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Gene: Cbx7 MGI:1196439

Gene Summary

Name:

chromobox 7

Synonyms:

1600014J01Rik, D15Ertd417e

Order Alleles

IMPC Data Collections

Body Weight Measurements
No Embryo Imaging Data
No Viability Data

IMPC Phenotype Summary

Significant

Not Significant

Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

No results meet the p-value threshold

Select physiological systems to view:

Viewing: all phenotypes

Select physiological systems to view:

Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Legacy Phenotype Associated Images

Cbx7^{tm1a(KOMP)Wtsi}
body, WT, Male, WTSI

Cbx7^{tm1a(KOMP)Wtsi}
head, WT, Male, WTSI

Cbx7^{tm1a(KOMP)Wtsi}
body, HOM, Female, WTSI

Cbx7^{tm1a(KOMP)Wtsi}
head, HOM, Female, WTSI

Cbx7^{tm1a(KOMP)Wtsi}
body, WT, Male, WTSI

View all 83 images

Cbx7^{tm1a(KOMP)Wtsi}
back skin, HOM, Female, WTSI

Cbx7^{tm1a(KOMP)Wtsi}
back skin, WT, Female, WTSI

Cbx7^{tm1a(KOMP)Wtsi}
back skin, HOM, Female, WTSI

View all 6 images

Cbx7^{tm1a(KOMP)Wtsi}
abnormal sebaceous gland morphology, HOM, Female, WTSI

Cbx7^{tm1a(KOMP)Wtsi}
tail skin, WT, Female, WTSI

Cbx7^{tm1a(KOMP)Wtsi}
abnormal sebaceous gland morphology, HOM, Female, WTSI

Human diseases caused by Cbx7 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

Human diseases associated with Cbx7 (0 diseases)
Human diseases predicted to be associated with Cbx7 (80 diseases)

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Cbx7 by phenotypic similarity.

