Gene: Pole2

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Name
polymerase (DNA directed), epsilon 2 (p59 subunit)
MGI ID
MGI:1197514
Synonyms
DNA polymerase epsilon small subunit
Viability
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal skin morphology Pole2em1(IMPC)Mbp HET Late adult 0.00
abnormal heart morphology Pole2em1(IMPC)Mbp HET Late adult 0.00
abnormal liver morphology Pole2em1(IMPC)Mbp HET Late adult 0.00
enlarged spleen Pole2em1(IMPC)Mbp HET Late adult 0.00
abnormal embryo turning Pole2em1(IMPC)Mbp HET E9.5 0.00
abnormal hindbrain development Pole2em1(IMPC)Mbp HET E9.5 0.00
thrombocytosis Pole2em1(IMPC)Mbp HET Early adult 2.51×10-05
abnormal neural tube closure Pole2em1(IMPC)Mbp HET E9.5 0.00
increased prepulse inhibition Pole2em1(IMPC)Mbp HET Early adult 8.43×10-09
abnormal midbrain development Pole2em1(IMPC)Mbp HET E9.5 0.00
small heart Pole2em1(IMPC)Mbp HET Late adult 0.00
abnormal skin morphology Pole2em1(IMPC)Mbp HET Early adult 0.00
abnormal spleen morphology Pole2em1(IMPC)Mbp HET Late adult 0.00
abnormal heart looping Pole2em1(IMPC)Mbp HET E9.5 0.00
preweaning lethality, complete penetrance Pole2em1(IMPC)Mbp HOM   Early adult 0.00
impaired glucose tolerance Pole2em1(IMPC)Mbp HET Late adult 6.61×10-06

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 Expression

Expression data not available

 Associated Images

X-ray: XRay Images Whole Body Dorso Ventral
39 Images
X-ray: XRay Images Whole Body Lateral Orientation
13 Images
X-ray: XRay Images Whole Body Dorso Ventral
30 Images
X-ray: XRay Images Whole Body Lateral Orientation
10 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Histopathology

 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Pole2em1(IMPC)Mbp Exon Deletion Mice, Tissue
Pole2tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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