Zfp106 | zinc finger protein 106

GeneMGI:1270153Synonyms: Cd-1, sirm, +2 more

Physiological systems

20 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Reproductive system Growth/size/body region Behavior/neurological

16 No significant impact

4 Not tested

Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues

Phenotypes

increased circulating calcium level1 supporting datasetZfp106tm1a(KOMP)WtsiheterozygoteEarly adult3.98x10-8 
increased thermal nociceptive threshold1 supporting datasetZfp106tm1a(KOMP)WtsihomozygoteEarly adult4.44x10-16 
abnormal posture1 supporting datasetZfp106tm1a(KOMP)WtsihomozygoteEarly adult6.85x10-12 
decreased body weight2 supporting datasetsZfp106tm1a(KOMP)WtsihomozygoteEarly adult1.76x10-9 
abnormal gait1 supporting datasetZfp106tm1a(KOMP)WtsihomozygoteEarly adult1.06x10-7 
abnormal external female genitalia morphology1 supporting datasetZfp106tm1a(KOMP)WtsihomozygoteEarly adult6.52x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a0% (0/2)0.7% (4/570)
aortaheterozygoten/an/a0.19% (1/533)
blood vesselheterozygoten/a0% (0/2)0% (0/173)
boneheterozygoten/a0% (0/2)0% (0/394)
brainheterozygoten/a100% (2/2)0.86% (5/579)
brainstemheterozygoten/an/a0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoten/a100% (2/2)0.22% (1/454)
cerebellumheterozygoten/an/a0.56% (3/532)
cerebral cortexheterozygoten/an/a0.41% (2/491)
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Histopathology

IMPC related publications

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Zfp106tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Zfp106tm1c(KOMP)WtsiWild type floxed exon (post-Flp)mouse
Zfp106tm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell

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