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Gene: Cd300lg MGI:1289168

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Gene Summary

Name:
CD300 molecule like family member G
Synonyms:
2310016B05Rik,  Clm9,  D11Ertd736e,  nepmucin

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased food intake Cd300lgtm1a(KOMP)Wtsi HOM Early adult 6.01×10-05
decreased total body fat amount Cd300lgtm1a(KOMP)Wtsi HOM Early adult 4.15×10-05
increased lean body mass Cd300lgtm1a(KOMP)Wtsi HOM Early adult 4.97×10-05
abnormal pelvic girdle bone morphology Cd300lgtm1a(KOMP)Wtsi HOM Early adult 8.75×10-05
increased bone mineral content Cd300lgtm1a(KOMP)Wtsi HOM Early adult 1.39×10-05

Download data as:  TSV  XLS

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Forepaw

16 Images

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X-ray

XRay Images Skull Lateral Orientation

13 Images

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X-ray

XRay Images Whole Body Dorso Ventral

14 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

14 Images

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DSS Histology

Images

8 Images

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X-ray

XRay Images Whole Body Lateral Orientation

13 Images

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Legacy Phenotype Associated Images
Cd300lgtm1a(KOMP)Wtsi
HOM, Male, WTSI
Cd300lgtm1a(KOMP)Wtsi
HOM, Male, WTSI
Cd300lgtm1a(KOMP)Wtsi
HOM, Female, WTSI
Cd300lgtm1a(KOMP)Wtsi
HOM, Female, WTSI
Cd300lgtm1a(KOMP)Wtsi
HOM, Male, WTSI

View all 70 images

Cd300lgtm1a(KOMP)Wtsi
left eye, HOM, Male, WTSI

Human diseases caused by Cd300lg mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Cd300lg by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Osteopathia Striata-Pigmentary Dermopathy-White Forelock Syndrome
Osteopathia striata, Abnormal pelvic girdle bone morphology, Abnormal diaphysis morphology, Abnor... ORPHA:2779
Osteodysplasty, Precocious, Of Danks, Mayne, And Kozlowski
Abnormal long bone morphology, Short toe, Short finger, Abnormal pelvic girdle bone morphology OMIM:259270
Body Mass Index Quantitative Trait Locus 20
Increased bone mineral density, Polyphagia, Obesity OMIM:618406
Ghosal Hematodiaphyseal Dysplasia
Craniofacial hyperostosis, Bowing of the long bones, Abnormal tibia morphology, Abnormal femur mo... ORPHA:1802
Obesity Due To Melanocortin 4 Receptor Deficiency
Polyphagia, Obesity, Childhood-onset truncal obesity, Increased adipose tissue ORPHA:71529
Bardet-Biedl Syndrome 22
Large for gestational age, Obesity, Postaxial foot polydactyly, Polydactyly, Polyphagia OMIM:617119
Obesity, Hyperphagia, And Developmental Delay
Abnormal repetitive mannerisms, Polyphagia, Obesity OMIM:613886
Coxopodopatellar Syndrome
Abnormal epiphysis morphology, Abnormal pelvic girdle bone morphology, Hip dysplasia, Aplasia/Hyp... ORPHA:1509
Metaphyseal Dysplasia Without Hypotrichosis
Metaphyseal dysplasia, Short metacarpal, Cone-shaped epiphyses of the phalanges of the hand, Meta... OMIM:250460
Kleine-Levin Hibernation Syndrome
Polyphagia OMIM:148840
Pick Disease Of Brain
Abnormal repetitive mannerisms, Polyphagia, Inappropriate laughter, Disinhibition OMIM:172700
Prader-Willi Syndrome Due To Imprinting Mutation
Small hand, Obesity, Short foot, Abnormal ulnar metaphysis morphology, Polyphagia ORPHA:177910
Severe Early-Onset Obesity-Insulin Resistance Syndrome Due To Sh2B1 Deficiency
Polyphagia, Obesity, Aggressive behavior ORPHA:329249
Obesity Due To Prohormone Convertase I Deficiency
Increased adipose tissue, Obesity, Failure to thrive, Polyphagia, Childhood-onset truncal obesity ORPHA:71528
Obesity Due To Pro-Opiomelanocortin Deficiency
Increased adipose tissue, Obesity, Failure to thrive, Polyphagia, Childhood-onset truncal obesity ORPHA:71526
Obesity And Hypopigmentation
Polyphagia, Obesity OMIM:620195
Bardet-Biedl Syndrome 9
Syndactyly, Postaxial polydactyly, Postaxial hand polydactyly, Obesity, Postaxial foot polydactyl... OMIM:615986
2Q23.1 Microdeletion Syndrome
Hyperactivity, Sandal gap, Abnormal repetitive mannerisms, Self-injurious behavior, Hip dysplasia... ORPHA:228402
Intellectual Developmental Disorder, Autosomal Dominant 39
Obesity, Polyphagia, Self-mutilation, Aggressive behavior OMIM:616521
Schaaf-Yang Syndrome
Failure to thrive in infancy, Rocker bottom foot, Impulsivity, Tapered finger, Flexion contractur... OMIM:615547
Larsen-Like Osseous Dysplasia-Short Stature Syndrome
Reduced bone mineral density, Abnormal pelvic girdle bone morphology, Hip dysplasia, Abnormal met... ORPHA:2370
Isolated Osteopoikilosis
Syndactyly, Abnormally ossified vertebrae, Increased bone mineral density, Abnormal pelvis bone m... ORPHA:166119
Frontotemporal Dementia
Polyphagia, Disinhibition, Inappropriate laughter OMIM:600274
Endosteal Hyperostosis, Autosomal Dominant
Hyperostosis, Abnormal pelvic girdle bone morphology, Metacarpal diaphyseal endosteal sclerosis, ... OMIM:144750
Leptin Deficiency Or Dysfunction
Polyphagia, Obesity OMIM:614962
Hypermetabolism Due To Uncoupled Mitochondrial Oxidative Phosphorylation 2
Failure to thrive, Polyphagia, Decreased body weight OMIM:620085
Leptin Receptor Deficiency
Abnormal eating behavior, Polyphagia, Obesity, Aggressive behavior OMIM:614963
14Q11.2 Microduplication Syndrome
Polyphagia, Obesity, Attention deficit hyperactivity disorder, Aggressive behavior ORPHA:261229
Renal Glucosuria
Polydipsia, Polyphagia OMIM:233100
Huntington Disease
Aggressive behavior, Oral-pharyngeal dysphagia, Weight loss, Addictive alcohol use, Agitation, Co... ORPHA:399
Temple Syndrome
Small for gestational age, Small hand, Obesity, Short foot, Clinodactyly of the 5th finger, Polyp... ORPHA:254516
Kleine-Levin Syndrome
Abnormal eating behavior, Repetitive compulsive behavior, Sweet craving, Hypersexuality, Agitatio... ORPHA:33543
6Q16 Microdeletion Syndrome
Polyphagia, Obesity, Abnormal temper tantrums, Tapered finger ORPHA:171829
Type 1 Diabetes Mellitus
Polydipsia, Polyphagia OMIM:222100
Hypotonia-Cystinuria Syndrome
Failure to thrive, Polyphagia ORPHA:163690
Obesity Due To Sim1 Deficiency
Polyphagia, Obesity, Attention deficit hyperactivity disorder ORPHA:369873
Angelman Syndrome Due To Imprinting Defect In 15Q11-Q13
Hyperactivity, Polyphagia, Inappropriate laughter, Obesity ORPHA:411515
Weismann-Netter Syndrome
Bowing of the long bones, Abnormal morphology of ulna, Abnormality of the humerus, Abnormal tibia... ORPHA:3344
Coxoauricular Syndrome
Abnormal pelvic girdle bone morphology, Hip dislocation, Abnormal femur morphology, Reduced bone ... ORPHA:1508
Osteopetrosis, Autosomal Dominant 1
Generalized osteosclerosis, Abnormal pelvic girdle bone morphology, Osteopetrosis, Calvarial oste... OMIM:607634
Graves Disease, Susceptibility To, 1
Hyperactivity, Polyphagia, Weight loss OMIM:275000
Hyperinsulinism Due To Ucp2 Deficiency
Agitation, Polyphagia, Large for gestational age ORPHA:276556
Hyperinsulinism Due To Hnf1A Deficiency
Small for gestational age, Agitation, Polyphagia, Large for gestational age ORPHA:324575
Body Mass Index Quantitative Trait Locus 19
Polyphagia, Obesity OMIM:617885
Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency
Agitation, Polyphagia, Large for gestational age ORPHA:276575
Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency
Agitation, Polyphagia, Large for gestational age ORPHA:276580
Polyneuropathy-Intellectual Disability-Acromicria-Premature Menopause Syndrome
Camptodactyly of finger, Ulnar deviation of finger, Truncal obesity, Abnormal pelvic girdle bone ... ORPHA:2928
Craniometaphyseal Dysplasia, Autosomal Dominant
Metaphyseal widening, Cranial hyperostosis, Flared metaphysis, Sclerosis of skull base, Abnormal ... OMIM:123000
Luscan-Lumish Syndrome
Obesity, Polyphagia, Advanced ossification of carpal bones, Aggressive behavior OMIM:616831
Man1B1-Cdg
Clinodactyly of the 5th finger, Truncal obesity, Polyphagia, 2-3 toe syndactyly ORPHA:397941
Cebalid Syndrome
Polyphagia, Congenital diaphragmatic hernia OMIM:618774
Satb2-Associated Syndrome Due To A Chromosomal Rearrangement
Osteopenia, Restlessness, Broad hallux, Aggressive behavior, Slender finger, Small hand, Tibial b... ORPHA:251028
Weaver Syndrome
Inguinal hernia, Short fourth metatarsal, Toe clinodactyly, Overlapping toe, Coxa valga, Hypoplas... OMIM:277590
Hypochondroplasia
Bowing of the long bones, Brachydactyly, Short toe, Abnormal femur morphology, Abnormal pelvic gi... ORPHA:429
Sim1-Related Prader-Willi-Like Syndrome
Osteopenia, Osteoporosis, Small hand, Obesity, Short foot, Hip dysplasia, Abdominal obesity, Skin... ORPHA:398079
Prader-Willi Syndrome Due To Paternal 15Q11Q13 Deletion
Osteopenia, Failure to thrive, Small for gestational age, Bulimia, Osteoporosis, Small hand, Obes... ORPHA:98793
Trisomy 18P
Abnormal finger morphology, Polyphagia, Attention deficit hyperactivity disorder ORPHA:1715
Prader-Willi Syndrome Due To Paternal Deletion Of 15Q11Q13 Type 2
Osteopenia, Failure to thrive, Small for gestational age, Bulimia, Osteoporosis, Small hand, Obes... ORPHA:177904
Magel2-Related Prader-Willi-Like Syndrome
Osteopenia, Impulsivity, Flexion contracture, Osteoporosis, Small hand, Increased body weight, Sh... ORPHA:398069
Léri-Weill Dyschondrosteosis
Abnormal tibia morphology, Abnormal carpal morphology, Abnormal femur morphology, Tibial bowing, ... ORPHA:240
