Gene Summary

formyl peptide receptor 3
Fprl1,  Fpr-rs1,  LXA4-R,  Lxa4r

IMPC Data Collections

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased exploration in new environment Fpr3tm1b(EUCOMM)Hmgu HOM Early adult 1.72×10-05
increased hematocrit Fpr3tm1b(EUCOMM)Hmgu HOM Early adult 9.95×10-07
persistence of hyaloid vascular system Fpr3tm1b(EUCOMM)Hmgu HOM   Early adult 2.39×10-05
abnormal vitreous body morphology Fpr3tm1b(EUCOMM)Hmgu HOM   Early adult 4.36×10-05
abnormal ileum morphology Fpr3tm1b(EUCOMM)Hmgu HOM Early adult 0.00
increased hemoglobin content Fpr3tm1b(EUCOMM)Hmgu HOM Early adult 6.84×10-06
increased circulating cholesterol level Fpr3tm1b(EUCOMM)Hmgu HOM Early adult 7.37×10-05
abnormal colon morphology Fpr3tm1b(EUCOMM)Hmgu HOM Early adult 0.00

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.


XRay Images Whole Body Dorso Ventral

10 Images


XRay Images Whole Body Lateral Orientation

10 Images


Panel A FCS file(s)

6 Images


Panel B FCS file(s)

6 Images

Human diseases caused by Fpr3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Fpr3 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Hemoglobin D Disease
Anemia, Reduced alpha/beta synthesis ratio, HbS hemoglobin, Increased HbA2 hemoglobin, Reduced he... ORPHA:90039
Hemoglobin E-Beta-Thalassemia Syndrome
Anemia, Increased circulating ferritin concentration, Abnormal hemoglobin ORPHA:231249
Polycythemia Vera
Increased red blood cell mass, Increased hematocrit, Thrombocytosis, Leukocytosis, Gastrointestin... OMIM:263300
Diarrhea 7, Protein-Losing Enteropathy Type
Villous atrophy, Hyperlipidemia, Hypercholesterolemia, Protein-losing enteropathy, Hypoalbuminemia OMIM:615863
Erythrocytosis, Familial, 3
Increased hematocrit, Increased red blood cell mass, Increased hemoglobin OMIM:609820
Erythrocytosis, Familial, 8
Increased hematocrit, Splenomegaly, Increased hemoglobin, Polycythemia OMIM:222800
Erythrocytosis, Familial, 5
Increased hematocrit, Increased hemoglobin, Polycythemia OMIM:617907
Hypertriglyceridemia 2
Hypertriglyceridemia, Decreased HDL cholesterol concentration, Hypercholesterolemia OMIM:619324
Erythrocytosis, Familial, 4
Increased hematocrit, Increased hemoglobin, Polycythemia OMIM:611783
Erythrocytosis, Familial, 6
Increased hematocrit, Increased hemoglobin, Polycythemia OMIM:617980
Hemoglobin-Delta locus
Imbalanced hemoglobin synthesis, Anemia OMIM:142000
Erythrocytosis, Familial, 7
Increased hematocrit, Polycythemia OMIM:617981
Anemia, Sideroblastic, 5
Anemia, Reduced hematocrit, Hypochromic microcytic anemia, Thrombocytopenia, Neutropenia OMIM:619523
Meckel Diverticulum
Meckel diverticulum OMIM:155140
Appendicitis, Proneness To
Abnormal large intestine morphology OMIM:107700
Blood Group, Cromer System
Protein-losing enteropathy OMIM:613793
Erythrocytosis, Familial, 1
Increased hematocrit, Increased red blood cell mass, Increased hemoglobin, Splenomegaly OMIM:133100
Cholesterol-Ester Transfer Protein Deficiency
Increased HDL cholesterol concentration, Hyperlipoproteinemia, Hyperlipidemia, Hypercholesterolem... ORPHA:79506
Sitosterolemia 2
Elevated circulating sitosterol concentration, Hypercholesterolemia OMIM:618666
Xanthomatosis, Susceptibility To
Hypercholesterolemia OMIM:602247
Anemia, Congenital Dyserythropoietic, Type Iv
Reduced haptoglobin level, Anemia, Reduced hematocrit, Hemolytic anemia, Circulating nucleated re... OMIM:613673
Thalassemia, Beta+, Silent Allele
Reduced beta/alpha synthesis ratio OMIM:187550
Hemoglobin H Disease
HbH hemoglobin, Splenomegaly, Hemolytic anemia, Reduced alpha/beta synthesis ratio OMIM:613978
Beta-Thalassemia, Dominant Inclusion Body Type
Increased HbA2 hemoglobin, Decreased mean corpuscular hemoglobin concentration, Persistence of he... OMIM:603902
Fetal Hemoglobin Quantitative Trait Locus 1
Persistence of hemoglobin F OMIM:141749
Thyroid Hormone Metabolism, Abnormal, 2
Hypercholesterolemia OMIM:619855
Glycogen Storage Disease Vi
Hypertriglyceridemia, Hyperlipidemia, Hypercholesterolemia OMIM:232700
Hemoglobin E Disease
Increased red blood cell count, Reduced hemoglobin A, Drug-sensitive hemolytic anemia, Hypochromi... ORPHA:2133
Hyperlipoproteinemia, Type Ii, And Deafness
Increased LDL cholesterol concentration, Hypertriglyceridemia, Hypercholesterolemia OMIM:144300
Cholestasis, Progressive Familial Intrahepatic, 10
Increased total bilirubin, Acholic stools, Increased serum bile acid concentration, Hypercholeste... OMIM:619868
Gaisböck Syndrome
Increased mean corpuscular hemoglobin concentration, Peptic ulcer, Hyperuricemia, Increased red b... ORPHA:90041
Beta-Thalassemia-X-Linked Thrombocytopenia Syndrome
Anemia, Thrombocytopenia, Abnormal hemoglobin, Splenomegaly ORPHA:231393
Hemoglobin C-Beta-Thalassemia Syndrome
Anemia, Abnormal hemoglobin, Splenomegaly, Microcytic anemia ORPHA:231242
Cholesteryl Ester Storage Disease
Esophageal varix, Hypertriglyceridemia, Splenomegaly, Hypercholesterolemia ORPHA:75234
Alpha-Heavy Chain Disease
Anemia, Malabsorption, Abnormal small intestine morphology, Hypocalcemia, Splenomegaly ORPHA:100025
Retinal degeneration, Fat malabsorption, Abetalipoproteinemia, Acanthocytosis OMIM:200100
Anemia, Abnormal hemoglobin, Microcytic anemia ORPHA:231237
Erythrocytosis, Familial, 2
Increased hematocrit, Increased red blood cell mass, Increased hemoglobin OMIM:263400
Hereditary Persistence Of Fetal Hemoglobin-Beta-Thalassemia Syndrome
Anemia, Splenomegaly, Persistence of hemoglobin F ORPHA:46532
Acetophenetidin Sensitivity
Methemoglobinemia, Hemolytic anemia OMIM:200300
Congenital Amegakaryocytic Thrombocytopenia
Anemia, Thrombocytopenia, Abnormal hemoglobin ORPHA:3319
Hypercholesterolemia, Familial, 4
Hypertriglyceridemia, Decreased LDL cholesterol concentration, Hypercholesterolemia OMIM:603813
Methemoglobinemia, Beta Type
Methemoglobinemia OMIM:617971
Methemoglobinemia, Alpha Type
Methemoglobinemia OMIM:617973
Anemia, Cognitive impairment, Hemolytic anemia, Hypersplenism, Abnormal hemoglobin, Splenomegaly,... ORPHA:846
Morbid Obesity And Spermatogenic Failure
Increased LDL cholesterol concentration, Hypertriglyceridemia, Decreased HDL cholesterol concentr... OMIM:615703
Coronary Artery Disease, Autosomal Dominant, 1
Hypercholesterolemia OMIM:608320
Tempi Syndrome
Increased hematocrit, Polycythemia ORPHA:284227
Congenital Disorder Of Glycosylation, Type Iip
Decreased circulating ceruloplasmin concentration, Increased LDL cholesterol concentration, Hyper... OMIM:616829
Autoinflammatory Disease, Familial, Behcet-Like 3
Ileitis OMIM:618287
Multiple Intestinal Atresia
Gastrointestinal atresia, Duodenal stenosis ORPHA:2300
Hyperlipidemia, Familial Combined, 3
Hypercholesterolemia, Increased VLDL cholesterol concentration, Elevated circulating apolipoprote... OMIM:144250
Hypothyroidism, Congenital, Nongoitrous, 8
Hypercholesterolemia OMIM:301033
Sitosterolemia 1
Stomatocytosis, Hypercholesterolemia, Anemia, Reduced haptoglobin level, Reticulocytosis, Elevate... OMIM:210250
Pancreatic Lipase Deficiency
Fat malabsorption, Hypolipidemia, Steatorrhea OMIM:614338
Alpha-Thalassemia Myelodysplasia Syndrome
Hypochromic microcytic anemia, HbH hemoglobin, Reduced alpha/beta synthesis ratio OMIM:300448
Eosinophilic Gastroenteritis
Anemia, Abnormality of the gastrointestinal tract, Malabsorption, Steatorrhea, Elevated circulati... ORPHA:2070
Duodenal Neuroendocrine Tumor
Intestinal fistula, Gastrointestinal obstruction, Increased hematocrit, Hematemesis, Iron deficie... ORPHA:100076
Congenital Disorder Of Glycosylation, Type Iio
Decreased circulating ceruloplasmin concentration, Elevated circulating creatine kinase concentra... OMIM:616828
Refractory Celiac Disease
Jejunitis, Villous atrophy, Malabsorption, Normocytic anemia, Hypophosphatemia, Hypocalcemia, Abn... ORPHA:398063
Lysosomal Acid Lipase Deficiency
Leukopenia, Anemia, Hypersplenism, Steatorrhea, Hepatosplenomegaly, Increased LDL cholesterol con... OMIM:278000
Hypobetalipoproteinemia, Familial, 1
Decreased LDL cholesterol concentration, Retinal degeneration, Steatorrhea, Decreased HDL cholest... OMIM:615558
Cyanosis, Transient Neonatal
Methemoglobinemia, Anemia, Reticulocytosis OMIM:613977
Inflammatory Bowel Disease (Crohn Disease) 30
Pancolitis, Ileitis, Abnormal intestine morphology, Gastritis, Esophagitis, Protein-losing entero... OMIM:619079
Hepatosplenomegaly, Hypercholesterolemia, Thrombocytopenia, Irritability, Recurrent infection of ... ORPHA:263501
Spinocerebellar Ataxia, Autosomal Recessive, With Axonal Neuropathy 1
Hypoalbuminemia, Hypercholesterolemia OMIM:607250
Glycogen Storage Disease Ixa1
Hypertriglyceridemia, Hyperuricemia, Splenomegaly, Hypercholesterolemia OMIM:306000
Lipodystrophy, Congenital Generalized, Type 3
Hepatosplenomegaly, Hypercholesterolemia, Hypocalcemia, Hypertriglyceridemia, Splenomegaly OMIM:612526
Hereditary Persistence Of Fetal Hemoglobin-Sickle Cell Disease Syndrome
Asplenia, Splenomegaly, HbS hemoglobin, Reticulocytosis, Persistence of hemoglobin F, Hypochromic... ORPHA:251380
Deafness, Nerve Type, With Mesenteric Diverticula Of Small Bowel And Progressive Sensory Neuropathy
Fat malabsorption, Hypoproteinemia, Jejunoileal ulceration, Small bowel diverticula OMIM:221400
Bile Acid Malabsorption, Primary, 1
Increased fecal bile acid, Fat malabsorption, Steatorrhea OMIM:613291
Increased LDL cholesterol concentration, Hypoalbuminemia, Elevated circulating transferrin concen... OMIM:616000
Smith-Magenis Syndrome
Head-banging, Velopharyngeal insufficiency, Hypercholesterolemia, Retinal detachment, Hypertrigly... OMIM:182290
Distal Myopathy, Tateyama Type
Abnormal circulating creatine kinase concentration, Hypercholesterolemia ORPHA:488650
Visceral Myopathy 2
Gastroesophageal reflux, Esophageal stricture, Ineffective esophageal peristalsis, Volvulus, Mega... OMIM:619350
Palmoplantar Keratoderma-Esophageal Carcinoma Syndrome
Gastroesophageal reflux, Abnormal large intestine morphology, Esophageal neoplasm, Abnormal esoph... ORPHA:2198
Ataxia, Early-Onset, With Oculomotor Apraxia And Hypoalbuminemia
Cognitive impairment, Dementia, Elevated circulating creatine kinase concentration, Hypercholeste... OMIM:208920
Reese Retinal Dysplasia
Retinal dysplasia, Remnants of the hyaloid vascular system OMIM:266400
Pancreatic Colipase Deficiency
Fat malabsorption, Megaloblastic anemia, Steatorrhea ORPHA:309108
Anemia, Abnormality of iron homeostasis, Thrombocytopenia, Irritability, Abnormal hemoglobin, Spl... ORPHA:848
Sickle Cell Anemia
Hemolytic anemia, Unconjugated hyperbilirubinemia, Reticulocytosis, Persistence of hemoglobin F, ... ORPHA:232
Congenital Tufting Enteropathy
Elevated fecal osmolality, Villous atrophy, Abnormal large intestinal mucosa morphology, Malabsor... ORPHA:92050
Microcornea-Posterior Megalolenticonus-Persistent Fetal Vasculature-Coloboma Syndrome
Remnants of the hyaloid vascular system, Iris coloboma, Chorioretinal coloboma, Posterior lenticonus ORPHA:231736
Spinocerebellar Ataxia With Axonal Neuropathy Type 1
Hypoalbuminemia, Hypercholesterolemia ORPHA:94124
Alpha-Thalassemia-Myelodysplastic Syndrome
Neutropenia, HbH hemoglobin, Thrombocytopenia, Acute leukemia, Splenomegaly, Microcytic anemia ORPHA:231401
Secondary Short Bowel Syndrome
Enterocolitis, Villous atrophy, Small intestinal dysmotility, Malabsorption, Aganglionic megacolo... ORPHA:95427
Hepatic Lipase Deficiency
Hypercholesterolemia, Hypertriglyceridemia, Increased HDL cholesterol concentration OMIM:614025
Morgagni-Stewart-Morel Syndrome
Hyperuricemia, Cognitive impairment, Suicidal ideation, Hypercholesterolemia, Memory impairment ORPHA:77296
Chronic Diarrhea Due To Glucoamylase Deficiency
Malabsorption, Decreased small intestinal mucosa lactase level, Abnormal small intestinal mucosa ... ORPHA:103907
Diamond-Blackfan Anemia 3
Reticulocytopenia, Persistence of hemoglobin F, Macrocytic anemia, Increased mean corpuscular vol... OMIM:610629
Agammaglobulinemia 4, Autosomal Recessive
Abnormal T cell morphology, Neutropenia, Protein-losing enteropathy OMIM:613502
Citrullinemia Type Ii
Aggressive behavior, Irritability, Hepatocellular carcinoma, Acute hyperammonemia, Hypoproteinemi... ORPHA:247585
Congenital Short Bowel Syndrome
Congenital shortened small intestine, Decreased intestinal transit time, Steatorrhea, Intestinal ... OMIM:615237
Growth Hormone Insensitivity Syndrome
Hypercholesterolemia ORPHA:181393
Diamond-Blackfan Anemia 14 With Mandibulofacial Dysostosis
Persistence of hemoglobin F, Macrocytic anemia, Increased mean corpuscular volume, Elevated red c... OMIM:300946
Neonatal Intrahepatic Cholestasis Due To Citrin Deficiency
Hyperlysinemia, Abnormal circulating lipid concentration, Hypergalactosemia, Hepatosplenomegaly, ... ORPHA:247598
Diarrhea 5, With Tufting Enteropathy, Congenital
Crypt hyperplasia, Villous atrophy OMIM:613217
Intestinal Pseudoobstruction, Neuronal, Chronic Idiopathic, X-Linked
Congenital shortened small intestine, Pyloric stenosis, Increased mean platelet volume, Intestina... OMIM:300048
Ataxia-Oculomotor Apraxia 4
Cognitive impairment, Hypoalbuminemia, Elevated circulating alpha-fetoprotein concentration, Hype... OMIM:616267
Autoinflammatory Syndrome, Familial, Behcet-Like 1
Ileal ulcer, Hemolytic anemia, Lymphopenia, Colitis, Thrombocytopenia OMIM:616744
Temple Syndrome Due To Paternal 14Q32.2 Hypomethylation
High palate, Hypercholesterolemia ORPHA:254531
Polyposis, Skin Pigmentation, Alopecia, And Fingernail Changes
Anemia, Malabsorption, Gastrointestinal carcinoma, Hypokalemia, Hypocalcemia, Glossitis, Xerostom... OMIM:175500
Galactokinase Deficiency
Hypergalactosemia, Increased level of galactitol in plasma, Psychomotor deterioration, Hepatosple... ORPHA:79237
Mitochondrial Complex Iv Deficiency, Nuclear Type 19
Protein-losing enteropathy, Hyperglycinemia OMIM:619063
Temple Syndrome
High palate, Bifid uvula, Hypercholesterolemia, Cleft palate, Hypertriglyceridemia OMIM:616222
Decreased LDL cholesterol concentration, Retinal degeneration, Macroglossia, Protein-losing enter... ORPHA:79320
Temple Syndrome Due To Maternal Uniparental Disomy Of Chromosome 14
High palate, Pyloric stenosis, Bifid uvula, Hypercholesterolemia, Cleft palate ORPHA:96184
Smith-Magenis Syndrome
Gastroesophageal reflux, Self-injurious behavior, Anxiety, Hypercholesterolemia, Retinal detachme... ORPHA:819
Bone Marrow Failure Syndrome 6
Anemia, Lymphopenia, Persistence of hemoglobin F, Squamous cell carcinoma of the tongue, Increase... OMIM:618849
Hypercholanemia, Familial 1
Fat malabsorption, Increased serum bile acid concentration, Steatorrhea OMIM:607748
Congenital Enterocyte Heparan Sulfate Deficiency
Abnormal circulating polysaccharide concentration, Abnormal circulating protein concentration, Pr... ORPHA:103910
Acquired Aneurysmal Subarachnoid Hemorrhage
Cognitive impairment, Progressive neurologic deterioration, Leukocytosis, Hypercholesterolemia, M... ORPHA:90065
Apolipoprotein C-Ii Deficiency
Decreased circulating apolipoprotein C-II concentration, Hypercholesterolemia, Increased circulat... OMIM:207750
Glycogen Storage Disease Due To Phosphorylase Kinase Deficiency
Hypercholesterolemia, Hepatocellular carcinoma, Abnormal erythrocyte enzyme level, Elevated circu... ORPHA:370
Acute Interstitial Pneumonia
Elevated circulating creatinine concentration, Reduced hematocrit, Elevated circulating C-reactiv... ORPHA:79126
Hypercholesterolemia, Familial, 3
Hypercholesterolemia, Abnormal LDL cholesterol concentration, Xanthelasma OMIM:603776
Cholestasis, Progressive Familial Intrahepatic, 8
Elevated circulating alpha-fetoprotein concentration, Increased serum bile acid concentration, Hy... OMIM:619662
Hypochromic microcytic anemia, Reduced beta/alpha synthesis ratio OMIM:613985
Hypochromic microcytic anemia, Reduced alpha/beta synthesis ratio OMIM:604131
Glycogen Storage Disease Due To Liver Phosphorylase Kinase Deficiency
Hypercholesterolemia, Anemia, Abnormal erythrocyte enzyme level, Elevated circulating creatine ki... ORPHA:264580
Lysosomal Acid Lipase Deficiency
Hypercholesterolemia, Anemia, Cognitive impairment, Hyponatremia, Hypersplenism, Hyperkalemia, Ps... ORPHA:275761
Chylomicron Retention Disease
Fat malabsorption, Steatorrhea, Hypocholesterolemia, Hypertriglyceridemia, Acanthocytosis ORPHA:71
Hypercholesterolemia, Familial, 2
Hypercholesterolemia, Increased LDL cholesterol concentration, Xanthelasma OMIM:144010
Nephrotic Syndrome, Type 11
Cleft palate, Hypoalbuminemia, High palate, Hypercholesterolemia OMIM:616730
Spinocerebellar Ataxia With Axonal Neuropathy Type 2
Elevated circulating creatine kinase concentration, Elevated circulating alpha-fetoprotein concen... ORPHA:64753
Juvenile Polyposis Syndrome
Neoplasm of the stomach, Anemia, Intussusception, Duodenal adenocarcinoma, Multiple gastric polyp... OMIM:174900
Citrullinemia, Type Ii, Neonatal-Onset
Hyperlysinemia, Hyperthreoninemia, Hypermethioninemia, Hyperbilirubinemia, Hypertyrosinemia, Decr... OMIM:605814
Ataxia With Vitamin E Deficiency
Hypercholesterolemia, Short term memory impairment, Increased LDL cholesterol concentration, Xant... OMIM:277460
Vascular Hyalinosis
Malabsorption, Protein-losing enteropathy, Hematochezia OMIM:277175
Glycogen Storage Disease Due To Liver And Muscle Phosphorylase Kinase Deficiency
Hypercholesterolemia, Anemia, Hepatocellular carcinoma, Elevated circulating creatine kinase conc... ORPHA:79240
Hyperlipoproteinemia, Type I
Lactescent serum, Hepatosplenomegaly, Hyperlipidemia, Hypercholesterolemia, Increased circulating... OMIM:238600
Maternal Uniparental Disomy Of Chromosome 4
Decreased LDL cholesterol concentration, Optic atrophy, Fat malabsorption, Elevated circulating c... ORPHA:96180
Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency Type Ib
Hypercholesterolemia, Chronic neutropenia, Anemia, Hyperuricemia, Enterocolitis, Cognitive impair... ORPHA:79259
Laron Syndrome
Hypercholesterolemia ORPHA:633
Shiga Toxin-Associated Hemolytic Uremic Syndrome
Intestinal perforation, Rectal prolapse, Intussusception, Unconjugated hyperbilirubinemia, Microa... ORPHA:90038
Optic Nerve Hypoplasia, Bilateral
Remnants of the hyaloid vascular system, Optic nerve aplasia, Optic nerve hypoplasia OMIM:165550
Hb Bart'S Hydrops Fetalis
Anemia, Abnormal hemoglobin, Splenomegaly ORPHA:163596
Lysinuric Protein Intolerance
Leukopenia, Anemia, Hyperalaninemia, Hyperglycinemia, Cognitive impairment, Hyperglutaminemia, St... ORPHA:470
Bile Acid Synthesis Defect, Congenital, 1
Fat malabsorption, Acholic stools, Steatorrhea, Hypocholesterolemia, Splenomegaly, Conjugated hyp... OMIM:607765
Oculopalatocerebral Syndrome
Cleft palate, Remnants of the hyaloid vascular system OMIM:257910
Congenital Generalized Lipodystrophy
Increased C-peptide level, Hypertriglyceridemia, Macroglossia, Hypercholesterolemia ORPHA:528
Beta-Thalassemia Intermedia
Abnormality of iron homeostasis, Increased HbA2 hemoglobin, Elevated hepatic iron concentration, ... ORPHA:231222
Nk-Cell Enteropathy
Abnormal gastric mucosa morphology, Gastroesophageal reflux, Colonic diverticula, Duodenal ulcer,... ORPHA:263665
Mandibuloacral Dysplasia
Increased circulating free fatty acid level, High palate, Abnormal tongue morphology, Hypercholes... ORPHA:2457
Idiopathic Steroid-Resistant Nephrotic Syndrome
Abnormal circulating lipid concentration, Hypertriglyceridemia, Hypoalbuminemia, Hypercholesterol... ORPHA:567548
Diamond-Blackfan Anemia 6
Bifid uvula, Persistence of hemoglobin F, Macrocytic anemia, Increased mean corpuscular volume, C... OMIM:612561
Congenital Disorder Of Glycosylation, Type Ih
Anemia, Protein-losing enteropathy, Elevated circulating creatinine concentration, Thrombocytopen... OMIM:608104
Gastrointestinal Ulceration, Recurrent, With Dysfunctional Platelets
Duodenal ulcer, Esophageal ulceration, Decreased serum thromboxane B2, Iron deficiency anemia, Ab... OMIM:618372
Primary Familial Polycythemia
Abnormal hemoglobin, Polycythemia ORPHA:90042
Galloway-Mowat Syndrome 7
Cleft palate, High palate, Hypercholesterolemia OMIM:618348
Primary Intestinal Lymphangiectasia
Anemia, Reduced proportion of CD4+ effector memory T cells, Increased stool alpha1-antitrypsin co... ORPHA:90362
Mitchell-Riley Syndrome
Jejunal atresia, Malabsorption, Hyperbilirubinemia, Acholic stools, Intestinal malrotation, Anter... OMIM:615710
Dominant Beta-Thalassemia
