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Gene: Selenow MGI:1100878

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Gene Summary

Name:
selenoprotein W
Synonyms:
Sepw1

Order Alleles

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

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Viewing: all phenotypes
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Viewing: all phenotypes

lacZ Expression

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Adrenal gland N/A heterozygote 100% (2 of 2)
Aorta N/A heterozygote 100% (2 of 2)
Blood vessel N/A heterozygote 0.0% (0 of 2)
Bone N/A heterozygote 0.0% (0 of 2)
Brain N/A heterozygote 100% (2 of 2)
Brainstem N/A heterozygote 100% (2 of 2)
Brown adipose tissue N/A heterozygote 0.0% (0 of 2)
Cartilage tissue N/A heterozygote 0.0% (0 of 2)
Cerebellum N/A heterozygote 100% (2 of 2)
Cerebral cortex N/A heterozygote 100% (2 of 2)
Eye N/A heterozygote 0.0% (0 of 2)
Gall bladder N/A heterozygote 0.0% (0 of 2)
Heart N/A heterozygote 100% (2 of 2)
Hippocampus N/A heterozygote 100% (2 of 2)
Hypothalamus N/A heterozygote 100% (2 of 2)
Kidney N/A heterozygote 100% (2 of 2)
Large intestine N/A heterozygote 100% (2 of 2)
Liver N/A heterozygote 0.0% (0 of 2)
Lower urinary tract N/A heterozygote 100% (2 of 2)
Lung N/A heterozygote 0.0% (0 of 2)
Lymph node N/A heterozygote 0.0% (0 of 2)
Mammary gland N/A heterozygote 0.0% (0 of 2)
Esophagus N/A heterozygote 0.0% (0 of 2)
Olfactory lobe N/A heterozygote 100% (2 of 2)
Ovary N/A heterozygote 0.0% (0 of 2)
Oviduct N/A heterozygote 50% (1 of 2)
Pancreas N/A heterozygote 0.0% (0 of 2)
Parathyroid gland N/A heterozygote 100% (2 of 2)
Peripheral nervous system N/A heterozygote 100% (2 of 2)
Peyer's patch N/A heterozygote 0.0% (0 of 2)
Pituitary gland N/A heterozygote 100% (2 of 2)
Prostate gland N/A heterozygote 0.0% (0 of 2)
Skeletal muscle tissue N/A heterozygote 100% (2 of 2)
Skin N/A heterozygote 0.0% (0 of 2)
Small intestine N/A heterozygote 100% (2 of 2)
Spinal cord N/A heterozygote 100% (2 of 2)
Spleen N/A heterozygote 0.0% (0 of 2)
Stomach N/A heterozygote 100% (2 of 2)
Striatum N/A heterozygote 100% (2 of 2)
Testis N/A heterozygote 50% (1 of 2)
Thymus N/A heterozygote 0.0% (0 of 2)
Thyroid gland N/A heterozygote Ambiguous
Trachea N/A heterozygote Ambiguous
Uterus N/A heterozygote 50% (1 of 2)
White adipose tissue N/A heterozygote 0.0% (0 of 2)
No Embryo expression data was found for this gene.

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)
adrenal gland 0.68% (4 of 585)
aorta 0.17% (1 of 585)
blood vessel 0.0%
bone 0.0%
brain 0.68% (4 of 585)
brainstem 0.34% (2 of 585)
brown adipose tissue 0.0%
cartilage tissue 0.17% (1 of 585)
cerebellum 0.51% (3 of 585)
cerebral cortex 0.34% (2 of 585)
eye 0.0%
gall bladder 0.0%
heart 0.34% (2 of 585)
hippocampus 0.51% (3 of 585)
hypothalamus 0.34% (2 of 585)
kidney 3.59% (21 of 585)
large intestine 1.71% (10 of 585)
liver 0.0%
lower urinary tract 0.17% (1 of 585)
lung 0.34% (2 of 585)
lymph node 0.17% (1 of 585)
mammary gland 0.0%
oesophagus 0.0%
olfactory lobe 0.34% (2 of 585)
ovary 0.17% (1 of 585)
oviduct 0.0%
pancreas 0.85% (5 of 585)
parathyroid gland 0.18% (1 of 563)
peripheral nervous system 0.34% (2 of 585)
peyer's patch 0.57% (1 of 176)
pituitary gland 0.17% (1 of 585)
prostate gland 2.05% (12 of 585)
skeletal muscle tissue 0.0%
skin 0.17% (1 of 585)
small intestine 1.54% (9 of 585)
spinal cord 0.51% (3 of 585)
spleen 0.51% (3 of 585)
stomach 2.22% (13 of 585)
striatum 0.51% (3 of 585)
testis 1.03% (6 of 585)
thymus 0.17% (1 of 585)
thyroid gland 2.91% (17 of 585)
trachea 0.51% (3 of 585)
uterus 0.0%
white adipose tissue 0.0%
No Embryo expression data was found for this gene.

