Gene Summary

Name:
actin-binding LIM protein 1
Synonyms:
abLIM-L,  abLIM-M,  2610209L21Rik,  2210411C18Rik,  9330196J19Rik,  abLIM-S,  4833406P10Rik,  Limab1

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased lean body mass Ablim1tm1H HOM Early adult 9.53×10-08
eye hemorrhage Ablim1tm1H HOM Early adult 8.43×10-08
decreased thermal nociceptive threshold Ablim1tm1H HOM Early adult 8.63×10-09
increased bone mineral content Ablim1tm1H HOM Early adult 9.22×10-08

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Ablim1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ablim1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Thrombophilia Due To Protein C Deficiency, Autosomal Recessive
Purpura, Pulmonary embolism, Vitreous hemorrhage OMIM:612304
Retinopathy Of Prematurity
Vitreous hemorrhage, Small for gestational age ORPHA:90050
Retinal Capillary Malformation
Vitreous hemorrhage, Hyphema ORPHA:71213
Retinoschisis 1, X-Linked, Juvenile
Vitreous hemorrhage OMIM:312700
Exudative Vitreoretinopathy 4
Vitreous hemorrhage, Osteopenia OMIM:601813
Vitreoretinopathy, Neovascular Inflammatory
Posterior retinal neovascularization, Vitreous hemorrhage, Peripheral retinal neovascularization OMIM:193235
Multifocal Lymphangioendotheliomatosis-Thrombocytopenia Syndrome
Cerebral hemorrhage, Hypertrophic cardiomyopathy, Intracranial hemorrhage, Retinal hemorrhage, Os... ORPHA:464321
Retinal Venous Beading
Retinal neovascularization, Vitreous hemorrhage OMIM:180080
Kaposiform Lymphangiomatosis
Ecchymosis, Epidural hemorrhage, Subconjunctival hemorrhage, Epistaxis, Abnormal bleeding, Bruisi... ORPHA:464329
Retinal Arteries, Tortuosity Of
Retinal hemorrhage OMIM:180000
Crimean-Congo Hemorrhagic Fever
Myocarditis, Subdural hemorrhage, Melena, Diffuse alveolar hemorrhage, Abnormal left ventricular ... ORPHA:99827
Familial Acute Necrotizing Encephalopathy
Choroid hemorrhage ORPHA:88619
Hemorrhagic Fever-Renal Syndrome
Ecchymosis, Hypertension, Shock, Intracranial hemorrhage, Petechiae, Palpitations, Subconjunctiva... ORPHA:340
Familial Exudative Vitreoretinopathy
Retinal neovascularization, Vitreous hemorrhage, Macular telangiectasia, Reduced bone mineral den... ORPHA:891
Exudative Vitreoretinopathy 1
Retinal neovascularization, Vitreous hemorrhage OMIM:133780
Lujo Hemorrhagic Fever
Myocarditis, Ecchymosis, Shock, Subconjunctival hemorrhage, Bradycardia, Excessive bleeding after... ORPHA:319213
Eales Disease
Epistaxis, Peripheral retinal neovascularization, Transient ischemic attack, Vitreous hemorrhage,... ORPHA:40923
Vitreoretinochoroidopathy
Retinal neovascularization, Vitreous hemorrhage OMIM:193220
Juvenile Xanthogranuloma
Hyphema ORPHA:158000
Marburg Hemorrhagic Fever
Shock, Pericarditis, Petechiae, Prolonged prothrombin time, Subconjunctival hemorrhage, Tachycard... ORPHA:99826
Uveal Melanoma
Vitreous hemorrhage ORPHA:39044
Fundus Dystrophy, Pseudoinflammatory, Recessive Form
Retinal hemorrhage OMIM:264420
Persistent Hyperplastic Primary Vitreous
Hemorrhage of the eye ORPHA:91495
Idiopathic Aplastic Anemia
Ecchymosis, Epistaxis, Gingival bleeding, Retinal hemorrhage ORPHA:88
Retinoblastoma
Vitreous hemorrhage, Subretinal pigment epithelium hemorrhage, Hyphema ORPHA:790
Macular Degeneration, Age-Related, 1
Macular hemorrhage OMIM:603075
Pseudoxanthoma Elasticum
Hypertension, Retinal hemorrhage, Renovascular hypertension, Restrictive cardiomyopathy, Mitral s... OMIM:264800
Leptospirosis
Pericarditis, Retinal hemorrhage, Subconjunctival hemorrhage, Pulmonary hemorrhage, First degree ... ORPHA:509
Angiopathy, Hereditary, With Nephropathy, Aneurysms, And Muscle Cramps
Supraventricular arrhythmia, Raynaud phenomenon, Retinal hemorrhage OMIM:611773
Persistent Hyperplastic Primary Vitreous, Autosomal Recessive
Hyphema OMIM:221900
Lethal Congenital Contracture Syndrome 5
Small for gestational age, Retinal hemorrhage OMIM:615368
Vasculopathy, Retinal, With Cerebral Leukoencephalopathy And Systemic Manifestations
Telangiectasia, Vasculitis in the skin, Raynaud phenomenon, Punctate vasculitis skin lesions, Ret... OMIM:192315
Pseudoxanthoma Elasticum, Forme Fruste
Cerebral hemorrhage, Gastrointestinal hemorrhage, Retinal hemorrhage, Angina pectoris OMIM:177850
Phacoanaphylactic Uveitis
Retinal arteritis, Hyphema ORPHA:209959
Central Retinal Vein Occlusion
Intraretinal hemorrhage, Retinal neovascularization ORPHA:411527
Pseudoxanthoma Elasticum
Hypertension, Angina pectoris, Restrictive cardiomyopathy, Telangiectasia of the skin, Gastrointe... ORPHA:758
Refractory Anemia With Excess Blasts
Palpitations, Abnormal bleeding, Retinal hemorrhage ORPHA:86839
Waldenström Macroglobulinemia
Gingival bleeding, Epistaxis, Gastrointestinal hemorrhage, Vasculitis, Purpura, Congestive heart ... ORPHA:33226
Granulomatosis With Polyangiitis
Diffuse alveolar hemorrhage, Weight loss, Localized pulmonary hemorrhage, Retinal hemorrhage OMIM:608710
Retinoblastoma
Vitreous hemorrhage OMIM:180200
Familial Drusen
Macular hemorrhage ORPHA:75376
Mowat-Wilson Syndrome Due To A Zeb2 Point Mutation
Right unicoronal synostosis, Failure to thrive, Pulmonic stenosis, Aortic valve stenosis, Hyphema ORPHA:261552
Incontinentia Pigmenti
Retinal hemorrhage, Pulmonary arterial hypertension, Telangiectasia of the skin, Cerebral ischemi... ORPHA:464
Rift Valley Fever
Gingival bleeding, Melena, Abnormal bleeding, Hematemesis, Retinal hemorrhage ORPHA:319251
Glutaryl-Coa Dehydrogenase Deficiency
Retinal hemorrhage, Subdural hemorrhage ORPHA:25
Autosomal Recessive Cutis Laxa Type 2, Classic Type
Failure to thrive, Subretinal pigment epithelium hemorrhage ORPHA:357074
Tubulointerstitial Nephritis And Uveitis Syndrome
Weight loss, Vitreous hemorrhage ORPHA:91500
Cockayne Syndrome Type 3
Retinal hemorrhage, Cardiomyopathy, Increased blood pressure, Subdural hemorrhage ORPHA:90324
Incontinentia Pigmenti
Retinal hemorrhage OMIM:308300
Trichinellosis
Retinal hemorrhage ORPHA:863
Cockayne Syndrome
Hypertension, Cachexia, Retinal hemorrhage ORPHA:191
Generalized Arterial Calcification Of Infancy
Abnormal calcification of the carpal bones, Hypertension, Failure to thrive in infancy, Pulmonary... ORPHA:51608

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ablim1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ablim1.

No publications found that use IMPC mice or data for Ablim1.

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MGI Allele Allele Type Produced
Ablim1tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Ablim1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ablim1tm1H Reporter-tagged deletion allele (with selection cassette) ES Cells

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