Gene: Psen1

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Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased basophil cell number Psen1tm1.1(KOMP)Vlcg HET Early adult 4.61×10-09
abnormal tail morphology Psen1tm1.1(KOMP)Vlcg HOM E18.5 0.00
preweaning lethality, complete penetrance Psen1tm1.1(KOMP)Vlcg HOM   Early adult 0.00
unresponsive to tactile stimuli Psen1tm1.1(KOMP)Vlcg HOM E18.5 0.00
hemorrhage Psen1tm1.1(KOMP)Vlcg HOM E18.5 0.00
abnormal tail morphology Psen1tm1.1(KOMP)Vlcg HOM E12.5 0.00
abnormal tail morphology Psen1tm1.1(KOMP)Vlcg HOM E15.5 0.00
abnormal limb morphology Psen1tm1.1(KOMP)Vlcg HOM E18.5 0.00
abnormal limb morphology Psen1tm1.1(KOMP)Vlcg HOM E15.5 0.00
decreased mean platelet volume Psen1tm1.1(KOMP)Vlcg HET Early adult 8.17×10-05
cyanosis Psen1tm1.1(KOMP)Vlcg HOM E18.5 0.00
decreased eosinophil cell number Psen1tm1.1(KOMP)Vlcg HET Early adult 2.06×10-05
edema Psen1tm1.1(KOMP)Vlcg HOM E18.5 0.00
edema Psen1tm1.1(KOMP)Vlcg HOM E15.5 0.00
edema Psen1tm1.1(KOMP)Vlcg HET E15.5 0.00

