Dsc3 | desmocollin 3

GeneMGI:1194993Synonyms: 5430426I24Rik

Physiological systems

16 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Nervous system Vision/eye Behavior/neurological Mortality/aging

11 No significant impact

8 Not tested

Gene metrics:6Significant phenotypes
2Associated diseases
Expression examined in:46Adult tissues
0Embryo tissues

Phenotypes

decreased fasting circulating glucose level1 supporting datasetDsc3tm1b(EUCOMM)WtsiheterozygoteEarly adult1.81x10-11 
hyperactivity1 supporting datasetDsc3tm1b(EUCOMM)WtsiheterozygoteEarly adult5.05x10-6 
abnormal behavior1 supporting datasetDsc3tm1b(EUCOMM)WtsiheterozygoteEarly adult3.91x10-5 
decreased thigmotaxis1 supporting datasetDsc3tm1b(EUCOMM)WtsiheterozygoteEarly adult3.91x10-5 
absent optic nerve1 supporting datasetDsc3tm1b(EUCOMM)WtsiheterozygoteEarly adultN/A * 
preweaning lethality, complete penetrance1 supporting datasetDsc3tm1b(EUCOMM)WtsihomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Dsc3tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Dsc3tm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Dsc3tm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell

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