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Gene: Cd300lg MGI:1289168

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Gene Summary

Name:
CD300 molecule like family member G
Synonyms:
nepmucin,  Clm9,  D11Ertd736e,  2310016B05Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased total body fat amount Cd300lgtm1a(KOMP)Wtsi HOM Early adult 4.15×10-05
increased lean body mass Cd300lgtm1a(KOMP)Wtsi HOM Early adult 4.97×10-05
increased food intake Cd300lgtm1a(KOMP)Wtsi HOM   Early adult 6.01×10-05
abnormal pelvic girdle bone morphology Cd300lgtm1a(KOMP)Wtsi HOM Early adult 8.75×10-05

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Skull Lateral Orientation

13 Images

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X-ray

XRay Images Whole Body Dorso Ventral

14 Images

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X-ray

XRay Images Forepaw

16 Images

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X-ray

XRay Images Whole Body Lateral Orientation

13 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

14 Images

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Legacy Phenotype Associated Images
Cd300lgtm1a(KOMP)Wtsi
HOM, Male, WTSI
Cd300lgtm1a(KOMP)Wtsi
HOM, Male, WTSI
Cd300lgtm1a(KOMP)Wtsi
HOM, Female, WTSI
Cd300lgtm1a(KOMP)Wtsi
HOM, Female, WTSI
Cd300lgtm1a(KOMP)Wtsi
HOM, Male, WTSI

View all 70 images

Cd300lgtm1a(KOMP)Wtsi
left eye, HOM, Male, WTSI

Human diseases caused by Cd300lg mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Cd300lg by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Osteopathia Striata-Pigmentary Dermopathy-White Forelock Syndrome
Osteopathia striata, Abnormality of the metaphysis, Coarse metaphyseal trabecularization, Abnorma... ORPHA:2779
Osteodysplasty, Precocious, Of Danks, Mayne, And Kozlowski
Abnormality of pelvic girdle bone morphology, Short toe, Abnormality of long bone morphology, Sho... OMIM:259270
Obesity Due To Melanocortin 4 Receptor Deficiency
Increased adipose tissue, Obesity, Childhood-onset truncal obesity, Polyphagia ORPHA:71529
Macrosomia Adiposa Congenita
Obesity, Polyphagia, Large for gestational age OMIM:248100
Bardet-Biedl Syndrome 22
Polydactyly, Polyphagia, Large for gestational age, Postaxial foot polydactyly, Obesity OMIM:617119
Kleine-Levin Hibernation Syndrome
Polyphagia OMIM:148840
Coxopodopatellar Syndrome
Abnormality of epiphysis morphology, Abnormality of pelvic girdle bone morphology, Aplasia/Hypopl... ORPHA:1509
Distal Arthrogryposis Type 1
Adducted thumb, Rocker bottom foot, Ulnar deviation of finger, Overlapping fingers, Camptodactyly... ORPHA:1146
Body Mass Index Quantitative Trait Locus 20
Obesity, Polyphagia OMIM:618406
Obesity, Hyperphagia, And Developmental Delay
Obesity, Polyphagia OMIM:613886
Prader-Willi Syndrome Due To Imprinting Mutation
Polyphagia, Small hand, Abnormality of ulnar metaphysis, Short foot, Obesity ORPHA:177910
Severe Early-Onset Obesity-Insulin Resistance Syndrome Due To Sh2B1 Deficiency
Obesity, Polyphagia ORPHA:329249
Obesity Due To Prohormone Convertase I Deficiency
Increased adipose tissue, Polyphagia, Failure to thrive, Obesity, Childhood-onset truncal obesity ORPHA:71528
Obesity Due To Pro-Opiomelanocortin Deficiency
Increased adipose tissue, Polyphagia, Failure to thrive, Obesity, Childhood-onset truncal obesity ORPHA:71526
Bardet-Biedl Syndrome 9
Polydactyly, Polyphagia, Postaxial polydactyly, Polydipsia, Truncal obesity, Syndactyly, Postaxia... OMIM:615986
Leptin Deficiency Or Dysfunction
Obesity, Abnormal eating behavior, Polyphagia OMIM:614962
Hypochondroplasia
Genu varum, Abnormality of pelvic girdle bone morphology, Flared metaphysis, Short long bone, Bra... OMIM:146000
Metaphyseal Dysplasia Without Hypotrichosis
Metaphyseal dysplasia, Genu varum, Metaphyseal cupping of metacarpals, Metaphyseal irregularity, ... OMIM:250460
Ghosal Hematodiaphyseal Dysplasia
Abnormality of femur morphology, Diaphyseal thickening, Bowing of the long bones, Abnormality of ... ORPHA:1802
Renal Glucosuria
Polyphagia, Polydipsia OMIM:233100
Schaaf-Yang Syndrome
Failure to thrive in infancy, Rocker bottom foot, Tapered finger, Polyphagia, Small hand, Arthrog... OMIM:615547
Type 1 Diabetes Mellitus
Polyphagia, Polydipsia OMIM:222100
Temple Syndrome
Small for gestational age, Polyphagia, Small hand, Short foot, Obesity, Clinodactyly of the 5th f... ORPHA:254516
Hypotonia-Cystinuria Syndrome
Failure to thrive, Polyphagia ORPHA:163690
Obesity Due To Sim1 Deficiency
Obesity, Polyphagia ORPHA:369873
Obesity, Early-Onset, With Adrenal Insufficiency And Red Hair
Obesity, Polyphagia OMIM:609734
Leptin Receptor Deficiency
Obesity, Abnormal eating behavior, Polyphagia OMIM:614963
Larsen-Like Osseous Dysplasia-Short Stature Syndrome
Abnormality of the metaphysis, Brachydactyly, Hip dysplasia, Abnormality of pelvic girdle bone mo... ORPHA:2370
6Q16 Microdeletion Syndrome
Obesity, Polyphagia, Tapered finger ORPHA:171829
Ankylosing Vertebral Hyperostosis With Tylosis
Abnormal pelvis bone morphology, Obesity ORPHA:2206
Pick Disease Of Brain
Polyphagia OMIM:172700
2Q23.1 Microdeletion Syndrome
Polyphagia, Sandal gap, Hip dysplasia, Short palm, Clinodactyly of the 5th finger ORPHA:228402
Frontotemporal Dementia
Polyphagia OMIM:600274
Polyneuropathy-Intellectual Disability-Acromicria-Premature Menopause Syndrome
Ulnar deviation of finger, Truncal obesity, Camptodactyly of finger, Abnormality of pelvic girdle... ORPHA:2928
Eye Defects-Arachnodactyly-Cardiopathy Syndrome
Bowing of the long bones, Arachnodactyly, Sandal gap, Abnormality of pelvic girdle bone morpholog... ORPHA:2725
Fibular Aplasia-Complex Brachydactyly Syndrome
Tarsal synostosis, Abnormality of tibia morphology, Abnormality of the ulna, Abnormality of epiph... ORPHA:2639
Graves Disease, Susceptibility To, 1
Weight loss, Polyphagia OMIM:275000
Angelman Syndrome Due To Imprinting Defect In 15Q11-Q13
Obesity, Polyphagia ORPHA:411515
Weismann-Netter Syndrome
Abnormality of tibia morphology, Abnormality of the ulna, Tibial bowing, Fibular bowing, Abnormal... ORPHA:3344
Huntington Disease
Polyphagia, Decreased body mass index, Weight loss, Choking episodes, Oral-pharyngeal dysphagia ORPHA:399
Hypochondroplasia
Genu varum, Abnormality of femur morphology, Bowing of the long bones, Abnormality of the metaphy... ORPHA:429
Hyperinsulinism Due To Hnf1A Deficiency
Polyphagia, Small for gestational age, Large for gestational age ORPHA:324575
Hyperinsulinism Due To Ucp2 Deficiency
Polyphagia, Large for gestational age ORPHA:276556
Léri-Weill Dyschondrosteosis
Abnormality of the ulna, Genu varum, Dorsal subluxation of ulna, Hypoplasia of the radius, Abnorm... ORPHA:240
Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency
Polyphagia, Large for gestational age ORPHA:276575
Acromesomelic Dysplasia, Hunter-Thompson Type
Tarsal synostosis, Abnormally shaped carpal bones, Cuboidal metacarpal, Hip dislocation, Short me... ORPHA:968
Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency
Polyphagia, Large for gestational age ORPHA:276580
Cebalid Syndrome
Congenital diaphragmatic hernia, Polyphagia OMIM:618774
Man1B1-Cdg
Clinodactyly of the 5th finger, 2-3 toe syndactyly, Polyphagia, Truncal obesity ORPHA:397941
Jeune Syndrome
Toe syndactyly, Cone-shaped epiphysis, Abnormality of the metaphysis, Short foot, Postaxial foot ... ORPHA:474
Endosteal Hyperostosis, Autosomal Dominant
Metatarsal diaphyseal endosteal sclerosis, Abnormality of pelvic girdle bone morphology, Thickene... OMIM:144750
Hypotonia-Cystinuria Syndrome
Failure to thrive, Polyphagia OMIM:606407
Coxoauricular Syndrome
Abnormality of pelvic girdle bone morphology, Hip dislocation, Abnormality of femur morphology ORPHA:1508
Trisomy 18P
Polyphagia, Abnormality of finger ORPHA:1715
Thin Ribs-Tubular Bones-Dysmorphism Syndrome
Abnormality of pelvic girdle bone morphology, Slender long bone ORPHA:1506
Thoracomelic Dysplasia
Diaphyseal thickening, Abnormality of the metaphysis, Genu valgum, Abnormality of fibula morpholo... ORPHA:1803
Atelosteogenesis, Type Ii
Short middle phalanx of finger, Short greater sciatic notch, Bifid humerus, Hitchhiker thumb, San... OMIM:256050
Chromosome 22Q13 Duplication Syndrome
Polyphagia OMIM:615538
Luscan-Lumish Syndrome
Obesity, Advanced ossification of carpal bones, Polyphagia OMIM:616831
Prader-Willi Syndrome
Failure to thrive in infancy, Polyphagia, Small hand, Acromicria, Genu valgum, Radial deviation o... OMIM:176270
Satb2-Associated Syndrome Due To A Chromosomal Rearrangement
Tibial bowing, Polyphagia, Prominent calcaneus, Small hand, Slender finger, Short foot, Broad hal... ORPHA:251028
Moebius Syndrome
Dysphagia, Lower limb undergrowth, Arthrogryposis multiplex congenita, Aplasia/Hypoplasia involvi... OMIM:157900
Intellectual Developmental Disorder, Autosomal Dominant 1
Short foot, Small hand, Polyphagia, Sandal gap OMIM:156200
Rhizomelic Chondrodysplasia Punctata, Type 2
Failure to thrive, Stippled calcification proximal humeral epiphyses, Flexion contracture, Short ... OMIM:222765
Insulinoma
Polyphagia, Increased body weight ORPHA:97279
Femoral-Facial Syndrome
Coxa vara, Hip dysplasia, Abnormality of fibula morphology, Abnormality of pelvic girdle bone mor... ORPHA:1988
Sim1-Related Prader-Willi-Like Syndrome
Polyphagia, Failure to thrive, Small hand, Short foot, Hip dysplasia, Abdominal obesity, Obesity ORPHA:398079
Pycnodysostosis
Abnormality of pelvic girdle bone morphology, Osteolytic defects of the distal phalanges of the h... OMIM:265800
Hypophosphatemic Rickets, X-Linked Dominant
Tibial bowing, Fibular bowing, Bowing of the legs, Enamel hypomineralization, Metaphyseal irregul... OMIM:307800
Obesity Due To Congenital Leptin Deficiency
Obesity, Polyphagia ORPHA:66628
Obesity Due To Leptin Receptor Gene Deficiency
Obesity, Polyphagia ORPHA:179494
Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15
Small for gestational age, Polyphagia, Failure to thrive, Bulimia, Small hand, Short foot, Hip dy... ORPHA:98754
Magel2-Related Prader-Willi-Like Syndrome
Polyphagia, Failure to thrive, Small hand, Short foot, Hip dysplasia, Abdominal obesity, Flexion ... ORPHA:398069
Pediatric-Onset Graves Disease
Failure to thrive, Polydipsia, Polyphagia ORPHA:525731
Prader-Willi Syndrome Due To Paternal 15Q11Q13 Deletion
Small for gestational age, Polyphagia, Failure to thrive, Bulimia, Small hand, Short foot, Hip dy... ORPHA:98793
Secondary Short Bowel Syndrome
Failure to thrive, Weight loss, Polyphagia ORPHA:95427
Prader-Willi Syndrome Due To Paternal Deletion Of 15Q11Q13 Type 2
Small for gestational age, Polyphagia, Failure to thrive, Bulimia, Small hand, Short foot, Hip dy... ORPHA:177904
Prader-Willi Syndrome Due To Paternal Deletion Of 15Q11Q13 Type 1
Small for gestational age, Polyphagia, Failure to thrive, Bulimia, Small hand, Short foot, Hip dy... ORPHA:177901
Osteogenesis Imperfecta, Type V
Abnormality of pelvic girdle bone morphology, Anterior radial head dislocation, Dentinogenesis im... OMIM:610967
Paternal Uniparental Disomy Of Chromosome 1
Obesity, Abnormal dental enamel morphology, Polyphagia ORPHA:251004
Adnp Syndrome
2-3 toe syndactyly, Polydactyly, Polyphagia, Abnormality of toe, Inguinal hernia, Abnormality of ... ORPHA:404448
Pseudohypoparathyroidism Type 1C
Short 3rd metacarpal, Short 5th metacarpal, Polyphagia, Short metatarsal, Short fifth metatarsal,... ORPHA:79444
Verloove Vanhorick-Brubakk Syndrome
Tarsal synostosis, Abnormality of femur morphology, Finger syndactyly, Abnormality of pelvic gird... ORPHA:3429
Prader-Willi-Like Syndrome
Small for gestational age, Polyphagia, Failure to thrive, Bulimia, Small hand, Short foot, Hip dy... ORPHA:398073
Aredyld Syndrome
Cachexia, Abnormal dental enamel morphology, Lipoatrophy, Abnormality of pelvic girdle bone morph... ORPHA:1133
Osteopetrosis, Autosomal Dominant 1
Abnormality of pelvic girdle bone morphology, Thickened cortex of long bones OMIM:607634
Craniometaphyseal Dysplasia, Autosomal Dominant
Metaphyseal widening, Abnormality of pelvic girdle bone morphology, Club-shaped distal femur, Erl... OMIM:123000
Grant Syndrome
Abnormality of the glenoid fossa, Abnormality of pelvic girdle bone morphology, Bowing of the lon... ORPHA:2097
Chromosome Xq26.3 Duplication Syndrome
Polyphagia OMIM:300942
Prader-Willi Syndrome
Polyphagia, Failure to thrive, Small hand, Short foot, Hip dysplasia, Abdominal obesity ORPHA:739
Codas Syndrome
Abnormality of epiphysis morphology, Abnormal dental enamel morphology, Congenital hip dislocatio... ORPHA:1458
Pseudohypoparathyroidism Type 1A
Short 3rd metacarpal, Short 5th metacarpal, Polyphagia, Short metatarsal, Short fifth metatarsal,... ORPHA:79443
Lipodystrophy, Congenital Generalized, Type 1
Polyphagia, Reduced intrathoracic adipose tissue, Lipodystrophy, Reduced subcutaneous adipose tis... OMIM:608594
Angelman Syndrome
Obesity, Dysphagia, Polyphagia ORPHA:72
Lipodystrophy, Congenital Generalized, Type 2
Polyphagia, Reduced intrathoracic adipose tissue, Lipodystrophy, Reduced subcutaneous adipose tis... OMIM:269700
Osteogenesis Imperfecta, Type Ii
Tibial bowing, Broad long bones, Small for gestational age, Crumpled long bones, Abnormality of p... OMIM:166210
7Q11.23 Microduplication Syndrome
Polyphagia, Long fingers, Congenital diaphragmatic hernia, Obesity, Inguinal hernia ORPHA:96121
Acrofacial Dysostosis, Rodríguez Type
Hand oligodactyly, Aplasia/Hypoplasia of the radius, Fibular hypoplasia, Finger syndactyly, Aplas... ORPHA:1788
Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-Related
Polyphagia OMIM:607485
Gangliocytoma
Polyphagia ORPHA:251937