Disease	Matching phenotypes	Source
Rhabdoid Tumor Predisposition Syndrome 2	Carcinoma, Neoplasm of the central nervous system	OMIM:613325
Colorectal Cancer, Susceptibility To, 12	Colorectal polyposis, Carcinoma	OMIM:615083
Tumor Predisposition Syndrome	Lung adenocarcinoma, Cutaneous melanoma, Meningioma, Uveal melanoma, Renal cell carcinoma	OMIM:614327
Lichen Sclerosus Et Atrophicus	Squamous cell carcinoma, Carcinoma	OMIM:151590
Li-Fraumeni Syndrome 2	Sarcoma, Breast carcinoma, Meningioma, Stomach cancer, Glioma	OMIM:609265
Lung Cancer	Non-small cell lung carcinoma, Lung adenocarcinoma, Alveolar cell carcinoma	OMIM:211980
Li-Fraumeni Syndrome	Prostate neoplasm, Adrenocortical carcinoma, Colon cancer, Breast carcinoma, Osteosarcoma, Lung a...	OMIM:151623
Reticulum Cell Sarcoma	Sarcoma, Neoplasm	OMIM:267730
Neuroendocrine Carcinoma Of Salivary Glands, Sensorineural Hearing Loss, And Enamel Hypoplasia	Carcinoma	OMIM:603641
Ewing Sarcoma	Ewing sarcoma	OMIM:612219
Melanoma-Pancreatic Cancer Syndrome	Squamous cell carcinoma, Sarcoma, Melanoma, Oropharyngeal squamous cell carcinoma, Pancreatic ade...	OMIM:606719
Cerebral Sarcoma	Fibrosarcoma, Neoplasm	OMIM:117600
Muir-Torre Syndrome	Benign genitourinary tract neoplasm, Adenoma sebaceum, Carcinoma, Colon cancer, Breast carcinoma,...	OMIM:158320
Alveolar Soft Part Sarcoma	Alveolar soft part sarcoma	OMIM:606243
Sarcoma, Synovial	Synovial sarcoma	OMIM:300813
Colorectal Cancer, Susceptibility To, 10	Colorectal polyposis, Endometrial carcinoma, Carcinoma	OMIM:612591
Squamous Cell Carcinoma, Head And Neck	Squamous cell carcinoma	OMIM:275355
Epidermodysplasia Verruciformis, Susceptibility To, 3	Basal cell carcinoma, Squamous cell carcinoma	OMIM:618267
Nut Midline Carcinoma	Ewing sarcoma, Squamous cell carcinoma, Leukemia, Neuroblastoma, Neoplasm, Oropharyngeal squamous...	ORPHA:443167
Cheilitis Glandularis	Squamous cell carcinoma, Carcinoma	OMIM:118330
Familial Adenomatous Polyposis 1	Multiple lipomas, Hepatoblastoma, Papillary thyroid carcinoma, Adrenocortical carcinoma, Colon ca...	OMIM:175100
Disseminated Superficial Actinic Porokeratosis	Squamous cell carcinoma	ORPHA:79152
Cheilitis Glandularis	Squamous cell carcinoma, Neoplasm	ORPHA:1221
Bazex Syndrome	Liposarcoma, Lung adenocarcinoma, Neoplasm	ORPHA:166113
Acquired Ichthyosis	Lymphoma, Sarcoma, Multiple myeloma, Neoplasm	ORPHA:454
Multiple Endocrine Neoplasia, Type Iv	Renal angiomyolipoma, Carcinoma, Parathyroid adenoma, Pancreatic endocrine tumor, Pituitary adeno...	OMIM:610755
Nthl1-Related Attenuated Familial Adenomatous Polyposis	Non-Hodgkin lymphoma, Squamous cell carcinoma, Colon cancer, Breast carcinoma, Neoplasm of the re...	ORPHA:454840
Palmoplantar Carcinoma, Multiple Self-Healing	Squamous cell carcinoma, Carcinoma	OMIM:615225
Schopf-Schulz-Passarge Syndrome	Poroma, Basal cell carcinoma, Squamous cell carcinoma, Apocrine hidrocystoma	OMIM:224750
Hyperkeratosis Lenticularis Perstans	Basal cell carcinoma, Squamous cell carcinoma	ORPHA:409
Acne Inversa, Familial, 2, With Or Without Dowling-Degos Disease	Squamous cell carcinoma	OMIM:613736
Epidermodysplasia Verruciformis, X-Linked	Squamous cell carcinoma of the skin, Verrucae	OMIM:305350
Maffucci Syndrome	Multiple enchondromatosis, Sarcoma, Neoplasm of the adrenal cortex, Chondrosarcoma, Hemangiomatos...	ORPHA:163634
Cancer, Alopecia, Pigment Dyscrasia, Onychodystrophy, And Keratoderma	Squamous cell carcinoma	OMIM:618373
Ollier Disease	Visceral angiomatosis, Multiple enchondromatosis, Sarcoma, Lymphangioma, Chondrosarcoma, Neoplasm...	ORPHA:296
Acquired Hemophagocytic Lymphohistiocytosis Associated With Malignant Disease	Hepatic failure, Hepatosplenomegaly, Multiple myeloma, Squamous cell carcinoma, Colon cancer, Hem...	ORPHA:158057
Paraneoplastic Pemphigus	Sarcoma, B-cell lymphoma, Thymoma	ORPHA:63455
Schöpf-Schulz-Passarge Syndrome	Basal cell carcinoma, Squamous cell carcinoma, Ovarian neoplasm	ORPHA:50944
Oncogenic Osteomalacia	Giant cell tumor of bone, Carcinoma, Neurofibromas, Osteosarcoma, Neoplasm of head and neck, Neop...	ORPHA:352540
Opsoclonus-Myoclonus Syndrome	Neuroblastoma, Melanoma, Breast carcinoma, Neoplasm, Neoplasm of the lung, Small cell lung carcin...	ORPHA:1183
Fanconi Renotubular Syndrome 5	Lung adenocarcinoma	OMIM:618913
Xeroderma Pigmentosum Variant	Basal cell carcinoma, Squamous cell carcinoma, Melanoma	ORPHA:90342
Gardner Syndrome	Hepatoblastoma, Adrenocortical carcinoma, Colon cancer, Osteoma, Lipoma, Pilomatrixoma, Adenomato...	ORPHA:79665
Mast Cell Sarcoma	Hepatomegaly, Sarcoma	ORPHA:66661
Punctate Palmoplantar Keratoderma Type 1	Esophageal neoplasm, Squamous cell carcinoma, Melanoma, Brain neoplasm, Breast carcinoma, Adenoca...	ORPHA:79501
Cowden Syndrome 1	Subcutaneous lipoma, Carcinoma, Breast carcinoma, Ovarian carcinoma, Meningioma, Hamartomatous po...	OMIM:158350
Cancer-Associated Retinopathy	Colon cancer, Thymoma, Neoplasm of the breast, Testicular neoplasm, Uterine neoplasm, Small cell ...	ORPHA:71505
Legius Syndrome	Multiple lipomas, Ovarian neoplasm, Desmoid tumors, Non-small cell lung carcinoma, Acute monocyti...	ORPHA:137605
Large Congenital Melanocytic Nevus	Sarcoma, Rhabdomyosarcoma, Cutaneous melanoma, Neoplasm, Neoplasm of the skin	ORPHA:626
Liposarcoma	Sarcoma	ORPHA:69078
Apc-Related Attenuated Familial Adenomatous Polyposis	Adrenocortical carcinoma, Colon cancer, Osteoma, Lipoma, Pilomatrixoma, Adenomatous colonic polyp...	ORPHA:247806
Combined Immunodeficiency Due To Dock8 Deficiency	Squamous cell carcinoma of the vulva, Squamous cell carcinoma, Verrucae, Anal canal squamous carc...	ORPHA:217390
Asbestos Intoxication	Lung adenocarcinoma, Malignant mesothelioma	ORPHA:2302
Infantile Myofibromatosis	Sarcoma, Fibroma, Gingival fibromatosis, Benign neoplasm of the central nervous system, Neoplasm ...	ORPHA:2591
Palmoplantar Hyperkeratosis With Squamous Cell Carcinoma Of Skin And 46,Xx Sex Reversal	Laryngeal carcinoma, Carcinoma	OMIM:610644
Familial Adenomatous Polyposis	Hepatoblastoma, Neoplasm of the gastrointestinal tract, Colon cancer, Osteoma, Neoplasm of the ga...	ORPHA:733
Adrenocortical Carcinoma	Lung adenocarcinoma, Increased body weight, Adrenocortical carcinoma	ORPHA:1501
Desmoplastic Small Round Cell Tumor	Sarcoma, Testicular neoplasm, Hepatomegaly, Ovarian neoplasm, Neoplasm of the central nervous sys...	ORPHA:83469
Lambert-Eaton Myasthenic Syndrome	Small cell lung carcinoma	ORPHA:43393
Ichthyosis, Hystrix-Like, With Deafness	Squamous cell carcinoma	OMIM:602540
Necrobiosis Lipoidica	Squamous cell carcinoma	ORPHA:542592
Oral Submucous Fibrosis	Oropharyngeal squamous cell carcinoma	ORPHA:357154
Epidermodysplasia Verruciformis	Squamous cell carcinoma, Verrucae	ORPHA:302
Xeroderma Pigmentosum, Variant Type	Basal cell carcinoma, Squamous cell carcinoma, Cutaneous melanoma	OMIM:278750
Gastrointestinal Stromal Tumor	Gastrointestinal stroma tumor, Esophageal neoplasm, Abnormality of the liver, Neoplasm of the gas...	ORPHA:44890
Turcot Syndrome With Polyposis	Hepatoblastoma, Colon cancer, Lymphoma, Pilomatrixoma, Adenomatous colonic polyposis, Glioma, Pap...	ORPHA:99818
Aicardi Syndrome	Teratoma, Hepatoblastoma, Carcinoma, Metastatic angiosarcoma, Hemangioma, Lipoma	OMIM:304050
Fanconi Anemia, Complementation Group E	Prolonged G2 phase of cell cycle, Leukemia	OMIM:600901
Fanconi Anemia, Complementation Group A	Prolonged G2 phase of cell cycle, Leukemia	OMIM:227650
Werner Syndrome	Gastrointestinal carcinoma, Renal neoplasm, Squamous cell carcinoma, Sarcoma, Melanoma, Slender b...	ORPHA:902
Recurrent Respiratory Papillomatosis	Squamous cell carcinoma	ORPHA:60032
Cushing Syndrome Due To Ectopic Acth Secretion	Pulmonary carcinoid tumor, Medullary thyroid carcinoma, Atypical pulmonary carcinoid tumor, Pancr...	ORPHA:99889
Fanconi Anemia, Complementation Group C	Prolonged G2 phase of cell cycle, Leukemia	OMIM:227645
Dyskeratosis Congenita, X-Linked	Squamous cell carcinoma, Carcinoma, Acute myeloid leukemia, Hodgkin lymphoma, Myelodysplasia, Cir...	OMIM:305000
Dermatomyositis	Gastrointestinal stroma tumor, Lymphoma, Breast carcinoma, Lung adenocarcinoma, Neoplasm	ORPHA:221
Fanconi Anemia, Complementation Group D2	Prolonged G2 phase of cell cycle, Leukemia, Patent ductus arteriosus	OMIM:227646
Retinoblastoma	Ewing sarcoma, Leukemia, Lymphoma, Pinealoma, Osteosarcoma, Retinoblastoma	OMIM:180200
Papillon-Lefèvre Syndrome	Squamous cell carcinoma, Neoplasm of the skin, Melanoma, Liver abscess	ORPHA:678
Fanconi Anemia, Complementation Group P	Squamous cell carcinoma	OMIM:613951
Sotos Syndrome	Neuroblastoma, Patent ductus arteriosus, Cholesteatoma, Neoplasm, Hemangioma, Sacrococcygeal tera...	ORPHA:821

