Gene Summary

Name:
PEAK1 related kinase activating pseudokinase 1
Synonyms:
NACK,  D8Ertd82e

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased exploration in new environment Prag1em2(IMPC)Tcp HOM Early adult 2.50×10-05
decreased fasting circulating glucose level Prag1em2(IMPC)Tcp HOM Early adult 1.01×10-05
decreased prepulse inhibition Prag1em2(IMPC)Tcp HOM Early adult 8.37×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Skull Lateral Orientation

10 Images

Gross Pathology and Tissue Collection

Images

8 Images

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

Human diseases caused by Prag1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Prag1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Hyperinsulinemic Hypoglycemia, Familial, 7
Hyperinsulinemic hypoglycemia, Hypoglycemic seizures, Hypoglycemia, Hyperinsulinemia OMIM:610021

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Prag1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Prag1.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
NACK is an integral component of the Notch transcriptional activation complex and is critical for development and tumorigenesis. Cancer research (July 2014) Prag1tm1a(KOMP)Mbp PMC4154994

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MGI Allele Allele Type Produced
Prag1tm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Prag1tm1e(KOMP)Mbp Targeted, non-conditional allele ES Cells
Prag1tm41666(L1L2_gt0) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Prag1em2(IMPC)Tcp Intra-exon deletion Mice, Tissue
Prag1tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells

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