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

14 Images

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X-ray

XRay Images Skull Lateral Orientation

14 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

14 Images

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X-ray

XRay Images Forepaw

14 Images

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X-ray

XRay Images Whole Body Lateral Orientation

14 Images

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Eye Morphology

Images Slit Lamp

1 Images

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Human diseases caused by Selenow mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Selenow by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Buschke-Ollendorff Syndrome
Joint stiffness, Osteopoikilosis, Flexion contracture OMIM:166700
12q14 microdeletion syndrome
Osteopoikilosis DECIPHER:76
Metaphyseal Modeling Abnormality, Skin Lesions, And Spastic Paraplegia
Increased bone mineral density OMIM:250500
Ribbing Disease
Diaphyseal sclerosis OMIM:601477
Osteomesopyknosis
Increased bone mineral density OMIM:166450
Pyknoachondrogenesis
Increased bone mineral density OMIM:265880
Ossification Of The Posterior Longitudinal Ligament Of Spine
Increased bone mineral density, Ectopic ossification OMIM:602475
Osteosclerosis-Ichthyosis-Premature Ovarian Failure Syndrome
Increased bone mineral density ORPHA:75325
Body Mass Index Quantitative Trait Locus 20
Obesity, Increased bone mineral density, Tall stature OMIM:618406
Dentin Dysplasia
Increased bone mineral density ORPHA:1653
Osteopoikilosis And Dacryocystitis
Osteopoikilosis OMIM:166705
Melorheostosis With Osteopoikilosis
Osteopoikilosis, Abnormal cortical bone morphology ORPHA:1879
Osteomesopyknosis
Increased bone mineral density, Abnormal cortical bone morphology ORPHA:2777
Prader-Willi Habitus, Osteopenia, And Camptodactyly
Osteoporosis, Joint contracture of the hand, Osteopenia, Camptodactyly, Obesity OMIM:264010
Melorheostosis, Isolated
Hyperostosis, Increased bone mineral density OMIM:155950
Osteomalacia, Sclerosing, With Cerebral Calcification
Generalized osteosclerosis, Osteomalacia, Increased bone mineral density OMIM:259660
Hyperostosis Corticalis Generalisata
Generalized osteosclerosis, Cranial hyperostosis, Abnormal cortical bone morphology ORPHA:3416
Craniodiaphyseal Dysplasia
Facial hyperostosis, Cranial hyperostosis, Diaphyseal sclerosis OMIM:218300
Sclerosteosis
Increased bone mineral density, Craniofacial hyperostosis, Abnormal cortical bone morphology, Tal... ORPHA:3152
Melorheostosis
Ectopic ossification in muscle tissue, Failure to thrive, Hyperostosis, Arthritis, Increased bone... ORPHA:2485
Van Buchem Disease
Cranial hyperostosis, Thickened cortex of long bones, Increased bone mineral density OMIM:239100
Dacryocystitis-Osteopoikilosis Syndrome
Osteopoikilosis, Increased bone mineral density ORPHA:1562
Endosteal Hyperostosis, Worth Type
Clavicular sclerosis, Generalized osteosclerosis, Craniofacial hyperostosis, Abnormal cortical bo... ORPHA:2790
Hypophosphatemic Rickets, Autosomal Recessive, 1
Craniosynostosis, Increased bone mineral density, Hypophosphatemic rickets, Rickets OMIM:241520
Trichodentoosseous Syndrome
Increased bone mineral density OMIM:190320
Dentin Dysplasia With Sclerotic Bones
Cortical sclerosis OMIM:125440
Osteosclerosis-Developmental Delay-Craniosynostosis Syndrome
Craniosynostosis, Increased bone mineral density ORPHA:178377
Distal Osteosclerosis
Craniofacial osteosclerosis, Hyperostosis, Diaphyseal sclerosis OMIM:126250
Isolated Osteopoikilosis
