Psen1 | presenilin 1

GeneMGI:1202717Synonyms: PS-1, Ad3h, +3 more

Physiological systems

23 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Limbs/digits/tail Behavior/neurological Mortality/aging Cardiovascular system

18 No significant impact

1 Not tested

Gene metrics:8Significant phenotypes
10Associated diseases
Expression examined in:74Adult tissues
53Embryo tissues

Phenotypes

abnormal tail morphology1 supporting datasetPsen1tm1.1(KOMP)VlcghomozygoteE12.5N/A * 
edema1 supporting datasetPsen1tm1.1(KOMP)VlcgheterozygoteE15.5N/A * 
abnormal limb morphology1 supporting datasetPsen1tm1.1(KOMP)VlcghomozygoteE18.5N/A * 
abnormal limb morphology1 supporting datasetPsen1tm1.1(KOMP)VlcghomozygoteE15.5N/A * 
edema1 supporting datasetPsen1tm1.1(KOMP)VlcghomozygoteE18.5N/A * 
edema1 supporting datasetPsen1tm1.1(KOMP)VlcghomozygoteE15.5N/A * 
increased startle reflex1 supporting datasetPsen1tm1.1(KOMP)VlcgheterozygoteEarly adult2.4x10-5 
abnormal tail morphology1 supporting datasetPsen1tm1.1(KOMP)VlcghomozygoteE15.5N/A * 
hemorrhage1 supporting datasetPsen1tm1.1(KOMP)VlcghomozygoteE18.5N/A * 
preweaning lethality, complete penetrance4 supporting datasetsPsen1tm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Psen1tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Psen1tm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse
Psen1tm2a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell

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