Gene Summary

Name:
formyl peptide receptor 3
Synonyms:
Fprl1,  Fpr-rs1,  LXA4-R,  Lxa4r

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal ileum morphology Fpr3tm1b(EUCOMM)Hmgu HOM Early adult 0.00
abnormal colon morphology Fpr3tm1b(EUCOMM)Hmgu HOM Early adult 0.00
decreased exploration in new environment Fpr3tm1b(EUCOMM)Hmgu HOM Early adult 1.72×10-05
abnormal vitreous body morphology Fpr3tm1b(EUCOMM)Hmgu HOM   Early adult 7.01×10-05
persistence of hyaloid vascular system Fpr3tm1b(EUCOMM)Hmgu HOM   Early adult 4.11×10-06
increased circulating cholesterol level Fpr3tm1b(EUCOMM)Hmgu HOM Early adult 7.37×10-05
increased hematocrit Fpr3tm1b(EUCOMM)Hmgu HOM Early adult 9.95×10-07
increased hemoglobin content Fpr3tm1b(EUCOMM)Hmgu HOM Early adult 6.84×10-06

Download data as:  TSV  XLS

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Viewing: all phenotypes
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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

Immunophenotyping

Panel B FCS file(s)

6 Images

Immunophenotyping

Panel A FCS file(s)

6 Images

Human diseases caused by Fpr3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Fpr3 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Hemoglobin D Disease
Anemia, HbS hemoglobin, Reduced alpha/beta synthesis ratio, Sickled erythrocytes, Decreased mean ... ORPHA:90039
Erythrocytosis, Familial, 8
Reduced erythrocyte bisphosphoglycerate mutase activity, Polycythemia, Increased circulating hemo... OMIM:222800
Hemoglobin E-Beta-Thalassemia Syndrome
Increased circulating ferritin concentration, Anemia, Abnormal hemoglobin ORPHA:231249
Cholesterol-Ester Transfer Protein Deficiency
Hypotriglyceridemia, Hyperlipidemia, Increased HDL cholesterol concentration, Hypercholesterolemi... ORPHA:79506
Polycythemia Vera
Gastrointestinal hemorrhage, Increased red blood cell mass, Leukocytosis, Increased circulating h... OMIM:263300
Diarrhea 7, Protein-Losing Enteropathy Type
Protein-losing enteropathy, Hyperlipidemia, Hypoalbuminemia, Hypercholesterolemia, Villous atrophy OMIM:615863
Erythrocytosis, Familial, 3
Increased circulating hemoglobin concentration, Increased red blood cell mass, Increased hematocrit OMIM:609820
Erythrocytosis, Familial, 5
Polycythemia, Increased circulating hemoglobin concentration, Increased hematocrit OMIM:617907
Hypertriglyceridemia 2
Hypertriglyceridemia, Decreased HDL cholesterol concentration, Hypercholesterolemia OMIM:619324
Erythrocytosis, Familial, 4
Polycythemia, Increased circulating hemoglobin concentration, Increased hematocrit OMIM:611783
Erythrocytosis, Familial, 7
Polycythemia, Increased circulating hemoglobin concentration, Increased hematocrit OMIM:617981
Erythrocytosis, Familial, 6
Polycythemia, Increased circulating hemoglobin concentration, Increased hematocrit OMIM:617980
Hemoglobin-Delta locus
Imbalanced hemoglobin synthesis, Anemia OMIM:142000
Anemia, Sideroblastic, 5
Reduced hematocrit, Hypochromic microcytic anemia, Anemia, Thrombocytopenia, Neutropenia OMIM:619523
Meckel Diverticulum
Meckel diverticulum OMIM:155140
Appendicitis, Proneness To
Abnormal large intestine morphology OMIM:107700
Blood Group, Cromer System
Protein-losing enteropathy OMIM:613793
Erythrocytosis, Familial, 1
Increased circulating hemoglobin concentration, Increased red blood cell mass, Splenomegaly, Incr... OMIM:133100
Hypothyroidism, Congenital, Nongoitrous, 8
Attention deficit hyperactivity disorder, Hypercholesterolemia, Diminished ability to concentrate OMIM:301033
Sitosterolemia 2
Elevated circulating sitosterol concentration, Hypercholesterolemia OMIM:618666
Anemia, Congenital Dyserythropoietic, Type Iv
Reduced hematocrit, Anemia, Reduced haptoglobin level, Hyperbilirubinemia, Anemia of inadequate p... OMIM:613673
Xanthomatosis, Susceptibility To
Hypercholesterolemia OMIM:602247
Thalassemia, Beta+, Silent Allele
Reduced beta/alpha synthesis ratio OMIM:187550
Hemoglobin H Disease
HbH hemoglobin, Splenomegaly, Hemolytic anemia, Reduced alpha/beta synthesis ratio OMIM:613978
Fetal Hemoglobin Quantitative Trait Locus 1
Persistence of hemoglobin F OMIM:141749
Thyroid Hormone Metabolism, Abnormal, 2
Hypercholesterolemia OMIM:619855
Beta-Thalassemia, Dominant Inclusion Body Type
Decreased mean corpuscular hemoglobin concentration, Persistence of hemoglobin F, Erythrocyte inc... OMIM:603902
Glycogen Storage Disease Vi
Hypertriglyceridemia, Hypercholesterolemia, Hyperlipidemia OMIM:232700
Cholestasis, Progressive Familial Intrahepatic, 10
Increased serum bile acid concentration, Increased total bilirubin, Splenomegaly, Conjugated hype... OMIM:619868
Hemoglobin E Disease
Hypochromic microcytic anemia, Increased red blood cell count, Drug-sensitive hemolytic anemia, H... ORPHA:2133
Hyperlipoproteinemia, Type Ii, And Deafness
Hypertriglyceridemia, Increased LDL cholesterol concentration, Hypercholesterolemia OMIM:144300
Beta-Thalassemia-X-Linked Thrombocytopenia Syndrome
Thrombocytopenia, Anemia, Splenomegaly, Abnormal hemoglobin ORPHA:231393
Hemoglobin C-Beta-Thalassemia Syndrome
Splenomegaly, Anemia, Microcytic anemia, Abnormal hemoglobin ORPHA:231242
Cholesteryl Ester Storage Disease
Hypertriglyceridemia, Esophageal varix, Hypercholesterolemia, Splenomegaly ORPHA:75234
Erythrocytosis, Familial, 2
Increased circulating hemoglobin concentration, Increased red blood cell mass, Increased hematocrit OMIM:263400
Gaisböck Syndrome
Peptic ulcer, Hypertriglyceridemia, Increased red blood cell count, Elevated plasma cell count, I... ORPHA:90041
Delta-Beta-Thalassemia
Anemia, Microcytic anemia, Abnormal hemoglobin ORPHA:231237
Acetophenetidin Sensitivity
Hemolytic anemia, Methemoglobinemia OMIM:200300
Hereditary Persistence Of Fetal Hemoglobin-Beta-Thalassemia Syndrome
Anemia, Splenomegaly, Persistence of hemoglobin F ORPHA:46532
Congenital Amegakaryocytic Thrombocytopenia
Thrombocytopenia, Anemia, Abnormal hemoglobin ORPHA:3319