Sclerotic foci in hand bones, Sclerosis of foot bone, Abnormal bone ossification, Tarsal sclerosi... ORPHA:166119
Osteochondrosis Of The Metatarsal Bone
Joint stiffness, Sclerosis of foot bone, Arthritis, Thickened cortex of bones ORPHA:564003
Osteopetrosis, Autosomal Dominant 1
Generalized osteosclerosis, Thickened cortex of long bones, Osteopetrosis, Calvarial osteosclerosis OMIM:607634
Flynn-Aird Syndrome
Increased bone density with cystic changes, Osteoporosis, Increased bone mineral density, Joint s... OMIM:136300
Hypogonadotropic Hypogonadism 21 With Or Without Anosmia
Osteoporosis, Osteopenia OMIM:615271
Hypogonadotropic Hypogonadism 19 With Or Without Anosmia
Osteoporosis, Osteopenia OMIM:615269
Osteopetrosis, Autosomal Recessive 6
Osteopetrosis OMIM:611497
Osteosclerosis With Ichthyosis And Fractures
Cortical thickening of long bone diaphyses, Recurrent fractures, Increased bone mineral density OMIM:166740
Mueller-Weiss Syndrome
Sclerosis of foot bone, Limitation of movement at ankles, Knee osteoarthritis, Arthritis, Joint s... ORPHA:566943
Ghosal Hematodiaphyseal Dysplasia
Leukopenia, Hyperostosis cranialis interna, Refractory anemia, Myelofibrosis, Increased bone mine... OMIM:231095
Dysplastic Cortical Hyperostosis
Increased bone mineral density, Abnormal cortical bone morphology, Splenomegaly ORPHA:2204
Summitt Syndrome
Obesity, Craniosynostosis OMIM:272350
Hypogonadotropic Hypogonadism 20 With Or Without Anosmia
Osteoporosis, Osteopenia OMIM:615270
Osteosclerotic Metaphyseal Dysplasia
Clavicular sclerosis OMIM:615198
Endosteal Hyperostosis, Autosomal Dominant
Thickened cortex of long bones, Hyperostosis, Metatarsal diaphyseal endosteal sclerosis, Clavicul... OMIM:144750
Osteopetrosis, Autosomal Recessive 8
Failure to thrive, Osteopetrosis, Anemia, Splenomegaly, Thrombocytopenia OMIM:615085
Osteopetrosis, Autosomal Dominant 2
Hip osteoarthritis, Generalized osteosclerosis, Osteopetrosis, Fractures of the long bones, Mandi... OMIM:166600
Intermediate Osteopetrosis
Abnormality of bone mineral density, Generalized osteosclerosis, Osteosclerosis of the base of th... ORPHA:210110
Osteopetrosis And Infantile Neuroaxonal Dystrophy
Osteopetrosis OMIM:600329
Axial Osteomalacia
Osteomalacia, Increased bone mineral density OMIM:109130
Craniodiaphyseal Dysplasia, Autosomal Dominant
Craniofacial osteosclerosis, Craniofacial hyperostosis, Diaphyseal sclerosis, Cortical sclerosis OMIM:122860
Osteoporosis
Osteoporosis OMIM:166710
Hyperostosis Frontalis Interna
Hyperostosis frontalis interna, Obesity OMIM:144800
Schnitzler Syndrome
Leukocytosis, Anemia, Arthritis, Splenomegaly, Increased bone mineral density ORPHA:37748
Osteogenesis Imperfecta, Type Xiii
Joint hypermobility, Decreased body weight, Osteoporosis, Increased bone mineral density OMIM:614856
Paget Disease Of Bone 3
Patchy osteosclerosis, Fractures of the long bones, Osteolysis OMIM:167250
Pycnodysostosis
Osteolytic defects of the distal phalanges of the hand, Increased bone mineral density OMIM:265800
Chondrodysplasia, Blomstrand Type
Generalized osteosclerosis, Advanced ossification of carpal bones, Advanced tarsal ossification OMIM:215045
Lethal Recessive Chondrodysplasia
Generalized osteosclerosis ORPHA:1423
Hip Dysplasia, Beukes Type
Abnormality of bone mineral density, Abnormal bone ossification, Osteoarthritis, Abnormal ossific... ORPHA:2114
Gnathodiaphyseal Dysplasia
Osteomyelitis, Increased susceptibility to fractures, Diaphyseal cortical sclerosis, Osteopenia OMIM:166260
Osteopetrosis, Autosomal Recessive 1
Failure to thrive, Osteopetrosis, Craniosynostosis, Anemia, Calvarial osteosclerosis, Pathologic ... OMIM:259700
Eiken Syndrome
Limited elbow flexion, Thin bony cortex, Delayed epiphyseal ossification, Abnormal trabecular bon... ORPHA:79106
Hypoinsulinemic Hypoglycemia With Hemihypertrophy
Truncal obesity, Large for gestational age OMIM:240900
Majeed Syndrome
Leukocytosis, Cachexia, Synovitis, Hypochromic microcytic anemia, Failure to thrive, Weight loss,... ORPHA:77297
Osteopetrosis, Autosomal Recessive 4
Osteopetrosis, Anemia, Splenomegaly, Hepatosplenomegaly, Reticulocytosis, Thrombocytopenia, Recur... OMIM:611490
Maturity-Onset Diabetes Of The Young, Type 11
Obesity, Overweight OMIM:613375
Osteopetrosis, Autosomal Recessive 2
Thrombocytopenia, Osteopetrosis, Anemia, Diaphyseal sclerosis, Osteomyelitis, Hepatosplenomegaly,... OMIM:259710
Buschke-Ollendorff Syndrome
Generalized osteosclerosis, Hyperostosis, Craniosynostosis, Abnormal bone structure, Arthritis, O... ORPHA:1306
Thumb Stiffness-Brachydactyly-Intellectual Disability Syndrome
Joint stiffness, Obesity ORPHA:1078
Craniometaphyseal Dysplasia
Osteopetrosis, Craniofacial hyperostosis ORPHA:1522
Otopalatodigital Syndrome Type 1
Abnormal vertebral segmentation and fusion, Synostosis of carpal bones, Increased bone mineral de... ORPHA:90650
Obesity-Colitis-Hypothyroidism-Cardiac Hypertrophy-Developmental Delay Syndrome
Obesity, Craniosynostosis ORPHA:88643
Vitamin D-Dependent Rickets, Type 2B, With Normal Vitamin D Receptor
Thin bony cortex, Generalized bone demineralization, Rickets, Delayed epiphyseal ossification, Sp... OMIM:600785
Dysosteosclerosis
Recurrent fractures, Craniofacial hyperostosis, Increased bone mineral density, Coarse metaphysea... ORPHA:1782
Pseudopseudohypoparathyroidism
Obesity, Ectopic ossification ORPHA:79445
Obesity
Obesity, Increased waist to hip ratio OMIM:601665
Beemer-Ertbruggen Syndrome
Thrombocytopenia, Increased bone mineral density ORPHA:1237
Albers-Schönberg Osteopetrosis
Generalized osteosclerosis, Anemia, Arthritis, Osteomyelitis, Mandibular osteomyelitis, Recurrent... ORPHA:53
Macrosomia Adiposa Congenita
Obesity, Eosinophilia, Large for gestational age OMIM:248100
Hypogonadotropic Hypogonadism 4 With Or Without Anosmia
Obesity, Osteoporosis OMIM:610628
Leukocyte Adhesion Deficiency, Type Iii
Leukocytosis, Osteopetrosis, Anemia, Splenomegaly, Hepatosplenomegaly, Extramedullary hematopoiesis OMIM:612840
Bardet-Biedl Syndrome 14
Obesity OMIM:615991
Angioosteohypotrophic Syndrome
Abnormal trabecular bone morphology, Thin bony cortex ORPHA:75508
Spermatogenic Failure, X-Linked, 1
Obesity OMIM:305700
Florid Cemento-Osseous Dysplasia
Abnormal trabecular bone morphology, Mandibular osteomyelitis, Multiple bony cystic lesions, Abno... ORPHA:83451
Triglyceride Storage Disease, Type Ii
Obesity OMIM:190430
Tricho-Dento-Osseous Syndrome
Periapical tooth abscess, Increased bone mineral density ORPHA:3352
Metaphyseal Dysplasia, Braun-Tinschert Type
Thin bony cortex, Sclerosis of middle finger phalanx, Osteopenia, Coarse metaphyseal trabeculariz... ORPHA:85188
Coloboma, Osteopetrosis, Microphthalmia, Macrocephaly, Albinism, And Deafness
Osteopetrosis OMIM:617306
Spondyloepiphyseal Dysplasia Tarda
Hip osteoarthritis, Failure to thrive, Abnormal epiphyseal ossification, Knee osteoarthritis, Pre... ORPHA:93284
Craniometadiaphyseal Dysplasia, Wormian Bone Type
Wide anterior fontanel, Thin bony cortex, Increased bone mineral density, Osteopenia ORPHA:85184
Intellectual Developmental Disorder, Autosomal Dominant 39
Obesity OMIM:616521
Gaucher Disease Type 1
Leukopenia, Anemia, Pathologic fracture, Osteopenia, Splenomegaly, Hypersplenism, Increased bone ... ORPHA:77259
Osteosclerosis With Ichthyosis And Premature Ovarian Failure
Osteosclerosis of the base of the skull, Subperiosteal bone formation OMIM:609993
Acth-Independent Macronodular Adrenal Hyperplasia 2
Osteoporosis, Abdominal obesity, Increased body weight OMIM:615954
Camurati-Engelmann Disease
Cortical thickening of long bone diaphyses, Slender build, Anemia, Diaphyseal sclerosis, Increase... OMIM:131300
Diastrophic Dysplasia
Joint stiffness, Joint hyperflexibility, Increased bone mineral density, Camptodactyly of finger ORPHA:628
Paget Disease Of Bone 5, Juvenile-Onset
Ankylosis, Recurrent fractures, Osteoporosis, Increased bone mineral density OMIM:239000
Spondyloepiphyseal Dysplasia, Nishimura Type
Abnormal bone ossification, Wide anterior fontanel, Increased bone mineral density, Delayed patel... ORPHA:163649
Chondrodysplasia, Lethal, With Long Bone Angulation And Mixed Bone Density
Absent ossification of cervical vertebral bodies, Sclerotic scapulae, Absent ossification of thor... OMIM:601376
Autosomal Recessive Hypophosphatemic Rickets
Craniosynostosis, Pseudo-fractures, Abnormal trabecular bone morphology, Increased bone mineral d... ORPHA:289176
Vitamin D Hydroxylation-Deficient Rickets, Type 1B
Thin bony cortex, Rickets, Failure to thrive, Delayed epiphyseal ossification, Recurrent fracture... OMIM:600081
Osteopathia Striata-Cranial Sclerosis Syndrome
Osteopetrosis, Coarse metaphyseal trabecularization, Increased bone mineral density, Facial hyper... ORPHA:2780
Osteopetrosis, Autosomal Recessive 3
Osteopetrosis, Anemia, Diaphyseal sclerosis, Hepatosplenomegaly, Extramedullary hematopoiesis, Cr... OMIM:259730
Pseudopseudohypoparathyroidism
Obesity, Osteoporosis OMIM:612463
Pseudohypoparathyroidism Type 1B
Increased bone density with cystic changes, Increased bone mineral density, Diaphyseal sclerosis ORPHA:94089
Diaphyseal Medullary Stenosis With Malignant Fibrous Histiocytoma
Diaphyseal cortical sclerosis, Patchy osteosclerosis, Fractures of the long bones, Pathologic fra... OMIM:112250
Pigmented Nodular Adrenocortical Disease, Primary, 4
Osteoporosis, Increased body weight, Osteopenia OMIM:615830
Summitt Syndrome
Obesity, Craniosynostosis, Camptodactyly of finger, Tall stature ORPHA:3210
Short Stature, Amelogenesis Imperfecta, And Skeletal Dysplasia With Scoliosis
Obesity, Hip contracture, Advanced ossification of carpal bones, Truncal obesity OMIM:618363
Osteopetrosis, Autosomal Recessive 5
Osteopetrosis, Anemia, Decreased osteoclast count, Splenomegaly, Extramedullary hematopoiesis, Pa... OMIM:259720
Autoimmune Hypoparathyroidism
Increased bone mineral density ORPHA:36913
Pycnodysostosis
Generalized osteosclerosis, Increased susceptibility to fractures, Osteolytic defects of the dist... ORPHA:763
Hypophosphatemic Rickets With Hypercalciuria, Hereditary
Thin bony cortex, Rickets, Failure to thrive, Delayed epiphyseal ossification, Recurrent fracture... OMIM:241530
Halothane Hepatitis
Obesity, Eosinophilia OMIM:234350
Hypophosphatemic Rickets, X-Linked Recessive
Thin bony cortex, Rickets, Delayed epiphyseal ossification, Recurrent fractures, Osteomalacia, Sp... OMIM:300554
Ankylosing Vertebral Hyperostosis With Tylosis
Obesity, Osteoarthritis ORPHA:2206
Kenny-Caffey Syndrome, Type 2
Thickened cortex of long bones, Anemia, Increased bone mineral density, Small for gestational age OMIM:127000
Dysosteosclerosis
Increased susceptibility to fractures, Sclerotic scapulae, Sclerosis of hand bone, Osteopenia, Cl... OMIM:224300
Morgagni-Stewart-Morel Syndrome
Hyperostosis frontalis interna, Osteoarthritis, Osteoporosis, Obesity ORPHA:77296
Urban-Rogers-Meyer Syndrome
Flexion contracture of toe, Osteoporosis, Camptodactyly of finger, Obesity, Recurrent fractures ORPHA:3409
Poems Syndrome
Thrombocytosis, Sclerosis of foot bone, Polycythemia, Weight loss, Sclerosis of hand bone, Sclero... ORPHA:2905
12Q14 Microdeletion Syndrome
Failure to thrive, Abnormality of the spleen, Osteopoikilosis ORPHA:94063
Desmosterolosis
Failure to thrive, Osteopetrosis, Increased bone mineral density, Splenomegaly ORPHA:35107
Vitamin D Hydroxylation-Deficient Rickets, Type 1A
Thin bony cortex, Rickets, Failure to thrive, Delayed epiphyseal ossification, Recurrent fracture... OMIM:264700
Brain Abnormalities, Neurodegeneration, And Dysosteosclerosis
Osteopetrosis OMIM:618476
Dysostosis, Stanescu Type
Massively thickened long bone cortices, Increased bone mineral density ORPHA:1798
Hypogonadotropic Hypogonadism-Retinitis Pigmentosa Syndrome
Obesity, Recurrent fractures, Osteoporosis, Reduced bone mineral density ORPHA:2235
Fanconi Renotubular Syndrome 4 With Maturity-Onset Diabetes Of The Young
Large for gestational age, Rickets OMIM:616026
Vitamin D-Dependent Rickets, Type 2A
Thin bony cortex, Rickets, Failure to thrive, Delayed epiphyseal ossification, Recurrent fracture... OMIM:277440
Gaucher Disease Type 3
Increased susceptibility to fractures, Anemia, Splenomegaly, Increased bone mineral density, Panc... ORPHA:77261
Osteopetrosis, Autosomal Recessive 7
Abnormal trabecular bone morphology, Osteopetrosis, Anemia, Splenomegaly OMIM:612301
Werner Syndrome
Slender build, Osteoporosis, Increased bone mineral density, Joint stiffness ORPHA:902
Perrault Syndrome 4
Disproportionate tall stature, Obesity, Osteoporosis OMIM:615300
Central Precocious Puberty
Obesity, Overgrowth, Increased body weight ORPHA:759
Pigmented Nodular Adrenocortical Disease, Primary, 2
Osteoporosis, Truncal obesity, Osteopenia OMIM:610475
Pigmented Nodular Adrenocortical Disease, Primary, 1
Osteoporosis, Truncal obesity, Osteopenia OMIM:610489
Hypocalcemic Vitamin D-Dependent Rickets
Thin bony cortex, Rickets, Failure to thrive, Increased susceptibility to fractures, Delayed epip... ORPHA:289157
Otopalatodigital Syndrome Type 2
Tarsal synostosis, Failure to thrive, Abnormal vertebral segmentation and fusion, Synostosis of c... ORPHA:90652
X-Linked Hypophosphatemia
Rickets, Vertebral hyperostosis, Generalized osteosclerosis, Craniosynostosis, Arthritis, Reduced... ORPHA:89936
Hypothyroidism, Congenital, Nongoitrous, 6
Increased body mass index, Anemia, Increased body weight OMIM:614450
Erdheim-Chester Disease
Weight loss, Anemia, Osteomyelitis, Increased bone mineral density, Osteolysis ORPHA:35687
Dent Disease 1
Thin bony cortex, Rickets, Delayed epiphyseal ossification, Recurrent fractures, Osteomalacia, Sp... OMIM:300009
Congenital Hypothyroidism Due To Maternal Intake Of Antithyroid Drugs
Absent ossification of capital femoral epiphysis, Delayed epiphyseal ossification, Large for gest... ORPHA:226313
Desmosterolosis
Failure to thrive, Generalized osteosclerosis, Arthrogryposis multiplex congenita, Joint contract... OMIM:602398
Gaucher Disease
Pancytopenia, Anemia, Abnormal bone structure, Arthrogryposis multiplex congenita, Osteopenia, Os... ORPHA:355
Lenz-Majewski Hyperostotic Dwarfism
Elbow ankylosis, Osteopetrosis, Abnormal cortical bone morphology, Increased bone mineral density... ORPHA:2658
Hyperoxaluria, Primary, Type I
Increased bone mineral density, Pathologic fracture OMIM:259900
Pseudohypoparathyroidism Type 1C
Obesity, Increased bone mineral density, Ectopic ossification ORPHA:79444
Sclerosteosis 1
Facial palsy secondary to cranial hyperostosis, Overgrowth, Sclerotic scapulae, Cortically dense ... OMIM:269500
Hypoparathyroidism-Retardation-Dysmorphism Syndrome
Patchy osteosclerosis OMIM:241410
Trichothiodystrophy
Neutropenia, Craniosynostosis, Anemia, Osteopenia, Increased bone mineral density, Increased mean... ORPHA:33364
X-Linked Intellectual Disability-Short Stature-Overweight Syndrome
Cranial hyperostosis, Overweight ORPHA:457240
Pseudohypoparathyroidism Type 1A
Ectopic ossification, Reduced bone mineral density, Hyperostosis frontalis interna, Increased bon... ORPHA:79443
Obesity Due To Melanocortin 4 Receptor Deficiency
Obesity, Childhood-onset truncal obesity ORPHA:71529
Pseudohypoparathyroidism, Type Ic
Obesity, Osteoporosis OMIM:612462
Raine Syndrome
Arthrogryposis multiplex congenita, Increased bone mineral density OMIM:259775
Schwartz-Jampel Syndrome
Cachexia, Shoulder flexion contracture, Flexion contracture of toe, Hip contracture, Osteoporosis... ORPHA:800
Momo Syndrome
Overgrowth, Tall stature, Large for gestational age, Abnormal bone ossification, Obesity ORPHA:2563
Hyperinsulinism Due To Hnf4A Deficiency
Increased body weight, Hypophosphatemic rickets, Large for gestational age ORPHA:263455
Rothmund-Thomson Syndrome
Neutropenia, Small for gestational age, Leukemia, Increased susceptibility to fractures, Anemia, ... ORPHA:2909
Hepatic Veno-Occlusive Disease
Increased body weight ORPHA:890
Wilson Disease
Failure to thrive, Weight loss, Anemia, Arthritis, Pathologic fracture, Splenomegaly, Thrombocyto... ORPHA:905
Carpenter Syndrome
Obesity, Craniosynostosis, Polysplenia ORPHA:65759
Aromatase Deficiency
Tall stature, Osteoporosis, Delayed epiphyseal ossification, Eunuchoid habitus, Osteopenia, Obesity ORPHA:91
Neurodevelopmental Disorder With Speech Impairment And Dysmorphic Facies
Joint hypermobility, Obesity, Craniosynostosis OMIM:619056
Pseudohypoparathyroidism, Type Ia
Obesity, Osteoporosis OMIM:103580
Macrocephaly/Autism Syndrome
Obesity, Lymphopenia, Splenomegaly OMIM:605309
Blomstrand Lethal Chondrodysplasia
Synostosis of joints, Increased bone mineral density ORPHA:50945
Sanjad-Sakati Syndrome
Patchy osteosclerosis ORPHA:2323
Luscan-Lumish Syndrome
Obesity, Overgrowth, Advanced ossification of carpal bones OMIM:616831
Primary Hyperoxaluria
Failure to thrive, Generalized osteosclerosis, Recurrent fractures ORPHA:416
Rothmund-Thomson Syndrome Type 2
Neutropenia, Small for gestational age, Leukemia, Anemia, Pathologic fracture, Abnormal trabecula... ORPHA:221016
Pituitary Adenoma 4, Acth-Secreting
Obesity, Osteoporosis, Abdominal obesity OMIM:219090
Rothmund-Thomson Syndrome Type 1
Neutropenia, Small for gestational age, Leukemia, Anemia, Finger symphalangism, Abnormal trabecul... ORPHA:221008
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome
Increased body weight ORPHA:276608
Cushing Syndrome Due To Macronodular Adrenal Hyperplasia
Increased susceptibility to fractures, Osteoporosis, Abdominal obesity, Increased body weight ORPHA:189427
Cleidocranial Dysplasia
Increased susceptibility to fractures, Delayed pubic bone ossification, Increased bone mineral de... OMIM:119600
Glycogen Storage Disease Due To Liver Phosphorylase Kinase Deficiency
Failure to thrive, Osteoporosis, Increased body weight, Anemia, Splenomegaly, Abnormal erythrocyt... ORPHA:264580
Osteopetrosis With Renal Tubular Acidosis
Leukopenia, Failure to thrive, Osteopetrosis, Anemia, Pancytopenia, Thrombocytopenia, Recurrent f... ORPHA:2785
Dent Disease
Thin bony cortex, Rickets, Delayed epiphyseal ossification, Recurrent fractures, Osteomalacia, Sp... ORPHA:1652
Glycogen Storage Disease Due To Liver And Muscle Phosphorylase Kinase Deficiency
