Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
potassium channel, subfamily K, member 3
Synonyms:
Task-1,  cTBAK-1

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Kcnk3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Kcnk3 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Pulmonary Hypertension, Primary, 4
OMIM:615344

The table below shows human diseases predicted to be associated to Kcnk3 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Photoparoxysmal Response 1
EEG with photoparoxysmal response OMIM:132100
Electroencephalographic Peculiarity: 14 And 6 Per Sec. Positive Spike Phenomenon
EEG abnormality OMIM:130200
Electroencephalographic Peculiarity: Fronto-Precentral Beta Wave Groups
EEG abnormality OMIM:130300
Hyperaldosteronism, Familial, Type I
Adrenal hyperplasia, Adrenogenital syndrome, Hyperaldosteronism, Decreased circulating renin level OMIM:103900
Adrenal Insufficiency, Congenital, With 46,Xy Sex Reversal, Partial Or Complete
Adrenal insufficiency, Adrenocorticotropic hormone excess, Hyperaldosteronism OMIM:613743
Hypokalemic Tubulopathy And Deafness
Increased circulating renin level, Hyperaldosteronism OMIM:619406
Pigmented Nodular Adrenocortical Disease, Primary, 3
Adrenal hyperplasia, Increased circulating cortisol level OMIM:614190
Adrenocortical Carcinoma
Adrenocortical carcinoma, Increased urinary cortisol level, Increased circulating androstenedione... ORPHA:1501
Pseudohypoaldosteronism, Type I, Autosomal Dominant
Increased circulating renin level, Pseudohypoaldosteronism, Hyperactive renin-angiotensin system,... OMIM:177735
Pseudohypoaldosteronism, Type I, Autosomal Recessive
Pseudohypoaldosteronism, Hyperactive renin-angiotensin system, Hyperaldosteronism OMIM:264350
Hyperaldosteronism, Familial, Type Iii
Adrenal hyperplasia, Hyperaldosteronism, Decreased circulating renin level OMIM:613677
Familial Hyperaldosteronism Type Ii
Adrenal hyperplasia, Abnormal circulating renin, Secretory adrenocortical adenoma, Glucocortocoid... ORPHA:404
Adrenocortical Carcinoma With Pure Aldosterone Hypersecretion
Neoplasm of the adrenal gland, Paresthesia, Decreased circulating renin level, Increased circulat... ORPHA:231625
Familial Hyperaldosteronism Type I
Adrenal hyperplasia, Abnormal circulating renin, Secretory adrenocortical adenoma, Dexamethasone-... ORPHA:403
Cushing Syndrome Due To Macronodular Adrenal Hyperplasia
Macronodular adrenal hyperplasia, Abnormal response to corticotropin releasing hormone stimulatio... ORPHA:189427
Primary Hyperaldosteronism-Seizures-Neurological Abnormalities Syndrome
Athetosis, Abnormal circulating renin, Adrenal hyperplasia, Hyperaldosteronism ORPHA:369929
East Syndrome
Ataxia, Increased circulating renin level, Hyperaldosteronism ORPHA:199343
Periodic Fever, Menstrual Cycle-Dependent
Increased circulating cortisol level OMIM:614674
Glucocorticoid Deficiency 5
Abnormal response to ACTH stimulation test, Decreased circulating cortisol level OMIM:617825
Familial Hyperaldosteronism Type Iii
Adrenal hyperplasia, Abnormal circulating renin, Glucocortocoid-insensitive primary hyperaldoster... ORPHA:251274
Seizures, Sensorineural Deafness, Ataxia, Mental Retardation, And Electrolyte Imbalance
Ataxia, Increased circulating renin level, Dysdiadochokinesis, Hyperaldosteronism OMIM:612780
Diarrhea 1, Secretory Chloride, Congenital
Hyperactive renin-angiotensin system, Hyperaldosteronism OMIM:214700
Primary Unilateral Adrenal Hyperplasia
Adrenal hyperplasia, Decreased circulating renin level, Glucocortocoid-insensitive primary hypera... ORPHA:231580
Ectopic Aldosterone-Producing Tumor
Decreased circulating renin level, Glucocortocoid-insensitive primary hyperaldosteronism ORPHA:231632
Bangstad Syndrome
Increased circulating cortisol level, Ataxia, Abnormality of the parathyroid gland, Type I diabet... ORPHA:1227
Generalized Pseudohypoaldosteronism Type 1
Increased circulating renin level, Abnormal circulating aldosterone, Glucocortocoid-insensitive p... ORPHA:171876
Bartter Syndrome, Type 3
Increased circulating renin level, Hyperactive renin-angiotensin system, Hyperaldosteronism OMIM:607364
Autoimmune Polyendocrinopathy Type 1
Adrenal hyperplasia, Decreased circulating aldosterone level, Hypoparathyroidism, Increased circu... ORPHA:3453
Autosomal Recessive Hyperinsulinism Due To Kir6.2 Deficiency
Multiple pancreatic beta-cell adenomas, Focal pancreatic islet hyperplasia, Hyperinsulinemic hypo... ORPHA:79644
Adrenocortical Hypofunction, Chronic Primary Congenital
Adrenal insufficiency, Decreased circulating cortisol level OMIM:103230
Glucocorticoid Deficiency 2
Increased circulating ACTH level, Decreased circulating cortisol level OMIM:607398
Andersen-Tawil Syndrome
Hyperaldosteronism ORPHA:37553
Pigmented Nodular Adrenocortical Disease, Primary, 2
Primary hypercortisolism, Increased circulating cortisol level, Decreased circulating ACTH level,... OMIM:610475
Pigmented Nodular Adrenocortical Disease, Primary, 1
Primary hypercortisolism, Increased circulating cortisol level, Decreased circulating ACTH level,... OMIM:610489
Mccune-Albright Syndrome
Increased circulating cortisol level, Pituitary adenoma, Hyperthyroidism, Hyperparathyroidism, El... OMIM:174800
Thymic Neuroendocrine Tumor
Neuroendocrine neoplasm, Neoplasm of the thymus, Increased circulating cortisol level, Pituitary ... ORPHA:97289
Bartter Syndrome, Type 4B, Neonatal, With Sensorineural Deafness
Hyperaldosteronism OMIM:613090
Acth-Independent Macronodular Adrenal Hyperplasia 2
Macronodular adrenal hyperplasia, Increased urinary cortisol level, Increased circulating cortiso... OMIM:615954
Late-Onset Familial Hypoaldosteronism
Elevated serum 11-deoxycortisol, Decreased circulating aldosterone level, Increased circulating r... ORPHA:556037
Bartter Syndrome, Type 4A, Neonatal, With Sensorineural Deafness
Hyperaldosteronism OMIM:602522
Gitelman Syndrome
Maternal diabetes, Type II diabetes mellitus, Paresthesia, Primary hyperaldosteronism, Diabetic k... ORPHA:358
Pigmented Nodular Adrenocortical Disease, Primary, 4
Adrenal hyperplasia, Primary hypercortisolism, Increased circulating cortisol level, Diabetes mel... OMIM:615830
Acth-Independent Macronodular Adrenal Hyperplasia
Adrenal hyperplasia, Macronodular adrenal hyperplasia, Primary hypercortisolism, Increased circul... OMIM:219080
Bartter Syndrome, Type 1, Antenatal
Hyperactive renin-angiotensin system, Paresthesia, Hyperparathyroidism, Hyperaldosteronism, Incre... OMIM:601678
Early-Onset Familial Hypoaldosteronism
Elevated serum 11-deoxycortisol, Decreased circulating aldosterone level, Increased circulating r... ORPHA:556030
Oculocerebrorenal Syndrome Of Lowe
Diabetes insipidus, Hypercholesterolemia, Hyperparathyroidism, Abnormal calcium-phosphate regulat... ORPHA:534
Multiple Endocrine Neoplasia Type 4
Increased circulating cortisol level, Insulinoma, Fasting hyperinsulinemia, Pituitary corticotrop... ORPHA:276152
Tubular Renal Disease-Cardiomyopathy Syndrome
Hyperaldosteronism ORPHA:73224
Multiple Endocrine Neoplasia, Type Iia
Pheochromocytoma, Increased circulating cortisol level, Medullary thyroid carcinoma, Hyperparathy... OMIM:171400
Bartter Syndrome, Type 2, Antenatal
Increased circulating renin level, Hyperactive renin-angiotensin system, Paresthesia, Hyperaldost... OMIM:241200
Multiple Endocrine Neoplasia, Type I
Adrenocortical adenoma, Increased circulating cortisol level, Insulinoma, Thyroid adenoma, Pituit... OMIM:131100
Leprechaunism
Central hypothyroidism, Increased circulating renin level, Hyperinsulinemia, Hyperaldosteronism ORPHA:508
Secondary Intestinal Lymphangiectasia
Hypocholesterolemia, Secondary hyperaldosteronism ORPHA:90363
Infantile Bartter Syndrome With Sensorineural Deafness
Increased circulating renin level, Hyperactive renin-angiotensin system, Hyperaldosteronism ORPHA:89938
Zollinger-Ellison Syndrome
Elevated circulating parathyroid hormone level, Neuroendocrine neoplasm, Increased urinary cortis... ORPHA:913
Mccune-Albright Syndrome
Increased serum testosterone level, Paresthesia, Goiter, Primary hypercortisolism, Increased circ... ORPHA:562
Pituitary Apoplexy
Increased circulating prolactin concentration, Hypergonadotropic hypogonadism, Increased circulat... ORPHA:95613
Nelson Syndrome
Increased urinary cortisol level, Type II diabetes mellitus, Diabetes insipidus, Increased circul... ORPHA:199244
Primary Pigmented Nodular Adrenocortical Disease
Adrenal hyperplasia, Increased urinary cortisol level, Type II diabetes mellitus, Hyperlipidemia,... ORPHA:189439
Adrenal Hyperplasia, Congenital, Due To Steroid 11-Beta-Hydroxylase Deficiency
Decreased circulating aldosterone level, Increased serum testosterone level, Increased circulatin... OMIM:202010
Bronchial Neuroendocrine Tumor
Increased serum serotonin, Increased circulating cortisol level, Pulmonary carcinoid tumor, Eleva... ORPHA:97287
Generalized Glucocorticoid Resistance Syndrome
Adrenal hyperplasia, Decreased circulating aldosterone level, Increased urinary cortisol level, I... ORPHA:786
Patterson Pseudoleprechaunism Syndrome
Premature adrenarche, Increased circulating cortisol level, Diabetes mellitus OMIM:169170
African Iron Overload
Increased circulating cortisol level, Diabetes mellitus, Abnormal thyroid morphology, Abnormality... ORPHA:139507
Somatostatinoma
Adrenocortical adenoma, Increased circulating cortisol level, Medullary thyroid carcinoma, Pituit... ORPHA:97283
Vipoma
Adrenocortical adenoma, Increased circulating cortisol level, Increased circulating gonadotropin ... ORPHA:97282
Ppoma
Adrenocortical adenoma, Increased circulating cortisol level, Increased circulating gonadotropin ... ORPHA:97278
Grfoma
Adrenocortical adenoma, Pheochromocytoma, Neoplasm of the thymus, Increased circulating cortisol ... ORPHA:97261
Multiple Endocrine Neoplasia Type 1
Thyroid carcinoma, Goiter, Increased circulating cortisol level, Insulinoma, Intestinal carcinoid... ORPHA:652
Fibrous Dysplasia Of Bone
Precocious puberty in females, Thyroid carcinoma, Paresthesia, Increased circulating cortisol lev... ORPHA:249
Glucagonoma
Adrenocortical adenoma, Increased circulating cortisol level, Increased circulating gonadotropin ... ORPHA:97280
Neuroendocrine Neoplasm Of Appendix
Increased serum serotonin, Intestinal carcinoid, Primary hypercortisolism, Adrenocorticotropic ho... ORPHA:100079
Cushing Disease
Adrenal hyperplasia, Increased urinary cortisol level, Increased circulating cortisol level, Para... ORPHA:96253
Cushing Syndrome Due To Ectopic Acth Secretion
Adrenal hyperplasia, Neuroendocrine neoplasm, Pancreatic endocrine tumor, Increased urinary corti... ORPHA:99889
Carney Complex
Thyroid carcinoma, Euthyroid multinodular goiter, Increased serum insulin-like growth factor 1, P... ORPHA:1359
Pulmonary Hypertension, Primary, 4
OMIM:615344

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Kcnk3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Kcnk3.

No publications found that use IMPC mice or data for Kcnk3.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

This service may be affected by the Covid-19 pandemic. See how

MGI Allele Allele Type Produced
Kcnk3tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter