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Genes Phenotypes Help, News, Blog

Gene: Mrpl23 MGI:1196612

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Gene Summary

Name:
mitochondrial ribosomal protein L23
Synonyms:
Rpl23l,  L23mrp

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IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased grip strength Mrpl23em1(IMPC)H HOM Early adult 8.19×10-05
preweaning lethality, complete penetrance Mrpl23tm2b(EUCOMM)Wtsi HOM   Early adult 0.00
decreased bone mineral content Mrpl23em1(IMPC)H HOM Early adult 1.46×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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MicroCT E18.5

Embryo reconstruction

4 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

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X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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DSS Histology

Images

8 Images

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Legacy Phenotype Associated Images
Mrpl23tm2b(EUCOMM)Wtsi
WT, Male, WTSI
Mrpl23tm2b(EUCOMM)Wtsi
WT, Male, WTSI
Mrpl23tm2b(EUCOMM)Wtsi
WT, Male, WTSI
Mrpl23tm2b(EUCOMM)Wtsi
WT, Male, WTSI
Mrpl23tm2b(EUCOMM)Wtsi
WT, Male, WTSI

View all 15 images

Mrpl23tm2b(EUCOMM)Wtsi
abnormal coat/hair pigmentation, HET, Female, WTSI

Human diseases caused by Mrpl23 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.
No human diseases associated to this gene by phenotypic similarity.

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Mrpl23

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Mrpl23.

There are 2 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Mrpl23tm2b(EUCOMM)Wtsi PMC7263671
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Mrpl23tm2b(EUCOMM)Wtsi Mrpl23tm2b(EUCOMM)Wtsi PMC6671969

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Mrpl23tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Mrpl23tm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Mrpl23tm2b(EUCOMM)Wtsi Reporter-tagged deletion allele (with selection cassette) Mice
Mrpl23em1(IMPC)H Exon Deletion Mice

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