Gene: Dnmt3a

Name
DNA methyltransferase 3A
MGI ID
MGI:1261827
Synonyms
N/A
Viability
Homozygous - Viable Homozygous - Subviable
Other links
View data by physiological system
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
increased grip strength Dnmt3atm1a(KOMP)Wtsi HOM postnatal 3.75×10-12
decreased bone mineral content Dnmt3atm1b(KOMP)Wtsi HET postnatal 6.12×10-09
decreased effector memory CD8-positive, alpha-beta T cell number Dnmt3atm1a(KOMP)Wtsi HOM postnatal 8.90×10-05
decreased lean body mass Dnmt3atm1b(KOMP)Wtsi HET postnatal 9.38×10-05
abnormal embryo size Dnmt3atm1b(KOMP)Wtsi HOM embryonic day 12.5 0.00
increased hemoglobin content Dnmt3atm1b(KOMP)Wtsi HET postnatal 1.08×10-05
cardiovascular system phenotype Dnmt3atm1b(KOMP)Wtsi HET postnatal 9.15×10-05
preweaning lethality, incomplete penetrance Dnmt3atm1b(KOMP)Wtsi HOM n/a 0.00
increased bone mineral content Dnmt3atm1b(KOMP)Wtsi HET postnatal 6.12×10-09
decreased circulating HDL cholesterol level Dnmt3atm1b(KOMP)Wtsi HET postnatal 3.22×10-05
increased total body fat amount Dnmt3atm1b(KOMP)Wtsi HET postnatal 2.17×10-12
increased circulating HDL cholesterol level Dnmt3atm1b(KOMP)Wtsi HET postnatal 3.22×10-05

Download data as:  TSV  XLS

Filtered by: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No N/A
Brain 2 No N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Epididymis 2 No  (18/134) N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Heart 2 No  (2/2) N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (2/2) N/A
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Midbrain 2 No N/A
Olfactory lobe 2 No N/A
Ovary 2 No  (1/584)  (1/2) N/A
Oviduct 2 No  (1/2) N/A
Pancreas 2 No  (5/584) N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No N/A
Submandibular gland 2 No  (2/132) N/A
Testis 2 No  (2/584)  (1/2) N/A
Thalamus 2 No N/A
Thymus 2 No N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No N/A
Urinary bladder 2 No N/A
Uterus 2 No N/A
Vascular system 2 No N/A
Vesicular gland 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/485) N/A
Dorsal root ganglion 2  (1/47) N/A
Ear 2  (1/485) N/A
Embryo 2  (1/485)  Wholemount images
Eye 2  (1/485) N/A
Foot 2  (1/485) N/A
Forebrain 2  (1/485) N/A
Forelimb 2  (1/485) N/A
Fronto-nasal process 2  (1/48) N/A
Hand 2  (1/485) N/A
Head 2  (5/485) N/A
Heart 2  (1/485) N/A
Hindbrain 2  (6/485) N/A
Hindlimb 2  (1/485) N/A
Liver 2  (1/485) N/A
Lung 2  (1/485) N/A
Mandibular process 2  (1/485) N/A
Maxillary process 2  (1/485) N/A
Midbrain 2  (1/485) N/A
Nose 2  (1/51) N/A
Oral cavity 2  (1/485) N/A
Skin 2  (1/485) N/A
Spinal cord 2  (1/50) N/A
Tail 2  (1/485) N/A
Tail somite 2  (1/485) N/A

 Associated Images

X-ray: XRay Images Skull Dorso Ventral Orientation
32 Images
X-ray: XRay Images Skull Lateral Orientation
31 Images
X-ray: XRay Images Dorso Ventral
60 Images
X-ray: XRay Images Lateral Orientation
45 Images
X-ray: XRay Images Forepaw
31 Images
Combined SHIRPA and Dysmorphology
11 Images
Anti-nuclear antibody assay
6 Images
DSS Histology
8 Images
Embryo LacZ: LacZ images wholemount
4 Images
Sleep Wake: Wake state (bmp file)
11 Images

 Disease Models

Please visit the desktop version to see this section

 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Dnmt3atm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Dnmt3atm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter