Gene: Itch

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Name
itchy, E3 ubiquitin protein ligase
MGI ID
MGI:1202301
Synonyms
6720481N21Rik 8030492O04Rik C230047C07Rik AIP4
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal startle reflex Itchtm1b(EUCOMM)Hmgu HOM Early adult 4.33×10-05
abnormal head size Itchtm1b(EUCOMM)Hmgu HOM Early adult 6.33×10-05
abnormal tooth morphology Itchtm1b(EUCOMM)Hmgu HOM Early adult 3.37×10-06
decreased bone mineral content Itchtm1b(EUCOMM)Hmgu HOM Early adult 6.27×10-06
abnormal circulating calcium level Itchtm1b(EUCOMM)Hmgu HOM Early adult 1.02×10-12
abnormal circulating fructosamine level Itchtm1b(EUCOMM)Hmgu HOM Early adult 6.13×10-14
abnormal lean body mass Itchtm1b(EUCOMM)Hmgu HOM Early adult 7.37×10-05
tremors Itchtm1b(EUCOMM)Hmgu HOM Early adult 1.90×10-09
abnormal circulating alkaline phosphatase level Itchtm1b(EUCOMM)Hmgu HOM Early adult 1.76×10-15
abnormal locomotor activation Itchtm1b(EUCOMM)Hmgu HOM Early adult 3.49×10-06
abnormal circulating phosphate level Itchtm1b(EUCOMM)Hmgu HOM Early adult 1.04×10-06
abnormal circulating glucose level Itchtm1b(EUCOMM)Hmgu HOM Early adult 2.32×10-05
enlarged gallbladder Itchtm1b(EUCOMM)Hmgu HOM Early adult 0.00
abnormal fasting circulating glucose level Itchtm1b(EUCOMM)Hmgu HOM Early adult 4.04×10-06
abnormal grip strength Itchtm1b(EUCOMM)Hmgu HOM Early adult 7.78×10-05
abnormal esophagus morphology Itchtm1b(EUCOMM)Hmgu HOM Early adult 0.00
abnormal bone mineralization Itchtm1b(EUCOMM)Hmgu HOM Early adult 0.00
increased mean corpuscular volume Itchtm1(NCOM)Cmhd HET Early adult 2.20×10-11
enlarged spleen Itchtm1b(EUCOMM)Hmgu HOM Early adult 0.00
abnormal bone structure Itchtm1b(EUCOMM)Hmgu HOM Early adult 0.00
abnormal bone mineral density Itchtm1b(EUCOMM)Hmgu HOM Early adult 0.00
enlarged kidney Itchtm1b(EUCOMM)Hmgu HOM Early adult 0.00
abnormal circulating total protein level Itchtm1b(EUCOMM)Hmgu HOM Early adult 4.00×10-09
decreased circulating cholesterol level Itchtm1b(EUCOMM)Hmgu HOM Early adult 4.61×10-05

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (3/589)  (2/2) N/A
Aorta 2 No  (1/589)  (2/2)  Wholemount images
Bone 2 No N/A
Brain 2 No  (3/589)  (2/2)  Wholemount images
Brainstem 2 No  (2/589)  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No  (3/589)  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/589)  (2/2)  Wholemount images
Esophagus 2 No  (7/415) N/A
Eye 2 No  (2/2)  Wholemount images
Gall bladder 2 No  (1/2)  Wholemount images
Heart 2 No  (1/589)  (2/2)  Wholemount images
Hippocampus 2 No  (3/589)  (2/2)  Wholemount images
Hypothalamus 2 No  (2/589)  (2/2)  Wholemount images
Kidney 2 No  (20/589)  (2/2)  Wholemount images
Large intestine 2 No  (10/589)  (2/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No  (1/589)  (2/2)  Wholemount images
Lung 2 No  (1/589)  (2/2)  Wholemount images
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/589)  (2/2)  Wholemount images
Oral epithelium 2 No N/A
Ovary 2 No  (1/589)  (1/2)  Wholemount images
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/589)  (2/2)  Wholemount images
Parathyroid gland 2 No  (2/2)  Wholemount images
Peripheral nervous system 2 No  (1/589)  (2/2)  Wholemount images
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/589) N/A
Prostate gland 2 No  (12/589) N/A
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/589)  (2/2)  Wholemount images
Spinal cord 2 No  (2/589)  (2/2)  Wholemount images
Spleen 2 No  (2/589) N/A
Stomach 2 No  (13/589)  (2/2)  Wholemount images
Striatum 2 No  (3/589)  (2/2)  Wholemount images
Testis 2 No  (5/589)  (1/2)  Wholemount images
Thymus 2 No N/A
Thyroid gland 2 No  (16/589)  (1/2)  Wholemount images
Trachea 2 No  (2/589) N/A
Uterus 2 No  (1/2)  Wholemount images
Vascular system 2 No  (2/2)  Wholemount images
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/506)  (4/4) N/A
Ear 2  (1/506)  (1/4) N/A
Embryo 2  (1/507)  (4/4) N/A
Eye 2  (1/506)  (4/4) N/A
Foot 2  (1/506)  (3/4) N/A
Forebrain 2  (1/506)  (4/4) N/A
Forelimb 2  (1/506)  (3/4) N/A
Hand 2  (1/505)  (3/4) N/A
Head 2  (5/506)  (4/4) N/A
Heart 2  (1/506)  (2/4) N/A
Hindbrain 2  (6/506)  (3/4) N/A
Hindlimb 2  (1/505)  (3/4) N/A
Liver 2  (1/506)  (2/4) N/A
Lung 2  (1/502)  (2/4) N/A
Mandibular process 2  (1/506)  (2/4) N/A
Maxillary process 2  (1/506)  (2/4) N/A
Midbrain 2  (1/506)  (4/4) N/A
Oral cavity 2  (1/506)  (2/4) N/A
Skin 2  (1/506)  (1/4) N/A
Tail 2  (1/506)  (3/4) N/A
Tail somite 2  (1/506)  (1/4) N/A

 Associated Images

Adult LacZ: LacZ Images Wholemount
40 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
12 Images
X-ray: XRay Images Whole Body Lateral Orientation
12 Images
X-ray: XRay Images Whole Body Dorso Ventral
12 Images
Embryo LacZ: LacZ images wholemount
8 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Itchtm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice
Itchtm1(NCOM)Cmhd Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Itchtm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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