Gene: Itch

Log in to follow

Name
itchy, E3 ubiquitin protein ligase
MGI ID
MGI:1202301
Synonyms
AIP4 8030492O04Rik C230047C07Rik 6720481N21Rik
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
enlarged kidney Itchtm1b(EUCOMM)Hmgu HOM Early adult 0.00
increased circulating total protein level Itchtm1b(EUCOMM)Hmgu HOM Early adult 2.74×10-05
megacephaly Itchtm1b(EUCOMM)Hmgu HOM Early adult 6.74×10-05
abnormal tooth morphology Itchtm1b(EUCOMM)Hmgu HOM Early adult 3.70×10-06
abnormal startle reflex Itchtm1b(EUCOMM)Hmgu HOM Early adult 8.87×10-05
abnormal bone structure Itchtm1b(EUCOMM)Hmgu HOM Early adult 2.04×10-25
abnormal esophagus morphology Itchtm1b(EUCOMM)Hmgu HOM Early adult 0.00
increased mean corpuscular volume Itchtm1(NCOM)Cmhd HET Early adult 7.59×10-08
increased circulating calcium level Itchtm1b(EUCOMM)Hmgu HOM Early adult 3.50×10-06
decreased grip strength Itchtm1b(EUCOMM)Hmgu HOM Early adult 2.14×10-05
enlarged gallbladder Itchtm1b(EUCOMM)Hmgu HOM Early adult 0.00
decreased bone mineral content Itchtm1b(EUCOMM)Hmgu HOM Early adult 7.78×10-39
tremors Itchtm1b(EUCOMM)Hmgu HOM Early adult 2.29×10-09
abnormal behavior Itchtm1b(EUCOMM)Hmgu HOM Early adult 3.79×10-05
decreased circulating fructosamine level Itchtm1b(EUCOMM)Hmgu HOM Early adult 5.38×10-10
increased lean body mass Itchtm1b(EUCOMM)Hmgu HOM Early adult 7.28×10-05
enlarged spleen Itchtm1b(EUCOMM)Hmgu HOM Early adult 0.00
decreased circulating glucose level Itchtm1b(EUCOMM)Hmgu HOM Early adult 2.39×10-05
decreased bone mineral density Itchtm1b(EUCOMM)Hmgu HOM Early adult 2.00×10-26
decreased circulating alkaline phosphatase level Itchtm1b(EUCOMM)Hmgu HOM Early adult 6.37×10-07

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2) N/A
Aorta 2 No  (2/2)  Wholemount images
Bone 2 No N/A
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/2)  Wholemount images
Esophagus 2 No  (7/415) N/A
Eye 2 No  (2/2)  Wholemount images
Gall bladder 2 No  (1/2)  Wholemount images
Heart 2 No  (2/2)  Wholemount images
Hippocampus 2 No  (2/2)  Wholemount images
Hypothalamus 2 No  (2/2)  Wholemount images
Kidney 2 No  (18/584)  (2/2)  Wholemount images
Large intestine 2 No  (10/584)  (2/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No  (2/2)  Wholemount images
Lung 2 No  (2/2)  Wholemount images
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/2)  Wholemount images
Oral epithelium 2 No N/A
Ovary 2 No  (1/584)  (1/2)  Wholemount images
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/584)  (2/2)  Wholemount images
Parathyroid gland 2 No  (2/2)  Wholemount images
Peripheral nervous system 2 No  (2/2)  Wholemount images
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584)  (2/2)  Wholemount images
Spinal cord 2 No  (2/2)  Wholemount images
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584)  (2/2)  Wholemount images
Striatum 2 No  (2/2)  Wholemount images
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No N/A
Thyroid gland 2 No  (15/584)  (1/2)  Wholemount images
Trachea 2 No N/A
Uterus 2 No  (1/2)  Wholemount images
Vascular system 2 No  (2/2)  Wholemount images
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 1  (6/504)  (2/2) N/A
Ear 1  (1/504) N/A
Embryo 1  (1/505)  (2/2) N/A
Eye 1  (1/504)  (2/2) N/A
Foot 1  (1/504)  (2/2) N/A
Forebrain 1  (1/504)  (2/2) N/A
Forelimb 1  (1/504)  (2/2) N/A
Hand 1  (1/503)  (2/2) N/A
Head 1  (5/504)  (2/2) N/A
Heart 1  (1/504) N/A
Hindbrain 1  (6/504)  (2/2) N/A
Hindlimb 1  (1/503)  (2/2) N/A
Liver 1  (1/504) N/A
Lung 1  (1/500) N/A
Mandibular process 1  (1/504) N/A
Maxillary process 1  (1/504) N/A
Midbrain 1  (1/504)  (2/2) N/A
Oral cavity 1  (1/504) N/A
Skin 1  (1/504) N/A
Tail 1  (1/504)  (2/2) N/A
Tail somite 1  (1/504) N/A

