Gene Summary

chromobox 7
1600014J01Rik,  D15Ertd417e

IMPC Data Collections

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Legacy Phenotype Associated Images

View all 83 images

View all 6 images

Human diseases caused by Cbx7 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Cbx7 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Rhabdoid Tumor Predisposition Syndrome 2
Carcinoma, Neoplasm of the central nervous system OMIM:613325
Colorectal Cancer, Susceptibility To, 12
Colorectal polyposis, Carcinoma OMIM:615083
Tumor Predisposition Syndrome
Lung adenocarcinoma, Cutaneous melanoma, Meningioma, Uveal melanoma, Renal cell carcinoma OMIM:614327
Lichen Sclerosus Et Atrophicus
Squamous cell carcinoma, Carcinoma OMIM:151590
Li-Fraumeni Syndrome 2
Sarcoma, Breast carcinoma, Meningioma, Stomach cancer, Glioma OMIM:609265
Lung Cancer
Non-small cell lung carcinoma, Lung adenocarcinoma, Alveolar cell carcinoma OMIM:211980
Li-Fraumeni Syndrome
Prostate neoplasm, Adrenocortical carcinoma, Colon cancer, Breast carcinoma, Osteosarcoma, Lung a... OMIM:151623
Reticulum Cell Sarcoma
Sarcoma, Neoplasm OMIM:267730
Neuroendocrine Carcinoma Of Salivary Glands, Sensorineural Hearing Loss, And Enamel Hypoplasia
Carcinoma OMIM:603641
Ewing Sarcoma
Ewing sarcoma OMIM:612219
Melanoma-Pancreatic Cancer Syndrome
Squamous cell carcinoma, Sarcoma, Melanoma, Oropharyngeal squamous cell carcinoma, Pancreatic ade... OMIM:606719
Cerebral Sarcoma
Fibrosarcoma, Neoplasm OMIM:117600
Muir-Torre Syndrome
Benign genitourinary tract neoplasm, Adenoma sebaceum, Carcinoma, Colon cancer, Breast carcinoma,... OMIM:158320
Alveolar Soft Part Sarcoma
Alveolar soft part sarcoma OMIM:606243
Sarcoma, Synovial
Synovial sarcoma OMIM:300813
Colorectal Cancer, Susceptibility To, 10
Colorectal polyposis, Endometrial carcinoma, Carcinoma OMIM:612591
Squamous Cell Carcinoma, Head And Neck
Squamous cell carcinoma OMIM:275355
Epidermodysplasia Verruciformis, Susceptibility To, 3
Basal cell carcinoma, Squamous cell carcinoma OMIM:618267
Nut Midline Carcinoma
Ewing sarcoma, Squamous cell carcinoma, Leukemia, Neuroblastoma, Neoplasm, Oropharyngeal squamous... ORPHA:443167
Cheilitis Glandularis
Squamous cell carcinoma, Carcinoma OMIM:118330
Familial Adenomatous Polyposis 1
Multiple lipomas, Hepatoblastoma, Papillary thyroid carcinoma, Adrenocortical carcinoma, Colon ca... OMIM:175100
Disseminated Superficial Actinic Porokeratosis
Squamous cell carcinoma ORPHA:79152
Cheilitis Glandularis
Squamous cell carcinoma, Neoplasm ORPHA:1221
Bazex Syndrome
Liposarcoma, Lung adenocarcinoma, Neoplasm ORPHA:166113
Acquired Ichthyosis
Lymphoma, Sarcoma, Multiple myeloma, Neoplasm ORPHA:454
Multiple Endocrine Neoplasia, Type Iv
Renal angiomyolipoma, Carcinoma, Parathyroid adenoma, Pancreatic endocrine tumor, Pituitary adeno... OMIM:610755
Nthl1-Related Attenuated Familial Adenomatous Polyposis
Non-Hodgkin lymphoma, Squamous cell carcinoma, Colon cancer, Breast carcinoma, Neoplasm of the re... ORPHA:454840
Palmoplantar Carcinoma, Multiple Self-Healing
Squamous cell carcinoma, Carcinoma OMIM:615225
Schopf-Schulz-Passarge Syndrome
