Adgrv1 | adhesion G protein-coupled receptor V1
Physiological systems
21 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Reproductive system Endocrine/exocrine gland Limbs/digits/tail Nervous system Hearing/vestibular/ear Behavior/neurological Skeleton
14 No significant impact
3 Not tested
Data collections
Gene metrics:8Significant phenotypes
4Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| abnormal startle reflex | 1 supporting dataset | Adgrv1tm1.1(KOMP)Vlcg | homozygote | Early adult | 1.07x10-8 | ||
| decreased prepulse inhibition | 4 supporting datasets | Adgrv1tm1.1(KOMP)Vlcg | homozygote | Early adult | 9.19x10-21 | ||
| abnormal auditory brainstem response | 6 supporting datasets | Adgrv1tm1.1(KOMP)Vlcg | homozygote | Early adult | 2.22x10-6 | ||
| abnormal testis morphology | 1 supporting dataset | Adgrv1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| short tibia | 1 supporting dataset | Adgrv1tm1.1(KOMP)Vlcg | homozygote | Early adult | 6.65x10-5 | ||
| small testis | 1 supporting dataset | Adgrv1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| decreased startle reflex | 1 supporting dataset | Adgrv1tm1.1(KOMP)Vlcg | homozygote | Early adult | 7.01x10-5 | ||
| hyperactivity | 1 supporting dataset | Adgrv1tm1.1(KOMP)Vlcg | homozygote | Early adult | 6.2x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
Human diseases caused by Adgrv1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Adgrv1.
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