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Gene: Naga MGI:1261422

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Gene Summary

Name:
N-acetyl galactosaminidase, alpha
Synonyms:
N/A

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased circulating alkaline phosphatase level Nagatm1a(EUCOMM)Wtsi HOM Early adult 3.45×10-22

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Viewing: all phenotypes
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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Skull Dorso Ventral Orientation

14 Images

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X-ray

XRay Images Whole Body Lateral Orientation

14 Images

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X-ray

XRay Images Skull Lateral Orientation

13 Images

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X-ray

XRay Images Whole Body Dorso Ventral

14 Images

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X-ray

XRay Images Forepaw

13 Images

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Legacy Phenotype Associated Images
Nagatm1a(EUCOMM)Wtsi
HOM, Male, WTSI
Nagatm1a(EUCOMM)Wtsi
HOM, Male, WTSI
Nagatm1a(EUCOMM)Wtsi
HOM, Male, WTSI
Nagatm1a(EUCOMM)Wtsi
HOM, Male, WTSI
Nagatm1a(EUCOMM)Wtsi
HOM, Male, WTSI

View all 68 images

Nagatm1a(EUCOMM)Wtsi
back skin, HOM, Female, WTSI

Human diseases caused by Naga mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Naga by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Alpha-N-Acetylgalactosaminidase Deficiency Type 2
ORPHA:79280
Alpha-N-Acetylgalactosaminidase Deficiency Type 3
ORPHA:79281
Schindler Disease, Type I
OMIM:609241
Alpha-N-Acetylgalactosaminidase Deficiency Type 1
ORPHA:79279
Kanzaki Disease
OMIM:609242

The table below shows human diseases predicted to be associated to Naga by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Cramps, Familial Adolescent
Elevated circulating creatine kinase concentration OMIM:218050
Isolated Asymptomatic Elevation Of Creatine Phosphokinase
Elevated circulating creatine kinase concentration ORPHA:206599
Muscle Cramps, Familial
Elevated circulating creatine kinase concentration OMIM:158400
Pentosuria
Abnormal circulating carbohydrate concentration, Abnormal circulating enzyme concentration ORPHA:2843
Hypokalemic Alkalosis, Familial, With Specific Renal Tubulopathy
Hypokalemia, Abnormal magnesium concentration, Increased serum prostaglandin E2, Increased circul... OMIM:241150
Pseudohypoaldosteronism, Type Ib3, Autosomal Recessive
Hyponatremia, Hyperkalemia, Increased circulating renin level OMIM:620126
Pseudohypoaldosteronism, Type Ib2, Autosomal Recessive
Hyponatremia, Hyperkalemia, Increased circulating renin level OMIM:620125
Alpha-N-Acetylgalactosaminidase Deficiency Type 2
ORPHA:79280
Alpha-N-Acetylgalactosaminidase Deficiency Type 3
ORPHA:79281
Schindler Disease, Type I
OMIM:609241
Alpha-N-Acetylgalactosaminidase Deficiency Type 1
ORPHA:79279
Kanzaki Disease
OMIM:609242

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Naga

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Naga.

There are 2 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Nagatm1a(EUCOMM)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Nagatm1a(EUCOMM)Wtsi PMC6459510

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MGI Allele Allele Type Produced
Nagatm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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