Poroma, Basal cell carcinoma, Squamous cell carcinoma, Apocrine hidrocystoma OMIM:224750
Hyperkeratosis Lenticularis Perstans
Basal cell carcinoma, Squamous cell carcinoma ORPHA:409
Acne Inversa, Familial, 2, With Or Without Dowling-Degos Disease
Squamous cell carcinoma OMIM:613736
Epidermodysplasia Verruciformis, X-Linked
Squamous cell carcinoma of the skin, Verrucae OMIM:305350
Maffucci Syndrome
Multiple enchondromatosis, Sarcoma, Neoplasm of the adrenal cortex, Chondrosarcoma, Hemangiomatos... ORPHA:163634
Cancer, Alopecia, Pigment Dyscrasia, Onychodystrophy, And Keratoderma
Squamous cell carcinoma OMIM:618373
Ollier Disease
Visceral angiomatosis, Multiple enchondromatosis, Sarcoma, Lymphangioma, Chondrosarcoma, Neoplasm... ORPHA:296
Acquired Hemophagocytic Lymphohistiocytosis Associated With Malignant Disease
Hepatic failure, Hepatosplenomegaly, Multiple myeloma, Squamous cell carcinoma, Colon cancer, Hem... ORPHA:158057
Paraneoplastic Pemphigus
Sarcoma, B-cell lymphoma, Thymoma ORPHA:63455
Schöpf-Schulz-Passarge Syndrome
Basal cell carcinoma, Squamous cell carcinoma, Ovarian neoplasm ORPHA:50944
Oncogenic Osteomalacia
Giant cell tumor of bone, Carcinoma, Neurofibromas, Osteosarcoma, Neoplasm of head and neck, Neop... ORPHA:352540
Opsoclonus-Myoclonus Syndrome
Neuroblastoma, Melanoma, Breast carcinoma, Neoplasm, Neoplasm of the lung, Small cell lung carcin... ORPHA:1183
Fanconi Renotubular Syndrome 5
Lung adenocarcinoma OMIM:618913
Xeroderma Pigmentosum Variant
Basal cell carcinoma, Squamous cell carcinoma, Melanoma ORPHA:90342
Gardner Syndrome
Hepatoblastoma, Adrenocortical carcinoma, Colon cancer, Osteoma, Lipoma, Pilomatrixoma, Adenomato... ORPHA:79665
Mast Cell Sarcoma
Hepatomegaly, Sarcoma ORPHA:66661
Punctate Palmoplantar Keratoderma Type 1
Esophageal neoplasm, Squamous cell carcinoma, Melanoma, Brain neoplasm, Breast carcinoma, Adenoca... ORPHA:79501
Cowden Syndrome 1
Subcutaneous lipoma, Carcinoma, Breast carcinoma, Ovarian carcinoma, Meningioma, Hamartomatous po... OMIM:158350
Cancer-Associated Retinopathy
Colon cancer, Thymoma, Neoplasm of the breast, Testicular neoplasm, Uterine neoplasm, Small cell ... ORPHA:71505
Legius Syndrome
Multiple lipomas, Ovarian neoplasm, Desmoid tumors, Non-small cell lung carcinoma, Acute monocyti... ORPHA:137605
Large Congenital Melanocytic Nevus
Sarcoma, Rhabdomyosarcoma, Cutaneous melanoma, Neoplasm, Neoplasm of the skin ORPHA:626
Sarcoma ORPHA:69078
Apc-Related Attenuated Familial Adenomatous Polyposis
Adrenocortical carcinoma, Colon cancer, Osteoma, Lipoma, Pilomatrixoma, Adenomatous colonic polyp... ORPHA:247806
Combined Immunodeficiency Due To Dock8 Deficiency
Squamous cell carcinoma of the vulva, Squamous cell carcinoma, Verrucae, Anal canal squamous carc... ORPHA:217390
Asbestos Intoxication
Lung adenocarcinoma, Malignant mesothelioma ORPHA:2302
Infantile Myofibromatosis
Sarcoma, Fibroma, Gingival fibromatosis, Benign neoplasm of the central nervous system, Neoplasm ... ORPHA:2591
Palmoplantar Hyperkeratosis With Squamous Cell Carcinoma Of Skin And 46,Xx Sex Reversal
Laryngeal carcinoma, Carcinoma OMIM:610644
