Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
myelin transcription factor 1
Synonyms:
NZF-2b,  Nztf2,  Nzf2,  NZF-2a

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Myt1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Myt1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Epidermolysis Bullosa With Diaphragmatic Hernia
Neonatal death, Congenital diaphragmatic hernia OMIM:226735
Hernia, Anterior Diaphragmatic
Neonatal death, Congenital diaphragmatic hernia OMIM:306950
Lethal Congenital Contracture Syndrome 3
Neonatal death, Multiple joint contractures, Arthrogryposis multiplex congenita, Skeletal muscle ... OMIM:611369
Granulomas, Congenital Cerebral
Neonatal death OMIM:306300
Genitourinary Tract Anomalies
Neonatal death OMIM:305690
Hyperinsulinemic Hypoglycemia, Familial, 2
Pancreatic islet-cell hyperplasia, Hyperinsulinemic hypoglycemia OMIM:601820
Hyperinsulinemic Hypoglycemia, Familial, 1
Pancreatic islet-cell hyperplasia, Hyperinsulinemic hypoglycemia OMIM:256450
Hyperinsulinemic Hypoglycemia, Familial, 7
Pancreatic islet-cell hyperplasia, Hyperinsulinemic hypoglycemia, Hyperinsulinemia OMIM:610021
Diaphragmatic Hernia, Congenital
Congenital diaphragmatic hernia OMIM:142340
Diaphragmatic Hernia 3
Congenital diaphragmatic hernia OMIM:610187
Diabetes Mellitus, Ketosis-Prone
Beta-cell dysfunction, Diabetes mellitus OMIM:612227
Pulmonary Hypoplasia, Primary
Neonatal death OMIM:265430
Mahvash Disease
Pancreatic alpha-cell hyperplasia, Type II diabetes mellitus, Recurrent pancreatitis, Increased g... OMIM:619290
Hereditary Continuous Muscle Fiber Activity
Congenital diaphragmatic hernia, Type 1 muscle fiber predominance ORPHA:972
Diaphragmatic Hernia 2
Agenesis of the diaphragm, Congenital diaphragmatic hernia OMIM:222400
Hemochromatosis Type 2
Congenital hepatic fibrosis, Diabetes mellitus, Hypogonadism, Abnormality of endocrine pancreas p... ORPHA:79230
Thanatophoric Dysplasia, Glasgow Variant
Neonatal death, Hepatosplenomegaly OMIM:273680
Arthrogryposis Multiplex Congenita 6
Nemaline bodies, Increased variability in muscle fiber diameter, Death in childhood, Arthrogrypos... OMIM:619334
Neutropenia, Lethal Congenital, With Eosinophilia
Neonatal death OMIM:257100
8p23.1 deletion syndrome
Congenital diaphragmatic hernia DECIPHER:39
Autosomal Recessive Hyperinsulinism Due To Kir6.2 Deficiency
Multiple pancreatic beta-cell adenomas, Abnormal response to glucagon stimulation test, Elevated ... ORPHA:79644
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome
Pancreatic islet-cell hyperplasia, Hyperinsulinemic hypoglycemia, Hyperinsulinemia, Hyperhidrosis ORPHA:276608
Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency
Excessive insulin response to glucagon test, Type I diabetes mellitus, Hyperinsulinemia, Hepatome... ORPHA:276575
Isolated Anencephaly
Thymus hyperplasia, Adrenal hypoplasia, Maternal diabetes, Congenital diaphragmatic hernia ORPHA:563609
Cutis Laxa-Marfanoid Syndrome
Flexion contracture, Congenital diaphragmatic hernia ORPHA:171719
Cleft Lip/Palate With Characteristic Facies, Intestinal Malrotation, And Lethal Congenital Heart Disease
Pancreatic islet-cell hyperplasia OMIM:601165
Insulinoma
Hyperinsulinemia, Pituitary prolactin cell adenoma, Primary hyperparathyroidism, Neoplasm of the ... ORPHA:97279
Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency
Excessive insulin response to glucagon test, Hyperinsulinemia, Hepatomegaly, Episodic hyperhidros... ORPHA:276580
Cutis Laxa, Neonatal, With Marfanoid Phenotype
Congenital diaphragmatic hernia OMIM:614100
Lethal Congenital Contracture Syndrome 1
Neonatal death, Hypoplasia of the musculature, Arthrogryposis multiplex congenita, Skeletal muscl... OMIM:253310
Congenital Diaphragmatic Hernia
Aplasia/Hypoplasia of the diaphragm, Congenital diaphragmatic hernia ORPHA:2140
Neuronal Intestinal Pseudoobstruction
Congenital diaphragmatic hernia ORPHA:99811
Medium Chain 3-Ketoacyl-Coa Thiolase Deficiency
Neonatal death, Rhabdomyolysis OMIM:602199
Hyperinsulinism Due To Ucp2 Deficiency
Excessive insulin response to glucagon test, Hepatomegaly, Episodic hyperhidrosis, Hyperinsulinem... ORPHA:276556
Diaphragmatic Defects, Limb Deficiencies, And Ossification Defects Of Skull
Abnormality of the diaphragm, Congenital diaphragmatic hernia, Testicular atrophy OMIM:601163
Pcna-Related Progressive Neurodegenerative Photosensitivity Syndrome
Congenital diaphragmatic hernia ORPHA:438134
Distal 7Q11.23 Microduplication Syndrome
Congenital diaphragmatic hernia ORPHA:261102
Fetal Encasement Syndrome
Congenital diaphragmatic hernia OMIM:613630
Microphthalmia, Syndromic 12
Congenital diaphragmatic hernia OMIM:615524
Diaphragmatic Defect-Limb Deficiency-Skull Defect Syndrome
Congenital diaphragmatic hernia ORPHA:2141
Donohue Syndrome
Hyperinsulinemia, Cholestasis, Skeletal muscle atrophy, Pancreatic islet-cell hyperplasia, Precoc... OMIM:246200
Hyperinsulinism Due To Hnf4A Deficiency
Hyperinsulinemia, Increased hepatic glycogen content, Pancreatic islet-cell hyperplasia, Hepatome... ORPHA:263455
Greig Cephalopolysyndactyly Syndrome
Congenital diaphragmatic hernia ORPHA:380
Hnf1B-Related Autosomal Dominant Tubulointerstitial Kidney Disease
Abnormality of exocrine pancreas physiology, Hypothyroidism, Hepatic steatosis, Jaundice, Diabete... ORPHA:93111
Congenital Unilateral Hypoplasia Of Depressor Anguli Oris
Congenital diaphragmatic hernia ORPHA:1166
Matthew-Wood Syndrome
Annular pancreas, Abnormal spleen morphology, Aplasia/Hypoplasia of the pancreas, Congenital diap... ORPHA:2470
Chromosome 1Q41-Q42 Deletion Syndrome
Congenital diaphragmatic hernia OMIM:612530
Acrocallosal Syndrome
Congenital diaphragmatic hernia ORPHA:36
Multicentric Carpotarsal Osteolysis Syndrome
Congenital diaphragmatic hernia OMIM:166300
Serkal Syndrome
Abnormality of the adrenal glands, Congenital diaphragmatic hernia ORPHA:139466
Non-Syndromic Posterior Hypospadias
Androgen insufficiency, Abnormality of the endocrine system, Congenital diaphragmatic hernia ORPHA:95706
Cebalid Syndrome
Congenital diaphragmatic hernia OMIM:618774
Gillessen-Kaesbach-Nishimura Syndrome
Periportal fibrosis, Flexion contracture, Congenital diaphragmatic hernia OMIM:263210
Tonne-Kalscheuer Syndrome
Congenital diaphragmatic hernia OMIM:300978
Chromosome 15Q25 Deletion Syndrome
Congenital diaphragmatic hernia OMIM:614294
Craniofrontonasal Dysplasia
Camptodactyly of finger, Congenital diaphragmatic hernia ORPHA:1520
Schisis Association
Congenital diaphragmatic hernia ORPHA:63862
Mullegama-Klein-Martinez Syndrome
Congenital diaphragmatic hernia OMIM:301022
Perlman Syndrome
Pancreatic islet-cell hyperplasia, Hypoplasia of the abdominal wall musculature, Congenital diaph... OMIM:267000
Intellectual Disability-Strabismus Syndrome
Achilles tendon contracture, Hypothyroidism, Hypohidrosis, Congenital diaphragmatic hernia, Decre... ORPHA:363528
Donnai-Barrow Syndrome
Congenital diaphragmatic hernia ORPHA:2143
Xp22.13P22.2 Duplication Syndrome
Congenital diaphragmatic hernia ORPHA:284180
Lung Agenesis-Heart Defect-Thumb Anomalies Syndrome
Death in infancy, Congenital diaphragmatic hernia ORPHA:1120
Proximal 16P11.2 Microduplication Syndrome
Congenital diaphragmatic hernia ORPHA:370079
Epiphyseal Dysplasia, Multiple, With Early-Onset Diabetes Mellitus
Reduced pancreatic beta cells, Type I diabetes mellitus, Hepatomegaly, Insulin-resistant diabetes... OMIM:226980
1Q41Q42 Microdeletion Syndrome
Hypergonadotropic hypogonadism, Congenital diaphragmatic hernia ORPHA:250999
Genitopalatocardiac Syndrome
Abnormality of the gallbladder, Congenital diaphragmatic hernia, Abnormality of mesentery morphology ORPHA:2075
13Q12.3 Microdeletion Syndrome
Camptodactyly, Congenital diaphragmatic hernia ORPHA:412035
Cooper-Jabs Syndrome
Camptodactyly of finger, Congenital diaphragmatic hernia ORPHA:1488
15Q24 Microdeletion Syndrome
Decreased response to growth hormone stimulation test, Congenital diaphragmatic hernia ORPHA:94065
Axial Mesodermal Dysplasia Spectrum
Abnormality of the liver, Abnormality of the spleen, Congenital diaphragmatic hernia ORPHA:1834
Diamond-Blackfan Anemia 15 With Mandibulofacial Dysostosis
Congenital diaphragmatic hernia OMIM:606164
Isolated Permanent Neonatal Diabetes Mellitus
Pancreatic hypoplasia, Neonatal insulin-dependent diabetes mellitus, Arthrogryposis multiplex con... ORPHA:99885
Ferguson-Bonni Neurodevelopmental Syndrome
Congenital diaphragmatic hernia OMIM:619699
Pericardial And Diaphragmatic Defect
Aplasia of the left hemidiaphragm, Congenital diaphragmatic hernia ORPHA:2847
Emanuel Syndrome
Hypogonadism, Multiple joint contractures, Congenital diaphragmatic hernia ORPHA:96170
Emanuel Syndrome
Congenital diaphragmatic hernia OMIM:609029
Simpson-Golabi-Behmel Syndrome
Hepatoblastoma, Camptodactyly of finger, Pancreatic islet-cell hyperplasia, Splenomegaly, Hepatom... ORPHA:373
Lowry-Maclean Syndrome
Abnormality of the abdominal organs, Congenital diaphragmatic hernia ORPHA:2409
Greenberg Dysplasia
Hepatosplenomegaly, Pancreatic islet-cell hyperplasia, Hepatomegaly, Neonatal death, Hepatic calc... OMIM:215140
Splenogonadal Fusion-Limb Defects-Micrognathia Syndrome
Congenital diaphragmatic hernia ORPHA:2063
Humerofemoral Hypoplasia With Radiotibial Ray Deficiency
Congenital diaphragmatic hernia OMIM:618022
Vacterl/Vater Association
Abnormality of the pancreas, Congenital diaphragmatic hernia, Abnormality of the gallbladder ORPHA:887
Trisomy 1Q
Camptodactyly of finger, Congenital diaphragmatic hernia ORPHA:261344
Halperin-Birk Syndrome
Flexion contracture, Congenital diaphragmatic hernia, Death in childhood OMIM:618651
Zaki Syndrome
Congenital diaphragmatic hernia OMIM:619648
Fetal Alcohol Syndrome
Congenital diaphragmatic hernia ORPHA:1915
Oculocerebrocutaneous Syndrome
Congenital diaphragmatic hernia ORPHA:1647
Donnai-Barrow Syndrome
Diaphragmatic eventration, Congenital diaphragmatic hernia OMIM:222448
Tyrosinemia, Type I
Pancreatic islet-cell hyperplasia, Splenomegaly, Hepatomegaly, Cirrhosis, Hepatocellular carcinoma OMIM:276700
Autosomal Recessive Spondylocostal Dysostosis
Camptodactyly of finger, Congenital diaphragmatic hernia ORPHA:2311
Congenital Heart Defects And Skeletal Malformations Syndrome
Camptodactyly, Congenital diaphragmatic hernia OMIM:617602
Tibia, Absence Or Hypoplasia Of, With Polydactyly, Retrocerebellar Arachnoid Cyst, And Other Anomalies
Agenesis of the diaphragm OMIM:601027
Mosaic Trisomy 1
Hepatic agenesis, Camptodactyly of finger, Elbow flexion contracture, Congenital diaphragmatic he... ORPHA:1692
46,Xx Sex Reversal With Dysgenesis Of Kidneys, Adrenals, And Lungs
Adrenal gland agenesis, Congenital diaphragmatic hernia OMIM:611812
Diamond-Blackfan Anemia 10
Congenital diaphragmatic hernia, Morgagni diaphragmatic hernia OMIM:613309
Pentalogy Of Cantrell
Polysplenia, Absent gallbladder, Congenital diaphragmatic hernia ORPHA:1335
White-Sutton Syndrome
Facial hypotonia, Congenital diaphragmatic hernia OMIM:616364
2Q37 Microdeletion Syndrome
Congenital diaphragmatic hernia ORPHA:1001
Craniorachischisis
Congenital diaphragmatic hernia ORPHA:63260
Microphthalmia, Syndromic 9
Hypoplastic spleen, Diaphragmatic eventration, Multilobulated spleen, Congenital diaphragmatic he... OMIM:601186
Arterial Tortuosity Syndrome
Flexion contracture, Congenital diaphragmatic hernia OMIM:208050
Cutis Laxa, Autosomal Recessive, Type Ia
Congenital diaphragmatic hernia OMIM:219100
Developmental Delay With Or Without Dysmorphic Facies And Autism
Congenital diaphragmatic hernia OMIM:618454
Proximal 16P11.2 Microdeletion Syndrome
Congenital diaphragmatic hernia ORPHA:261197
Multiple Pterygium Syndrome, Escobar Variant
Bilateral camptodactyly, Congenital diaphragmatic hernia, Diaphragmatic eventration, Camptodactyl... OMIM:265000
8P23.1 Microdeletion Syndrome
Congenital diaphragmatic hernia ORPHA:251071
Pancreatic Hypoplasia-Diabetes-Congenital Heart Disease Syndrome
Exocrine pancreatic insufficiency, Pancreatic hypoplasia, Congenital diaphragmatic hernia, Aplasi... ORPHA:2255
Seckel Syndrome 9
Congenital diaphragmatic hernia OMIM:616777
Acro-Renal-Mandibular Syndrome
Congenital diaphragmatic hernia ORPHA:958
White-Sutton Syndrome
Facial hypotonia, Congenital diaphragmatic hernia ORPHA:468678
Thakker-Donnai Syndrome
Congenital diaphragmatic hernia ORPHA:1780
Beckwith-Wiedemann Syndrome
Exocrine pancreatic insufficiency, Hypothyroidism, Hepatoblastoma, Pseudohypoparathyroidism, Rhab... ORPHA:116
Multiple Joint Dislocations, Short Stature, And Craniofacial Dysmorphism With Or Without Congenital Heart Defects
Elbow flexion contracture, Left ventricular hypertrophy, Congenital diaphragmatic hernia OMIM:245600
Holoprosencephaly
Diabetes insipidus, Panhypopituitarism, Anterior hypopituitarism, Congenital diaphragmatic hernia... ORPHA:2162
Pagod Syndrome
Death in infancy, Abnormality of the spleen, Congenital diaphragmatic hernia ORPHA:991
Focal Dermal Hypoplasia
Camptodactyly of finger, Congenital diaphragmatic hernia, Diastasis recti ORPHA:2092
Denys-Drash Syndrome
Congenital diaphragmatic hernia OMIM:194080
Hydrolethalus Syndrome 1
Agenesis of the diaphragm, Stillbirth, Accessory spleen, Adrenal gland dysgenesis OMIM:236680
Fryns Syndrome
Congenital diaphragmatic hernia ORPHA:2059
Oligomeganephronia
Congenital diaphragmatic hernia ORPHA:2260
7Q11.23 Microduplication Syndrome
Congenital diaphragmatic hernia ORPHA:96121
Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome 1
Congenital diaphragmatic hernia OMIM:614080
Trisomy 18
Camptodactyly of finger, Congenital diaphragmatic hernia ORPHA:3380
Heart Defects, Congenital, And Other Congenital Anomalies
Absent gallbladder, Pancreatic hypoplasia, Congenital diaphragmatic hernia, Aplasia of the left h... OMIM:600001
Simpson-Golabi-Behmel Syndrome, Type 1
Hepatoblastoma, Facial hypotonia, Diastasis recti, Pancreatic islet-cell hyperplasia, Splenomegal... OMIM:312870
Craniofrontonasal Syndrome
Congenital diaphragmatic hernia OMIM:304110
Short-Rib Thoracic Dysplasia 14 With Polydactyly
Congenital diaphragmatic hernia OMIM:616546
Cornelia De Lange Syndrome 1
Elbow flexion contracture, Congenital diaphragmatic hernia OMIM:122470
Aymé-Gripp Syndrome
Camptodactyly, Congenital diaphragmatic hernia ORPHA:1272
Thoracoabdominal Syndrome
Congenital diaphragmatic hernia OMIM:313850
Meacham Syndrome
Abnormality of the spleen, Congenital diaphragmatic hernia ORPHA:3097
Opitz Gbbb Syndrome
Thyroglossal cyst, Congenital diaphragmatic hernia ORPHA:2745
Mycophenolate Mofetil Embryopathy
Congenital diaphragmatic hernia ORPHA:268249
Wolf-Hirschhorn Syndrome
Abdominal situs inversus, Congenital diaphragmatic hernia, Abnormality of the gallbladder ORPHA:280
Tetraamelia Syndrome 1
Adrenal gland agenesis, Asplenia, Congenital diaphragmatic hernia OMIM:273395
Acrorenal-Mandibular Syndrome
Elbow flexion contracture, Congenital diaphragmatic hernia OMIM:200980
Kabuki Syndrome
Precocious puberty, Congenital diaphragmatic hernia ORPHA:2322
Smith-Lemli-Opitz Syndrome
Congenital diaphragmatic hernia, Abnormality of the gallbladder ORPHA:818
Poland Syndrome
Abnormality of the liver, Aplasia of the pectoralis major muscle, Diabetes mellitus, Congenital d... ORPHA:2911
Linear Skin Defects With Multiple Congenital Anomalies 1
Congenital diaphragmatic hernia OMIM:309801
C Syndrome
Death in infancy, Aplasia/Hypoplasia of the abdominal wall musculature, Congenital diaphragmatic ... ORPHA:1308
Witteveen-Kolk Syndrome
Decreased response to growth hormone stimulation test, Congenital diaphragmatic hernia OMIM:613406
Iniencephaly
Congenital diaphragmatic hernia, Arthrogryposis multiplex congenita ORPHA:63259
Congenital Anomalies Of Kidney And Urinary Tract Syndrome With Or Without Hearing Loss, Abnormal Ears, Or Developmental Delay
Congenital diaphragmatic hernia OMIM:617641
Developmental And Epileptic Encephalopathy 85 With Or Without Midline Brain Defects
Camptodactyly, Contracture of the proximal interphalangeal joint of the 3rd finger, Congenital di... OMIM:301044
Monosomy 9P
Congenital diaphragmatic hernia ORPHA:261112
Diets-Jongmans Syndrome
Congenital diaphragmatic hernia OMIM:618846
Limb Body Wall Complex
Congenital diaphragmatic hernia, Abnormality of the liver, Diastasis recti ORPHA:2369
Distal Monosomy 15Q
Decreased serum insulin-like growth factor 1, Congenital diaphragmatic hernia ORPHA:1596
Microphthalmia With Linear Skin Defects Syndrome
Congenital diaphragmatic hernia ORPHA:2556
Cutis Laxa, Autosomal Recessive, Type Ib
Congenital diaphragmatic hernia OMIM:614437
Focal Dermal Hypoplasia
Congenital diaphragmatic hernia, Diastasis recti OMIM:305600
Cornelia De Lange Syndrome
Delayed puberty, Congenital diaphragmatic hernia ORPHA:199
Coffin-Siris Syndrome 1
Congenital diaphragmatic hernia OMIM:135900
Pallister-Killian Syndrome
Flexion contracture, Hypohidrosis, Congenital diaphragmatic hernia, Macroglossia, Camptodactyly o... OMIM:601803

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Myt1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Myt1.

There are 4 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Myt1ltm1a(EUCOMM)Wtsi PMC7263671
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Myt1ltm1a(EUCOMM)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Myt1ltm1a(EUCOMM)Wtsi PMC6459510
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Myt1ltm1a(EUCOMM)Wtsi PMC5827107

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MGI Allele Allele Type Produced
Myt1tm299770(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Myt1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Myt1tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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