Gene Summary

Name:
dynein, axonemal, heavy chain 9
Synonyms:
D11Ertd686e,  Dnahc9

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Dnah9 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Dnah9 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Primary Ciliary Dyskinesia
Abnormal sputum, Anomalous pulmonary venous return, Respiratory tract infection, Bronchiectasis, ... ORPHA:244
Ciliary Dyskinesia, Primary, 40
Azoospermia OMIM:618300

The table below shows human diseases predicted to be associated to Dnah9 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Ciliary Dyskinesia With Transposition Of Ciliary Microtubules
Abnormal respiratory motile cilium morphology, Recurrent sinopulmonary infections OMIM:215520
Ciliary Dyskinesia, Primary, 6
Recurrent sinusitis, Sinusitis, Abnormal respiratory motile cilium morphology, Recurrent respirat... OMIM:610852
Spermatogenic Failure 38
Absent sperm flagella, Abnormal sperm head morphology, Oligospermia, Abnormal axonemal organizati... OMIM:618433
Ciliary Dyskinesia, Primary, 10
Recurrent sinusitis, Abnormal respiratory motile cilium morphology, Chronic sinusitis OMIM:612518
Familial Nasal Acilia
Bronchiectasis, Recurrent upper respiratory tract infections, Atelectasis, Chronic sinusitis, Abn... ORPHA:922
Ciliary Dyskinesia With Excessively Long Cilia
Recurrent bronchitis, Nasal polyposis, Abnormal respiratory motile cilium morphology, Sinusitis OMIM:242680
Ciliary Dyskinesia, Primary, 12
Bronchiectasis, Recurrent respiratory infections, Abnormal central microtubular pair morphology o... OMIM:612650
Ciliary Dyskinesia, Primary, 13
Recurrent bronchitis, Bronchiectasis, Absent inner dynein arms, Absent outer dynein arms, Sinusitis OMIM:613193
Ciliary Dyskinesia, Primary, 17
Abnormal respiratory motile cilium morphology, Recurrent respiratory infections, Bronchiectasis, ... OMIM:614679
Ciliary Dyskinesia With Defective Radial Spokes
Absent respiratory ciliary axoneme radial spokes, Nasal polyposis, Sinusitis OMIM:242670
Ciliary Dyskinesia, Primary, 34
Absent central microtubular pair morphology of respiratory motile cilia, Recurrent sinusitis, Rec... OMIM:617091
Ciliary Dyskinesia, Primary, 11
Bronchiectasis, Recurrent sinusitis, Chronic bronchitis, Recurrent respiratory infections, Abnorm... OMIM:612649
Ciliary Dyskinesia, Primary, 45
Absent inner and outer dynein arms, Recurrent respiratory infections, Bronchiectasis OMIM:618801
Ectodermal Dysplasia, Hypohidrotic, With Hypothyroidism And Ciliary Dyskinesia
Abnormal respiratory motile cilium morphology OMIM:225050
Ciliary Dyskinesia, Primary, 15
Chronic sinusitis, Bronchiectasis, Nasal polyposis, Abnormal axonemal organization of respiratory... OMIM:613808
Ciliary Dyskinesia, Primary, 14
Chronic sinusitis, Bronchiectasis, Absent inner dynein arms, Abnormal axonemal organization of re... OMIM:613807
Ciliary Dyskinesia, Primary, 20
Bronchiectasis, Absent outer dynein arms, Recurrent sinusitis, Atelectasis, Recurrent pneumonia, ... OMIM:615067
Ciliary Dyskinesia, Primary, 16
Absent outer dynein arms, Bronchiectasis, Chronic sinusitis OMIM:614017
Ciliary Dyskinesia, Primary, 30
Bronchiectasis, Absent outer dynein arms, Nasal polyposis, Chronic bronchitis, Recurrent respirat... OMIM:616037
Ciliary Dyskinesia, Primary, 1
Bronchiectasis, Nasal polyposis, Pneumonia, Sinusitis, Chronic sinusitis, Absent frontal sinuses,... OMIM:244400
Ciliary Dyskinesia, Primary, 26
Bronchiectasis, Absent outer dynein arms, Recurrent sinusitis, Chronic bronchitis, Recurrent resp... OMIM:615500
Ciliary Dyskinesia, Primary, 18
Absent outer dynein arms, Recurrent sinusitis, Chronic bronchitis OMIM:614874
Ciliary Dyskinesia, Primary, 22
Bronchiectasis, Nasal polyposis, Absent inner and outer dynein arms, Recurrent sinusitis, Recurre... OMIM:615444
Ciliary Dyskinesia, Primary, 19
Bronchiectasis, Nasal polyposis, Absent inner and outer dynein arms, Recurrent sinusitis, Recurre... OMIM:614935
Ciliary Dyskinesia, Primary, 2
Bronchiectasis, Nasal polyposis, Absent inner and outer dynein arms, Sinusitis, Recurrent respira... OMIM:606763
Ciliary Dyskinesia, Primary, 38
Absent inner and outer dynein arms, Bronchiectasis, Chronic sinusitis OMIM:618063
Primary Ciliary Dyskinesia
Abnormal sputum, Anomalous pulmonary venous return, Respiratory tract infection, Bronchiectasis, ... ORPHA:244
Ciliary Dyskinesia, Primary, 40
Azoospermia OMIM:618300

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Dnah9

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Dnah9.

No publications found that use IMPC mice or data for Dnah9.

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MGI Allele Allele Type Produced
Dnah9tm44288(L1L2_Bact_P) Targeting vectors
Dnah9tm44288(L1L2_gt2) Targeting vectors
Dnah9em1(IMPC)Tcp Exon Deletion Mice, Tissue
Dnah9tm44288(L1L2_gt1) Targeting vectors

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