Gene Summary

Name:
src homology three (SH3) and cysteine rich domain
Synonyms:
N/A

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal locomotor behavior Stacem1(IMPC)J HOM Early adult 6.28×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Eye Morphology

Images Slit Lamp

4 Images

Electrocardiogram (ECG)

Waveform Image

16 Images

Auditory Brain Stem Response

Click-evoked + 6 to 30kHz tone waveforms (pdf format)

6 Images

Human diseases caused by Stac mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.
No human diseases associated to this gene by phenotypic similarity.

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Stac

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Stac.

There are 5 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Stac proteins associate with the critical domain for excitation-contraction coupling in the II-III loop of CaV1.1. The Journal of general physiology (February 2018) Stac3tm1a(KOMP)Wtsi 29467163
Stac3 has a direct role in skeletal muscle-type excitation-contraction coupling that is disrupted by a myopathy-causing mutation. Proceedings of the National Academy of Sciences of the United States of America (September 2016) Stac3tm1a(KOMP)Wtsi PMC5047181
Defective excitation-contraction coupling is partially responsible for impaired contractility in hindlimb muscles of Stac3 knockout mice. Scientific reports (May 2016) Stac3tm1a(KOMP)Wtsi PMC4868984
Skeletal muscle-specific T-tubule protein STAC3 mediates voltage-induced Ca2+ release and contractility. Proceedings of the National Academy of Sciences of the United States of America (July 2013) Stac3tm1a(KOMP)Wtsi PMC3718085
Stac3 is a novel regulator of skeletal muscle development in mice. PloS one (April 2013) Stac3tm1a(KOMP)Wtsi PMC3633831

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MGI Allele Allele Type Produced
Stactm2e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Stacem1(IMPC)J Exon Deletion Mice
Stactm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Stactm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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