Sorl1 | sortilin-related receptor, LDLR class A repeats-containing

GeneMGI:1202296Synonyms: LR11, Sorla, +2 more

Physiological systems

21 / 24 physiological systems tested

8 Significantly impacted by the knock-out

 Reproductive system Endocrine/exocrine gland Growth/size/body region Nervous system Vision/eye Behavior/neurological Cardiovascular system Craniofacial

13 No significant impact

3 Not tested

Gene metrics:7Significant phenotypes
1Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues

Phenotypes

enlarged seminal vesicle1 supporting datasetSorl1tm1b(EUCOMM)WtsihomozygoteLate adultN/A * 
increased heart rate1 supporting datasetSorl1tm1a(EUCOMM)WtsihomozygoteLate adult9.85x10-5 
abnormal gait1 supporting datasetSorl1tm1b(EUCOMM)WtsihomozygoteEarly adult4.76x10-7 
decreased prepulse inhibition1 supporting datasetSorl1tm1a(EUCOMM)WtsihomozygoteLate adult2.84x10-5 
decreased startle reflex1 supporting datasetSorl1tm1a(EUCOMM)WtsihomozygoteLate adult5.26x10-7 
abnormal snout morphology1 supporting datasetSorl1tm1b(EUCOMM)WtsihomozygoteEarly adult2.01x10-5 
abnormal retina morphology1 supporting datasetSorl1tm1b(EUCOMM)WtsihomozygoteLate adult8.9x10-12 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Sorl1tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Sorl1tm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Sorl1tm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell

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