Psen1 | presenilin 1
Physiological systems
23 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Limbs/digits/tail Behavior/neurological Mortality/aging Cardiovascular system
18 No significant impact
1 Not tested
Gene metrics:8Significant phenotypes
10Associated diseases
Expression examined in:74Adult tissues
53Embryo tissues
abnormal tail morphology | 1 supporting dataset | Psen1tm1.1(KOMP)Vlcg | homozygote | E12.5 | N/A * | ||
edema | 1 supporting dataset | Psen1tm1.1(KOMP)Vlcg | heterozygote | E15.5 | N/A * | ||
abnormal limb morphology | 1 supporting dataset | Psen1tm1.1(KOMP)Vlcg | homozygote | E18.5 | N/A * | ||
abnormal limb morphology | 1 supporting dataset | Psen1tm1.1(KOMP)Vlcg | homozygote | E15.5 | N/A * | ||
edema | 1 supporting dataset | Psen1tm1.1(KOMP)Vlcg | homozygote | E18.5 | N/A * | ||
edema | 1 supporting dataset | Psen1tm1.1(KOMP)Vlcg | homozygote | E15.5 | N/A * | ||
increased startle reflex | 1 supporting dataset | Psen1tm1.1(KOMP)Vlcg | heterozygote | Early adult | 2.4x10-5 | ||
abnormal tail morphology | 1 supporting dataset | Psen1tm1.1(KOMP)Vlcg | homozygote | E15.5 | N/A * | ||
hemorrhage | 1 supporting dataset | Psen1tm1.1(KOMP)Vlcg | homozygote | E18.5 | N/A * | ||
preweaning lethality, complete penetrance | 4 supporting datasets | Psen1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * |
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External links
No external links available for Psen1.
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Psen1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
Psen1tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
Psen1tm2a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |