Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
vacuolar protein sorting 4B
Synonyms:
Skd1,  8030489C12Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Vps4b mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Vps4b by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Placental Insufficiency
Eclampsia, Preeclampsia, Intrauterine growth retardation, Maternal hypertension, Proportionate sh... ORPHA:439167
Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency
Severe intrauterine growth retardation, Intrauterine growth retardation, Severe postnatal growth ... ORPHA:73272
Silver-Russell Syndrome Due To A Point Mutation
Oligohydramnios, Postnatal growth retardation, Intrauterine growth retardation, Small placenta ORPHA:397590
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Hypermethylation
Postnatal growth retardation, Large placenta, Umbilical hernia, Polyhydramnios ORPHA:254534
Fetal Akinesia Deformation Sequence 1
Short umbilical cord, Intrauterine growth retardation, Fetal akinesia sequence, Premature birth, ... OMIM:208150
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Microdeletion
Intrauterine growth retardation, Polyhydramnios, Postnatal growth retardation, Large placenta, Um... ORPHA:254528
Neu-Laxova Syndrome 1
Short umbilical cord, Intrauterine growth retardation, Decreased fetal movement, Stillbirth, Smal... OMIM:256520
Restrictive Dermopathy
Short umbilical cord, Intrauterine growth retardation, Premature delivery because of cervical ins... ORPHA:1662
Trichohepatoenteric Syndrome 1
Intrauterine growth retardation, Short stature, Aortic regurgitation, Polyhydramnios, Pulmonic st... OMIM:222470
Mosaic Trisomy 16
Maternal diabetes, Preeclampsia, Intrauterine growth retardation, Premature birth, Single umbilic... ORPHA:1708
Kagami-Ogata Syndrome
Premature birth, Postnatal growth retardation, Large placenta, Polyhydramnios ORPHA:254519
Restrictive Dermopathy 1
Short umbilical cord, Intrauterine growth retardation, Premature rupture of membranes, Premature ... OMIM:275210
Meckel Syndrome, Type 1
Intrauterine growth retardation, Breech presentation, Single umbilical artery, Oligohydramnios, L... OMIM:249000
Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14
Hypertrophic cardiomyopathy, Intrauterine growth retardation, Growth delay, Short stature, Premat... ORPHA:96334
Beckwith-Wiedemann Syndrome
Hypertrophic cardiomyopathy, Subchorionic septal cyst, Premature birth, Polyhydramnios, Large pla... ORPHA:116

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Vps4b

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Vps4b.

No publications found that use IMPC mice or data for Vps4b.

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MGI Allele Allele Type Produced
Vps4btm48834(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Vps4bem1(IMPC)Marc Deletion Mice

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