Trmt1 | tRNA methyltransferase 1
Physiological systems
21 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Vision/eye Liver/biliary system Hematopoietic system Cardiovascular system Mortality/aging Renal/urinary system
14 No significant impact
3 Not tested
Data collections
Gene metrics:8Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| prolonged QRS complex duration | 1 supporting dataset | Trmt1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 2.91x10-6 | ||
| increased mean corpuscular volume | 1 supporting dataset | Trmt1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 2.29x10-5 | ||
| abnormal kidney morphology | 1 supporting dataset | Trmt1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | N/A * | ||
| decreased circulating cholesterol level | 1 supporting dataset | Trmt1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 9x10-6 | ||
| abnormal liver morphology | 1 supporting dataset | Trmt1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | N/A * | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Trmt1tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| abnormal retina vasculature morphology | 1 supporting dataset | Trmt1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 8.47x10-8 | ||
| abnormal retina blood vessel morphology | 1 supporting dataset | Trmt1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 2.54x10-7 |
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External links
No external links available for Trmt1.
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| Trmt1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Trmt1tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Trmt1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |