Tbc1d22a | TBC1 domain family, member 22a

GeneMGI:1289265Synonyms: D15Ertd781e

Physiological systems

18 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Homeostasis/metabolism Hematopoietic system

16 No significant impact

6 Not tested

Gene metrics:11Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues

Phenotypes

increased circulating amylase level1 supporting datasetTbc1d22atm1b(KOMP)WtsihomozygoteEarly adult5.33x10-12 
decreased circulating fructosamine level1 supporting datasetTbc1d22atm1b(KOMP)WtsihomozygoteEarly adult2.16x10-6 
thrombocytopenia1 supporting datasetTbc1d22atm1b(KOMP)WtsihomozygoteEarly adult1.94x10-5 
increased circulating aspartate transaminase level1 supporting datasetTbc1d22atm1b(KOMP)WtsihomozygoteEarly adult3.05x10-19 
increased circulating alanine transaminase level1 supporting datasetTbc1d22atm1b(KOMP)WtsihomozygoteEarly adult9.95x10-34 
increased circulating creatinine level1 supporting datasetTbc1d22atm1b(KOMP)WtsihomozygoteEarly adult4.88x10-5 
increased circulating free fatty acids level1 supporting datasetTbc1d22atm1b(KOMP)WtsihomozygoteEarly adult1.54x10-6 
increased mean platelet volume1 supporting datasetTbc1d22atm1b(KOMP)WtsihomozygoteEarly adult2.66x10-6 
increased red blood cell distribution width1 supporting datasetTbc1d22atm1b(KOMP)WtsihomozygoteEarly adult7.08x10-6 
increased circulating alkaline phosphatase level1 supporting datasetTbc1d22atm1b(KOMP)WtsihomozygoteEarly adult2.62x10-53 
* Does not have a P-value assigned because it was manually marked as significant.
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* Does not have a P-value assigned because it was manually marked as significant.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Tbc1d22atm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
mouse
Tbc1d22atm1b(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Tbc1d22atm1e(KOMP)WtsiTargeted, non-conditional allelees cell

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