Abnormality of iron homeostasis, Hypersplenism, Reduced hemoglobin A, Decreased mean corpuscular ... ORPHA:231226
Protein-losing enteropathy, Hypoalbuminemia, Abnormality of the gastrointestinal tract ORPHA:79327
Juvenile Polyposis Of Infancy
Anemia, High, narrow palate, Intussusception, Hematochezia, Intestinal bleeding, Refractory anemi... ORPHA:79076
Alpha-Thalassemia-X-Linked Intellectual Disability Syndrome
Gastroesophageal reflux, Anemia, Self-injurious behavior, Optic atrophy, Volvulus, Aganglionic me... ORPHA:847
Coloboma, Ocular, Autosomal Dominant
Remnants of the hyaloid vascular system, Optic disc coloboma, Optic nerve aplasia, Chorioretinal ... OMIM:120200
Megalocornea-Mental Retardation Syndrome
Hypercholesterolemia, Bifid uvula, High palate, Dysphagia OMIM:249310
Beta-Thalassemia Major
Abnormality of iron homeostasis, Hypersplenism, Reduced hemoglobin A, Anisopoikilocytosis, Decrea... ORPHA:231214
Hypereosinophilia, Gastroesophageal reflux, Gastrointestinal telangiectasia, Cognitive impairment... ORPHA:801
Proprotein Convertase 1/3 Deficiency
Malabsorption, Decreased circulating cortisol level, Villous atrophy OMIM:600955
Methemoglobinemia Due To Deficiency Of Methemoglobin Reductase
Methemoglobinemia, Polycythemia OMIM:250800
Congenital Analbuminemia
Increased alpha-globulin, Hypoproteinemia, Hyperlipidemia, Hypercholesterolemia, Hypoalbuminemia ORPHA:86816
Hypercholesterolemia Due To Cholesterol 7Alpha-Hydroxylase Deficiency
Increased LDL cholesterol concentration, Hypertriglyceridemia, Hypercholesterolemia ORPHA:209902
X-Linked Intellectual Disability-Limb Spasticity-Retinal Dystrophy-Diabetes Insipidus Syndrome
HbH hemoglobin, Optic disc pallor, Macular coloboma, Elevated amniotic fluid alpha-fetoprotein ORPHA:423479
Congenital Disorder Of Glycosylation, Type Ib
Protein-losing enteropathy, Steatorrhea, Villous atrophy, Hypoalbuminemia OMIM:602579
Alpha-Thalassemia-Intellectual Disability Syndrome Linked To Chromosome 16
HbH hemoglobin, High palate, Microcytic anemia ORPHA:98791
Cholestasis, Progressive Familial Intrahepatic, 2
Fat malabsorption, Hepatocellular carcinoma, Splenomegaly, Conjugated hyperbilirubinemia OMIM:601847
Hereditary Methemoglobinemia
Methemoglobinemia ORPHA:621
Mednik Syndrome
Volvulus, Microcolon, Increased circulating very long-chain fatty acid concentration, Jejunal atr... OMIM:609313
Hypercholesterolemia, Increased LDL cholesterol concentration, Decreased HDL cholesterol concentr... ORPHA:412
Megalocornea-Intellectual Disability Syndrome
High palate, Hypercholesterolemia ORPHA:2479
9Q31.1Q31.3 Microdeletion Syndrome
Hypercholesterolemia ORPHA:401923
Macrocephaly, Neurodevelopmental Delay, Lymphoid Hyperplasia, And Persistent Fetal Hemoglobin
Gastroesophageal reflux, Hiatus hernia, Persistence of hemoglobin F OMIM:619769
Protein-losing enteropathy, Gastrointestinal hemorrhage, Hypoalbuminemia ORPHA:79319
Low Phospholipid-Associated Cholelithiasis
Neoplasm of the liver, Hepatocellular carcinoma, Hypercholesterolemia ORPHA:69663
Immunodeficiency 47
Leukopenia, Normocytic anemia, Decreased circulating copper concentration, Accessory spleen, Hype... OMIM:300972
Shwachman-Diamond Syndrome 1
Acute myeloid leukemia, Anemia, Pancytopenia, Persistence of hemoglobin F, Steatorrhea, Thrombocy... OMIM:260400
Abdominal Obesity-Metabolic Syndrome 3
Increased LDL cholesterol concentration, Hypertriglyceridemia, Hypercholesterolemia OMIM:615812
Acquired Methemoglobinemia
Methemoglobinemia, Anxiety ORPHA:464453
Congenital Bile Acid Synthesis Defect Type 2
Fat malabsorption, Abnormal serum bile acid concentration, Hyperbilirubinemia, Steatorrhea, Extra... ORPHA:79303
Disorder Of Bile Acid Synthesis
Fat malabsorption ORPHA:79168
Neoplasm of the gastrointestinal tract, Leukemia, Ulcerative colitis, Imbalanced hemoglobin synth... ORPHA:99867
Lead Poisoning
Abnormal T cell morphology, Anemia, Cognitive impairment, Imbalanced hemoglobin synthesis, Increa... ORPHA:330015
Intellectual Developmental Disorder With Persistence Of Fetal Hemoglobin
Self-injurious behavior, Persistence of hemoglobin F OMIM:617101
Diarrhea 10, Protein-Losing Enteropathy Type
Coloboma, Hypomagnesemia, Protein-losing enteropathy, Hyponatremia, Hypocalcemia, Hypertriglyceri... OMIM:618183
Annular Pancreas
High intestinal obstruction, Duodenal stenosis ORPHA:675
Pancreas, Annular
High intestinal obstruction, Duodenal stenosis OMIM:167750
Mungan Syndrome
Megaduodenum, Intestinal pseudo-obstruction, Barrett esophagus, Hypoperistalsis OMIM:611376
Congenital Bile Acid Synthesis Defect Type 3
Fat malabsorption, Hyperbilirubinemia, Hepatosplenomegaly ORPHA:79302
Oculocerebrorenal Syndrome Of Lowe
Hypercholesterolemia, Gastroesophageal reflux, Anemia, Hyperaldosteronism, Narrow palate, Self-in... ORPHA:534
Cat Eye Syndrome
Rectal atresia, Volvulus, Anal atresia, Intestinal malrotation, Iris coloboma, Meckel diverticulu... OMIM:115470
