Gene: Itch

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Name
itchy, E3 ubiquitin protein ligase
MGI ID
MGI:1202301
Synonyms
6720481N21Rik 8030492O04Rik C230047C07Rik AIP4
View
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased circulating fructosamine level Itchtm1b(EUCOMM)Hmgu HOM postnatal 3.09×10-09
decreased mean corpuscular volume Itchtm1b(EUCOMM)Hmgu HOM postnatal 7.60×10-05
increased large unstained cell number Itchtm1b(EUCOMM)Hmgu HOM postnatal 6.14×10-05
abnormal head size Itchtm1b(EUCOMM)Hmgu HOM postnatal 8.16×10-05
abnormal bone structure Itchtm1b(EUCOMM)Hmgu HOM postnatal 1.14×10-25
decreased bone mineral content Itchtm1b(EUCOMM)Hmgu HOM postnatal 5.25×10-43
abnormal tooth morphology Itchtm1b(EUCOMM)Hmgu HOM postnatal 4.93×10-06
decreased lymphocyte cell number Itchtm1b(EUCOMM)Hmgu HOM postnatal 7.58×10-05
tremors Itchtm1b(EUCOMM)Hmgu HOM postnatal 1.78×10-09
decreased circulating alkaline phosphatase level Itchtm1b(EUCOMM)Hmgu HOM postnatal 1.13×10-26
increased lean body mass Itchtm1b(EUCOMM)Hmgu HOM postnatal 8.63×10-05
increased neutrophil cell number Itchtm1b(EUCOMM)Hmgu HOM postnatal 1.05×10-24
decreased total body fat amount Itchtm1b(EUCOMM)Hmgu HOM postnatal 1.23×10-05
increased eosinophil cell number Itchtm1b(EUCOMM)Hmgu HOM postnatal 2.79×10-05
increased mean corpuscular volume Itchtm1(NCOM)Cmhd HET postnatal 7.59×10-08
increased heart weight Itchtm1b(EUCOMM)Hmgu HOM postnatal 7.75×10-08
decreased bone mineral density Itchtm1b(EUCOMM)Hmgu HOM postnatal 2.00×10-33
increased circulating total protein level Itchtm1b(EUCOMM)Hmgu HOM postnatal 2.30×10-05
absent startle reflex Itchtm1b(EUCOMM)Hmgu HOM postnatal 8.17×10-05
increased red blood cell distribution width Itchtm1b(EUCOMM)Hmgu HOM postnatal 1.13×10-06
increased circulating calcium level Itchtm1b(EUCOMM)Hmgu HOM postnatal 1.98×10-06
decreased grip strength Itchtm1b(EUCOMM)Hmgu HOM postnatal 2.35×10-05

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2) N/A
Aorta 2 No  (2/2)  Wholemount images
Bone 2 No N/A
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/2)  Wholemount images
Esophagus 2 No  (7/415) N/A
Eye 2 No  (2/2)  Wholemount images
Gall bladder 2 No  (1/2)  Wholemount images
Heart 2 No  (2/2)  Wholemount images
Hippocampus 2 No  (2/2)  Wholemount images
Hypothalamus 2 No  (2/2)  Wholemount images
Kidney 2 No  (18/584)  (2/2)  Wholemount images
Large intestine 2 No  (10/584)  (2/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No  (2/2)  Wholemount images
Lung 2 No  (2/2)  Wholemount images
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/2)  Wholemount images
Oral epithelium 2 No N/A
Ovary 2 No  (1/584)  (1/2)  Wholemount images
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/584)  (2/2)  Wholemount images
Parathyroid gland 2 No  (2/2)  Wholemount images
Peripheral nervous system 2 No  (2/2)  Wholemount images
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584)  (2/2)  Wholemount images
Spinal cord 2 No  (2/2)  Wholemount images
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584)  (2/2)  Wholemount images
Striatum 2 No  (2/2)  Wholemount images
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No N/A
Thyroid gland 2 No  (15/584)  (1/2)  Wholemount images
Trachea 2 No N/A
Uterus 2 No  (1/2)  Wholemount images
Vascular system 2 No  (2/2)  Wholemount images
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 1  (6/485)  (2/2) N/A
Ear 1  (1/485) N/A
Embryo 1  (1/485)  (2/2) N/A
Eye 1  (1/485)  (2/2) N/A
Foot 1  (1/485)  (2/2) N/A
Forebrain 1  (1/485)  (2/2) N/A
Forelimb 1  (1/485)  (2/2) N/A
Hand 1  (1/485)  (2/2) N/A
Head 1  (5/485)  (2/2) N/A
Heart 1  (1/485) N/A
Hindbrain 1  (6/485)  (2/2) N/A
Hindlimb 1  (1/485)  (2/2) N/A
Liver 1  (1/485) N/A
Lung 1  (1/485) N/A
Mandibular process 1  (1/485) N/A
Maxillary process 1  (1/485) N/A
Midbrain 1  (1/485)  (2/2) N/A
Oral cavity 1  (1/485) N/A
Skin 1  (1/485) N/A
Tail 1  (1/485)  (2/2) N/A
Tail somite 1  (1/485) N/A

 Associated Images

X-ray: XRay Images Dorso Ventral
12 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
12 Images
Adult LacZ: LacZ Images Wholemount
19 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images
X-ray: XRay Images Lateral Orientation
12 Images
Embryo LacZ: LacZ images wholemount
8 Images

 Disease Models

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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Itchtm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Itchtm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice
Itchtm1(NCOM)Cmhd Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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