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 5 No  (4/584)  (5/5)  Section images
Aorta 5 No  (1/584)  (4/5)  Section images
Blood 1 No N/A
Bone marrow 3 No  (3/3)  Section images
Brain 5 No  (4/584)  (4/5)  Section images
Brainstem 5 No  (2/584)  (4/5)  Section images
Brown adipose tissue 3 No  (3/3)  Section images
Cartilage tissue 5 No  (1/584)  (4/5)  Section images
Cecum 1 No  (11/370) N/A
Cerebellum 5 No  (3/584)  (5/5)  Section images
Cerebral cortex 5 No  (2/584)  (4/5)  Section images
Chest bone 1 No N/A
Colon 1 No  (11/126)  (1/1)  Section images
Diaphragm 1 No  (1/1)  Section images
Duodenum 1 No  (1/126)  (1/1)  Section images
Epididymis 3 No  (17/133)  (2/3)  Section images
Esophagus 5 No  (7/408)  (5/5)  Section images
Eye 5 No  (5/5)  Section images
Gall bladder 1 No N/A
Gonadal fat pad 1 No  (1/1)  Section images
Harderian gland 1 No  (1/1)  Section images
Heart 5 No  (2/584)  (4/5)  Section images
Hindlimb 1 No N/A
Hippocampus 5 No  (3/584)  (2/5)  Section images
Hypothalamus 5 No  (2/584)  (2/5)  Section images
Ileum 1 No  (13/126)  (1/1)  Section images
Jejunum 1 No  (5/126) N/A
Kidney 5 No  (21/584)  (5/5)  Section images
Large intestine 5 No  (10/584)  (4/5)  Section images
Liver 5 No  (5/5)  Section images
Lower urinary tract 5 No  (1/584)  (2/5) N/A
Lung 5 No  (2/584)  (5/5)  Section images
Lymph node 5 No  (1/584)  (2/5)  Section images
Mammary gland 5 No  (2/5)  Section images
Mesenteric adipose tissue 1 No N/A
Mesenteric lymph node 1 No N/A
Midbrain 3 No  (3/3)  Section images
Olfactory lobe 5 No  (2/584)  (5/5)  Section images
Ovary 5 No  (1/584)  (2/5)  Section images
Oviduct 5 No  (2/5)  Section images
Pancreas 5 No  (5/584)  (5/5)  Section images
Parathyroid gland 1 No  (1/562) N/A
Parotid gland 1 No N/A
Penis 1 No  (1/1)  Section images
Peripheral nervous system 5 No  (2/584)  (2/5)  Section images
Peyer's patch 5 No  (2/5)  Section images
Pituitary gland 5 No  (1/584)  (3/5)  Section images
Prostate gland 5 No  (12/584) N/A
Quadriceps 1 No  (1/1)  Section images
Sciatic nerve 1 No  (1/1)  Section images
Skeletal muscle 5 No  (4/5)  Section images
Skin 5 No  (1/584)  (5/5)  Section images
Small intestine 5 No  (9/584)  (4/5)  Section images
Spinal cord 5 No  (3/584)  (4/5)  Section images
Spleen 5 No  (3/584)  (5/5)  Section images
Stomach 5 No  (12/584)  (5/5)  Section images
Stomach pyloric region 1 No N/A
Striatum 5 No  (3/584)  (2/5)  Section images
Sublingual gland 1 No  (1/1)  Section images
Submandibular gland 3 No  (2/131)  (3/3)  Section images
Testis 5 No  (6/584)  (2/5)  Section images
Thalamus 2 No  (2/2)  Section images
Thymus 5 No  (1/584)  (5/5)  Section images
Thyroid gland 5 No  (16/584)  (4/5)  Section images
Tongue 1 No  (5/126)  (1/1)  Section images
Trachea 5 No  (3/584)  (5/5)  Section images
Trigeminal V nerve 1 No  (1/1)  Section images
Urinary bladder 3 No  (3/3)  Section images
Uterus 5 No  (2/5)  Section images
Vagina 1 No N/A
Vas deferens 1 No  (14/381)  (1/1)  Section images
Vascular system 5 No  (4/5)  Section images
Vesicular gland 3 No  (1/3)  Section images
White adipose tissue 5 No  (2/5)  Section images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 2  (1/63)  (2/2) N/A
Brain 6  (6/507)  (4/7) N/A
Central nervous system ganglion 2  (1/72)  (2/2) N/A
Dorsal root ganglion 1  (1/59) N/A
Ear 6  (1/507)  (4/7) N/A
Embryo 6  (1/508)  (4/7)  Wholemount images
Eye 6  (1/507)  (4/7) N/A
Footplate 6  (1/507)  (4/7) N/A
Forebrain 6  (1/507)  (4/7) N/A
Forelimb 6  (1/507)  (4/7) N/A
Fronto-nasal process 1  (1/60) Image Only N/A
Gut 2  (1/58)  (2/2) N/A
Handplate 6  (1/507)  (4/7) N/A
Head 6  (5/507)  (4/7) N/A
Heart 6  (1/507)  (4/7) N/A
Hindbrain 6  (6/507)  (4/7) N/A
Hindlimb 6  (1/507)  (4/7) N/A
Liver 6  (1/502)  (3/7) N/A
Lung 6  (1/502)  (3/7) N/A
Mandibular process 6  (1/507)  (4/7) N/A
Maxillary process 6  (1/507)  (4/7) N/A
Meckel's cartilage 0 Image Only N/A
Midbrain 6  (1/507)  (4/7) N/A
Nose 3  (1/77)  (3/3) N/A
Oral cavity 6  (1/502)  (3/7) N/A
Skeleton 2  (1/77)  (2/2) N/A
Skin 6  (1/507)  (3/7) N/A
Spinal cord 3  (1/71)  (3/3) N/A
Tail 6  (1/507)  (4/7) N/A
Tail somite group 6  (1/507)  (4/7) N/A
Trachea 2  (1/58)  (2/2) N/A
Urinary system 2  (1/58)  (2/2) N/A

 Associated Images

Adult LacZ: LacZ Images Section
134 Images
Eye Morphology: Images Slit Lamp
2 Images
Sleep Wake: Wake state (bmp file)
15 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
9 Images
Gross Morphology Embryo E18.5
4 Images
Embryo LacZ: LacZ images wholemount
28 Images
X-ray: XRay Images Forepaw
9 Images
X-ray: XRay Images Whole Body Lateral Orientation
19 Images
X-ray: XRay Images Skull Lateral Orientation
9 Images
X-ray: XRay Images Whole Body Dorso Ventral
19 Images
Gross Morphology Embryo E14.5-E15.5
8 Images
Combined SHIRPA and Dysmorphology
2 Images
Eye Morphology: Images Ophthalmoscopy
2 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Psen1tm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Psen1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells
Psen1tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice, Tissue