIM:193400
Thrombocytopenia With Beta-Thalassemia, X-Linked
Bruising susceptibility, Petechiae, Prolonged bleeding time, Epistaxis OMIM:314050
Gray Platelet Syndrome
Impaired thrombin-induced platelet aggregation, Bruising susceptibility, Menorrhagia, Abnormal bl... OMIM:139090
Aplasia Cutis Congenita
Prolonged bleeding time ORPHA:1114
Platelet Responsiveness To Adrenaline, Depressed
Impaired epinephrine-induced platelet aggregation OMIM:173580
Bleeding Disorder, Platelet-Type, 17
Bruising susceptibility, Petechiae, Ecchymosis, Gastrointestinal hemorrhage, Abnormal bleeding, P... OMIM:187900
Hermansky-Pudlak Syndrome 5
Bruising susceptibility, Menorrhagia, Abnormal bleeding, Prolonged bleeding time, Epistaxis OMIM:614074
Fechtner syndrome
Menorrhagia, Bruising susceptibility, Prolonged bleeding time, Abnormal bleeding OMIM:153640
Congenital Factor Ii Deficiency
Abnormal umbilical stump bleeding, Epistaxis, Oral cavity bleeding, Prolonged bleeding following ... ORPHA:325
Slc35A1-Cdg
Subcutaneous hemorrhage, Pulmonary hemorrhage, Prolonged bleeding time, Abnormal bleeding ORPHA:238459
Platelet Signal Processing Defect
Impaired ADP-induced platelet aggregation, Impaired epinephrine-induced platelet aggregation, Abn... OMIM:173590
Blue Rubber Bleb Nevus
Intestinal bleeding, Prolonged bleeding time ORPHA:1059
Platelet Disorder, Familial, With Associated Myeloid Malignancy
Epistaxis, Bruising susceptibility, Prolonged bleeding time, Impaired platelet aggregation OMIM:601399
Congenital Factor Vii Deficiency
Epistaxis, Bruising susceptibility, Gastrointestinal hemorrhage, Menorrhagia, Gingival bleeding, ... ORPHA:327
Neurofibromatosis-Noonan Syndrome
Prolonged bleeding time ORPHA:638
Hermansky-Pudlak Syndrome 6
Bruising susceptibility, Impaired ADP-induced platelet aggregation, Ecchymosis, Abnormal bleeding... OMIM:614075
Myh9-Related Disease
Menorrhagia, Bruising susceptibility, Prolonged bleeding time, Spontaneous, recurrent epistaxis ORPHA:182050
Factor X Deficiency
Menorrhagia, Gingival bleeding, Joint hemorrhage, Prolonged prothrombin time, Intracranial hemorr... OMIM:227600
Bleeding Disorder, Platelet-Type, 13, Susceptibility To
Impaired thromboxane A2 agonist-induced platelet aggregation, Bruising susceptibility, Ecchymosis... OMIM:614009
Congenital Factor X Deficiency
Abnormal umbilical stump bleeding, Bruising susceptibility, Epistaxis, Gastrointestinal hemorrhag... ORPHA:328
Combined Deficiency Of Factor V And Factor Viii
Epistaxis, Bruising susceptibility, Gastrointestinal hemorrhage, Menorrhagia, Gingival bleeding, ... ORPHA:35909
Bleeding Disorder, Platelet-Type, 12
Bruising susceptibility, Impaired platelet aggregation, Menorrhagia, Intestinal bleeding, Joint h... OMIM:605735
Klippel-Trénaunay Syndrome
Prolonged bleeding time, Gastrointestinal hemorrhage, Internal hemorrhage ORPHA:90308
Deafness-Lymphedema-Leukemia Syndrome
Intracranial hemorrhage, Bruising susceptibility, Prolonged bleeding time ORPHA:3226
Hermansky-Pudlak Syndrome 1
Hematochezia, Bruising susceptibility, Ecchymosis, Gingival bleeding, Prolonged bleeding time, Ep... OMIM:203300
Dentinogenesis Imperfecta
Bruising susceptibility, Prolonged bleeding time ORPHA:49042
Essential Thrombocythemia
Prolonged bleeding time ORPHA:3318
Pseudoxanthoma Elasticum-Like Disorder With Multiple Coagulation Factor Deficiency
Prolonged prothrombin time, Abnormal bleeding, Epistaxis OMIM:610842
Macs Syndrome
Bruising susceptibility, Prolonged bleeding time OMIM:613075
Mixed Connective Tissue Disease
Purpura, Prolonged bleeding time, Gastrointestinal hemorrhage ORPHA:809
Wiskott-Aldrich Syndrome
Hematochezia, Bruising susceptibility, Petechiae, Abnormal platelet function, Recurrent intrapulm... ORPHA:906
Dermatosparaxis Ehlers-Danlos Syndrome
Prolonged bleeding time ORPHA:1901
Congenital Fibrinogen Deficiency
Abnormal umbilical stump bleeding, Bruising susceptibility, Subcutaneous hemorrhage, Gingival ble... ORPHA:335
Hermansky-Pudlak Syndrome 2
Impaired ADP-induced platelet aggregation, Prolonged bleeding time OMIM:608233
Acquired Purpura Fulminans
Prolonged prothrombin time, Intracranial hemorrhage, Macular purpura, Internal hemorrhage ORPHA:49566
