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Gene: Bloc1s1 MGI:1195276

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Gene Summary

Name:
biogenesis of lysosomal organelles complex-1, subunit 1
Synonyms:
Gcn5l1,  BLOS1

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Bloc1s1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Bloc1s1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Bloc1s1.

There are 9 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
The endo-lysosomal regulatory protein BLOC1S1 modulates hepatic lysosomal content and lysosomal lipolysis. Biochemical and biophysical research communications (December 2022) Bloc1s1tm1c(EUCOMM)Hmgu PMC9852072
GCN5L1 impairs diastolic function in mice exposed to a high fat diet by restricting cardiac pyruvate oxidation. Physiological reports (August 2022) Bloc1s1tm1c(EUCOMM)Hmgu PMC9350469
BLOC1S1/GCN5L1/BORCS1 is a critical mediator for the initiation of autolysosomal tubulation. Autophagy (March 2021) Bloc1s1tm1c(EUCOMM)Hmgu PMC8632325
Cardiomyocyte-specific deletion of GCN5L1 in mice restricts mitochondrial protein hyperacetylation in response to a high fat diet. Scientific reports (June 2020) Bloc1s1tm1c(EUCOMM)Hmgu PMC7326908
Cardiac-specific deletion of GCN5L1 restricts recovery from ischemia-reperfusion injury. Journal of molecular and cellular cardiology (February 2019) Bloc1s1tm1a(EUCOMM)Hmgu 30776374
GCN5L1 interacts with αTAT1 and RanBP2 to regulate hepatic α-tubulin acetylation and lysosome trafficking. Journal of cell science (November 2018) Bloc1s1tm1c(EUCOMM)Hmgu PMC6262773
The protein acetylase GCN5L1 modulates hepatic fatty acid oxidation activity via acetylation of the mitochondrial β-oxidation enzyme HADHA. The Journal of biological chemistry (October 2018) Bloc1s1tm1a(EUCOMM)Hmgu PMC6240879
GCN5L1 modulates cross-talk between mitochondria and cell signaling to regulate FoxO1 stability and gluconeogenesis. Nature communications (September 2017) Bloc1s1tm1a(EUCOMM)Hmgu PMC5595826
GCN5-like protein 1 (GCN5L1) controls mitochondrial content through coordinated regulation of mitochondrial biogenesis and mitophagy. The Journal of biological chemistry (December 2013) Bloc1s1tm1a(EUCOMM)Hmgu PMC3908418

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Bloc1s1tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Bloc1s1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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