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Gene: Bmx MGI:1101778

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Gene Summary

Name:
BMX non-receptor tyrosine kinase
Synonyms:
Tyro8,  Etk,  Etk/Bmx

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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FCS thumbnail FCS
Immunophenotyping

Panel A FCS file(s)

6 Images

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FCS thumbnail FCS
Immunophenotyping

Panel B FCS file(s)

6 Images

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Human diseases caused by Bmx mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Bmx by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Osteoarthritis Susceptibility 1
Hip osteoarthritis OMIM:165720
Osteoarthritis Susceptibility 2
Osteoarthritis, Heberden's node OMIM:140600
Chondrocalcinosis 1
Chondrocalcinosis, Osteoarthritis OMIM:600668
Chondrocalcinosis 2
Polyarticular chondrocalcinosis, Osteoarthritis, Arthropathy OMIM:118600
Glycoprotein Storage Disease
Gout OMIM:232900
Osteoarthritis Susceptibility 3
Osteoarthritis of the first carpometacarpal joint, Osteoarthritis of the distal interphalangeal j... OMIM:607850
Slipped Femoral Capital Epiphyses
Hip osteoarthritis OMIM:182260
Talo-Patello-Scaphoid Osteolysis
Osteolysis of talus, Synovitis, Osteolysis of patellae, Osteolysis of scaphoids, Enlarged joints ORPHA:50809
Complement Component C1R/C1S Deficiency
Discoid lupus rash, Arthritis, Autoimmunity, Nephritis OMIM:216950
Talo-Patello-Scaphoid Osteolysis, Synovitis, And Short Fourth Metacarpals
Osteolysis of talus, Osteolysis of scaphoids, Synovitis, Osteolysis of patellae OMIM:609655
Developmental Dysplasia Of The Hip 2
Arthritis, Hip osteoarthritis OMIM:615612
Angel-Shaped Phalangoepiphyseal Dysplasia
Premature osteoarthritis, Delayed ossification of carpal bones, Hyperextensibility of the finger ... OMIM:105835
Kienbock Disease
Osteochondritis dissecans, Osteoarthritis, Abnormality of the wrist, Limitation of joint mobility ORPHA:97332
Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome
Wrist flexion contracture, Congenital finger flexion contractures, Synovial hypertrophy, Arthropa... OMIM:208250
Peripheral Dysostosis
Hip osteoarthritis OMIM:170700
Familial Calcium Pyrophosphate Deposition
Joint dislocation, Arthritis, Limitation of joint mobility, Joint swelling, Chondrocalcinosis, Os... ORPHA:1416
Sjogren Syndrome
Tubulointerstitial nephritis, Keratoconjunctivitis sicca, Autoimmunity, Rheumatoid arthritis OMIM:270150
Felty Syndrome
Rheumatoid arthritis OMIM:134750
Spondyloepiphyseal Dysplasia Tarda, Autosomal Recessive
Osteoarthritis, Hip osteoarthritis OMIM:271600
Interstitial Granulomatous Dermatitis With Arthritis
Rheumatoid factor positive, Inflammatory abnormality of the skin, Rheumatoid arthritis ORPHA:79099
Psoriasis 1, Susceptibility To
Arthritis, Psoriasiform dermatitis OMIM:177900
Systemic Lupus Erythematosus, Susceptibility To, 6
Malar rash, Arthritis, Pericarditis, Systemic lupus erythematosus, Antinuclear antibody positivity OMIM:609939
Achalasia, Familial Esophageal
Keratoconjunctivitis sicca, Rheumatoid arthritis OMIM:200400
Oligoarticular Juvenile Idiopathic Arthritis
Oligoarthritis, Rheumatoid arthritis, Autoimmunity, Uveitis, Joint hypermobility, Abnormality of ... ORPHA:85410
Systemic Lupus Erythematosus
Malar rash, Antiphospholipid antibody positivity, Arthritis, Nephritis, Pericarditis, Systemic lu... OMIM:152700
Secondary Non-Traumatic Avascular Necrosis