Methemoglobinemia, Beta Type
Methemoglobinemia OMIM:617971
Methemoglobinemia, Alpha Type
Methemoglobinemia OMIM:617973
Hypercholesterolemia, Familial, 4
Hypertriglyceridemia, Decreased LDL cholesterol concentration, Hypercholesterolemia OMIM:603813
Morbid Obesity And Spermatogenic Failure
Hypertriglyceridemia, Decreased HDL cholesterol concentration, Hypercholesterolemia, Increased LD... OMIM:615703
Tempi Syndrome
Polycythemia, Increased hematocrit ORPHA:284227
Coronary Artery Disease, Autosomal Dominant, 1
Hypercholesterolemia OMIM:608320
Alpha-Heavy Chain Disease
Hypocalcemia, Abnormal small intestine morphology, Anemia, Splenomegaly ORPHA:100025
Congenital Disorder Of Glycosylation, Type Iip
Increased LDL cholesterol concentration, Hypercholesterolemia, Decreased circulating ceruloplasmi... OMIM:616829
Abetalipoproteinemia
Retinal degeneration, Fat malabsorption, Acanthocytosis, Abetalipoproteinemia OMIM:200100
Multiple Intestinal Atresia
Gastrointestinal atresia, Duodenal stenosis ORPHA:2300
Hyperlipidemia, Familial Combined, 3
Xanthelasma, Increased LDL cholesterol concentration, Hyperlipidemia, Increased VLDL cholesterol ... OMIM:144250
Autoinflammatory Disease, Familial, Behcet-Like 3
Ileitis OMIM:618287
Sitosterolemia 1
Xanthelasma, Chronic hemolytic anemia, Giant platelets, Anemia, Reduced haptoglobin level, Elevat... OMIM:210250
Hyperinsulinemic Hypoglycemia, Familial, 8
Attention deficit hyperactivity disorder, Hyperammonemia, Increased C-peptide level, Hypercholest... OMIM:620211
Cholesteryl Ester Storage Disease
Hypertriglyceridemia, Steatorrhea, Decreased HDL cholesterol concentration, Anemia, Bone-marrow f... OMIM:278000
Inflammatory Bowel Disease (Crohn Disease) 30
Protein-losing enteropathy, Gastritis, Pancolitis, Abnormal intestine morphology, Esophagitis, Du... OMIM:619079
Cog4-Cdg
Irritability, Recurrent infection of the gastrointestinal tract, Thrombocytopenia, Hepatosplenome... ORPHA:263501
Alpha-Thalassemia Myelodysplasia Syndrome
HbH hemoglobin, Hypochromic microcytic anemia, Reduced alpha/beta synthesis ratio OMIM:300448
Pancreatic Lipase Deficiency
Steatorrhea, Fat malabsorption, Hypocholesterolemia OMIM:614338
Hypobetalipoproteinemia, Familial, 1
Hypertriglyceridemia, Decreased HDL cholesterol concentration, Steatorrhea, Hypocholesterolemia, ... OMIM:615558
Cyanosis, Transient Neonatal
Anemia, Methemoglobinemia, Reticulocytosis OMIM:613977
Congenital Disorder Of Glycosylation, Type Iio
Decreased circulating ceruloplasmin concentration, Increased LDL cholesterol concentration, Eleva... OMIM:616828
Chylomicron Retention Disease
Steatorrhea, Hypotriglyceridemia, Accumulation of lipid droplets in small-bowel enterocytes, Decr... OMIM:246700
Glycogen Storage Disease Ixa1
Hypertriglyceridemia, Hypercholesterolemia, Splenomegaly, Hyperuricemia OMIM:306000
Lipodystrophy, Congenital Generalized, Type 3
Hypertriglyceridemia, Hypocalcemia, Hepatosplenomegaly, Splenomegaly, Hypercholesterolemia OMIM:612526
Citrullinemia Type Ii
Hypertriglyceridemia, Irritability, Decreased HDL cholesterol concentration, Elevated plasma citr... ORPHA:247585
Hereditary Persistence Of Fetal Hemoglobin-Sickle Cell Disease Syndrome
Hypochromic microcytic anemia, HbS hemoglobin, Splenic infarction, Persistence of hemoglobin F, R... ORPHA:251380
Refractory Celiac Disease
Normocytic anemia, Protein-losing enteropathy, Iron deficiency anemia, Macrocytic anemia, Jejunit... ORPHA:398063
Distal Myopathy, Tateyama Type
Abnormal circulating creatine kinase concentration, Hypercholesterolemia ORPHA:488650
Visceral Myopathy 2
Intestinal obstruction, Rectal prolapse, Gastroesophageal reflux, Intestinal pseudo-obstruction, ... OMIM:619350
Eosinophilic Gastroenteritis
Steatorrhea, Protein-losing enteropathy, Anemia, Abnormality of the gastrointestinal tract, Eleva... ORPHA:2070
Analbuminemia
Hypoalbuminemia, Increased LDL cholesterol concentration, Elevated circulating transferrin concen... OMIM:616000
Deafness, Nerve Type, With Mesenteric Diverticula Of Small Bowel And Progressive Sensory Neuropathy
Jejunoileal ulceration, Hypoproteinemia, Small bowel diverticula, Fat malabsorption OMIM:221400
Palmoplantar Keratoderma-Esophageal Carcinoma Syndrome
Esophageal neoplasm, Gastrointestinal hemorrhage, Abnormal esophagus physiology, Gastroesophageal... ORPHA:2198
Reese Retinal Dysplasia
Remnants of the hyaloid vascular system, Retinal dysplasia OMIM:266400
Beta-Thalassemia
Irritability, Abnormality of iron homeostasis, Anemia, Thrombocytopenia, Splenomegaly, Abnormal h... ORPHA:848
Ataxia, Early-Onset, With Oculomotor Apraxia And Hypoalbuminemia
Elevated circulating creatine kinase concentration, Cognitive impairment, Dementia, Hypoalbuminem... OMIM:208920
Microcornea-Posterior Megalolenticonus-Persistent Fetal Vasculature-Coloboma Syndrome
Posterior lenticonus, Chorioretinal coloboma, Remnants of the hyaloid vascular system, Iris coloboma ORPHA:231736
Neonatal Intrahepatic Cholestasis Due To Citrin Deficiency
Hypertriglyceridemia, Abnormal circulating lipid concentration, Gastrointestinal hemorrhage, Decr... ORPHA:247598
Spinocerebellar Ataxia With Axonal Neuropathy Type 1
Hypoalbuminemia, Hypercholesterolemia ORPHA:94124
Alpha-Thalassemia-Myelodysplastic Syndrome
Acute leukemia, HbH hemoglobin, Thrombocytopenia, Splenomegaly, Microcytic anemia, Neutropenia ORPHA:231401
Alpha-Thalassemia
Anisopoikilocytosis, Hemoglobin Barts, Anemia, Reticulocytosis, Cognitive impairment, Hepatosplen... ORPHA:846
Spinocerebellar Ataxia, Autosomal Recessive, With Axonal Neuropathy 1
Hypoalbuminemia, Hypercholesterolemia OMIM:607250
Morgagni-Stewart-Morel Syndrome
Memory impairment, Depression, Hyperuricemia, Cognitive impairment, Hypercholesterolemia ORPHA:77296
Diamond-Blackfan Anemia 14 With Mandibulofacial Dysostosis
Elevated red cell adenosine deaminase activity, Macrocytic anemia, Increased mean corpuscular vol... OMIM:300946
Hepatic Lipase Deficiency
Hypertriglyceridemia, Increased HDL cholesterol concentration, Hypercholesterolemia OMIM:614025
Agammaglobulinemia 4, Autosomal Recessive
Abnormal T cell morphology, Protein-losing enteropathy, Neutropenia OMIM:613502
Bile Acid Malabsorption, Primary, 1
Increased fecal bile acid, Steatorrhea, Fat malabsorption OMIM:613291
Diamond-Blackfan Anemia 3
Elevated red cell adenosine deaminase activity, Macrocytic anemia, Increased mean corpuscular vol... OMIM:610629
Congenital Short Bowel Syndrome
Steatorrhea, Abnormal peristalsis, Congenital shortened small intestine, Intestinal malrotation, ... OMIM:615237
Congenital Tufting Enteropathy
Irritability, Steatorrhea, Elevated fecal osmolality, Abnormal small intestinal mucosa morphology... ORPHA:92050
Diarrhea 5, With Tufting Enteropathy, Congenital
Crypt hyperplasia, Villous atrophy OMIM:613217
Intestinal Pseudoobstruction, Neuronal, Chronic Idiopathic, X-Linked
Intestinal pseudo-obstruction, Congenital shortened small intestine, Intestinal malrotation, Incr... OMIM:300048
Smith-Magenis Syndrome
Retinal detachment, Velopharyngeal insufficiency, Hypercholesterolemia, Hypertriglyceridemia OMIM:182290
Mitochondrial Complex Iv Deficiency, Nuclear Type 19
Hyperglycinemia, Protein-losing enteropathy OMIM:619063
Secondary Short Bowel Syndrome
Steatorrhea, Aganglionic megacolon, Small intestinal dysmotility, Enterocolitis, Volvulus, Abnorm... ORPHA:95427
Temple Syndrome Due To Paternal 14Q32.2 Hypomethylation
Hypercholesterolemia, High palate ORPHA:254531
Galactokinase Deficiency
Increased level of galactitol in plasma, Hypergalactosemia, Hepatosplenomegaly, Psychomotor deter... ORPHA:79237
Autoinflammatory Syndrome, Familial, Behcet-Like 1
Ileal ulcer, Thrombocytopenia, Lymphopenia, Hemolytic anemia, Colitis OMIM:616744
Pancreatic Colipase Deficiency
Megaloblastic anemia, Fat malabsorption, Steatorrhea ORPHA:309108
Temple Syndrome
Hypertriglyceridemia, High palate, Bifid uvula, Cleft palate, Hypercholesterolemia OMIM:616222
Temple Syndrome Due To Maternal Uniparental Disomy Of Chromosome 14
High palate, Pyloric stenosis, Bifid uvula, Cleft palate, Hypercholesterolemia ORPHA:96184
Alg6-Cdg
Protein-losing enteropathy, Decreased LDL cholesterol concentration, Hypoalbuminemia, Retinal deg... ORPHA:79320
Ataxia-Oculomotor Apraxia 4
Hypoalbuminemia, Hypercholesterolemia, Elevated circulating alpha-fetoprotein concentration, Cogn... OMIM:616267
Acute Interstitial Pneumonia
Elevated circulating creatinine concentration, Reduced hematocrit, Elevated circulating C-reactiv... ORPHA:79126
Bone Marrow Failure Syndrome 6
Anemia, Increased mean corpuscular volume, Squamous cell carcinoma of the tongue, Persistence of ... OMIM:618849
Smith-Magenis Syndrome
Hypertriglyceridemia, Gastroesophageal reflux, Retinal detachment, Cleft palate, Attention defici... ORPHA:819
Congenital Enterocyte Heparan Sulfate Deficiency
Protein-losing enteropathy, Abnormal circulating protein concentration, Hematochezia, Abnormal ci... ORPHA:103910
Citrullinemia, Type Ii, Neonatal-Onset
Hypertriglyceridemia, Decreased HDL cholesterol concentration, Elevated plasma citrulline, Increa... OMIM:605814
Polyposis, Skin Pigmentation, Alopecia, And Fingernail Changes
Protein-losing enteropathy, Anemia, Hypokalemia, Glossitis, Hypocalcemia, Hamartomatous polyposis... OMIM:175500
Chronic Diarrhea Due To Glucoamylase Deficiency
Decreased small intestinal mucosa lactase level, Abnormal small intestinal mucosa morphology ORPHA:103907
Apolipoprotein C-Ii Deficiency
Hypertriglyceridemia, Increased circulating chylomicron concentration, Decreased circulating apol... OMIM:207750
Hypercholesterolemia, Familial, 3
Xanthelasma, Hypercholesterolemia, Abnormal LDL cholesterol concentration OMIM:603776
Glycogen Storage Disease Due To Liver Phosphorylase Kinase Deficiency
Hypertriglyceridemia, Hepatocellular adenoma, Anemia, Esophageal varix, Abnormal erythrocyte enzy... ORPHA:264580
Cholestasis, Progressive Familial Intrahepatic, 8
Increased serum bile acid concentration, Esophageal varix, Elevated circulating alpha-fetoprotein... OMIM:619662
Beta-Thalassemia
Reduced beta/alpha synthesis ratio, Hypochromic microcytic anemia OMIM:613985
Alpha-Thalassemia
Hypochromic microcytic anemia, Reduced alpha/beta synthesis ratio OMIM:604131
Acquired Aneurysmal Subarachnoid Hemorrhage
Memory impairment, Leukocytosis, Cognitive impairment, Progressive neurologic deterioration, Hype... ORPHA:90065
Lysosomal Acid Lipase Deficiency
Hypertriglyceridemia, Xanthelasma, Steatorrhea, Hyperkalemia, Anemia, Vacuolated lymphocytes, Bon... ORPHA:275761
Hypercholesterolemia, Familial, 2
Xanthelasma, Increased LDL cholesterol concentration, Hypercholesterolemia OMIM:144010
Nephrotic Syndrome, Type 11
Hypoalbuminemia, Cleft palate, High palate, Hypercholesterolemia OMIM:616730
Hypercholanemia, Familial 1
Steatorrhea, Fat malabsorption, Increased serum bile acid concentration OMIM:607748
Maternal Uniparental Disomy Of Chromosome 4
Optic atrophy, Depression, Elevated circulating creatine kinase concentration, Abetalipoproteinem... ORPHA:96180
Ataxia With Vitamin E Deficiency
Hypertriglyceridemia, Xanthelasma, Increased LDL cholesterol concentration, Hypercholesterolemia,... OMIM:277460
Juvenile Polyposis Syndrome
Neoplasm of the stomach, Rectal prolapse, Anemia, Hypokalemia, Colon cancer, Hematochezia, Hypoal... OMIM:174900
Glycogen Storage Disease Due To Liver And Muscle Phosphorylase Kinase Deficiency
Hypertriglyceridemia, Hepatocellular adenoma, Anemia, Hepatocellular carcinoma, Elevated circulat... ORPHA:79240
Lysinuric Protein Intolerance
Hypertriglyceridemia, Hyperglycinemia, Steatorrhea, Decreased HDL cholesterol concentration, Anem... ORPHA:470
Spinocerebellar Ataxia With Axonal Neuropathy Type 2
Elevated circulating creatine kinase concentration, Dysphagia, Elevated circulating alpha-fetopro... ORPHA:64753
Shiga Toxin-Associated Hemolytic Uremic Syndrome
Irritability, Rectal prolapse, Hypokalemia, Acute colitis, Intestinal perforation, Leukocytosis, ... ORPHA:90038
Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency Type Ib
Hypertriglyceridemia, Xanthelasma, Hepatocellular adenoma, Anemia, Hypercholesterolemia, Hyperuri... ORPHA:79259
Neuhauser Syndrome
Retinal detachment, High palate, Bifid uvula, Dysphagia, Hypercholesterolemia OMIM:249310
Laron Syndrome
Hypercholesterolemia ORPHA:633
Primary Biliary Cholangitis
Gastrointestinal inflammation, Abnormal circulating lipid concentration, Steatorrhea, Xanthelasma... ORPHA:186
Hb Bart'S Hydrops Fetalis
Anemia, Splenomegaly, Abnormal hemoglobin ORPHA:163596
Optic Nerve Hypoplasia, Bilateral
Optic nerve hypoplasia, Optic nerve aplasia, Remnants of the hyaloid vascular system OMIM:165550
Gastrointestinal Ulceration, Recurrent, With Dysfunctional Platelets
Duodenal ulcer, Abnormal circulating eicosanoid concentration, Iron deficiency anemia, Decreased ... OMIM:618372
Congenital Disorder Of Glycosylation, Type Ih
Protein-losing enteropathy, Anemia, Thrombocytopenia, Hypoalbuminemia, Elevated circulating creat... OMIM:608104
Hyperlipoproteinemia, Type I
Lactescent serum, Increased circulating chylomicron concentration, Hyperlipidemia, Hepatosplenome... OMIM:238600
Primary Familial Polycythemia
Polycythemia, Abnormal hemoglobin ORPHA:90042
Nk-Cell Enteropathy
Duodenal ulcer, Gastroesophageal reflux, Increased T cell count, Abnormal gastric mucosa morpholo... ORPHA:263665
Oculopalatocerebral Syndrome
Cleft palate, Remnants of the hyaloid vascular system OMIM:257910
Congenital Generalized Lipodystrophy
Hypertriglyceridemia, Increased C-peptide level, Macroglossia, Hypercholesterolemia ORPHA:528
Mandibuloacral Dysplasia
Hypertriglyceridemia, Abnormal tongue morphology, High palate, Increased circulating free fatty a... ORPHA:2457
Diamond-Blackfan Anemia 6
Macrocytic anemia, Increased mean corpuscular volume, Persistence of hemoglobin F, Bifid uvula, C... OMIM:612561
Sickle Cell Anemia
Chronic hemolytic anemia, Iron deficiency anemia, Increased mean corpuscular volume, Leukocytosis... ORPHA:232
Idiopathic Steroid-Resistant Nephrotic Syndrome
Hypertriglyceridemia, Hypoalbuminemia, Hypercholesterolemia, Abnormal circulating lipid concentra... ORPHA:567548
Beta-Thalassemia Intermedia
Abnormality of iron homeostasis, Anemia of inadequate production, Hepatocellular carcinoma, Leuko... ORPHA:231222
Galloway-Mowat Syndrome 7
Hypercholesterolemia, Cleft palate, High palate OMIM:618348
Chylomicron Retention Disease
Steatorrhea, Fat malabsorption, Acanthocytosis, Hypocholesterolemia ORPHA:71
Alg1-Cdg
Hypoalbuminemia, Protein-losing enteropathy, Abnormality of the gastrointestinal tract ORPHA:79327
Dominant Beta-Thalassemia
Irritability, Abnormality of iron homeostasis, Hypochromic microcytic anemia, Decreased mean corp... ORPHA:231226
Primary Intestinal Lymphangiectasia
Intestinal lymphangiectasia, Anemia, Decreased proportion of CD3-positive T cells, Functional abn... ORPHA:90362
Juvenile Polyposis Of Infancy
Gastrointestinal hemorrhage, Rectal prolapse, Anemia, Protein-losing enteropathy, Melena, High, n... ORPHA:79076
Bile Acid Synthesis Defect, Congenital, 1
Steatorrhea, Splenomegaly, Conjugated hyperbilirubinemia, Acholic stools, Hypocholesterolemia, Fa... OMIM:607765
Alpha-Thalassemia-X-Linked Intellectual Disability Syndrome
Optic atrophy, Aganglionic megacolon, Anemia, Gastroesophageal reflux, Depression, Volvulus, Abno... ORPHA:847
Microphthalmia/Coloboma 12
Optic disc coloboma, Optic nerve aplasia, Chorioretinal coloboma, Remnants of the hyaloid vascula... OMIM:120200
Beta-Thalassemia Major
Anisopoikilocytosis, Irritability, Abnormality of iron homeostasis, Hypochromic microcytic anemia... ORPHA:231214
Atelis Syndrome 2
Anemia, Gastroesophageal reflux, High palate, Remnants of the hyaloid vascular system, Thrombocyt... OMIM:620185
Vascular Hyalinosis
Protein-losing enteropathy, Hematochezia OMIM:277175
Isolated Thyroid-Stimulating Hormone Deficiency
Depression, Abnormal circulating thyroglobulin concentration, Neonatal hyperbilirubinemia, Attent... ORPHA:90674
Congenital Analbuminemia
Hypoproteinemia, Hyperlipidemia, Hypoalbuminemia, Increased alpha-globulin, Hypercholesterolemia ORPHA:86816
Hypercholesterolemia Due To Cholesterol 7Alpha-Hydroxylase Deficiency
Hypertriglyceridemia, Increased LDL cholesterol concentration, Hypercholesterolemia ORPHA:209902
Lead Poisoning
Abnormal T cell morphology, Decreased HDL cholesterol concentration, Anemia, Memory impairment, D... ORPHA:330015
Mitchell-Riley Syndrome
Meckel diverticulum, Hyperbilirubinemia, Intestinal malrotation, Acholic stools, Jejunal atresia,... OMIM:615710
Congenital Disorder Of Glycosylation, Type Ib
Hypoalbuminemia, Steatorrhea, Protein-losing enteropathy, Villous atrophy OMIM:602579
Dysbetalipoproteinemia
Hypertriglyceridemia, Xanthelasma, Decreased HDL cholesterol concentration, Increased LDL cholest... ORPHA:412
Alpha-Thalassemia-Intellectual Disability Syndrome Linked To Chromosome 16
HbH hemoglobin, High palate, Microcytic anemia ORPHA:98791
Macrocephaly, Neurodevelopmental Delay, Lymphoid Hyperplasia, And Persistent Fetal Hemoglobin
Hiatus hernia, Persistence of hemoglobin F, Gastroesophageal reflux OMIM:619769
Hereditary Methemoglobinemia
Methemoglobinemia ORPHA:621
Mednik Syndrome
Volvulus, Jejunal atresia, Increased circulating very long-chain fatty acid concentration, Microc... OMIM:609313
Megalocornea-Intellectual Disability Syndrome
Hypercholesterolemia, High palate ORPHA:2479
Ziegler-Huang Syndrome
Persistence of hemoglobin F, Macrocytic anemia, Neutropenia OMIM:620501
Mpi-Cdg
Hypoalbuminemia, Gastrointestinal hemorrhage, Protein-losing enteropathy ORPHA:79319
9Q31.1Q31.3 Microdeletion Syndrome
Hypercholesterolemia ORPHA:401923
Low Phospholipid-Associated Cholelithiasis
Neoplasm of the liver, Hepatocellular carcinoma, Hypercholesterolemia ORPHA:69663
Acquired Methemoglobinemia
Confusion, Methemoglobinemia ORPHA:464453
Visceral Myopathy 1
Thinning of outer muscular layer of small bowel, Aganglionic megacolon, Intestinal pseudo-obstruc... OMIM:155310
Immunodeficiency 47
Normocytic anemia, Decreased circulating copper concentration, Accessory spleen, Thrombocytopenia... OMIM:300972
Shwachman-Diamond Syndrome 1
Steatorrhea, Anemia, Acute myeloid leukemia, Pancytopenia, Persistence of hemoglobin F, Thrombocy... OMIM:260400
Methemoglobinemia Due To Deficiency Of Methemoglobin Reductase
Polycythemia, Methemoglobinemia OMIM:250800
Diarrhea 10, Protein-Losing Enteropathy Type
Hypertriglyceridemia, Protein-losing enteropathy, Hypocalcemia, Coloboma, Hyponatremia, Hematoche... OMIM:618183
Abdominal Obesity-Metabolic Syndrome 3
Hypertriglyceridemia, Increased LDL cholesterol concentration, Hypercholesterolemia OMIM:615812
Thymoma
Aplastic anemia, Pure red cell aplasia, Neoplasm of the gastrointestinal tract, Imbalanced hemogl... ORPHA:99867
Trichothiodystrophy 6, Nonphotosensitive
Increased HbA2 hemoglobin, Decreased mean corpuscular volume OMIM:616943
Annular Pancreas
High intestinal obstruction, Duodenal stenosis ORPHA:675
Pancreas, Annular
High intestinal obstruction, Duodenal stenosis OMIM:167750
Mungan Syndrome
Hypoperistalsis, Barrett esophagus, Intestinal pseudo-obstruction, Megaduodenum OMIM:611376
Inflammatory Skin And Bowel Disease, Neonatal, 1
Duodenitis, Villous atrophy OMIM:614328
Cat Eye Syndrome
Rectal fistula, Anal stenosis, Meckel diverticulum, Anal atresia, Intestinal malrotation, Volvulu... OMIM:115470
Tubulointerstitial Nephritis And Uveitis Syndrome
Normocytic anemia, Reduced hematocrit, Normochromic anemia, Elevated circulating C-reactive prote... ORPHA:91500
Prader-Willi Syndrome
Attention deficit hyperactivity disorder, Decreased HDL cholesterol concentration, Hypercholester... OMIM:176270
Systemic Sclerosis
Abnormality of the gastrointestinal tract, Gastroesophageal reflux, Gastrointestinal telangiectas... ORPHA:90291
Hennekam Lymphangiectasia-Lymphedema Syndrome 3
Protein-losing enteropathy OMIM:618154
Oculocerebrorenal Syndrome Of Lowe
Narrow palate, Anemia, Gastroesophageal reflux, Hypokalemia, Depression, Hyponatremia, Thrombocyt... ORPHA:534
Meconium Ileus
Meconium ileus, Microcolon OMIM:614665
Oculo-Palato-Cerebral Syndrome
Retinal detachment, High, narrow palate, Cleft palate, Remnants of the hyaloid vascular system ORPHA:2714
Juvenile Polyposis Syndrome
Gastrointestinal hemorrhage, Protein-losing enteropathy, Anemia, Stomach cancer, Hamartomatous st... ORPHA:2929
Bone Marrow Failure Syndrome 3
Aplastic anemia, Anemia, Acute myeloid leukemia, Retinal dysplasia, Pancytopenia, Increased mean ... OMIM:617052
Immunodeficiency 31C
Autoimmune hemolytic anemia, Protein-losing enteropathy, Impaired lymphocyte transformation with ... OMIM:614162
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 7
Retinal dysplasia, Retinal detachment, Optic nerve hypoplasia, Elevated circulating creatine kina... OMIM:614643
Congenital Disorder Of Glycosylation, Type Iiaa
Hyperammonemia, Hypercholesterolemia OMIM:620454
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 5
Intestinal malrotation, Microcolon OMIM:619431
Oculoskeletodental Syndrome
Protein-losing enteropathy, Hypocalcemia, Hypercalcemia, Splenomegaly, Macroglossia OMIM:618440
Palmoplantar Hyperkeratosis With Squamous Cell Carcinoma Of Skin And 46,Xx Sex Reversal
Hypertriglyceridemia, Hypercholesterolemia OMIM:610644
Mandibuloacral Dysplasia With Type A Lipodystrophy
Hyperlipidemia, Calcinosis, Hypercholesterolemia, High palate OMIM:248370
Bardet-Biedl Syndrome 20
Papilledema, Hypercholesterolemia OMIM:619471
Steinert Myotonic Dystrophy
Intestinal pseudo-obstruction, Oral-pharyngeal dysphagia, Emotional lability, Depression, Short a... ORPHA:273
Diamond-Blackfan Anemia
Elevated red cell adenosine deaminase activity, Acute myeloid leukemia, Normochromic anemia, Eryt... ORPHA:124
Fg Syndrome Type 1
Gastroesophageal reflux, Optic nerve hypoplasia, High palate, Anal atresia, Abnormal large intest... ORPHA:93932
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome
Intestinal malrotation, Hypoperistalsis, Abnormality of the gastrointestinal tract, Microcolon ORPHA:2241
Intellectual Developmental Disorder With Persistence Of Fetal Hemoglobin
Persistence of hemoglobin F OMIM:617101
Persistent Hyperplastic Primary Vitreous
Hyaloid vascular remnant and retrolental mass, Tractional retinal detachment, Remnants of the hya... ORPHA:91495
Methemoglobinemia And Ambiguous Genitalia
Methemoglobinemia OMIM:250790
Mullerian Derivatives, Persistence Of, With Lymphangiectasia And Postaxial Polydactyly
Protein-losing enteropathy, Hypocalcemia, Hypoproteinemia, High palate, Cleft palate, Splenomegaly OMIM:235255
Cog8-Cdg
Protein-losing enteropathy ORPHA:95428
Metachromatic Leukodystrophy
Neoplasm of the gallbladder, Emotional lability, Abnormal duodenum morphology, Dementia, Abnormal... ORPHA:512
Lipodystrophy, Familial Partial, Type 2
Hypertriglyceridemia, Decreased HDL cholesterol concentration, Hypercholesterolemia OMIM:151660
Diamond-Blackfan Anemia 1
Elevated red cell adenosine deaminase activity, Macrocytic anemia, Increased mean corpuscular vol... OMIM:105650
Microvillus Inclusion Disease
Abnormal small intestinal villus morphology, Villous atrophy ORPHA:2290
Alagille Syndrome 1
Hypertriglyceridemia, Hepatocellular carcinoma, Hypercholesterolemia, Pigmentary retinopathy OMIM:118450
Alpha-Thalassemia/Impaired Intellectual Development Syndrome, X-Linked
HbH hemoglobin, Hypochromic microcytic anemia, Gastroesophageal reflux, Reduced alpha/beta synthe... OMIM:301040
Müllerian Derivatives-Lymphangiectasia-Polydactyly Syndrome
Protein-losing enteropathy, Hypocalcemia, Hypoproteinemia, High palate, Hepatosplenomegaly, Splen... ORPHA:1655
Pericardial And Diaphragmatic Defect
Meckel diverticulum, Intestinal malrotation, Abnormal gastrointestinal tract morphology ORPHA:2847
Persistent Hyperplastic Primary Vitreous, Autosomal Recessive
Retinal nonattachment, Remnants of the hyaloid vascular system, Iris coloboma OMIM:221900
Whim Syndrome
Parotitis, Abnormal neutrophil morphology, Lymphopenia, Abnormal small intestine morphology, Neut... ORPHA:51636
Peripheral Demyelinating Neuropathy-Central Dysmyelinating Leukodystrophy-Waardenburg Syndrome-Hirschsprung Disease
Aganglionic megacolon, Ileus, Splenomegaly, Microcolon ORPHA:163746
Autosomal Recessive Polycystic Kidney Disease
Gastrointestinal hemorrhage, Protein-losing enteropathy, Increased serum bile acid concentration,... ORPHA:731
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 3
Microcolon OMIM:619362
Lmna-Related Cardiocutaneous Progeria Syndrome
Hypertriglyceridemia, Hypercholesterolemia ORPHA:363618
Hennekam Lymphangiectasia-Lymphedema Syndrome 1
Narrow palate, Rectal prolapse, Protein-losing enteropathy, Intestinal lymphangiectasia, Hypoalbu... OMIM:235510
Scedosporiosis
Abnormal jejunum morphology ORPHA:449280
Lipodystrophy, Familial Partial, Type 7
Hypertriglyceridemia, Hypercholesterolemia, Dysphagia, Pigmentary retinopathy OMIM:606721
Tarp Syndrome
Optic atrophy, Extramedullary hematopoiesis, Glossoptosis, Cleft palate, Abnormal duodenum morpho... ORPHA:2886
Full Nf2-Related Schwannomatosis
Dysphagia, Remnants of the hyaloid vascular system, Memory impairment ORPHA:637
Pierson Syndrome
Posterior lenticonus, Retinal detachment, Hypoproteinemia, Remnants of the hyaloid vascular syste... OMIM:609049
Zygomycosis
Hematemesis, Gastrointestinal hemorrhage, Gastritis, Melena, Retinal detachment, Splenic abscess,... ORPHA:73263
Dextrocardia
Meckel diverticulum, Intestinal malrotation, Abnormality of the spleen ORPHA:1666
Biliary, Renal, Neurologic, And Skeletal Syndrome
Gastroesophageal reflux, Hyperbilirubinemia, Coloboma, Esophageal varix, Splenomegaly, Conjugated... OMIM:619534
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 2
Ileal atresia, Microcolon OMIM:619351
Acrocephalopolydactylous Dysplasia
Hypoplasia of the small intestine, Polysplenia, Hypoplastic colon OMIM:200995
Holoprosencephaly 2
Cyclopia, Bilateral cleft palate, Remnants of the hyaloid vascular system, Median cleft palate, B... OMIM:157170
Liver Disease, Severe Congenital
Irritability, Protein-losing enteropathy, Anemia, Lymphocytosis, Chronic gastritis, Hyperbilirubi... OMIM:619991
Acromelic Frontonasal Dysostosis
Optic nerve hypoplasia, Cleft palate, Submucous cleft soft palate, Remnants of the hyaloid vascul... OMIM:603671
Congenital Tracheal Stenosis
Meckel diverticulum, Abnormal gastrointestinal tract morphology, Anal atresia, Tracheoesophageal ... ORPHA:141127
Bannayan-Riley-Ruvalcaba Syndrome
Narrow palate, Intestinal polyposis, Hamartomatous polyposis, Abnormal large intestine morphology ORPHA:109
Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Esophageal atresia, Meckel diverticulum, Congenital shortened small intestine, Tracheoesophageal ... OMIM:265380
Lowe Oculocerebrorenal Syndrome
Bicarbonaturia, Elevated amniotic fluid alpha-fetoprotein, Hypercholesterolemia, Elevated circula... OMIM:309000
Neuroocular Syndrome
Short uvula, Remnants of the hyaloid vascular system, Ankyloglossia, Lens coloboma, Attention def... OMIM:619539
Ehlers-Danlos Syndrome, Musculocontractural Type, 1
Retinal detachment, High palate, Intestinal malrotation, Cleft palate, Abnormal duodenum morpholo... OMIM:601776
Microphthalmia, Syndromic 2
Retinal detachment, Remnants of the hyaloid vascular system, Bifid uvula, Submucous cleft hard pa... OMIM:300166
Homozygous Familial Hypercholesterolemia
Increased LDL cholesterol concentration, Hypercholesterolemia, Hyperlipidemia, Optic neuropathy ORPHA:391665
Heart Defects, Congenital, And Other Congenital Anomalies
Intestinal malrotation, Colon perforation, Microcolon OMIM:600001
Norrie Disease
Optic atrophy, Irritability, Retinal detachment, Remnants of the hyaloid vascular system, Attenti... ORPHA:649
Plague
Hematemesis, Depression, Glossitis, Inflammation of the large intestine, Enterocolitis, Splenomeg... ORPHA:707
Fraser Syndrome 1
Abnormal small intestine morphology, Cleft palate, Abnormality of the anus OMIM:219000
Alkaptonuria
Hemolytic anemia, Methemoglobinemia ORPHA:56
Restrictive Dermopathy
Submucous cleft hard palate, Microcolon ORPHA:1662

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Fpr3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Fpr3.

There are 2 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Chemosensory Cell-Derived Acetylcholine Drives Tracheal Mucociliary Clearance in Response to Virulence-Associated Formyl Peptides. Immunity (April 2020) Fpr3tm1b(EUCOMM)Hmgu 32294408
Bacterial MgrB peptide activates chemoreceptor Fpr3 in mouse accessory olfactory system and drives avoidance behaviour. Nature communications (October 2019) Fpr3tm1b(EUCOMM)Hmgu PMC6814738

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Fpr3tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Fpr3tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Fpr3tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (with selection cassette) Mice

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