Itch | itchy, E3 ubiquitin protein ligase
Physiological systems
21 / 24 physiological systems tested
13 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Endocrine/exocrine gland Adipose tissue Growth/size/body region Digestive/alimentary Liver/biliary system Hematopoietic system Behavior/neurological Skeleton Cardiovascular system Craniofacial Renal/urinary system
8 No significant impact
3 Not tested
Data collections
Gene metrics:39Significant phenotypes
2Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
Human diseases caused by Itch mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
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