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Gene: Fpr3 MGI:1194495

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Gene Summary

Name:
formyl peptide receptor 3
Synonyms:
Fprl1,  Fpr-rs1,  LXA4-R,  Lxa4r

Order Alleles

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased exploration in new environment Fpr3tm1b(EUCOMM)Hmgu HOM Early adult 1.75×10-05
increased hematocrit Fpr3tm1b(EUCOMM)Hmgu HOM Early adult 9.95×10-07
abnormal colon morphology Fpr3tm1b(EUCOMM)Hmgu HOM Early adult 0.00
increased circulating cholesterol level Fpr3tm1b(EUCOMM)Hmgu HOM Early adult 7.37×10-05
abnormal ileum morphology Fpr3tm1b(EUCOMM)Hmgu HOM Early adult 0.00
persistence of hyaloid vascular system Fpr3tm1b(EUCOMM)Hmgu HOM   Early adult 4.11×10-06
increased hemoglobin content Fpr3tm1b(EUCOMM)Hmgu HOM Early adult 6.84×10-06
abnormal vitreous body morphology Fpr3tm1b(EUCOMM)Hmgu HOM   Early adult 7.01×10-05

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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X-ray

XRay Images Whole Body Dorso Ventral

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FCS thumbnail FCS
Immunophenotyping

Panel A FCS file(s)

6 Images

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FCS thumbnail FCS
Immunophenotyping

Panel B FCS file(s)

6 Images

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Human diseases caused by Fpr3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Fpr3 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Hemoglobin D Disease
Reduced beta/alpha synthesis ratio, Reduced hemoglobin A, Imbalanced hemoglobin synthesis, Spleno... ORPHA:90039
Erythrocytosis, Familial, 8
Polycythemia, Increased hematocrit, Splenomegaly, Increased circulating hemoglobin concentration,... OMIM:222800
Cholesterol-Ester Transfer Protein Deficiency
Hypotriglyceridemia, Increased HDL cholesterol concentration, Hyperlipidemia, Hyperlipoproteinemi... ORPHA:79506
Hemoglobin E-Beta-Thalassemia Syndrome
Anemia, Abnormal hemoglobin, Increased circulating ferritin concentration ORPHA:231249
Polycythemia Vera
Gastrointestinal hemorrhage, Increased hematocrit, Leukocytosis, Splenomegaly, Increased red bloo... OMIM:263300
Diarrhea 7, Protein-Losing Enteropathy Type
Hypoalbuminemia, Protein-losing enteropathy, Villous atrophy, Hyperlipidemia, Hypercholesterolemia OMIM:615863
Erythrocytosis, Familial, 3
Increased circulating hemoglobin concentration, Increased hematocrit, Increased red blood cell mass OMIM:609820
Erythrocytosis, Familial, 5
Increased circulating hemoglobin concentration, Increased hematocrit, Polycythemia OMIM:617907
Hypertriglyceridemia 2
Hypercholesterolemia, Hypertriglyceridemia, Decreased HDL cholesterol concentration OMIM:619324
Erythrocytosis, Familial, 4
Increased circulating hemoglobin concentration, Increased hematocrit, Polycythemia OMIM:611783
Erythrocytosis, Familial, 7
Increased circulating hemoglobin concentration, Increased hematocrit, Polycythemia OMIM:617981
Erythrocytosis, Familial, 6
Increased circulating hemoglobin concentration, Increased hematocrit, Polycythemia OMIM:617980
Hemoglobin-Delta locus
Anemia, Imbalanced hemoglobin synthesis OMIM:142000
Anemia, Sideroblastic, 5
Reduced hematocrit, Hypochromic microcytic anemia, Thrombocytopenia, Anemia, Neutropenia OMIM:619523
Meckel Diverticulum
Meckel diverticulum OMIM:155140
Appendicitis, Proneness To
Abnormal large intestine morphology OMIM:107700
Blood Group, Cromer System
Protein-losing enteropathy OMIM:613793
Erythrocytosis, Familial, 1
Increased circulating hemoglobin concentration, Increased hematocrit, Splenomegaly, Increased red... OMIM:133100
Hypothyroidism, Congenital, Nongoitrous, 8
Diminished ability to concentrate, Attention deficit hyperactivity disorder, Hypercholesterolemia OMIM:301033
Sitosterolemia 2
Hypercholesterolemia, Elevated circulating sitosterol concentration OMIM:618666
Anemia, Congenital Dyserythropoietic, Type Iv
Increased RBC distribution width, Persistence of hemoglobin F, Hepatosplenomegaly, Hyperbilirubin... OMIM:613673
Xanthomatosis, Susceptibility To
Hypercholesterolemia OMIM:602247
Thalassemia, Beta+, Silent Allele
Reduced beta/alpha synthesis ratio OMIM:187550
Glycogen Storage Disease Vi
Hyperlipidemia, Hypertriglyceridemia, Hypercholesterolemia OMIM:232700
Hemoglobin H Disease
Splenomegaly, Reduced alpha/beta synthesis ratio, Hemolytic anemia, HbH hemoglobin OMIM:613978
Fetal Hemoglobin Quantitative Trait Locus 1
Persistence of hemoglobin F OMIM:141749
Thyroid Hormone Metabolism, Abnormal, 2
Hypercholesterolemia OMIM:619855
Beta-Thalassemia, Dominant Inclusion Body Type
Persistence of hemoglobin F, Microcytic anemia, Splenomegaly, Erythrocyte inclusion bodies, Incre... OMIM:603902
Cholestasis, Progressive Familial Intrahepatic, 10
Hypoalbuminemia, Increased total bilirubin, Splenomegaly, Increased serum bile acid concentration... OMIM:619868
Hyperlipoproteinemia, Type Ii, And Deafness
Increased LDL cholesterol concentration, Hypercholesterolemia, Hypertriglyceridemia OMIM:144300
Hemoglobin E Disease
Increased red blood cell count, Reduced hemoglobin A, Drug-sensitive hemolytic anemia, Splenomega... ORPHA:2133
Beta-Thalassemia-X-Linked Thrombocytopenia Syndrome
Anemia, Splenomegaly, Thrombocytopenia, Abnormal hemoglobin ORPHA:231393
Hemoglobin C-Beta-Thalassemia Syndrome
Anemia, Splenomegaly, Microcytic anemia, Abnormal hemoglobin ORPHA:231242
Cholesteryl Ester Storage Disease
Hypercholesterolemia, Splenomegaly, Esophageal varix, Hypertriglyceridemia ORPHA:75234
Erythrocytosis, Familial, 2
Increased circulating hemoglobin concentration, Increased hematocrit, Increased red blood cell mass OMIM:263400
Gaisböck Syndrome
Increased red blood cell count, Peptic ulcer, Increased mean corpuscular hemoglobin concentration... ORPHA:90041
Delta-Beta-Thalassemia
Anemia, Microcytic anemia, Abnormal hemoglobin ORPHA:231237
Acetophenetidin Sensitivity
Methemoglobinemia, Hemolytic anemia OMIM:200300
Hereditary Persistence Of Fetal Hemoglobin-Beta-Thalassemia Syndrome
Anemia, Splenomegaly, Persistence of hemoglobin F ORPHA:46532
Congenital Amegakaryocytic Thrombocytopenia
