banner
Genes Phenotypes Help, News, Blog

Gene: Supt5 MGI:1202400

Log in to follow

Gene Summary

Name:
suppressor of Ty 5, DSIF elongation factor subunit
Synonyms:
Supt5h,  Spt5

Order Alleles

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
vertebral transformation Supt5tm2a(KOMP)Wtsi HET Early adult 4.61×10-06
preweaning lethality, complete penetrance Supt5tm2a(KOMP)Wtsi HOM   Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

14 Images

View images
X-ray

XRay Images Skull Lateral Orientation

14 Images

View images
X-ray

XRay Images Forepaw

14 Images

View images
X-ray

XRay Images Skull Dorso Ventral Orientation

14 Images

View images
X-ray

XRay Images Whole Body Dorso Ventral

14 Images

View images
Download thumbnail Download
Anti-nuclear antibody assay

Images

6 Images

View images
Eye Morphology

Images Slit Lamp

4 Images

View images
Download thumbnail Download
DSS Histology

Images

8 Images

View images
FCS thumbnail FCS
Ear epidermis immunophenotyping

Images

12 Images

View images
Legacy Phenotype Associated Images
Supt5tm2a(KOMP)Wtsi
HET, Female, WTSI
Supt5tm2a(KOMP)Wtsi
HET, Female, WTSI
Supt5tm2a(KOMP)Wtsi
HET, Female, WTSI
Supt5tm2a(KOMP)Wtsi
HET, Female, WTSI
Supt5tm2a(KOMP)Wtsi
HET, Female, WTSI

View all 155 images

Supt5tm2a(KOMP)Wtsi
head, abnormal snout morphology, asymmetric snout, WT, Female, WTSI
Supt5tm2a(KOMP)Wtsi
abnormal digit morphology, WT, Male, WTSI
Supt5tm2a(KOMP)Wtsi
tail, WT, Male, WTSI
Supt5tm2a(KOMP)Wtsi
head, abnormal snout morphology, asymmetric snout, WT, Female, WTSI
Supt5tm2a(KOMP)Wtsi
head, abnormal snout morphology, upturned snout, WT, Female, WTSI
Supt5tm2a(KOMP)Wtsi
cataracts, HET, Female, WTSI
Supt5tm2a(KOMP)Wtsi
cataracts, HET, Female, WTSI
Supt5tm2a(KOMP)Wtsi
cataracts, HET, Female, WTSI
Supt5tm2a(KOMP)Wtsi
cataracts, HET, Female, WTSI

Human diseases caused by Supt5 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Supt5

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Supt5.

There are 5 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Supt5tm2a(KOMP)Wtsi PMC7263671
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation. Nature immunology (December 2019) Supt5tm2a(KOMP)Wtsi PMC7338221
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Supt5tm2a(KOMP)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Supt5tm2a(KOMP)Wtsi PMC6459510
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Supt5tm2a(KOMP)Wtsi PMC5827107

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

This service may be affected by the Covid-19 pandemic. See how

MGI Allele Allele Type Produced
Supt5tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Supt5tm2e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Supt5tm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Supt5tm1e(KOMP)Mbp Targeted, non-conditional allele ES Cells
Supt5tm192872(L1L2_gt2) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Supt5tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Supt5tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter