Gene: Axin2

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Phenotype System Allele Zyg Sex Life Stage P Value
abnormal embryo development Axin2tm1b(KOMP)Wtsi HOM embryonic day 18.5 0.00
abnormal embryo size Axin2tm1b(KOMP)Wtsi HET embryonic day 18.5 0.00
abnormal head shape Axin2tm1b(KOMP)Wtsi HET embryonic day 18.5 0.00
abnormal limb morphology Axin2tm1b(KOMP)Wtsi HOM embryonic day 18.5 0.00
microphthalmia Axin2tm1b(KOMP)Wtsi HET embryonic day 18.5 0.00
abnormal skin coloration Axin2tm1b(KOMP)Wtsi HET postnatal 5.56×10-06
persistence of hyaloid vascular system Axin2tm1b(KOMP)Wtsi HET postnatal 6.17×10-05
abnormal retinal blood vessel morphology Axin2tm1b(KOMP)Wtsi HET postnatal 3.42×10-06
abnormal facial morphology Axin2tm1b(KOMP)Wtsi HOM embryonic day 18.5 0.00
protruding tongue Axin2tm1b(KOMP)Wtsi HOM embryonic day 18.5 0.00
abnormal embryo size Axin2tm1b(KOMP)Wtsi HOM embryonic day 18.5 0.00
abnormal head shape Axin2tm1b(KOMP)Wtsi HOM embryonic day 18.5 0.00
abnormal body wall morphology Axin2tm1b(KOMP)Wtsi HOM embryonic day 18.5 0.00
abnormal facial morphology Axin2tm1b(KOMP)Wtsi HET embryonic day 18.5 0.00
abnormal eyelid fusion Axin2tm1b(KOMP)Wtsi HOM embryonic day 18.5 0.00
microphthalmia Axin2tm1b(KOMP)Wtsi HOM embryonic day 18.5 0.00
polydactyly Axin2tm1b(KOMP)Wtsi HOM embryonic day 18.5 0.00
decreased body length Axin2tm1b(KOMP)Wtsi HET postnatal 5.27×10-07
anophthalmia Axin2tm1b(KOMP)Wtsi HOM embryonic day 18.5 0.00
preweaning lethality, complete penetrance Axin2tm1b(KOMP)Wtsi HOM n/a 0.00
increased blood urea nitrogen level Axin2tm1b(KOMP)Wtsi HET postnatal 9.02×10-05

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2)  Wholemount images
Aorta 2 No  (2/2) N/A
Bone 2 No  (2/2) N/A
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No  (2/2)  Wholemount images
Brown adipose tissue 2 No  (2/2)  Wholemount images
Cartilage tissue 2 No  (2/2) N/A
Cecum 2 No  (12/383) N/A
Cerebellum 2 No  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/2)  Wholemount images
Esophagus 2 No  (7/415)  (2/2) N/A
Eye 2 No N/A
Gall bladder 2 No  (2/2)  Wholemount images
Heart 2 No  (2/2) N/A
Hippocampus 2 No  (2/2)  Wholemount images
Hypothalamus 2 No  (2/2)  Wholemount images
Kidney 2 No  (18/584)  (2/2)  Wholemount images
Large intestine 2 No  (10/584)  (2/2)  Wholemount images
Liver 2 No  (2/2)  Wholemount images
Lower urinary tract 2 No  (2/2) N/A
Lung 2 No  (2/2)  Wholemount images
Lymph node 2 No  (2/2) N/A
Mammary gland 2 No  (1/2)  Wholemount images
Mesenteric lymph node 2 No  (2/2)  Wholemount images
Olfactory lobe 2 No  (2/2)  Wholemount images
Oral epithelium 2 No N/A
Ovary 2 No  (1/584)  (1/2)  Wholemount images
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/584)  (2/2)  Wholemount images
Parathyroid gland 2 No  (2/2)  Wholemount images
Peripheral nervous system 2 No  (2/2)  Wholemount images
Peyer's patch 2 No  (2/2) N/A
Pituitary gland 2 No  (1/2)  Wholemount images
Prostate gland 2 No  (12/584)  (1/2) N/A
Skeletal muscle 2 No  (2/2) N/A
Skin 2 No  (2/2)  Wholemount images
Small intestine 2 No  (9/584)  (2/2) N/A
Spinal cord 2 No  (2/2)  Wholemount images
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584)  (2/2) N/A
Striatum 2 No  (2/2)  Wholemount images
Testis 2 No  (2/584)  (1/2) N/A
Thymus 2 No  (2/2) N/A
Thyroid gland 2 No  (15/584)  (2/2)  Wholemount images
Trachea 2 No  (2/2)  Wholemount images
Trigeminal V nerve 2 No  (2/2)  Wholemount images
Urinary bladder 2 No  (2/2) N/A
Uterus 2 No  (1/2)  Wholemount images
Vas deferens 2 No  (15/388)  (1/2) N/A
Vascular system 2 No N/A
White adipose tissue 2 No  (2/2) N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 2  (1/47)  (2/2) N/A
Axial skeleton 2  (1/51)  (2/2) N/A
Brain 2  (6/485)  (2/2) N/A
Central nervous system ganglion 2  (1/51)  (2/2) N/A
Cranium 2  (1/46)  (2/2) N/A
Dorsal root ganglion 2  (1/47)  (2/2) N/A
Ear 2  (1/485)  (2/2) N/A
Embryo 2  (1/485)  (2/2) N/A
Outer ear 2  (1/47)  (2/2) N/A
Eye 2  (1/485)  (2/2) N/A
Femur pre-cartilage condensation 2  (1/46)  (2/2) N/A
Foot 2  (1/485)  (2/2) N/A
Forearm 2  (1/282)  (2/2) N/A
Forebrain 2  (1/485)  (2/2) N/A
Forelimb 2  (1/485)  (2/2) N/A
Fronto-nasal process 2  (1/48)  (2/2) N/A
Gut 2  (1/50)  (2/2) N/A
Hand 2  (1/485)  (2/2) N/A
Head 2  (5/485)  (2/2) N/A
Head mesenchyme 2  (1/47)  (2/2) N/A
Heart 2  (1/485)  (2/2) N/A
Heart ventricle 2  (1/47)  (2/2) N/A
Hindbrain 2  (6/485)  (2/2) N/A
Hindlimb 2  (1/485)  (2/2) N/A
Humerus pre-cartilage condensation 2  (1/46)  (2/2) N/A
Inner ear 2  (1/46)  (2/2) N/A
Intestine 2  (1/47)  (2/2) N/A
Liver 2  (1/485)  (2/2) N/A
Lower leg 2  (1/282)  (2/2) N/A
Lung 2  (1/485)  (2/2) N/A
Mandibular process 2  (1/485)  (2/2) N/A
Maxillary process 2  (1/485)  (2/2) N/A
Mesonephros of female 2  (1/46)  (1/2) N/A
Mesonephros of male 2  (1/46)  (1/2) N/A
Metanephros 2  (1/46)  (2/2) N/A
Midbrain 2  (1/485)  (2/2) N/A
Nasal septum 2  (1/47)  (2/2) N/A
Nose 2  (1/51)  (2/2) N/A
Notochord 2  (1/47)  (2/2) N/A
Oral cavity 2  (1/485)  (2/2) N/A
Outflow tract 2  (1/47)  (2/2) N/A
Pancreas 2  (1/46)  (2/2) N/A
Pericardium 2  (1/46)  (2/2) N/A
Pharynx 2  (1/46)  (2/2) N/A
Radius-ulna pre-cartilage condensation 2  (1/46)  (2/2) N/A
Rib pre-cartilage condensation 2  (1/46)  (2/2) N/A
Skeleton 2  (1/51)  (2/2) N/A
Skin 2  (1/485)  (2/2) N/A
Spinal cord 2  (1/50)  (2/2) N/A
Stomach 2  (1/46)  (2/2) N/A
Tail 2  (1/485)  (2/2) N/A
Tail somite 2  (1/485)  (2/2) N/A
Thoracic vertebral cartilage condensation 2  (1/46)  (2/2) N/A
Tongue 2  (1/46)  (2/2) N/A
Trachea 2  (1/50)  (2/2) N/A
Trunk mesenchyme 2  (1/47)  (2/2) N/A
Umbilical artery embryonic part 2  (1/47)  (2/2) N/A
Umbilical vein embryonic part 2  (1/47)  (2/2) N/A
Upper arm 2  (1/282)  (2/2) N/A
Upper leg 2  (1/282)  (2/2) N/A
Urinary system 2  (1/50)  (2/2) N/A
Vibrissa 2  (1/47)  (2/2) N/A

 Associated Images

Adult LacZ: LacZ Images Wholemount
21 Images

 Disease Models

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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Axin2tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Axin2tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue

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