Anemia, Abnormal hemoglobin, Thrombocytopenia ORPHA:3319
Hypercholesterolemia, Familial, 4
Decreased LDL cholesterol concentration, Hypercholesterolemia, Hypertriglyceridemia OMIM:603813
Methemoglobinemia, Beta Type
Methemoglobinemia OMIM:617971
Methemoglobinemia, Alpha Type
Methemoglobinemia OMIM:617973
Morbid Obesity And Spermatogenic Failure
Increased LDL cholesterol concentration, Hypercholesterolemia, Hypertriglyceridemia, Decreased HD... OMIM:615703
Tempi Syndrome
Increased hematocrit, Polycythemia ORPHA:284227
Coronary Artery Disease, Autosomal Dominant, 1
Hypercholesterolemia OMIM:608320
Alpha-Heavy Chain Disease
Anemia, Splenomegaly, Abnormal small intestine morphology, Hypocalcemia ORPHA:100025
Congenital Disorder Of Glycosylation, Type Iip
Increased LDL cholesterol concentration, Hypercholesterolemia, Decreased circulating ceruloplasmi... OMIM:616829
Abetalipoproteinemia
Fat malabsorption, Acanthocytosis, Abetalipoproteinemia, Retinal degeneration OMIM:200100
Multiple Intestinal Atresia
Gastrointestinal atresia, Duodenal stenosis ORPHA:2300
Hyperlipidemia, Familial Combined, 3
Xanthelasma, Increased LDL cholesterol concentration, Hyperlipidemia, Increased VLDL cholesterol ... OMIM:144250
Autoinflammatory Disease, Familial, Behcet-Like 3
Ileitis OMIM:618287
Sitosterolemia 1
Stomatocytosis, Giant platelets, Hyperapobetalipoproteinemia, Xanthelasma, Reticulocytosis, Reduc... OMIM:210250
Hyperinsulinemic Hypoglycemia, Familial, 8
Attention deficit hyperactivity disorder, Increased C-peptide level, Hypercholesterolemia, Hypera... OMIM:620211
Cholesteryl Ester Storage Disease
Increased LDL cholesterol concentration, Hepatosplenomegaly, Hypersplenism, Hypertriglyceridemia,... OMIM:278000
Inflammatory Bowel Disease (Crohn Disease) 30
Protein-losing enteropathy, Esophagitis, Pancolitis, Ileitis, Abnormal intestine morphology, Gast... OMIM:619079
Cog4-Cdg
Hepatosplenomegaly, Recurrent infection of the gastrointestinal tract, Irritability, Hypercholest... ORPHA:263501
Alpha-Thalassemia Myelodysplasia Syndrome
Reduced alpha/beta synthesis ratio, HbH hemoglobin, Hypochromic microcytic anemia OMIM:300448
Cyanosis, Transient Neonatal
Anemia, Methemoglobinemia, Reticulocytosis OMIM:613977
Congenital Disorder Of Glycosylation, Type Iio
Increased LDL cholesterol concentration, Hepatosplenomegaly, Splenomegaly, Elevated circulating c... OMIM:616828
Pancreatic Lipase Deficiency
Steatorrhea, Hypocholesterolemia, Fat malabsorption OMIM:614338
Chylomicron Retention Disease
Hypoalbuminemia, Hypotriglyceridemia, Hypocholesterolemia, Accumulation of lipid droplets in smal... OMIM:246700
Glycogen Storage Disease Ixa1
Hypercholesterolemia, Splenomegaly, Hyperuricemia, Hypertriglyceridemia OMIM:306000
Lipodystrophy, Congenital Generalized, Type 3
Hepatosplenomegaly, Splenomegaly, Hypocalcemia, Hypercholesterolemia, Hypertriglyceridemia OMIM:612526
Citrullinemia Type Ii
Hypoalbuminemia, Mania, Memory impairment, Decreased HDL cholesterol concentration, Confusion, Hy... ORPHA:247585
Hereditary Persistence Of Fetal Hemoglobin-Sickle Cell Disease Syndrome
Splenic infarction, Persistence of hemoglobin F, Increased red cell sickling tendency, Reticulocy... ORPHA:251380
Distal Myopathy, Tateyama Type
Abnormal circulating creatine kinase concentration, Hypercholesterolemia ORPHA:488650
Eosinophilic Gastroenteritis
Hypoalbuminemia, Protein-losing enteropathy, Hematochezia, Leukocytosis, Anemia, Eosinophilia, Ab... ORPHA:2070
Refractory Celiac Disease
Hypoalbuminemia, Normocytic anemia, Protein-losing enteropathy, Hypomagnesemia, Microcytic anemia... ORPHA:398063
Visceral Myopathy 2
Barrett esophagus, Gastroesophageal reflux, Volvulus, Intestinal pseudo-obstruction, Intestinal m... OMIM:619350
Deafness, Nerve Type, With Mesenteric Diverticula Of Small Bowel And Progressive Sensory Neuropathy
Fat malabsorption, Hypoproteinemia, Jejunoileal ulceration, Small bowel diverticula OMIM:221400
Analbuminemia
Hypoalbuminemia, Increased LDL cholesterol concentration, Hypercholesterolemia, Elevated circulat... OMIM:616000
Palmoplantar Keratoderma-Esophageal Carcinoma Syndrome
Gastrointestinal hemorrhage, Abnormal large intestine morphology, Gastroesophageal reflux, Abnorm... ORPHA:2198
Reese Retinal Dysplasia
Retinal dysplasia, Remnants of the hyaloid vascular system OMIM:266400
Beta-Thalassemia
Microcytic anemia, Abnormal hemoglobin, Splenomegaly, Irritability, Thrombocytopenia, Anemia, Abn... ORPHA:848
Hypobetalipoproteinemia, Familial, 1
Decreased HDL cholesterol concentration, Hypocholesterolemia, Acanthocytosis, Retinal degeneratio... OMIM:615558
Ataxia, Early-Onset, With Oculomotor Apraxia And Hypoalbuminemia
Hypoalbuminemia, Mental deterioration, Elevated circulating creatine kinase concentration, Hyperc... OMIM:208920
Microcornea-Posterior Megalolenticonus-Persistent Fetal Vasculature-Coloboma Syndrome
Posterior lenticonus, Iris coloboma, Chorioretinal coloboma, Remnants of the hyaloid vascular system ORPHA:231736
Neonatal Intrahepatic Cholestasis Due To Citrin Deficiency
Increased LDL cholesterol concentration, Hyperbilirubinemia, Hyperthreoninemia, Hepatosplenomegal... ORPHA:247598
Spinocerebellar Ataxia With Axonal Neuropathy Type 1
Hypoalbuminemia, Hypercholesterolemia ORPHA:94124
Alpha-Thalassemia-Myelodysplastic Syndrome
Acute leukemia, HbH hemoglobin, Microcytic anemia, Splenomegaly, Neutropenia, Thrombocytopenia ORPHA:231401
Alpha-Thalassemia
Extramedullary hematopoiesis, Microcytic anemia, Hemoglobin Barts, Hepatosplenomegaly, Hypersplen... ORPHA:846
Spinocerebellar Ataxia, Autosomal Recessive, With Axonal Neuropathy 1
Hypoalbuminemia, Hypercholesterolemia OMIM:607250
Morgagni-Stewart-Morel Syndrome
Memory impairment, Depression, Hyperuricemia, Hypercholesterolemia, Cognitive impairment ORPHA:77296
Bile Acid Malabsorption, Primary, 1
Steatorrhea, Increased fecal bile acid, Fat malabsorption OMIM:613291
Hepatic Lipase Deficiency
Increased HDL cholesterol concentration, Hypertriglyceridemia, Hypercholesterolemia OMIM:614025
Diamond-Blackfan Anemia 14 With Mandibulofacial Dysostosis
Increased mean corpuscular volume, Elevated red cell adenosine deaminase activity, Persistence of... OMIM:300946
Agammaglobulinemia 4, Autosomal Recessive
Protein-losing enteropathy, Neutropenia, Abnormal T cell morphology OMIM:613502
Congenital Short Bowel Syndrome
Congenital shortened small intestine, Decreased intestinal transit time, Intestinal malrotation, ... OMIM:615237
Diamond-Blackfan Anemia 3
Increased mean corpuscular volume, Elevated red cell adenosine deaminase activity, Persistence of... OMIM:610629
Congenital Tufting Enteropathy
Optic disc coloboma, Abnormal large intestinal mucosa morphology, Villous atrophy, Abnormal small... ORPHA:92050
Diarrhea 5, With Tufting Enteropathy, Congenital
Villous atrophy, Crypt hyperplasia OMIM:613217
Intestinal Pseudoobstruction, Neuronal, Chronic Idiopathic, X-Linked
Congenital shortened small intestine, Intestinal pseudo-obstruction, Intestinal malrotation, Thro... OMIM:300048
Smith-Magenis Syndrome
Retinal detachment, Hypercholesterolemia, Velopharyngeal insufficiency, Hypertriglyceridemia OMIM:182290
Mitochondrial Complex Iv Deficiency, Nuclear Type 19
Protein-losing enteropathy, Hyperglycinemia OMIM:619063
Secondary Short Bowel Syndrome
Volvulus, Villous atrophy, Abnormal small intestine morphology, Aganglionic megacolon, Small inte... ORPHA:95427
Temple Syndrome Due To Paternal 14Q32.2 Hypomethylation
High palate, Hypercholesterolemia ORPHA:254531
Galactokinase Deficiency
Hepatosplenomegaly, Hypercholesterolemia, Increased level of galactitol in plasma, Psychomotor de... ORPHA:79237
Autoinflammatory Syndrome, Familial, Behcet-Like 1
Lymphopenia, Ileal ulcer, Thrombocytopenia, Colitis, Hemolytic anemia OMIM:616744
Pancreatic Colipase Deficiency
Steatorrhea, Fat malabsorption, Megaloblastic anemia ORPHA:309108
Temple Syndrome
Bifid uvula, Hypercholesterolemia, Hypertriglyceridemia, High palate, Cleft palate OMIM:616222
Alg6-Cdg
Hypoalbuminemia, Protein-losing enteropathy, Retinal degeneration, Decreased LDL cholesterol conc... ORPHA:79320
Temple Syndrome Due To Maternal Uniparental Disomy Of Chromosome 14
Bifid uvula, Hypercholesterolemia, High palate, Cleft palate, Pyloric stenosis ORPHA:96184
Ataxia-Oculomotor Apraxia 4
Hypoalbuminemia, Hypercholesterolemia, Cognitive impairment, Elevated circulating alpha-fetoprote... OMIM:616267
Acute Interstitial Pneumonia
Elevated circulating C-reactive protein concentration, Elevated circulating creatinine concentrat... ORPHA:79126
Smith-Magenis Syndrome
Gastroesophageal reflux, Attention deficit hyperactivity disorder, Hypercholesterolemia, Retinal ... ORPHA:819
Bone Marrow Failure Syndrome 6
Increased mean corpuscular volume, Persistence of hemoglobin F, Lymphopenia, Neutropenia, Squamou... OMIM:618849
Citrullinemia, Type Ii, Neonatal-Onset
Hypermethioninemia, Decreased HDL cholesterol concentration, Hyperbilirubinemia, Hyperthreoninemi... OMIM:605814
Congenital Enterocyte Heparan Sulfate Deficiency
Hypoalbuminemia, Protein-losing enteropathy, Hematochezia, Abnormal circulating protein concentra... ORPHA:103910
Apolipoprotein C-Ii Deficiency
Increased circulating chylomicron concentration, Splenomegaly, Hypercholesterolemia, Decreased ci... OMIM:207750
Chronic Diarrhea Due To Glucoamylase Deficiency
Abnormal small intestinal mucosa morphology, Decreased small intestinal mucosa lactase level ORPHA:103907
Polyposis, Skin Pigmentation, Alopecia, And Fingernail Changes
Protein-losing enteropathy, Hematochezia, Gastrointestinal carcinoma, Xerostomia, Hypomagnesemia,... OMIM:175500
Hypercholesterolemia, Familial, 3
