Gene: Itch

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Name
itchy, E3 ubiquitin protein ligase
MGI ID
MGI:1202301
Synonyms
6720481N21Rik C230047C07Rik 8030492O04Rik AIP4
Viability
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
increased lean body mass Itchtm1b(EUCOMM)Hmgu HOM Early adult 7.69×10-05
abnormal head size Itchtm1b(EUCOMM)Hmgu HOM Early adult 5.88×10-05
decreased circulating fructosamine level Itchtm1b(EUCOMM)Hmgu HOM Early adult 5.55×10-14
enlarged gallbladder Itchtm1b(EUCOMM)Hmgu HOM Early adult 0.00
enlarged spleen Itchtm1b(EUCOMM)Hmgu HOM Early adult 0.00
decreased circulating alkaline phosphatase level Itchtm1b(EUCOMM)Hmgu HOM Early adult 1.04×10-15
decreased bone mineral density Itchtm1b(EUCOMM)Hmgu HOM Early adult 1.00×10-24
abnormal tooth morphology Itchtm1b(EUCOMM)Hmgu HOM Early adult 3.02×10-06
abnormal startle reflex Itchtm1b(EUCOMM)Hmgu HOM Early adult 5.82×10-05
enlarged kidney Itchtm1b(EUCOMM)Hmgu HOM Early adult 0.00
decreased circulating cholesterol level Itchtm1b(EUCOMM)Hmgu HOM Early adult 5.06×10-05
decreased circulating glucose level Itchtm1b(EUCOMM)Hmgu HOM   Early adult 2.05×10-05
increased circulating total protein level Itchtm1b(EUCOMM)Hmgu HOM Early adult 3.78×10-09
decreased fasting circulating glucose level Itchtm1b(EUCOMM)Hmgu HOM   Early adult 4.31×10-06
increased circulating calcium level Itchtm1b(EUCOMM)Hmgu HOM Early adult 9.84×10-13
decreased bone mineral content Itchtm1b(EUCOMM)Hmgu HOM Early adult 3.21×10-36
increased mean corpuscular volume Itchtm1(NCOM)Cmhd HET Early adult 9.69×10-08
decreased grip strength Itchtm1b(EUCOMM)Hmgu HOM Early adult 7.15×10-05
tremors Itchtm1b(EUCOMM)Hmgu HOM Early adult 6.71×10-10
increased circulating phosphate level Itchtm1b(EUCOMM)Hmgu HOM Early adult 6.90×10-07
abnormal bone structure Itchtm1b(EUCOMM)Hmgu HOM Early adult 1.66×10-17
abnormal esophagus morphology Itchtm1b(EUCOMM)Hmgu HOM Early adult 0.00

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (4/584)  (2/2) N/A
Aorta 2 No  (1/584)  (2/2)  Wholemount images
Bone 2 No N/A
Brain 2 No  (4/584)  (2/2)  Wholemount images
Brainstem 2 No  (2/584)  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (1/584) N/A
Cerebellum 2 No  (3/584)  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/584)  (2/2)  Wholemount images
Esophagus 2 No  (7/408) N/A
Eye 2 No  (2/2)  Wholemount images
Gall bladder 2 No  (1/2)  Wholemount images
Heart 2 No  (2/584)  (2/2)  Wholemount images
Hippocampus 2 No  (3/584)  (2/2)  Wholemount images
Hypothalamus 2 No  (2/584)  (2/2)  Wholemount images
Kidney 2 No  (21/584)  (2/2)  Wholemount images
Large intestine 2 No  (10/584)  (2/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No  (1/584)  (2/2)  Wholemount images
Lung 2 No  (2/584)  (2/2)  Wholemount images
Lymph node 2 No  (1/584) N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/584)  (2/2)  Wholemount images
Oral epithelium 2 No N/A
Ovary 2 No  (1/584)  (1/2)  Wholemount images
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/584)  (2/2)  Wholemount images
Parathyroid gland 2 No  (1/562)  (2/2)  Wholemount images
Peripheral nervous system 2 No  (2/584)  (2/2)  Wholemount images
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/584) N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (1/584) N/A
Small intestine 2 No  (9/584)  (2/2)  Wholemount images
Spinal cord 2 No  (3/584)  (2/2)  Wholemount images
Spleen 2 No  (3/584) N/A
Stomach 2 No  (12/584)  (2/2)  Wholemount images
Striatum 2 No  (3/584)  (2/2)  Wholemount images
Testis 2 No  (6/584)  (1/2)  Wholemount images
Thymus 2 No  (1/584) N/A
Thyroid gland 2 No  (16/584)  (1/2)  Wholemount images
Trachea 2 No  (3/584) N/A
Uterus 2 No  (1/2)  Wholemount images
Vascular system 2 No  (2/2)  Wholemount images
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/507)  (4/4) N/A
Ear 2  (1/507)  (1/4) N/A
Embryo 2  (1/508)  (4/4) N/A
Eye 2  (1/507)  (4/4) N/A
Footplate 2  (1/507)  (3/4) N/A
Forebrain 2  (1/507)  (4/4) N/A
Forelimb 2  (1/507)  (3/4) N/A
Handplate 2  (1/507)  (3/4) N/A
Head 2  (5/507)  (4/4) N/A
Heart 2  (1/507)  (2/4) N/A
Hindbrain 2  (6/507)  (3/4) N/A
Hindlimb 2  (1/507)  (3/4) N/A
Liver 2  (1/502)  (2/4) N/A
Lung 2  (1/502)  (2/4) N/A
Mandibular process 2  (1/507)  (2/4) N/A
Maxillary process 2  (1/507)  (2/4) N/A
Midbrain 2  (1/507)  (4/4) N/A
Oral cavity 2  (1/502)  (2/4) N/A
Skin 2  (1/507)  (1/4) N/A
Tail 2  (1/507)  (3/4) N/A
Tail somite group 2  (1/507)  (1/4) N/A

 Associated Images

Embryo LacZ: LacZ images wholemount
8 Images
Adult LacZ: LacZ Images Wholemount
19 Images
X-ray: XRay Images Whole Body Lateral Orientation
12 Images
X-ray: XRay Images Whole Body Dorso Ventral
12 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
12 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images

 Disease Models

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 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Skeletal muscle - inflammation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Spleen - MPATH diagnostic term extramedullary hemopoiesis Itchtm1b(EUCOMM)Hmgu HOM Early adult
Pancreas - inflammation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Trachea - intracellular and extracellular accumulation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Nasal cavity - inflammation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Tongue - inflammation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Skin - inflammation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Skeletal muscle - healing and repair process Itchtm1b(EUCOMM)Hmgu HOM Early adult
Lung - MPATH diagnostic term acidophilic macrophage pneumonia Itchtm1b(EUCOMM)Hmgu HOM Early adult
Knee joint - acute inflammation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Stomach - tissue specific degenerative process Itchtm1b(EUCOMM)Hmgu HOM Early adult
Kidney - inflammation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Bone marrow - hyperplasia Itchtm1b(EUCOMM)Hmgu HOM Early adult
Stomach - MPATH diagnostic term hyperkeratosis Itchtm1b(EUCOMM)Hmgu HOM Early adult
Trachea - inflammation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Lung - tissue specific degenerative process Itchtm1b(EUCOMM)Hmgu HOM Early adult
Uterus - chronic inflammation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Small intestine - inflammation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Eye with optic nerve - developmental and structural abnormality Itchtm1b(EUCOMM)Hmgu HOM Early adult
Femur - hyperplasia Itchtm1b(EUCOMM)Hmgu HOM Early adult
Trachea - intracellular and extracellular depletion Itchtm1b(EUCOMM)Hmgu HOM Early adult
Heart - inflammation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Gall bladder - hyperplasia Itchtm1b(EUCOMM)Hmgu HOM Early adult
Esophagus - inflammation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Spleen - hyperplasia Itchtm1b(EUCOMM)Hmgu HOM Early adult
Kidney - tissue specific degenerative process Itchtm1b(EUCOMM)Hmgu HOM Early adult
Sternum - hyperplasia Itchtm1b(EUCOMM)Hmgu HOM Early adult
Kidney - MPATH diagnostic term hydronephrosis Itchtm1b(EUCOMM)Hmgu HOM Early adult
Liver - inflammation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Urinary bladder - inflammation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Thymus - inflammation Itchtm1b(EUCOMM)Hmgu HOM Early adult

 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Itchtm1(NCOM)Cmhd Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Itchtm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Itchtm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice

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