Genes Phenotypes

Gene: Frs2

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Name
fibroblast growth factor receptor substrate 2
MGI ID
MGI:1100860
Synonyms
SNT1 Frs2alpha C330018A15Rik
Viability
Homozygous - Lethal
View
N/A
Other links
MGI   Ensembl  
Significant phenotypes (3) Measurements chart (244) All data table (249)
Expression & images (67) Disease models (0) Order (2)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
decreased threshold for auditory brainstem response Frs2tm1b(EUCOMM)Wtsi HET postnatal 6.00×10-06
preweaning lethality, complete penetrance Frs2tm1b(EUCOMM)Wtsi HOM n/a 0.00
decreased bone mineral content Frs2tm1b(EUCOMM)Wtsi HET postnatal 5.42×10-05

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Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  Wholemount images
Aorta 2 No  (2/2)  Wholemount images
Bone 2 No N/A
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No  (2/2)  Wholemount images
Gall bladder 2 No N/A
Heart 2 No  (2/2)  Wholemount images
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (2/2)  Wholemount images
Large intestine 2 No  (10/584)  (2/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No  (2/2)  Wholemount images
Lung 2 No  (2/2)  Wholemount images
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No N/A
Oral epithelium 2 No N/A
Ovary 2 No  (1/584)  (1/2)  Wholemount images
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/584)  (2/2)  Wholemount images
Parathyroid gland 2 No  (2/2)  Wholemount images
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (2/2)  Wholemount images
Small intestine 2 No  (9/584)  (2/2)  Wholemount images
Spinal cord 2 No  (2/2)  Wholemount images
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584)  (2/2)  Wholemount images
Striatum 2 No N/A
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No  (2/2)  Wholemount images
Thyroid gland 2 No  (15/584)  Wholemount images
Trachea 2 No N/A
Uterus 2 No  (1/2)  Wholemount images
Vascular system 2 No  (1/2)  Wholemount images
White adipose tissue 2 No N/A
LacZ Wholemount Images
cardiovascular system (2)
Heart expression
Aorta expression
MA:0000072
MA:0000062
digestive system (3)
Large Intestine expression
MA:0000333
endocrine system (2)
Adrenal gland ambiguous
MA:0000116
immune system (1)
Thymus expression
MA:0000142
integumental system (1)
Skin expression
MA:0000151
nervous system (3)
Brain expression
MA:0000168
postnatal mouse (19)
Adrenal gland ambiguous
MA:0000116
reproductive system (2)
Testis expression
MA:0000411
respiratory system (1)
Lung expression
MA:0000415
sensory organ (1)
Eye expression
MA:0000261
trunk (12)
Adrenal gland ambiguous
MA:0000116
urinary system (2)
Kidney expression
MA:0000368
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 3  (6/485) N/A
Ear 3  (1/485) N/A
Embryo 3  (1/485)  (3/3) N/A
Eye 3  (1/485)  (1/3) N/A
Foot 3  (1/485) N/A
Forebrain 3  (1/485) N/A
Forelimb 3  (1/485)  (1/3) N/A
Hand 3  (1/485) N/A
Head 3  (5/485)  (1/3) N/A
Heart 3  (1/485)  (1/3) N/A
Hindbrain 3  (6/485) N/A
Hindlimb 3  (1/485)  (1/3) N/A
Liver 3  (1/485)  (1/3) N/A
Lung 3  (1/485)  (1/3) N/A
Mandibular process 3  (1/485)  (1/3) N/A
Maxillary process 3  (1/485)  (1/3) N/A
Midbrain 3  (1/485) N/A
Oral cavity 3  (1/485)  (1/3) N/A
Skin 3  (1/485) N/A
Tail 3  (1/485) N/A
Tail somite 3  (1/485) N/A

 Associated Images

Echo: M-Mode Images
28 Images
Embryo LacZ: LacZ images wholemount
4 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images
X-ray: XRay Images Dorso Ventral
10 Images
X-ray: XRay Images Lateral Orientation
10 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
Adult LacZ: LacZ Images Wholemount
19 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Frs2tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Frs2tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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