Osteoporosis, Anemia, Increased body weight, Splenomegaly ORPHA:79240
Primary Pigmented Nodular Adrenocortical Disease
Increased susceptibility to fractures, Osteoporosis, Abdominal obesity, Increased body weight ORPHA:189439
Encephalomyopathy, Mitochondrial, Due To Voltage-Dependent Anion Channel Deficiency
Neutropenia, Failure to thrive, Anemia, Large for gestational age, Thrombocytopenia OMIM:614520
Atypical Werner Syndrome
Failure to thrive, Osteoporosis, Sclerosis of hand bone, Reduced bone mineral density, Decreased ... ORPHA:79474
Faciocardiomelic Syndrome
Thin bony cortex, Large for gestational age, Osteopenia OMIM:612731
Prolactin Deficiency With Obesity And Enlarged Testes
Obesity OMIM:264120
Autosomal Recessive Malignant Osteopetrosis
Osteopetrosis, Craniosynostosis, Anemia, Splenomegaly, Reduced bone mineral density, Recurrent fr... ORPHA:667
Paternal Uniparental Disomy Of Chromosome 1
Obesity, Recurrent fractures, Craniosynostosis, Episodic hemolytic anemia ORPHA:251004
Magel2-Related Prader-Willi-Like Syndrome
Failure to thrive, Osteoporosis, Osteopenia, Abdominal obesity, Flexion contracture, Increased bo... ORPHA:398069
Kallmann Syndrome
Obesity, Recurrent fractures, Reduced bone mineral density ORPHA:478
Odontochondrodysplasia 2 With Hearing Loss And Diabetes
Obesity, Osteopenia OMIM:619269
3Q29 Microduplication Syndrome
Obesity, Craniosynostosis, Camptodactyly of toe ORPHA:251038
Smith-Magenis Syndrome
Increased body weight OMIM:182290
Intellectual Developmental Disorder, X-Linked, Syndromic, Nascimento Type
Increased body weight OMIM:300860
Schinzel-Giedion Midface Retraction Syndrome
Splenopancreatic fusion, Failure to thrive, Thickened cortex of long bones, Sclerosis of skull ba... OMIM:269150
Williams Syndrome
Failure to thrive in infancy, Joint laxity, Osteoporosis, Osteopenia, Synostosis of joints, Incre... ORPHA:904
Blue Diaper Syndrome
Increased body weight ORPHA:94086
Cushing Disease
Leukocytosis, Osteoporosis, Truncal obesity, Abdominal obesity, Lymphopenia, Decreased eosinophil... ORPHA:96253
Insulinoma
Increased body weight ORPHA:97279
Pruritic Urticarial Papules And Plaques Of Pregnancy
Increased body weight ORPHA:64745
Insulin-Resistance Syndrome Type B
Abnormality of body weight, Leukopenia, Weight loss, Thrombocytopenia, Decreased body weight, Ost... ORPHA:2298
Abdominal Obesity-Metabolic Syndrome 4
Obesity, Elevated hemoglobin A1c OMIM:618620
Hellp Syndrome
Microangiopathic hemolytic anemia, Increased body weight, Thrombocytopenia, Hemolytic anemia, Dec... ORPHA:244242
Adrenocortical Carcinoma
Weight loss, Increased body weight ORPHA:1501
Cushing Syndrome Due To Ectopic Acth Secretion
Leukocytosis, Weight loss, Osteoporosis, Truncal obesity, Abdominal obesity, Lymphopenia, Decreas... ORPHA:99889
Carney Complex
Abdominal obesity, Increased body weight, Tall stature ORPHA:1359

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Selenow

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Selenow.

There are 2 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Selenowtm1b(EUCOMM)Wtsi PMC7263671
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation. Nature immunology (December 2019) Selenowtm1b(EUCOMM)Wtsi PMC7338221

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MGI Allele Allele Type Produced
Selenowtm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Selenowtm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (with selection cassette) Mice
Selenowtm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Selenowtm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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