Systemic lupus erythematosus, Autoimmunity, Limitation of joint mobility, Rheumatoid arthritis ORPHA:399180
Vertical Talus, Congenital
Arthritis OMIM:192950
Rheumatoid Arthritis
Rheumatoid arthritis, Rheumatoid factor positive, Anti-citrullinated protein antibody positivity,... OMIM:180300
Subcorneal Pustular Dermatosis
Pustule, Systemic lupus erythematosus, Autoimmunity, Rheumatoid arthritis ORPHA:48377
Rheumatoid Factor-Negative Polyarticular Juvenile Idiopathic Arthritis
Oligoarthritis, Flexion contracture, Synovial hypertrophy, Hip osteoarthritis, Enthesitis, Arthri... ORPHA:85408
Spondyloarthropathy, Susceptibility To, 1
Sacroiliac arthritis, Oligoarthritis, Hip osteoarthritis, Enthesitis, Inflammation of the large i... OMIM:106300
Systemic-Onset Juvenile Idiopathic Arthritis
Juvenile rheumatoid arthritis, Skin rash, Autoimmunity, Pericarditis, Joint swelling, Anterior uv... ORPHA:85414
Severe Combined Immunodeficiency Due To Dclre1C Deficiency
Recurrent aphthous stomatitis, Chronic oral candidiasis, Juvenile rheumatoid arthritis, Skin rash... ORPHA:275
Gamma-Heavy Chain Disease
Rheumatoid arthritis, Skin rash, Autoimmunity, Autoimmune thrombocytopenia, Autoimmune hemolytic ... ORPHA:100026
Pyoderma Gangrenosum
Myositis, Inflammation of the large intestine, Pustule, Rheumatoid arthritis ORPHA:48104
Selective Igm Deficiency
Recurrent vulvovaginal candidiasis, Bronchiectasis, Fasciitis, Recurrent sinusitis, Antinuclear a... ORPHA:331235
Myasthenia Gravis
Anti-muscle-specific tyrosine kinase antibody, Rheumatoid arthritis, Hepatitis, Anti-acetylcholin... ORPHA:589
Recurrent Infections Associated With Rare Immunoglobulin Isotypes Deficiency
Bronchiectasis, Allergic rhinitis, Rheumatoid arthritis, Skin rash, Arthritis, Autoimmunity, Chro... ORPHA:183675
Overlap Myositis
Subluxation of the small joints of the hand, Rheumatoid arthritis, Arthritis, Autoimmunity, Syste... ORPHA:206572
Autoimmune Polyendocrinopathy Type 4
Tubulointerstitial nephritis, Atrophic gastritis, Iridocyclitis, Hepatitis, Rheumatoid arthritis,... ORPHA:227990
Congenital Tricuspid Stenosis
Bacterial endocarditis, Rheumatoid arthritis ORPHA:95459
Autoimmune Polyendocrinopathy Type 3
Tubulointerstitial nephritis, Atrophic gastritis, Iridocyclitis, Hepatitis, Rheumatoid arthritis,... ORPHA:227982
Thymoma
Rheumatoid arthritis, Anti-acetylcholine receptor antibody positivity, Autoimmunity, Ulcerative c... ORPHA:99867
Spondyloenchondrodysplasia With Immune Dysregulation
Juvenile rheumatoid arthritis, Rheumatoid arthritis, Autoimmunity, Recurrent sinusitis, Recurrent... OMIM:607944
Lymphoid Interstitial Pneumonia
Bronchiectasis, Rheumatoid arthritis, Skin rash, Keratoconjunctivitis sicca, Autoimmunity, Eczema... ORPHA:79128
Igg4-Related Retroperitoneal Fibrosis
Anti-thyroid peroxidase antibody positivity, Rheumatoid arthritis, Deep dermal perivascular infla... ORPHA:49041
Hereditary Xanthinuria
Gout, Arthropathy, Rheumatoid arthritis ORPHA:3467

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Bmx

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Bmx.

No publications found that use IMPC mice or data for Bmx.

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MGI Allele Allele Type Produced
Bmxtm40596(L1L2_gt0) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Bmxtm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Bmxtm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Bmxtm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (with selection cassette) Mice

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