Xanthelasma, Hypercholesterolemia, Abnormal LDL cholesterol concentration OMIM:603776
Glycogen Storage Disease Due To Liver Phosphorylase Kinase Deficiency
Splenomegaly, Elevated circulating creatine kinase concentration, Abnormal erythrocyte enzyme con... ORPHA:264580
Cholestasis, Progressive Familial Intrahepatic, 8
Increased serum bile acid concentration, Hypercholesterolemia, Conjugated hyperbilirubinemia, Eso... OMIM:619662
Beta-Thalassemia
Reduced beta/alpha synthesis ratio, Hypochromic microcytic anemia OMIM:613985
Alpha-Thalassemia
Reduced alpha/beta synthesis ratio, Hypochromic microcytic anemia OMIM:604131
Acquired Aneurysmal Subarachnoid Hemorrhage
Memory impairment, Leukocytosis, Hypercholesterolemia, Cognitive impairment, Progressive neurolog... ORPHA:90065
Lysosomal Acid Lipase Deficiency
Xanthelasma, Hepatosplenomegaly, Hypersplenism, Bone-marrow foam cells, Hyponatremia, Anemia, Hyp... ORPHA:275761
Hypercholesterolemia, Familial, 2
Xanthelasma, Increased LDL cholesterol concentration, Hypercholesterolemia OMIM:144010
Nephrotic Syndrome, Type 11
Hypoalbuminemia, High palate, Hypercholesterolemia, Cleft palate OMIM:616730
Hypercholanemia, Familial 1
Steatorrhea, Fat malabsorption, Increased serum bile acid concentration OMIM:607748
Ataxia With Vitamin E Deficiency
Short term memory impairment, Xanthelasma, Increased LDL cholesterol concentration, Hypercholeste... OMIM:277460
Maternal Uniparental Disomy Of Chromosome 4
Optic atrophy, Pigmentary retinopathy, Depression, Hypocholesterolemia, Abnormal erythrocyte morp... ORPHA:96180
Juvenile Polyposis Syndrome
Hypoalbuminemia, Hematochezia, Intussusception, Duodenal adenocarcinoma, Hypokalemia, Multiple ga... OMIM:174900
Glycogen Storage Disease Due To Liver And Muscle Phosphorylase Kinase Deficiency
Splenomegaly, Elevated circulating creatine kinase concentration, Hypercholesterolemia, Hypertrig... ORPHA:79240
Lysinuric Protein Intolerance
Hemophagocytosis, Increased circulating ferritin concentration, Decreased HDL cholesterol concent... ORPHA:470
Spinocerebellar Ataxia With Axonal Neuropathy Type 2
Hypoalbuminemia, Elevated circulating creatine kinase concentration, Hypercholesterolemia, Dyspha... ORPHA:64753
Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency Type Ib
Inflammation of the large intestine, Ulcerative colitis, Xanthelasma, Hyperlipidemia, Hyperuricem... ORPHA:79259
Shiga Toxin-Associated Hemolytic Uremic Syndrome
Microangiopathic hemolytic anemia, Acute colitis, Elevated circulating creatinine concentration, ... ORPHA:90038
Neuhauser Syndrome
Bifid uvula, Retinal detachment, Hypercholesterolemia, High palate, Dysphagia OMIM:249310
Laron Syndrome
Hypercholesterolemia ORPHA:633
Hb Bart'S Hydrops Fetalis
Anemia, Splenomegaly, Abnormal hemoglobin ORPHA:163596
Primary Biliary Cholangitis
Hypoalbuminemia, Abnormal circulating lipid concentration, Xanthelasma, Splenomegaly, Hypercholes... ORPHA:186
Optic Nerve Hypoplasia, Bilateral
Optic nerve aplasia, Remnants of the hyaloid vascular system, Optic nerve hypoplasia OMIM:165550
Hyperlipoproteinemia, Type I
Lactescent serum, Increased circulating chylomicron concentration, Hepatosplenomegaly, Hyperlipid... OMIM:238600
Congenital Disorder Of Glycosylation, Type Ih
Hypoalbuminemia, Protein-losing enteropathy, Elevated circulating creatinine concentration, Throm... OMIM:608104
Gastrointestinal Ulceration, Recurrent, With Dysfunctional Platelets
Abnormal circulating eicosanoid concentration, Decreased serum thromboxane B2, Decreased circulat... OMIM:618372
Primary Familial Polycythemia
Polycythemia, Abnormal hemoglobin ORPHA:90042
Nk-Cell Enteropathy
Hematochezia, Colonic diverticula, Gastroesophageal reflux, Stercoral ulcer, Abnormal gastric muc... ORPHA:263665
Mandibuloacral Dysplasia
Increased circulating free fatty acid level, Abnormal tongue morphology, Hypercholesterolemia, Hy... ORPHA:2457
Congenital Generalized Lipodystrophy
Macroglossia, Hypercholesterolemia, Increased C-peptide level, Hypertriglyceridemia ORPHA:528
Oculopalatocerebral Syndrome
Cleft palate, Remnants of the hyaloid vascular system OMIM:257910
Diamond-Blackfan Anemia 6
Bifid uvula, Increased mean corpuscular volume, Persistence of hemoglobin F, Macrocytic anemia, C... OMIM:612561
Idiopathic Steroid-Resistant Nephrotic Syndrome
Hypoalbuminemia, Hypercholesterolemia, Abnormal circulating lipid concentration, Hypertriglycerid... ORPHA:567548
Sickle Cell Anemia
Splenic infarction, Hypochromic anemia, Increased mean corpuscular volume, Persistence of hemoglo... ORPHA:232
Beta-Thalassemia Intermedia
Extramedullary hematopoiesis, Persistence of hemoglobin F, Hepatosplenomegaly, Erythroid hyperpla... ORPHA:231222
Galloway-Mowat Syndrome 7
High palate, Hypercholesterolemia, Cleft palate OMIM:618348
Chylomicron Retention Disease
Steatorrhea, Hypocholesterolemia, Fat malabsorption, Acanthocytosis ORPHA:71
Alg1-Cdg
Hypoalbuminemia, Protein-losing enteropathy, Abnormality of the gastrointestinal tract ORPHA:79327
Dominant Beta-Thalassemia
Reduced hemoglobin A, Extramedullary hematopoiesis, Persistence of hemoglobin F, Hepatosplenomega... ORPHA:231226
Juvenile Polyposis Of Infancy
Hypoalbuminemia, High, narrow palate, Intestinal bleeding, Gastrointestinal hemorrhage, Protein-l... ORPHA:79076
Primary Intestinal Lymphangiectasia
Hypoalbuminemia, Increased stool alpha1-antitrypsin concentration, Hypomagnesemia, Intestinal lym... ORPHA:90362
Alpha-Thalassemia-X-Linked Intellectual Disability Syndrome
Optic atrophy, Gastroesophageal reflux, Depression, Volvulus, Abnormal hemoglobin, Aganglionic me... ORPHA:847
Microphthalmia/Coloboma 12
Optic nerve aplasia, Remnants of the hyaloid vascular system, Optic disc coloboma, Chorioretinal ... OMIM:120200
Beta-Thalassemia Major
Reduced hemoglobin A, Extramedullary hematopoiesis, Persistence of hemoglobin F, Hepatosplenomega... ORPHA:231214
Bile Acid Synthesis Defect, Congenital, 1
Hypocholesterolemia, Splenomegaly, Acholic stools, Steatorrhea, Fat malabsorption, Conjugated hyp... OMIM:607765
Atelis Syndrome 2
Gastroesophageal reflux, Attention deficit hyperactivity disorder, Thrombocytopenia, Remnants of ... OMIM:620185
Vascular Hyalinosis
Protein-losing enteropathy, Hematochezia OMIM:277175
Isolated Thyroid-Stimulating Hormone Deficiency
Neonatal hyperbilirubinemia, Depression, Abnormal circulating thyroglobulin concentration, Attent... ORPHA:90674
Congenital Analbuminemia
Hypoalbuminemia, Hyperlipidemia, Hypercholesterolemia, Hypoproteinemia, Increased alpha-globulin ORPHA:86816
Hypercholesterolemia Due To Cholesterol 7Alpha-Hydroxylase Deficiency
Increased LDL cholesterol concentration, Hypercholesterolemia, Hypertriglyceridemia ORPHA:209902
Congenital Disorder Of Glycosylation, Type Ib
Hypoalbuminemia, Protein-losing enteropathy, Villous atrophy, Steatorrhea OMIM:602579
Lead Poisoning
Memory impairment, Depression, Imbalanced hemoglobin synthesis, Increased LDL cholesterol concent... ORPHA:330015
Mitchell-Riley Syndrome
Meckel diverticulum, Anteriorly placed anus, Intestinal malrotation, Hyperbilirubinemia, Jejunal ... OMIM:615710
Dysbetalipoproteinemia
Xanthelasma, Increased LDL cholesterol concentration, Hypertriglyceridemia, Hypercholesterolemia,... ORPHA:412
Alpha-Thalassemia-Intellectual Disability Syndrome Linked To Chromosome 16
Microcytic anemia, High palate, HbH hemoglobin ORPHA:98791
Macrocephaly, Neurodevelopmental Delay, Lymphoid Hyperplasia, And Persistent Fetal Hemoglobin
Hiatus hernia, Gastroesophageal reflux, Persistence of hemoglobin F OMIM:619769
Hereditary Methemoglobinemia
Methemoglobinemia ORPHA:621
Mednik Syndrome
Increased circulating very long-chain fatty acid concentration, Microcolon, Volvulus, Jejunal atr... OMIM:609313
Megalocornea-Intellectual Disability Syndrome
High palate, Hypercholesterolemia ORPHA:2479
Ziegler-Huang Syndrome
Neutropenia, Macrocytic anemia, Persistence of hemoglobin F OMIM:620501
9Q31.1Q31.3 Microdeletion Syndrome
Hypercholesterolemia ORPHA:401923
Mpi-Cdg
Hypoalbuminemia, Protein-losing enteropathy, Gastrointestinal hemorrhage ORPHA:79319
Low Phospholipid-Associated Cholelithiasis
Neoplasm of the liver, Hypercholesterolemia, Hepatocellular carcinoma ORPHA:69663
Acquired Methemoglobinemia
Confusion, Methemoglobinemia ORPHA:464453
Visceral Myopathy 1
Microcolon, Intestinal pseudo-obstruction, Megaduodenum, Thinning of outer muscular layer of smal... OMIM:155310
Immunodeficiency 47
Accessory spleen, Normocytic anemia, Leukopenia, Splenomegaly, Hypercholesterolemia, Thrombocytop... OMIM:300972
Shwachman-Diamond Syndrome 1
Persistence of hemoglobin F, Pancytopenia, Anemia, Acute myeloid leukemia, Neutropenia, Thrombocy... OMIM:260400
Methemoglobinemia Due To Deficiency Of Methemoglobin Reductase
Methemoglobinemia, Polycythemia OMIM:250800
Diarrhea 10, Protein-Losing Enteropathy Type
Hypoalbuminemia, Protein-losing enteropathy, Hematochezia, Hypomagnesemia, Hypocalcemia, Hyponatr... OMIM:618183
Abdominal Obesity-Metabolic Syndrome 3
Increased LDL cholesterol concentration, Hypercholesterolemia, Hypertriglyceridemia OMIM:615812
Thymoma
Aplastic anemia, Imbalanced hemoglobin synthesis, Ulcerative colitis, Leukemia, Pure red cell apl... ORPHA:99867
Trichothiodystrophy 6, Nonphotosensitive
Increased HbA2 hemoglobin, Decreased mean corpuscular volume OMIM:616943
Annular Pancreas
High intestinal obstruction, Duodenal stenosis ORPHA:675
Pancreas, Annular
High intestinal obstruction, Duodenal stenosis OMIM:167750
Mungan Syndrome
Barrett esophagus, Megaduodenum, Hypoperistalsis, Intestinal pseudo-obstruction OMIM:611376
Inflammatory Skin And Bowel Disease, Neonatal, 1
Villous atrophy, Duodenitis OMIM:614328
Cat Eye Syndrome
Anal stenosis, Meckel diverticulum, Volvulus, Chorioretinal coloboma, Intestinal malrotation, Rec... OMIM:115470
Tubulointerstitial Nephritis And Uveitis Syndrome
Normocytic anemia, Elevated circulating creatinine concentration, Reduced hematocrit, Abnormality... ORPHA:91500
Prader-Willi Syndrome
Attention deficit hyperactivity disorder, Hypercholesterolemia, Hypertriglyceridemia, Decreased H... OMIM:176270
Systemic Sclerosis
Barrett esophagus, Intestinal bleeding, Abnormal large intestine morphology, Gastroesophageal ref... ORPHA:90291
Hennekam Lymphangiectasia-Lymphedema Syndrome 3
Protein-losing enteropathy OMIM:618154
Oculocerebrorenal Syndrome Of Lowe
Depression, Gastroesophageal reflux, Hyperaldosteronism, Hyponatremia, Hypokalemia, Attention def... ORPHA:534
Meconium Ileus
Microcolon, Meconium ileus OMIM:614665
Oculo-Palato-Cerebral Syndrome
High, narrow palate, Retinal detachment, Cleft palate, Remnants of the hyaloid vascular system ORPHA:2714
Juvenile Polyposis Syndrome
Rectocele, Gastrointestinal hemorrhage, Hamartomatous stomach polyps, Protein-losing enteropathy,... ORPHA:2929
Bone Marrow Failure Syndrome 3
Aplastic anemia, Increased mean corpuscular volume, Persistence of hemoglobin F, Pancytopenia, Ac... OMIM:617052
Immunodeficiency 31C
Protein-losing enteropathy, Lymphopenia, Villous atrophy, Autoimmune hemolytic anemia, Splenomega... OMIM:614162
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 7
Elevated circulating creatine kinase concentration, Retinal detachment, Remnants of the hyaloid v... OMIM:614643
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 5
Intestinal malrotation, Microcolon OMIM:619431
Congenital Disorder Of Glycosylation, Type Iiaa
Hypercholesterolemia, Hyperammonemia OMIM:620454
Palmoplantar Hyperkeratosis With Squamous Cell Carcinoma Of Skin And 46,Xx Sex Reversal
Hypercholesterolemia, Hypertriglyceridemia OMIM:610644
Oculoskeletodental Syndrome
Protein-losing enteropathy, Splenomegaly, Hypocalcemia, Macroglossia, Hypercalcemia OMIM:618440
Mandibuloacral Dysplasia With Type A Lipodystrophy
Hyperlipidemia, Hypercholesterolemia, Calcinosis, High palate OMIM:248370
Bardet-Biedl Syndrome 20
Papilledema, Hypercholesterolemia OMIM:619471
Steinert Myotonic Dystrophy
Abnormality of the tongue muscle, Mental deterioration, Depression, Intestinal pseudo-obstruction... ORPHA:273
Diamond-Blackfan Anemia
Adenocarcinoma of the colon, Macrocytic dyserythropoietic anemia, Increased mean corpuscular volu... ORPHA:124
Fg Syndrome Type 1
Abnormal large intestine morphology, Gastroesophageal reflux, Optic nerve hypoplasia, Attention d... ORPHA:93932
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome
Intestinal malrotation, Microcolon, Abnormality of the gastrointestinal tract, Hypoperistalsis ORPHA:2241
Intellectual Developmental Disorder With Persistence Of Fetal Hemoglobin
Persistence of hemoglobin F OMIM:617101
Persistent Hyperplastic Primary Vitreous
Hyaloid vascular remnant and retrolental mass, Tractional retinal detachment, Remnants of the hya... ORPHA:91495
Methemoglobinemia And Ambiguous Genitalia
Methemoglobinemia OMIM:250790
Mullerian Derivatives, Persistence Of, With Lymphangiectasia And Postaxial Polydactyly
Protein-losing enteropathy, Splenomegaly, Hypocalcemia, High palate, Hypoproteinemia, Cleft palate OMIM:235255
Cog8-Cdg
Protein-losing enteropathy ORPHA:95428
Lipodystrophy, Familial Partial, Type 2
Hypercholesterolemia, Decreased HDL cholesterol concentration, Hypertriglyceridemia OMIM:151660
Metachromatic Leukodystrophy
Abnormal stomach morphology, Emotional lability, Abnormal duodenum morphology, Dementia, Neoplasm... ORPHA:512
Diamond-Blackfan Anemia 1
Increased mean corpuscular volume, Persistence of hemoglobin F, Elevated red cell adenosine deami... OMIM:105650
Microvillus Inclusion Disease
Villous atrophy, Abnormal small intestinal villus morphology ORPHA:2290
Alagille Syndrome 1
Hepatocellular carcinoma, Pigmentary retinopathy, Hypercholesterolemia, Hypertriglyceridemia OMIM:118450
Alpha-Thalassemia/Impaired Intellectual Development Syndrome, X-Linked
Gastroesophageal reflux, HbH hemoglobin, Protruding tongue, Hypochromic microcytic anemia, Macrog... OMIM:301040
Müllerian Derivatives-Lymphangiectasia-Polydactyly Syndrome
Protein-losing enteropathy, Hepatosplenomegaly, Splenomegaly, Hypocalcemia, High palate, Hypoprot... ORPHA:1655
Pericardial And Diaphragmatic Defect
Intestinal malrotation, Meckel diverticulum, Abnormal gastrointestinal tract morphology ORPHA:2847
Persistent Hyperplastic Primary Vitreous, Autosomal Recessive
Retinal nonattachment, Iris coloboma, Remnants of the hyaloid vascular system OMIM:221900
Whim Syndrome
Parotitis, Abnormal neutrophil morphology, Lymphopenia, Abnormal small intestine morphology, Neut... ORPHA:51636
Peripheral Demyelinating Neuropathy-Central Dysmyelinating Leukodystrophy-Waardenburg Syndrome-Hirschsprung Disease
Aganglionic megacolon, Microcolon, Ileus, Splenomegaly ORPHA:163746
Lmna-Related Cardiocutaneous Progeria Syndrome
Hypercholesterolemia, Hypertriglyceridemia ORPHA:363618
Autosomal Recessive Polycystic Kidney Disease
Protein-losing enteropathy, Gastrointestinal hemorrhage, Hypersplenism, Hepatosplenomegaly, Splen... ORPHA:731
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 3
Microcolon OMIM:619362
Hennekam Lymphangiectasia-Lymphedema Syndrome 1
Hypoalbuminemia, Protein-losing enteropathy, Intestinal lymphangiectasia, Narrow palate, Rectal p... OMIM:235510
Lipodystrophy, Familial Partial, Type 7
Pigmentary retinopathy, Hypercholesterolemia, Dysphagia, Hypertriglyceridemia OMIM:606721
Scedosporiosis
Abnormal jejunum morphology ORPHA:449280
Tarp Syndrome
Optic atrophy, Extramedullary hematopoiesis, Abnormal duodenum morphology, Glossoptosis, Tongue n... ORPHA:2886
Full Nf2-Related Schwannomatosis
Memory impairment, Dysphagia, Remnants of the hyaloid vascular system ORPHA:637
Pierson Syndrome
Retinal detachment, Remnants of the hyaloid vascular system, Retinal hemorrhage, Posterior lentic... OMIM:609049
Zygomycosis
Colon perforation, Hematochezia, Gastrointestinal hemorrhage, Ileitis, Gastritis, Enterocolitis, ... ORPHA:73263
Dextrocardia
Intestinal malrotation, Abnormality of the spleen, Meckel diverticulum ORPHA:1666
Biliary, Renal, Neurologic, And Skeletal Syndrome
Hypoalbuminemia, Gastroesophageal reflux, Increased circulating ferritin concentration, Elevated ... OMIM:619534
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 2
Microcolon, Ileal atresia OMIM:619351
Acrocephalopolydactylous Dysplasia
Hypoplastic colon, Hypoplasia of the small intestine, Polysplenia OMIM:200995
Holoprosencephaly 2
Bifid uvula, Chorioretinal coloboma, Median cleft palate, Submucous cleft hard palate, Bilateral ... OMIM:157170
Liver Disease, Severe Congenital
Protein-losing enteropathy, Increased circulating ferritin concentration, Chronic gastritis, Leuk... OMIM:619991
Acromelic Frontonasal Dysostosis
Optic nerve hypoplasia, Submucous cleft soft palate, Cleft palate, Remnants of the hyaloid vascul... OMIM:603671
Congenital Tracheal Stenosis
Meckel diverticulum, Duodenal stenosis, Abnormal stomach morphology, Abnormal gastrointestinal tr... ORPHA:141127
Bannayan-Riley-Ruvalcaba Syndrome
Intestinal polyposis, Narrow palate, Abnormal large intestine morphology, Hamartomatous polyposis ORPHA:109
Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Congenital shortened small intestine, Meckel diverticulum, Intestinal malrotation, Tracheoesophag... OMIM:265380
Lowe Oculocerebrorenal Syndrome
Elevated amniotic fluid alpha-fetoprotein, Elevated circulating creatine kinase concentration, Hy... OMIM:309000
Neuroocular Syndrome 1
Short uvula, Ankyloglossia, Submucous cleft hard palate, Attention deficit hyperactivity disorder... OMIM:619539
Ehlers-Danlos Syndrome, Musculocontractural Type, 1
Intestinal malrotation, Hiatus hernia, Abnormal duodenum morphology, Retinal detachment, High pal... OMIM:601776
Homozygous Familial Hypercholesterolemia
Hyperlipidemia, Increased LDL cholesterol concentration, Hypercholesterolemia, Optic neuropathy ORPHA:391665
Microphthalmia, Syndromic 2
Bifid uvula, Submucous cleft hard palate, Retinal detachment, Remnants of the hyaloid vascular sy... OMIM:300166
Heart Defects, Congenital, And Other Congenital Anomalies
Colon perforation, Microcolon, Intestinal malrotation OMIM:600001
Norrie Disease
Optic atrophy, Irritability, Attention deficit hyperactivity disorder, Retinal detachment, Remnan... ORPHA:649
Plague
Inflammation of the large intestine, Depression, Splenomegaly, Ileitis, Enterocolitis, Hematemesi... ORPHA:707
Fraser Syndrome 1
Abnormal small intestine morphology, Abnormality of the anus, Cleft palate OMIM:219000
Alkaptonuria
Methemoglobinemia, Hemolytic anemia ORPHA:56
Restrictive Dermopathy
Microcolon, Submucous cleft hard palate ORPHA:1662

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Fpr3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Fpr3.

There are 2 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Chemosensory Cell-Derived Acetylcholine Drives Tracheal Mucociliary Clearance in Response to Virulence-Associated Formyl Peptides. Immunity (April 2020) Fpr3tm1b(EUCOMM)Hmgu 32294408
Bacterial MgrB peptide activates chemoreceptor Fpr3 in mouse accessory olfactory system and drives avoidance behaviour. Nature communications (October 2019) Fpr3tm1b(EUCOMM)Hmgu PMC6814738

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Fpr3tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Fpr3tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Fpr3tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (with selection cassette) Mice

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