Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Zwint by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Intellectual Developmental Disorder, Autosomal Recessive 54 | Hyperactivity | OMIM:617028 | |
Attention Deficit-Hyperactivity Disorder | Hyperactivity, Attention deficit hyperactivity disorder | OMIM:143465 | |
Schizophrenia 15 | Hyperactivity | OMIM:613950 | |
22q13 deletion syndrome (Phelan-Mcdermid syndrome) | Hyperactivity | DECIPHER:20 | |
Intellectual Developmental Disorder, Autosomal Recessive 2 | Attention deficit hyperactivity disorder | OMIM:607417 | |
Potocki-Lupski syndrome (17p11.2 duplication syndrome) | Hyperactivity | DECIPHER:19 | |
Intellectual Developmental Disorder, Autosomal Dominant 45 | Hyperactivity, Attention deficit hyperactivity disorder | OMIM:617600 | |
Intellectual Developmental Disorder, Autosomal Recessive 3 | Hyperactivity | OMIM:608443 | |
Autism, Susceptibility To, 20 | Attention deficit hyperactivity disorder | OMIM:618830 | |
Intellectual Developmental Disorder, Autosomal Dominant 50, With Behavioral Abnormalities | Attention deficit hyperactivity disorder | OMIM:617787 | |
Immunodeficiency 8 | Hyperactivity | OMIM:615401 | |
Microcephaly 25, Primary, Autosomal Recessive | Attention deficit hyperactivity disorder | OMIM:618351 | |
Intellectual Developmental Disorder, X-Linked 77 | Hyperactivity | OMIM:300454 | |
Intellectual Developmental Disorder, X-Linked 72 | Hyperactivity | OMIM:300271 | |
Intellectual Developmental Disorder, Autosomal Dominant 52 | Hyperactivity | OMIM:617796 | |
Developmental And Epileptic Encephalopathy 43 | Hyperactivity | OMIM:617113 | |
Hyperlysinemia, Type I | Hyperactivity | OMIM:238700 | |
Intellectual Developmental Disorder, Autosomal Dominant 33 | Hyperactivity | OMIM:616311 | |
Intellectual Developmental Disorder, Autosomal Recessive 37 | Hyperactivity | OMIM:615493 | |
Ank3-Related Intellectual Disability-Sleep Disturbance Syndrome | Hyperactivity | ORPHA:356996 | |
Smith-Magenis syndrome | Hyperactivity | DECIPHER:8 | |
Intellectual Disability-Expressive Aphasia-Facial Dysmorphism Syndrome | Hyperactivity | ORPHA:436151 | |
Language Delay And Attention Deficit-Hyperactivity Disorder/Cognitive Impairment With Or Without Cardiac Arrhythmia | Hyperactivity, Attention deficit hyperactivity disorder | OMIM:617182 | |
Spastic Tetraplegia, Thin Corpus Callosum, And Progressive Microcephaly | Hyperactivity | OMIM:616657 | |
Intellectual Developmental Disorder, X-Linked, Syndromic, Houge Type | Hyperactivity, Attention deficit hyperactivity disorder | OMIM:301008 | |
Insulin-Like Growth Factor I Deficiency | Hyperactivity | OMIM:608747 | |
Microcephaly, Seizures, And Developmental Delay | Hyperactivity | OMIM:613402 | |
8p23.1 deletion syndrome | Hyperactivity | DECIPHER:39 | |
Aminoacylase 1 Deficiency | Hyperactivity | OMIM:609924 | |
Intellectual Developmental Disorder, X-Linked 101 | Hyperactivity | OMIM:300928 | |
Intellectual Developmental Disorder With Epilepsy, Behavioral Abnormalities, And Coarse Facies | Hyperactivity | OMIM:619031 | |
Morm Syndrome | Hyperactivity | ORPHA:75858 | |
Mannosidosis, Beta A, Lysosomal | Hyperactivity | OMIM:248510 | |
Hyperprolinemia, Type I | Hyperactivity | OMIM:239500 | |
Histidinemia | Hyperactivity | ORPHA:2157 | |
Intellectual Developmental Disorder, Autosomal Recessive 74 | Hyperactivity | OMIM:617169 | |
Neurodevelopmental Disorder With Epilepsy And Hypoplasia Of The Corpus Callosum | Hyperactivity | OMIM:618090 | |
Intellectual Developmental Disorder, Autosomal Recessive 71 | Hyperactivity, Attention deficit hyperactivity disorder | OMIM:618504 | |
Intellectual Developmental Disorder, X-Linked 107 | Hyperactivity, Attention deficit hyperactivity disorder | OMIM:301013 | |
Dystonia, Dopa-Responsive, Due To Sepiapterin Reductase Deficiency | Hyperactivity | OMIM:612716 | |
Chromosome 15Q25 Deletion Syndrome | Hyperactivity, Attention deficit hyperactivity disorder | OMIM:614294 | |
Mitochondrial Complex Iii Deficiency, Nuclear Type 7 | Hyperactivity | OMIM:615824 | |
Graves Disease, Susceptibility To, 1 | Hyperactivity | OMIM:275000 | |
X-Linked Intellectual Disability-Acromegaly-Hyperactivity Syndrome | Hyperactivity | ORPHA:85327 | |
Hypomagnesemia, Seizures, And Mental Retardation 2 | Hyperactivity | OMIM:618314 | |
Hyperthyroidism, Nonautoimmune | Hyperactivity | OMIM:609152 | |
Familial Gestational Hyperthyroidism | Hyperactivity | ORPHA:99819 | |
Familial Hyperthyroidism Due To Mutations In Tsh Receptor | Hyperactivity | ORPHA:424 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Zwintem1(IMPC)J | Exon Deletion | Mice |
Zwinttm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Zwinttm1e(KOMP)Wtsi | Targeted, non-conditional allele | ES Cells |
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