Cholestasis, Progressive Familial Intrahepatic, 1
Fat malabsorption, Splenomegaly, Conjugated hyperbilirubinemia OMIM:211600
Inflammatory Skin And Bowel Disease, Neonatal, 1
Villous atrophy, Duodenitis OMIM:614328
Anemia, Decreased LDL cholesterol concentration, Fat malabsorption, Hyperbilirubinemia, Reticuloc... ORPHA:14
Visceral Myopathy 1
Megaduodenum, Aganglionic megacolon, Microcolon, Dysphagia, Intestinal pseudo-obstruction OMIM:155310
Systemic Sclerosis
Gastroesophageal reflux, Gastrointestinal telangiectasia, Abnormal large intestine morphology, Ab... ORPHA:90291
Meconium Ileus
Meconium ileus, Microcolon OMIM:614665
Mandibuloacral Dysplasia With Type A Lipodystrophy
Calcinosis, High palate, Hyperlipidemia, Hypercholesterolemia OMIM:248370
Oculo-Palato-Cerebral Syndrome
Retinal detachment, Cleft palate, Remnants of the hyaloid vascular system, High, narrow palate ORPHA:2714
Hennekam Lymphangiectasia-Lymphedema Syndrome 3
Protein-losing enteropathy OMIM:618154
Tubulointerstitial Nephritis And Uveitis Syndrome
Reduced hematocrit, Normocytic anemia, Abnormality of retinal pigmentation, Elevated circulating ... ORPHA:91500
Shwachman-Diamond Syndrome
Acute myeloid leukemia, Chronic neutropenia, Leukopenia, Anemia, Neutropenia, Hypoamylasemia, Abn... ORPHA:811
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 5
Intestinal malrotation, Microcolon OMIM:619431
Isolated Thyroid-Stimulating Hormone Deficiency
Abnormal circulating thyroglobulin level, Neonatal hyperbilirubinemia, Macroglossia, Hypercholest... ORPHA:90674
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 7
Elevated circulating creatine kinase concentration, Optic nerve hypoplasia, Retinal dysplasia, Re... OMIM:614643
Juvenile Polyposis Syndrome
Hamartomatous stomach polyps, Stomach cancer, Anemia, Juvenile colonic polyposis, Neoplasm of the... ORPHA:2929
Palmoplantar Hyperkeratosis With Squamous Cell Carcinoma Of Skin And 46,Xx Sex Reversal
Hypertriglyceridemia, Hypercholesterolemia OMIM:610644
Steinert Myotonic Dystrophy
Aggressive behavior, Cognitive impairment, Anxiety, Emotional lability, Colon cancer, Abnormality... ORPHA:273
Immunodeficiency 31C
Villous atrophy, Intussusception, Lymphopenia, Impaired lymphocyte transformation with phytohemag... OMIM:614162
Oculoskeletodental Syndrome
Hypocalcemia, Macroglossia, Hypercalcemia, Protein-losing enteropathy, Splenomegaly OMIM:618440
Blackfan-Diamond Anemia
Acute myeloid leukemia, Leukopenia, High palate, Cleft soft palate, Reticulocytopenia, Adenocarci... ORPHA:124
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome
Intestinal malrotation, Microcolon, Hypoperistalsis, Abnormality of the gastrointestinal tract ORPHA:2241
Bile Acid Synthesis Defect, Congenital, 4
Fat malabsorption, Hyperbilirubinemia, Hematochezia, Decreased serum bile acid concentration OMIM:214950
Bardet-Biedl Syndrome 20
Papilledema, Hypercholesterolemia OMIM:619471
Methemoglobinemia And Ambiguous Genitalia
Methemoglobinemia OMIM:250790
Persistent Hyperplastic Primary Vitreous
Tractional retinal detachment, Remnants of the hyaloid vascular system, Hyaloid vascular remnant ... ORPHA:91495
Mullerian Derivatives, Persistence Of, With Lymphangiectasia And Postaxial Polydactyly
High palate, Hypoproteinemia, Protein-losing enteropathy, Cleft palate, Hypocalcemia, Splenomegaly OMIM:235255
Protein-losing enteropathy ORPHA:95428
Fg Syndrome Type 1
Gastroesophageal reflux, High palate, Abnormal large intestine morphology, Pyloric stenosis, Anal... ORPHA:93932
Lipodystrophy, Familial Partial, Type 2
Hypertriglyceridemia, Decreased HDL cholesterol concentration, Hypercholesterolemia OMIM:151660
Microvillus Inclusion Disease
Villous atrophy, Abnormality of small intestinal villus morphology ORPHA:2290
Metachromatic Leukodystrophy
Abnormal duodenum morphology, Intussusception, Abnormal stomach morphology, Dementia, Emotional l... ORPHA:512
Alagille Syndrome 1
Hypertriglyceridemia, Hepatocellular carcinoma, Pigmentary retinopathy, Hypercholesterolemia OMIM:118450
Alpha-Thalassemia/Impaired Intellectual Development Syndrome, X-Linked
Gastroesophageal reflux, Reduced alpha/beta synthesis ratio, Macroglossia, Hypochromic microcytic... OMIM:301040
Müllerian Derivatives-Lymphangiectasia-Polydactyly Syndrome
High palate, Hepatosplenomegaly, Hypoproteinemia, Protein-losing enteropathy, Hypocalcemia, Splen... ORPHA:1655
Peripheral Demyelinating Neuropathy-Central Dysmyelinating Leukodystrophy-Waardenburg Syndrome-Hirschsprung Disease
Microcolon, Aganglionic megacolon, Splenomegaly, Ileus ORPHA:163746
Pericardial And Diaphragmatic Defect
Intestinal malrotation, Morphological abnormality of the gastrointestinal tract, Meckel diverticulum ORPHA:2847
Whim Syndrome
Abnormality of neutrophil morphology, Lymphopenia, Parotitis, Abnormal small intestine morphology... ORPHA:51636
