Prss12 | serine protease 12 neurotrypsin (motopsin)

GeneMGI:1100881Synonyms: motopsin, Bssp-3

Physiological systems

21 / 24 physiological systems tested

7 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Endocrine/exocrine gland Growth/size/body region Hearing/vestibular/ear Vision/eye Hematopoietic system

14 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:6Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

enlarged thymus1 supporting datasetPrss12em1(IMPC)CcpczhomozygoteEarly adultN/A * 
abnormal thymus morphology1 supporting datasetPrss12em1(IMPC)CcpczhomozygoteEarly adultN/A * 
abnormal auditory brainstem response1 supporting datasetPrss12em1(IMPC)CcpczhomozygoteEarly adult7.81x10-4 
abnormal eye morphology1 supporting datasetPrss12em1(IMPC)CcpczhomozygoteEarly adultN/A * 
decreased body weight1 supporting datasetPrss12em1(IMPC)CcpczhomozygoteEarly adult7.62x10-5 
increased circulating lactate dehydrogenase level1 supporting datasetPrss12em1(IMPC)CcpczhomozygoteEarly adult5.05x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* Does not have a P-value assigned because it was manually marked as significant.
Download data as:  

lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Prss12em1(IMPC)CcpczExon Deletionmouse
Prss12tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
Prss12tm1e(EUCOMM)HmguTargeted, non-conditional allelees cell

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