IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Supt5 by phenotypic similarity.
|Sacral Agenesis With Vertebral Anomalies||
||Abnormal vertebral morphology, Absence of the sacrum||OMIM:615709|
|Cervical Vertebral Dysplasia||
||Anterior atlanto-occipital dislocation, Cervical vertebral facet hypoplasia, Cervical vertebral d...||OMIM:118005|
|Spondylocostal Dysostosis 6, Autosomal Recessive||
||Cervical kyphosis, Butterfly vertebrae, Spinal canal stenosis, Scoliosis, Hemivertebrae||OMIM:616566|
|Vertebral Hypoplasia With Lumbar Kyphosis||
||Lumbar kyphosis, Vertebral hypoplasia||OMIM:192900|
|Primary Basilar Invagination||
||Short neck, Abnormality of the cervical spine, Abnormal vertebral morphology||ORPHA:2285|
||Sclerotic vertebral body, Scoliosis, Kyphosis, Abnormal form of the vertebral bodies||ORPHA:2777|
||Spina bifida occulta, Vertebral segmentation defect, Scoliosis||ORPHA:2956|
||Spina bifida occulta, Spondylolysis, Cervical spondylosis, Spondylolisthesis||OMIM:184300|
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Supt5.
There are 5 publications which use IMPC produced mice or data.
|Title||Journal||IMPC Allele||PubMed ID|
|A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation.||G3 (Bethesda, Md.) (June 2020)||Supt5tm2a(KOMP)Wtsi||PMC7263671|
|High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation.||Nature immunology (December 2019)||Supt5tm2a(KOMP)Wtsi||PMC7338221|
|Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis.||Nature communications (August 2019)||Supt5tm2a(KOMP)Wtsi||PMC6671969|
|Mouse screen reveals multiple new genes underlying mouse and human hearing loss.||PLoS biology (April 2019)||Supt5tm2a(KOMP)Wtsi||PMC6459510|
|Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation.||Scientific data (September 2017)||Supt5tm2a(KOMP)Wtsi||PMC5827107|
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|MGI Allele||Allele Type||Produced|
|Supt5tm1e(KOMP)Wtsi||Targeted, non-conditional allele||ES Cells|
|Supt5tm2e(KOMP)Wtsi||Targeted, non-conditional allele||ES Cells|
|Supt5tm1a(KOMP)Mbp||KO first allele (reporter-tagged insertion with conditional potential)||Targeting vectors, ES Cells|
|Supt5tm1e(KOMP)Mbp||Targeted, non-conditional allele||ES Cells|
|Supt5tm192872(L1L2_gt2)||KO first allele (reporter-tagged insertion with conditional potential)||Targeting vectors|
|Supt5tm1a(KOMP)Wtsi||KO first allele (reporter-tagged insertion with conditional potential)||Targeting vectors, ES Cells|
|Supt5tm2a(KOMP)Wtsi||KO first allele (reporter-tagged insertion with conditional potential)||Mice, Targeting vectors, ES Cells|
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