Osteopetrosis, Autosomal Dominant 2
Fractures of the long bones, Abnormality of pelvic girdle bone morphology OMIM:166600
Cleidocranial Dysplasia
Short clavicles, Hypoplastic scapulae, Tapered finger, Abnormality of epiphysis morphology, Hypop... ORPHA:1452
Chondrodysplasia-Disorder Of Sex Development Syndrome
Broad long bones, Short metacarpal, Abnormality of pelvic girdle bone morphology, Short phalanx o... ORPHA:1422
Harrod Syndrome
Failure to thrive, Abnormality of pelvic girdle bone morphology, Arachnodactyly, Abnormal shoulde... ORPHA:2115
Paget Disease Of Bone 2, Early-Onset
Fractures of the long bones, Bowing of the long bones, Abnormality of pelvic girdle bone morphology OMIM:602080
1P36 Deletion Syndrome
Dysphagia, Polyphagia, Failure to thrive, Foot polydactyly, Short foot, Hip dysplasia, Camptodact... ORPHA:1606
Meier-Gorlin Syndrome 1
Cutaneous finger syndactyly, Absent glenoid fossa, Genu varum, Aplasia/Hypoplasia of the patella,... OMIM:224690
Isolated Epispadias
Abnormality of pelvic girdle bone morphology ORPHA:93928
Craniopharyngioma
Obesity, Polyphagia ORPHA:54595
X-Linked Acrogigantism
Polyphagia ORPHA:300373
Bladder Exstrophy And Epispadias Complex
Abnormality of pelvic girdle bone morphology, Inguinal hernia OMIM:600057
Camurati-Engelmann Disease
Cortical thickening of long bone diaphyses, Abnormal diaphysis morphology, Abnormality of the uln... ORPHA:1328
Chondrodysplasia Punctata 2, X-Linked Dominant
Tarsal stippling, Polydactyly, Postaxial polydactyly, Epiphyseal stippling, Failure to thrive, St... OMIM:302960
Spastic Paraplegia 9A, Autosomal Dominant
Abnormality of pelvic girdle bone morphology, Hiatus hernia, Carpal bone hypoplasia OMIM:601162
Cartilage-Hair Hypoplasia
Metaphyseal dysplasia, Metaphyseal widening, Short palm, Femoral bowing, Abnormality of pelvic gi... OMIM:250250
Intellectual Disability, Buenos-Aires Type
Abnormality of pelvic girdle bone morphology, Clinodactyly of the 5th finger, Umbilical hernia ORPHA:3079
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Obesity, Polydipsia, Polyphagia, Brachydactyly ORPHA:293987
Cartilage-Hair Hypoplasia
Metaphyseal dysplasia, Diaphyseal thickening, Tibial bowing, Abnormality of epiphysis morphology,... ORPHA:175
Aphalangy-Hemivertebrae-Urogenital-Intestinal Dysgenesis Syndrome
Toe syndactyly, Aplasia/Hypoplasia of the phalanges of the toes, Aplasia/Hypoplasia of the phalan... ORPHA:1112
Chromosome 1P36 Deletion Syndrome, Distal
Metatarsus adductus, Dysphagia, Polyphagia, Short 5th finger, Short foot, Hip dysplasia, Camptoda... OMIM:607872
Sclerosteosis 1
Deviation of finger, Abnormality of pelvic girdle bone morphology, 2-3 finger syndactyly, Cortica... OMIM:269500
Early-Onset Schizophrenia
Polyphagia ORPHA:96369
Spondylocarpotarsal Synostosis Syndrome
Tarsal synostosis, Capitate-hamate fusion, Epiphyseal dysplasia, Coxa vara, Carpal synostosis, Sh... OMIM:272460
Ellis Van Creveld Syndrome
Capitate-hamate fusion, Failure to thrive, Synostosis of carpal bones, Genu valgum, Foot polydact... ORPHA:289
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due To Adenosine Deaminase Deficiency
Failure to thrive, Abnormality of pelvic girdle bone morphology, Growth arrest lines OMIM:102700
Fetal Akinesia Deformation Sequence 1
Rocker bottom foot, Small for gestational age, Arthrogryposis multiplex congenita, Slender long b... OMIM:208150
Saethre-Chotzen Syndrome
Absent first metatarsal, Toe syndactyly, Hallux valgus, Partial duplication of the distal phalanx... OMIM:101400
Alström Syndrome
Polyphagia, Short finger, Dorsocervical fat pad, Truncal obesity, Short toe, Obesity ORPHA:64

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cd300lg

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cd300lg.

There are 4 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Cd300lgtm1a(KOMP)Wtsi PMC7263671
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Cd300lgtm1a(KOMP)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Cd300lgtm1a(KOMP)Wtsi PMC6459510
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Cd300lgtm1a(KOMP)Wtsi