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cbx7

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cbx7.

There are 5 publications which use IMPC produced mice or data.

Title	Journal	IMPC Allele	PubMed ID
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis.	Nature communications (August 2019)	Cbx7^{tm1a(KOMP)Wtsi}	PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	PLoS biology (April 2019)	Cbx7^{tm1a(KOMP)Wtsi}	PMC6459510
Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen.	Nature communications (April 2014)	Cbx7^{tm1a(KOMP)Wtsi}	PMC3996542
KAP1 represses differentiation-inducible genes in embryonic stem cells through cooperative binding with PRC1 and derepresses pluripotency-associated genes.	Molecular and cellular biology (March 2014)	Cbx7^{tm1a(KOMP)Wtsi}	PMC4019052
Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.	Cell (July 2013)	Cbx7^{tm1a(KOMP)Wtsi}	PMC3717207

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MGI Allele	Allele Type	Produced
Cbx7^{tm1e(KOMP)Wtsi}	Targeted, non-conditional allele	ES Cells
Cbx7^{tm42029(pL1L2_GT2_DelLacZ_bsd)}	KO first allele (reporter-tagged insertion with conditional potential)	Targeting vectors
Cbx7^{tm1a(KOMP)Wtsi}	KO first allele (reporter-tagged insertion with conditional potential)	Mice, Targeting vectors, ES Cells

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