 Associated Images

X-ray: XRay Images Skull Dorso Ventral Orientation
12 Images
X-ray: XRay Images Whole Body Lateral Orientation
12 Images
Adult LacZ: LacZ Images Wholemount
19 Images
X-ray: XRay Images Whole Body Dorso Ventral
12 Images
Embryo LacZ: LacZ images wholemount
8 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images

 Disease Models

Please visit the desktop version to see this section

 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Kidney - inflammation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Heart - dilatation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Esophagus - inflammation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Lung - MPATH diagnostic term acidophilic macrophage pneumonia Itchtm1b(EUCOMM)Hmgu HOM Early adult
Knee joint - acute inflammation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Femur - hyperplasia Itchtm1b(EUCOMM)Hmgu HOM Early adult
Eye with optic nerve - developmental and structural abnormality Itchtm1b(EUCOMM)Hmgu HOM Early adult
Small intestine - inflammation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Skeletal muscle - healing and repair process Itchtm1b(EUCOMM)Hmgu HOM Early adult
Stomach - metaplasia Itchtm1b(EUCOMM)Hmgu HOM Early adult
Gall bladder - hyalinosis Itchtm1b(EUCOMM)Hmgu HOM Early adult
Trachea - intracellular and extracellular depletion Itchtm1b(EUCOMM)Hmgu HOM Early adult
Heart - inflammation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Stomach - MPATH diagnostic term intestinal metaplasia Itchtm1b(EUCOMM)Hmgu HOM Early adult
Skeletal muscle - inflammation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Thymus - inflammation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Stomach - ulcerative inflammation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Stomach - inflammation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Urinary bladder - inflammation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Kidney - MPATH diagnostic term hydronephrosis Itchtm1b(EUCOMM)Hmgu HOM Early adult
Esophagus - tissue specific degenerative process Itchtm1b(EUCOMM)Hmgu HOM Early adult
Tongue - inflammation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Lung - tissue specific degenerative process Itchtm1b(EUCOMM)Hmgu HOM Early adult
Spleen - MPATH diagnostic term extramedullary hemopoiesis Itchtm1b(EUCOMM)Hmgu HOM Early adult
Spleen - hyperplasia Itchtm1b(EUCOMM)Hmgu HOM Early adult
Liver - hyperplasia Itchtm1b(EUCOMM)Hmgu HOM Early adult
Small intestine - hypertrophy Itchtm1b(EUCOMM)Hmgu HOM Early adult
Skin - inflammation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Kidney - tissue specific degenerative process Itchtm1b(EUCOMM)Hmgu HOM Early adult
Liver - inflammation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Gall bladder - inflammation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Nasal cavity - inflammation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Liver - tissue specific degenerative process Itchtm1b(EUCOMM)Hmgu HOM Early adult
Bone marrow - hyperplasia Itchtm1b(EUCOMM)Hmgu HOM Early adult
Stomach - MPATH diagnostic term ulcer Itchtm1b(EUCOMM)Hmgu HOM Early adult
Nasal cavity - hyalinosis Itchtm1b(EUCOMM)Hmgu HOM Early adult
Gall bladder - hyperplasia Itchtm1b(EUCOMM)Hmgu HOM Early adult
Pancreas - inflammation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Sternum - hyperplasia Itchtm1b(EUCOMM)Hmgu HOM Early adult
Lung - inflammation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Trachea - inflammation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Trachea - intracellular and extracellular accumulation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Nasal cavity - intracellular and extracellular accumulation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Stomach - MPATH diagnostic term hyperkeratosis Itchtm1b(EUCOMM)Hmgu HOM Early adult
Uterus - chronic inflammation Itchtm1b(EUCOMM)Hmgu HOM Early adult
Stomach - tissue specific degenerative process Itchtm1b(EUCOMM)Hmgu HOM Early adult

 Order Mouse and ES Cells

This service may be affected by the Covid-19 pandemic. See how

MGI Allele Allele Type Produced
Itchtm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Itchtm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice
Itchtm1(NCOM)Cmhd Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter