The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
|Phenotype||System||Allele||Zyg||Sex||Life Stage||P Value|
|increased exploration in new environment||Ankle2em1(IMPC)Bay||HET||Early adult||1.21×10-05|
|thin ventricular wall||Ankle2em1(IMPC)Bay||HET||Early adult||6.21×10-07|
|abnormal retina vasculature morphology||Ankle2em1(IMPC)Bay||HET||Early adult||8.19×10-09|
|preweaning lethality, incomplete penetrance||Ankle2em1(IMPC)Bay||HOM||Early adult||0.00|
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
Human diseases caused by Ankle2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Ankle2 by orthology or direct annotation.
|Autosomal Recessive Primary Microcephaly||
|Microcephaly 16, Primary, Autosomal Recessive||
The table below shows human diseases predicted to be associated to Ankle2 by phenotypic similarity.
Order Mouse and ES Cells
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|MGI Allele||Allele Type||Produced|
|Ankle2em1(IMPC)Bay||Exon Deletion||Mice, Tissue|
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