Familial Adenomatous Polyposis
Hepatoblastoma, Neoplasm of the gastrointestinal tract, Colon cancer, Osteoma, Neoplasm of the ga... ORPHA:733
Adrenocortical Carcinoma
Lung adenocarcinoma, Increased body weight, Adrenocortical carcinoma ORPHA:1501
Desmoplastic Small Round Cell Tumor
Sarcoma, Testicular neoplasm, Hepatomegaly, Ovarian neoplasm, Neoplasm of the central nervous sys... ORPHA:83469
Lambert-Eaton Myasthenic Syndrome
Small cell lung carcinoma ORPHA:43393
Ichthyosis, Hystrix-Like, With Deafness
Squamous cell carcinoma OMIM:602540
Necrobiosis Lipoidica
Squamous cell carcinoma ORPHA:542592
Oral Submucous Fibrosis
Oropharyngeal squamous cell carcinoma ORPHA:357154
Epidermodysplasia Verruciformis
Squamous cell carcinoma, Verrucae ORPHA:302
Xeroderma Pigmentosum, Variant Type
Basal cell carcinoma, Squamous cell carcinoma, Cutaneous melanoma OMIM:278750
Gastrointestinal Stromal Tumor
Gastrointestinal stroma tumor, Esophageal neoplasm, Abnormality of the liver, Neoplasm of the gas... ORPHA:44890
Turcot Syndrome With Polyposis
Hepatoblastoma, Colon cancer, Lymphoma, Pilomatrixoma, Adenomatous colonic polyposis, Glioma, Pap... ORPHA:99818
Aicardi Syndrome
Teratoma, Hepatoblastoma, Carcinoma, Metastatic angiosarcoma, Hemangioma, Lipoma OMIM:304050
Fanconi Anemia, Complementation Group E
Prolonged G2 phase of cell cycle, Leukemia OMIM:600901
Fanconi Anemia, Complementation Group A
Prolonged G2 phase of cell cycle, Leukemia OMIM:227650
Werner Syndrome
Gastrointestinal carcinoma, Renal neoplasm, Squamous cell carcinoma, Sarcoma, Melanoma, Slender b... ORPHA:902
Recurrent Respiratory Papillomatosis
Squamous cell carcinoma ORPHA:60032
Cushing Syndrome Due To Ectopic Acth Secretion
Pulmonary carcinoid tumor, Medullary thyroid carcinoma, Atypical pulmonary carcinoid tumor, Pancr... ORPHA:99889
Fanconi Anemia, Complementation Group C
Prolonged G2 phase of cell cycle, Leukemia OMIM:227645
Dyskeratosis Congenita, X-Linked
Squamous cell carcinoma, Carcinoma, Acute myeloid leukemia, Hodgkin lymphoma, Myelodysplasia, Cir... OMIM:305000
Gastrointestinal stroma tumor, Lymphoma, Breast carcinoma, Lung adenocarcinoma, Neoplasm ORPHA:221
Fanconi Anemia, Complementation Group D2
Prolonged G2 phase of cell cycle, Leukemia, Patent ductus arteriosus OMIM:227646
Ewing sarcoma, Leukemia, Lymphoma, Pinealoma, Osteosarcoma, Retinoblastoma OMIM:180200
Papillon-Lefèvre Syndrome
Squamous cell carcinoma, Neoplasm of the skin, Melanoma, Liver abscess ORPHA:678
Fanconi Anemia, Complementation Group P
Squamous cell carcinoma OMIM:613951
Sotos Syndrome
Neuroblastoma, Patent ductus arteriosus, Cholesteatoma, Neoplasm, Hemangioma, Sacrococcygeal tera... ORPHA:821


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cbx7

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cbx7.

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MGI Allele Allele Type Produced
Cbx7tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Cbx7tm42029(pL1L2_GT2_DelLacZ_bsd) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Cbx7tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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