Prader-Willi Syndrome Due To Paternal Deletion Of 15Q11Q13 Type 1
Osteopenia, Failure to thrive, Small for gestational age, Bulimia, Osteoporosis, Small hand, Obes... ORPHA:177901
Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15
Osteopenia, Small for gestational age, Bulimia, Osteoporosis, Small hand, Obesity, Short foot, Se... ORPHA:98754
Intellectual Developmental Disorder, Autosomal Dominant 1
Short palm, Sandal gap, Aggressive behavior, Short foot, Self-injurious behavior, Hip dysplasia, ... OMIM:156200
Prader-Willi Syndrome
Osteopenia, Syndactyly, Failure to thrive in infancy, Acromicria, Osteoporosis, Small hand, Obesi... OMIM:176270
Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-Related
Repetitive compulsive behavior, Hypersexuality, Agitation, Disinhibition, Polyphagia OMIM:607485
Chromosome 22Q13 Duplication Syndrome
Attention deficit hyperactivity disorder, Polyphagia, Impulsivity OMIM:615538
Hypophosphatemic Rickets, X-Linked Dominant
Shortening of the talar neck, Osteomalacia, Bowing of the legs, Enamel hypomineralization, Ricket... OMIM:307800
Acromesomelic Dysplasia, Hunter-Thompson Type
Short metacarpal, Brachydactyly, Tarsal synostosis, Cuboidal metacarpal, Short thumb, Hip disloca... ORPHA:968
Osteogenesis Imperfecta, Type V
Osteopenia, Hyperextensibility of the finger joints, Abnormal pelvic girdle bone morphology, Ante... OMIM:610967
Hypotonia-Cystinuria Syndrome
Failure to thrive, Polyphagia OMIM:606407
Jeune Syndrome
Toe syndactyly, Postaxial hand polydactyly, Postaxial foot polydactyly, Cone-shaped epiphysis, Ab... ORPHA:474
Osteopetrosis, Autosomal Dominant 2
Generalized osteosclerosis, Abnormal pelvic girdle bone morphology, Fractures of the long bones, ... OMIM:166600
Grant Syndrome
Bowing of the long bones, Decreased skull ossification, Abnormal pelvic girdle bone morphology, A... ORPHA:2097
Adnp Syndrome
Inguinal hernia, Broad hallux, Sandal gap, Aggressive behavior, Oral-pharyngeal dysphagia, Abnorm... ORPHA:404448
Angelman Syndrome
Hyperactivity, Aggressive behavior, Tongue thrusting, Obesity, Self-injurious behavior, Inappropr... ORPHA:72
Pediatric-Onset Graves Disease
Hyperactivity, Craniosynostosis, Polydipsia, Failure to thrive, Polyphagia ORPHA:525731
Wagro Syndrome
Aggressive behavior, Obesity, Agitation, Compulsive behaviors, Polyphagia OMIM:612469
Pseudohypoparathyroidism Type 1C
Increased bone mineral density, Short metacarpal, Short fifth metatarsal, Short metatarsal, Obesi... ORPHA:79444
Obesity, Early-Onset, With Adrenal Insufficiency And Red Hair
Polyphagia, Obesity OMIM:609734
Thin Ribs-Tubular Bones-Dysmorphism Syndrome
Slender long bone, Abnormal pelvic girdle bone morphology ORPHA:1506
Moebius Syndrome
Syndactyly, Brachydactyly, Split hand, Abnormal pelvic girdle bone morphology, Lower limb undergr... OMIM:157900
Atelosteogenesis, Type Ii
Sandal gap, Bifid humerus, Flat acetabular roof, Short greater sciatic notch, Abnormal pelvic gir... OMIM:256050
Thoracomelic Dysplasia
Abnormal fibula morphology, Genu valgum, Abnormal pelvic girdle bone morphology, Abnormal metaphy... ORPHA:1803
Paternal Uniparental Disomy Of Chromosome 1
Polyphagia, Abnormal dental enamel morphology, Craniosynostosis, Obesity ORPHA:251004
Pseudohypoparathyroidism Type 1A
Increased bone mineral density, Short metacarpal, Short fifth metatarsal, Broad 1st metacarpal, S... ORPHA:79443
Insulinoma
Polyphagia, Increased body weight ORPHA:97279
Aredyld Syndrome
Craniofacial hyperostosis, Lipoatrophy, Abnormal dental enamel morphology, Cachexia, Abnormal pel... ORPHA:1133
Obesity Due To Congenital Leptin Deficiency
Polyphagia, Obesity ORPHA:66628
Prader-Willi Syndrome
Osteopenia, Osteoporosis, Small hand, Short foot, Hip dysplasia, Abdominal obesity, Attention def... ORPHA:739
Obesity Due To Leptin Receptor Gene Deficiency
Polyphagia, Obesity ORPHA:179494
Secondary Short Bowel Syndrome
Failure to thrive, Polyphagia, Weight loss ORPHA:95427
7Q11.23 Microduplication Syndrome
Inguinal hernia, Collectionism, Hyperactivity, Congenital diaphragmatic hernia, Aggressive behavi... ORPHA:96121
Lipodystrophy, Congenital Generalized, Type 1
Reduced subcutaneous adipose tissue, Cystic angiomatosis of bone, Lipodystrophy, Reduced intraabd... OMIM:608594
Rhizomelic Chondrodysplasia Punctata, Type 2
Osteopenia, Short humerus, Inguinal hernia, Flexion contracture, Epiphyseal stippling, Abnormal p... OMIM:222765
Helsmoortel-Van Der Aa Syndrome
Prominent fingertip pads, Hyperactivity, Sandal gap, Broad hallux, Tapered finger, Abnormal repet... OMIM:615873
Osteogenesis Imperfecta, Type Ii
Crumpled long bones, Broad long bones, Small for gestational age, Absent ossification of calvaria... OMIM:166210
Lipodystrophy, Congenital Generalized, Type 2
Reduced subcutaneous adipose tissue, Cystic angiomatosis of bone, Lipodystrophy, Reduced intraabd... OMIM:269700
Cleidocranial Dysplasia
Hypoplastic scapulae, Abnormal dental enamel morphology, Down-sloping shoulders, Tapered finger, ... ORPHA:1452
Chromosome Xq26.3 Duplication Syndrome
Polyphagia OMIM:300942
Camurati-Engelmann Disease
Abnormal morphology of the radius, Metaphyseal dysplasia, Abnormal morphology of ulna, Anorexia, ... ORPHA:1328
Chondrodysplasia-Difference Of Sex Development Syndrome
Short metacarpal, Broad long bones, Increased skull ossification, Abnormal shoulder morphology, A... ORPHA:1422
Verloove Vanhorick-Brubakk Syndrome
Finger syndactyly, Tarsal synostosis, Abnormal femur morphology, Abnormal pelvic girdle bone morp... ORPHA:3429
Acrofacial Dysostosis, Rodríguez Type
Finger syndactyly, Hand oligodactyly, Fibular hypoplasia, Radioulnar synostosis, Abnormal pelvic ... ORPHA:1788
Gangliocytoma
Polyphagia ORPHA:251937
Intellectual Developmental Disorder, Autosomal Dominant 71, With Behavioral Abnormalities
Nail-biting, Sandal gap, Aggressive behavior, Hair-pulling, Long fingers, Polyphagia, Cutaneous s... OMIM:620330
1P36 Deletion Syndrome
Camptodactyly of finger, Abnormal repetitive mannerisms, Obesity, Short foot, Self-injurious beha... ORPHA:1606
Chromosome 1P36 Deletion Syndrome, Distal
Camptodactyly of finger, Aggressive behavior, Metatarsus adductus, Obesity, Dysphagia, Short foot... OMIM:607872
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Aggressive behavior, Obesity, Self-injurious behavior, Compulsive behaviors, Polydipsia, Polyphag... ORPHA:293987
Craniopharyngioma
Polyphagia, Obesity ORPHA:54595
X-Linked Acrogigantism
Polyphagia ORPHA:300373
Isolated Epispadias
Abnormal pelvic girdle bone morphology ORPHA:93928
Bladder Exstrophy And Epispadias Complex
Abnormal pelvic girdle bone morphology, Inguinal hernia OMIM:600057
Aphalangy-Hemivertebrae-Urogenital-Intestinal Dysgenesis Syndrome
Finger syndactyly, Toe syndactyly, Aplasia/Hypoplasia of the phalanges of the hand, Aplasia/Hypop... ORPHA:1112
Alström Syndrome
Dorsocervical fat pad, Short toe, Obesity, Truncal obesity, Hyperostosis frontalis interna, Short... ORPHA:64

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cd300lg

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cd300lg.

There are 4 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Cd300lgtm1a(KOMP)Wtsi PMC7263671
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Cd300lgtm1a(KOMP)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Cd300lgtm1a(KOMP)Wtsi PMC6459510
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Cd300lgtm1a(KOMP)Wtsi PMC5827107

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Cd300lgtm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Cd300lgtm356589(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Cd300lgtm41201(L1L2_st1) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Cd300lgtm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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