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Gene: Dnah9 MGI:1289279

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Gene Summary

Name:
dynein, axonemal, heavy chain 9
Synonyms:
D11Ertd686e,  Dnahc9

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Select physiological systems to view:
Viewing: all phenotypes
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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Dnah9 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Dnah9 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Ciliary Dyskinesia, Primary, 40
Absent outer dynein arms, Azoospermia OMIM:618300
Primary Ciliary Dyskinesia
Nasal polyposis ORPHA:244

The table below shows human diseases predicted to be associated to Dnah9 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Ciliary Dyskinesia With Transposition Of Ciliary Microtubules
Abnormal respiratory motile cilium morphology OMIM:215520
Spermatogenic Failure 38
Absent sperm flagella, Tapered sperm head, Abnormal axonemal organization of respiratory motile c... OMIM:618433
Ciliary Dyskinesia, Primary, 6
Abnormal respiratory motile cilium morphology, Absent/shortened outer dynein arms OMIM:610852
Ciliary Dyskinesia, Primary, 48, Without Situs Inversus
Absent central microtubular pair morphology of respiratory motile cilia OMIM:620032
Ciliary Dyskinesia, Primary, 10
Abnormal respiratory motile cilium morphology OMIM:612518
Familial Nasal Acilia
Abnormal respiratory motile cilium morphology ORPHA:922
Ectodermal Dysplasia, Hypohidrotic, With Hypothyroidism And Ciliary Dyskinesia
Abnormal respiratory motile cilium morphology OMIM:225050
Ciliary Dyskinesia With Defective Radial Spokes
Absent respiratory ciliary axoneme radial spokes, Nasal polyposis OMIM:242670
Ciliary Dyskinesia, Primary, 13
Absent inner dynein arms, Absent outer dynein arms OMIM:613193
Ciliary Dyskinesia, Primary, 34
Absent central microtubular pair morphology of respiratory motile cilia OMIM:617091
Ciliary Dyskinesia, Primary, 17
Dynein arm defect of respiratory motile cilia OMIM:614679
Ciliary Dyskinesia, Primary, 45
Absent inner and outer dynein arms OMIM:618801
Ciliary Dyskinesia, Primary, 11
Abnormal central microtubular pair morphology of respiratory motile cilia OMIM:612649
Ciliary Dyskinesia, Primary, 28
Dynein arm defect of respiratory motile cilia OMIM:615505
Ciliary Dyskinesia, Primary, 32
Absent respiratory ciliary axoneme radial spokes OMIM:616481
Ciliary Dyskinesia, Primary, 16
Absent outer dynein arms OMIM:614017
Ciliary Dyskinesia, Primary, 14
Absent inner dynein arms, Abnormal axonemal organization of respiratory motile cilia OMIM:613807
Ciliary Dyskinesia, Primary, 12
Abnormal central microtubular pair morphology of respiratory motile cilia OMIM:612650
Ciliary Dyskinesia, Primary, 15
Nasal polyposis, Abnormal axonemal organization of respiratory motile cilia OMIM:613808
Ciliary Dyskinesia, Primary, 18
Absent inner dynein arms, Absent outer dynein arms OMIM:614874
Ciliary Dyskinesia, Primary, 20
Absent outer dynein arms OMIM:615067
Ciliary Dyskinesia, Primary, 9
Absent outer dynein arms OMIM:612444
Ciliary Dyskinesia, Primary, 40
Absent outer dynein arms, Azoospermia OMIM:618300
Ciliary Dyskinesia, Primary, 26
Absent outer dynein arms OMIM:615500
Ciliary Dyskinesia, Primary, 30
Absent outer dynein arms, Nasal polyposis OMIM:616037
Ciliary Dyskinesia, Primary, 2
Absent inner and outer dynein arms, Nasal polyposis OMIM:606763
Ciliary Dyskinesia, Primary, 19
Absent inner and outer dynein arms, Nasal polyposis OMIM:614935
Ciliary Dyskinesia, Primary, 38
Absent inner and outer dynein arms OMIM:618063
Ciliary Dyskinesia, Primary, 22
Absent inner and outer dynein arms, Nasal polyposis OMIM:615444
Ciliary Dyskinesia, Primary, 1
Absent outer dynein arms, Nasal polyposis OMIM:244400
Primary Ciliary Dyskinesia
Nasal polyposis ORPHA:244

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Dnah9

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Dnah9.

No publications found that use IMPC mice or data for Dnah9.

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MGI Allele Allele Type Produced
Dnah9tm44288(L1L2_gt2) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Dnah9tm44288(L1L2_gt1) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Dnah9em1(IMPC)Tcp Exon Deletion Mice, Tissue
Dnah9tm44288(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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