The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
|Esophagus||Section images||heterozygote||50% (1 of 2)|
|Pancreas||Section images||heterozygote||50% (1 of 2)|
|Skin||Section images||heterozygote||50% (1 of 2)|
|Tongue||Section images||heterozygote||100% (2 of 2)|
|Trachea||Section images||heterozygote||100% (2 of 2)|
|Adrenal gland||N/A||heterozygote||0.0% (0 of 2)|
|Aorta||N/A||heterozygote||0.0% (0 of 2)|
|Brain||N/A||heterozygote||0.0% (0 of 2)|
|Brainstem||N/A||heterozygote||0.0% (0 of 2)|
|Cartilage tissue||N/A||heterozygote||0.0% (0 of 2)|
|Cerebellum||N/A||heterozygote||0.0% (0 of 2)|
|Cerebral cortex||N/A||heterozygote||0.0% (0 of 2)|
|Eye||N/A||heterozygote||0.0% (0 of 2)|
|Heart||N/A||heterozygote||0.0% (0 of 2)|
|Hippocampus||N/A||heterozygote||0.0% (0 of 2)|
|Hypothalamus||N/A||heterozygote||0.0% (0 of 2)|
|Kidney||N/A||heterozygote||100% (2 of 2)|
|Large intestine||N/A||heterozygote||50% (1 of 2)|
|Liver||N/A||heterozygote||0.0% (0 of 2)|
|Lower urinary tract||N/A||heterozygote||0.0% (0 of 2)|
|Lung||N/A||heterozygote||0.0% (0 of 2)|
|Lymph node||N/A||heterozygote||0.0% (0 of 2)|
|Mammary gland||N/A||heterozygote||0.0% (0 of 2)|
|Olfactory lobe||N/A||heterozygote||0.0% (0 of 2)|
|Ovary||N/A||heterozygote||0.0% (0 of 2)|
|Oviduct||N/A||heterozygote||0.0% (0 of 2)|
|Peripheral nervous system||N/A||heterozygote||0.0% (0 of 2)|
|Peyer's patch||N/A||heterozygote||0.0% (0 of 2)|
|Pituitary gland||N/A||heterozygote||0.0% (0 of 2)|
|Prostate gland||N/A||heterozygote||50% (1 of 2)|
|Skeletal muscle||N/A||heterozygote||0.0% (0 of 2)|
|Small intestine||N/A||heterozygote||100% (2 of 2)|
|Spinal cord||N/A||heterozygote||0.0% (0 of 2)|
|Spleen||N/A||heterozygote||0.0% (0 of 2)|
|Stomach||N/A||heterozygote||100% (2 of 2)|
|Striatum||N/A||heterozygote||0.0% (0 of 2)|
|Testis||N/A||heterozygote||0.0% (0 of 2)|
|Thymus||N/A||heterozygote||0.0% (0 of 2)|
|Thyroid gland||N/A||heterozygote||100% (2 of 2)|
|Uterus||N/A||heterozygote||0.0% (0 of 2)|
|Vascular system||N/A||heterozygote||0.0% (0 of 2)|
|White adipose tissue||N/A||heterozygote||0.0% (0 of 2)|
Background staining occurs in wild type mice and embryos at an incidental rate.
|Anatomy||Background staining in controls (WT)|
|lower urinary tract||0.0%|
|peripheral nervous system||0.0%|
|white adipose tissue||0.0%|
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Ppl by phenotypic similarity.
|Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation||
||Generalized lymphadenopathy, Aplasia of the thymus, Splenomegaly, Lymph node hypoplasia, Absent t...||OMIM:602450|
||Lymph node hypoplasia, Absence of lymph node germinal center||ORPHA:90186|
|T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency||
||Lymph node hypoplasia, Absent tonsils||ORPHA:276|
|Purine Nucleoside Phosphorylase Deficiency||
||Splenomegaly, Lymph node hypoplasia||OMIM:613179|
||Lymph node hypoplasia||OMIM:300755|
Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.
|Skin - MPATH pathological process term liquefactive necrosis||Ppltm1b(KOMP)Wtsi||HOM||Early adult|
|Skin - MPATH pathological process term dystrophy||Ppltm1b(KOMP)Wtsi||HOM||Early adult|
|Pancreas - MPATH pathological process term hypoplasia||Ppltm1b(KOMP)Wtsi||HOM||Early adult|
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|MGI Allele||Allele Type||Produced|
|Ppltm1a(KOMP)Wtsi||KO first allele (reporter-tagged insertion with conditional potential)||Mice, Targeting vectors, ES Cells|
|Ppltm1e(KOMP)Wtsi||Targeted, non-conditional allele||ES Cells|
|Ppltm1b(KOMP)Wtsi||Reporter-tagged deletion allele (with selection cassette)||Mice, Tissue|