Genes Phenotypes

Gene: Sorl1

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Name
sortilin-related receptor, LDLR class A repeats-containing
MGI ID
MGI:1202296
Synonyms
mSorLA LR11 2900010L19Rik Sorla
Viability
Homozygous - Viable
Embryo viewer
N/A
Other links
MGI   Ensembl  
Significant phenotypes (5) Measurements chart (222) All data table (731)
Expression & images (67) Disease models (0) Order (2)
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal gait Sorl1tm1b(EUCOMM)Wtsi HOM Early adult 8.32×10-07
increased blood urea nitrogen level Sorl1tm1b(EUCOMM)Wtsi HOM Late adult 3.44×10-05
abnormal snout morphology Sorl1tm1b(EUCOMM)Wtsi HOM Early adult 1.99×10-05
increased fasting circulating glucose level Sorl1tm1b(EUCOMM)Wtsi HOM Early adult 2.41×10-05
enlarged seminal vesicle Sorl1tm1b(EUCOMM)Wtsi HOM Late adult 0.00

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2)  Wholemount images
Aorta 2 No  (2/2)  Wholemount images
Bone 2 No  (1/2)  Wholemount images
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No  (2/2)  Wholemount images
Brown adipose tissue 2 No  (2/2)  Wholemount images
Cartilage tissue 2 No  (2/2)  Wholemount images
Cerebellum 2 No  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/2)  Wholemount images
Esophagus 2 No  (7/415)  (2/2)  Wholemount images
Eye 2 No  (2/2)  Wholemount images
Gall bladder 2 No  (2/2)  Wholemount images
Heart 2 No  (2/2)  Wholemount images
Hippocampus 2 No  (2/2)  Wholemount images
Hypothalamus 2 No  (2/2)  Wholemount images
Kidney 2 No  (18/584)  (2/2)  Wholemount images
Large intestine 2 No  (10/584)  (2/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No  (2/2)  Wholemount images
Lung 2 No  (2/2)  Wholemount images
Lymph node 2 No  (1/2)  Wholemount images
Mammary gland 2 No  (1/2)  Wholemount images
Olfactory lobe 2 No  (2/2)  Wholemount images
Oral epithelium 2 No N/A
Ovary 2 No  (1/584)  (1/2)  Wholemount images
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/584)  (2/2)  Wholemount images
Parathyroid gland 2 No  (2/2)  Wholemount images
Peripheral nervous system 2 No  (2/2)  Wholemount images
Peyer's patch 2 No  (2/2)  Wholemount images
Pituitary gland 2 No  (2/2)  Wholemount images
Prostate gland 2 No  (12/584)  (1/2)  Wholemount images
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584)  (2/2)  Wholemount images
Spinal cord 2 No  (2/2)  Wholemount images
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584)  (2/2)  Wholemount images
Striatum 2 No  (2/2)  Wholemount images
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No  (2/2)  Wholemount images
Thyroid gland 2 No  (15/584)  (2/2)  Wholemount images
Trachea 2 No  (2/2)  Wholemount images
Uterus 2 No N/A
Vascular system 2 No  (2/2)  Wholemount images
White adipose tissue 2 No  (1/2)  Wholemount images
LacZ Wholemount Images
adipose tissue (5)
Adrenal gland expression
White Adipose Tissue expression
MA:0000116
MA:0000058
cardiovascular system (4)
Cartilage tissue expression
Bone no expression
Brown adipose tissue expression
Vascular System expression
MA:0000104
MA:0001459
MA:0000057
MA:0002718
digestive system (4)
Gall Bladder expression
MA:0000356
endocrine system (2)
Adrenal gland expression
White Adipose Tissue expression
MA:0000116
MA:0000058
exocrine system (2)
Lower Urinary Tract expression
Prostate gland expression
MA:0002636
MA:0000404
immune system (3)
Lymph Node expression
MA:0000139
integumental system (1)
Mammary gland expression
MA:0000145
musculoskeletal system (2)
Cartilage tissue expression
Bone no expression
Brown adipose tissue expression
Vascular System expression
MA:0000104
MA:0001459
MA:0000057
MA:0002718
nervous system (5)
Cerebral Cortex expression
Striatum expression
Hippocampus expression
Brain expression
MA:0000185
MA:0000891
MA:0000191
MA:0000168
postnatal mouse (26)
Adrenal gland expression
White Adipose Tissue expression
MA:0000116
MA:0000058
reproductive system (3)
Lower Urinary Tract expression
Prostate gland expression
MA:0002636
MA:0000404
respiratory system (2)
Lung expression
MA:0000415
sensory organ (1)
Eye expression
MA:0000261
set of connective tissues (6)
Adrenal gland expression
White Adipose Tissue expression
MA:0000116
MA:0000058
trunk (15)
Adrenal gland expression
White Adipose Tissue expression
MA:0000116
MA:0000058
urinary system (2)
Kidney expression
MA:0000368
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/504)  (4/4) N/A
Ear 2  (1/504) N/A
Embryo 2  (1/505)  (4/4) N/A
Eye 2  (1/504)  (2/4) N/A
Foot 2  (1/504)  (2/4) N/A
Forebrain 2  (1/504)  (4/4) N/A
Forelimb 2  (1/504)  (2/4) N/A
Hand 2  (1/503)  (2/4) N/A
Head 2  (5/504)  (4/4) N/A
Heart 2  (1/504)  (2/4) N/A
Hindbrain 2  (6/504)  (4/4) N/A
Hindlimb 2  (1/503)  (2/4) N/A
Liver 2  (1/504) N/A
Lung 2  (1/500)  (2/4) N/A
Mandibular process 2  (1/504) N/A
Maxillary process 2  (1/504) N/A
Midbrain 2  (1/504)  (1/4) N/A
Oral cavity 2  (1/504)  (2/4) N/A
Skin 2  (1/504) N/A
Tail 2  (1/504)  (4/4) N/A
Tail somite 2  (1/504)  (4/4) N/A

 Associated Images

X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
X-ray: XRay Images Whole Body Lateral Orientation
9 Images
Echo: M-Mode Images
32 Images
Adult LacZ: LacZ Images Wholemount
26 Images
X-ray: XRay Images Whole Body Dorso Ventral
10 Images
Echo: M-Mode Images
32 Images
X-ray: XRay Images Whole Body Dorso Ventral
12 Images
X-ray: XRay Images Whole Body Lateral Orientation
12 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
12 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

MGI Allele Allele Type Produced
Sorl1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Sorl1tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice

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