Acquired Von Willebrand Syndrome
Persistent bleeding after trauma, Bruising susceptibility, Gastrointestinal hemorrhage, Subcutane... ORPHA:99147
Infantile Liver Failure Syndrome 2
Prolonged prothrombin time OMIM:616483
Wiskott-Aldrich Syndrome, Autosomal Dominant
Gingival bleeding, Prolonged bleeding time, Epistaxis OMIM:600903
Wiskott-Aldrich Syndrome
Petechiae, Purpura, Gingival bleeding, Hematemesis, Melena, Prolonged bleeding time, Epistaxis OMIM:301000
Cog8-Cdg
Prolonged prothrombin time, Spontaneous hematomas ORPHA:95428
Noonan Syndrome 9
Prolonged prothrombin time OMIM:616559
Relapsing Fever
Prolonged prothrombin time, Abnormal bleeding, Epistaxis ORPHA:91547
Infantile Liver Failure Syndrome 3
Prolonged prothrombin time OMIM:618641
Hepatoportal Sclerosis
Prolonged prothrombin time, Abnormal bleeding, Gastrointestinal hemorrhage ORPHA:64743
Cholestasis, Progressive Familial Intrahepatic, 5
Prolonged prothrombin time OMIM:617049
Classical Ehlers-Danlos Syndrome
Bruising susceptibility, Prolonged bleeding time, Ecchymosis ORPHA:287
Monosomy 13Q34
Hematochezia, Prolonged prothrombin time, Epistaxis ORPHA:96168
Sialuria
Prolonged prothrombin time ORPHA:3166
Acyl-Coa Dehydrogenase 9 Deficiency
Cerebellar hemorrhage, Prolonged prothrombin time ORPHA:99901
Congenital Bile Acid Synthesis Defect Type 2
Prolonged prothrombin time ORPHA:79303
Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency
Prolonged prothrombin time ORPHA:367
S-Adenosylhomocysteine Hydrolase Deficiency
Prolonged prothrombin time ORPHA:88618
Hyperinsulinism Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency
Prolonged prothrombin time ORPHA:71212
Mitochondrial Complex Iv Deficiency, Nuclear Type 12
Intraventricular hemorrhage, Prolonged prothrombin time OMIM:619055
Hemophagocytic Lymphohistiocytosis, Familial, 1
Prolonged prothrombin time OMIM:267700
Combined Oxidative Phosphorylation Deficiency 37
Prolonged prothrombin time OMIM:618329
Congenital Disorder Of Glycosylation, Type Ia
Prolonged prothrombin time OMIM:212065
Hellp Syndrome
Cerebral hemorrhage, Prolonged prothrombin time, Internal hemorrhage ORPHA:244242
Shwachman-Diamond Syndrome 2
Prolonged prothrombin time OMIM:617941
Hemophagocytic Lymphohistiocytosis, Familial, 2
Prolonged prothrombin time OMIM:603553
Celiac Disease, Susceptibility To, 1
Prolonged prothrombin time OMIM:212750
Congenital Disorder Of Glycosylation, Type It
Prolonged prothrombin time OMIM:614921
Kasabach-Merritt Syndrome
Petechiae, Prolonged prothrombin time, Purpura ORPHA:2330
3-Hydroxy-3-Methylglutaric Aciduria
Prolonged prothrombin time ORPHA:20
Alg12-Cdg
Prolonged prothrombin time ORPHA:79324
Isolated Biliary Atresia
Prolonged prothrombin time ORPHA:30391
Abetalipoproteinemia
Prolonged prothrombin time, Abnormal bleeding ORPHA:14
Cirrhosis-Dystonia-Polycythemia-Hypermanganesemia Syndrome
Prolonged prothrombin time ORPHA:309854
Marburg Hemorrhagic Fever
Subconjunctival hemorrhage, Bruising susceptibility, Petechiae, Excessive bleeding after a venipu... ORPHA:99826
Neonatal Intrahepatic Cholestasis Due To Citrin Deficiency
Prolonged prothrombin time, Abnormal bleeding, Gastrointestinal hemorrhage ORPHA:247598
Acute Liver Failure
Bruising susceptibility, Gastrointestinal hemorrhage, Abnormal bleeding, Prolonged prothrombin ti... ORPHA:90062
Alacrimia-Choreoathetosis-Liver Dysfunction Syndrome
Prolonged prothrombin time ORPHA:404454
Yellow Fever
Excessive bleeding after a venipuncture, Hematemesis, Prolonged prothrombin time, Abnormal bleedi... ORPHA:99829
Primary Sclerosing Cholangitis
Prolonged prothrombin time ORPHA:171
Congenital Disorder Of Glycosylation, Type Iiw
Prolonged prothrombin time, Bleeding with minor or no trauma OMIM:619525

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for F2rl3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to F2rl3.

No publications found that use IMPC mice or data for F2rl3.

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MGI Allele Allele Type Produced
F2rl3tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells

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