Acromelic Frontonasal Dysostosis
Cleft palate, Remnants of the hyaloid vascular system, Optic nerve hypoplasia OMIM:603671
Lmna-Related Cardiocutaneous Progeria Syndrome
Hypertriglyceridemia, Hypercholesterolemia ORPHA:363618
Persistent Hyperplastic Primary Vitreous, Autosomal Recessive
Retinal nonattachment, Iris coloboma, Remnants of the hyaloid vascular system OMIM:221900
Autosomal Recessive Polycystic Kidney Disease
Cognitive impairment, Hyponatremia, Fat malabsorption, Hypersplenism, Cholangiocarcinoma, Hepatos... ORPHA:731
Tarp Syndrome
Optic atrophy, Tongue nodules, Abnormal duodenum morphology, Extramedullary hematopoiesis, Cleft ... ORPHA:2886
Hennekam Lymphangiectasia-Lymphedema Syndrome 1
Narrow palate, Protein-losing enteropathy, Rectal prolapse, Intestinal lymphangiectasia, Hypoalbu... OMIM:235510
Abnormal jejunum morphology ORPHA:449280
Full Nf2-Related Schwannomatosis
Remnants of the hyaloid vascular system, Memory impairment, Dysphagia ORPHA:637
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 3
Microcolon OMIM:619362
Lipodystrophy, Familial Partial, Type 7
Hypercholesterolemia, Hypertriglyceridemia, Pigmentary retinopathy, Dysphagia OMIM:606721
Pierson Syndrome
Retinal hemorrhage, Posterior lenticonus, Remnants of the hyaloid vascular system, Hypoproteinemi... OMIM:609049
Lowe Oculocerebrorenal Syndrome
Elevated maternal serum alpha-fetoprotein, Aggressive behavior, Elevated amniotic fluid alpha-fet... OMIM:309000
Biliary, Renal, Neurologic, And Skeletal Syndrome
Gastroesophageal reflux, Coloboma, Hyperbilirubinemia, Increased circulating ferritin concentrati... OMIM:619534
Intestinal malrotation, Abnormality of the spleen, Meckel diverticulum ORPHA:1666
Enterocolitis, Colon perforation, Ileitis, Melena, Gastritis, Hematemesis, Gastrointestinal hemor... ORPHA:73263
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 2
Microcolon, Ileal atresia OMIM:619351
Isolated Biliary Atresia
Fat malabsorption, Acholic stools, Xanthelasma, Splenomegaly, Conjugated hyperbilirubinemia ORPHA:30391
Acrocephalopolydactylous Dysplasia
Hypoplasia of the small intestine, Polysplenia, Hypoplastic colon OMIM:200995
Holoprosencephaly 2
Bifid uvula, Submucous cleft hard palate, Median cleft lip and palate, Iris coloboma, Remnants of... OMIM:157170
Homozygous Familial Hypercholesterolemia
Increased LDL cholesterol concentration, Hyperlipidemia, Optic neuropathy, Hypercholesterolemia ORPHA:391665
Congenital Tracheal Stenosis
Morphological abnormality of the gastrointestinal tract, Abnormal stomach morphology, Anal atresi... ORPHA:141127
Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Asplenia, Congenital shortened small intestine, Esophageal atresia, Anal atresia, Tracheoesophage... OMIM:265380
Bannayan-Riley-Ruvalcaba Syndrome
Hamartomatous polyposis, Narrow palate, Intestinal polyposis, Abnormal large intestine morphology ORPHA:109
Liver Disease, Severe Congenital
Leukopenia, Anemia, Hyperalaninemia, Lymphocytosis, Hyperbilirubinemia, Elevated hepatic iron con... OMIM:619991
Ehlers-Danlos Syndrome, Musculocontractural Type, 1
High palate, Abnormal duodenum morphology, Intestinal malrotation, Retinal detachment, Cleft pala... OMIM:601776
Neuroocular Syndrome
Anxiety, Ankyloglossia, Submucous cleft hard palate, Lens coloboma, Remnants of the hyaloid vascu... OMIM:619539
Microphthalmia, Syndromic 2
Bifid uvula, Submucous cleft hard palate, Iris coloboma, Remnants of the hyaloid vascular system,... OMIM:300166
Norrie Disease
Self-injurious behavior, Optic atrophy, Remnants of the hyaloid vascular system, Anxiety, Retinal... ORPHA:649
Heart Defects, Congenital, And Other Congenital Anomalies
Intestinal malrotation, Microcolon, Colon perforation OMIM:600001
Fraser Syndrome 1
Cleft palate, Abnormal small intestine morphology, Abnormality of the anus OMIM:219000
Restrictive Dermopathy
Microcolon, Submucous cleft hard palate ORPHA:1662


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Fpr3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Fpr3.

There are 2 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Chemosensory Cell-Derived Acetylcholine Drives Tracheal Mucociliary Clearance in Response to Virulence-Associated Formyl Peptides. Immunity (April 2020) Fpr3tm1b(EUCOMM)Hmgu 32294408
Bacterial MgrB peptide activates chemoreceptor Fpr3 in mouse accessory olfactory system and drives avoidance behaviour. Nature communications (October 2019) Fpr3tm1b(EUCOMM)Hmgu PMC6814738

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MGI Allele Allele Type Produced
Fpr3tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Fpr3tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Fpr3tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (with selection cassette) Mice

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