Gene: Pitx3

Name
paired-like homeodomain transcription factor 3
MGI ID
MGI:1100498
Synonyms
Ptx3
View
N/A
Other links
View data by physiological system
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
increased coping response Pitx3tm1.1(KOMP)Vlcg HOM postnatal 1.41×10-10
increased heart rate Pitx3tm1.1(KOMP)Vlcg HOM postnatal 5.14×10-05
decreased vertical activity Pitx3eyl HOM postnatal 3.37×10-09
decreased bone mineral content Pitx3tm1.1(KOMP)Vlcg HOM postnatal 3.39×10-05
abnormal behavioral response to light Pitx3tm1.1(KOMP)Vlcg HOM postnatal 5.35×10-12
anophthalmia Pitx3tm1.1(KOMP)Vlcg HOM postnatal 1.54×10-19
decreased body weight Pitx3eyl HOM postnatal 4.23×10-07
abnormal bone structure Pitx3tm1.1(KOMP)Vlcg HOM postnatal 1.80×10-06
increased circulating alkaline phosphatase level Pitx3eyl HOM postnatal 5.92×10-06
decreased exploration in new environment Pitx3eyl HOM postnatal 4.18×10-06
decreased total body fat amount Pitx3tm1.1(KOMP)Vlcg HOM postnatal 1.90×10-08
abnormal sleep behavior Pitx3tm1.1(KOMP)Vlcg HOM postnatal 2.27×10-17
decreased circulating triglyceride level Pitx3eyl HOM postnatal 4.71×10-06
decreased circulating amylase level Pitx3eyl HOM postnatal 1.90×10-05
increased fasted circulating glucose level Pitx3tm1.1(KOMP)Vlcg HOM postnatal 2.02×10-07
hypoactivity Pitx3eyl HOM postnatal 1.16×10-06
increased grip strength Pitx3tm1.1(KOMP)Vlcg HOM postnatal 8.04×10-09
shortened ST segment Pitx3tm1.1(KOMP)Vlcg HOM postnatal 8.62×10-08
increased exploration in new environment Pitx3eyl HOM postnatal 8.78×10-08
decreased lean body mass Pitx3tm1.1(KOMP)Vlcg HOM postnatal 7.98×10-08
decreased exploration in new environment Pitx3tm1.1(KOMP)Vlcg HOM postnatal 5.70×10-06
abnormal social/conspecific interaction Pitx3eyl HOM postnatal 4.45×10-05

Download data as:  TSV  XLS

Filtered by: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No N/A
Brain 2 No  (2/2) N/A
Brainstem 2 No  (2/2) N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No  (2/2) N/A
Cerebral cortex 2 No N/A
Epididymis 2 No  (18/134) N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No  (2/2) N/A
Heart 2 No  (2/2) N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (2/2) N/A
Large intestine 2 No  (10/584) N/A
Liver 2 No  (1/2) N/A
Lower urinary tract 2 No N/A
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Midbrain 2 No  (2/2) N/A
Olfactory lobe 2 No N/A
Ovary 2 No  (1/584)  (1/2) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584) N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No  (2/2) N/A
Skin 2 No N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No  (2/2) N/A
Spleen 2 No  (2/584)  (1/2) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No  (2/2) N/A
Submandibular gland 2 No  (2/132)  (1/2) N/A
Testis 2 No  (2/584)  (1/2) N/A
Thalamus 2 No  (2/2) N/A
Thymus 2 No  (1/2) N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No  (1/2) N/A
Urinary bladder 2 No N/A
Uterus 2 No  (1/2) N/A
Vascular system 2 No N/A
Vesicular gland 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 2  (1/51)  (1/2) N/A
Brain 2  (6/485)  (2/3) N/A
Dorsal root ganglion 2  (1/47) N/A
Ear 2  (1/485) N/A
Embryo 2  (1/485)  (2/3)  Wholemount images
Eye 2  (1/485)  (2/3) N/A
Foot 2  (1/485) N/A
Forebrain 2  (1/485) N/A
Forelimb 2  (1/485)  (2/3) N/A
Fronto-nasal process 2  (1/48) N/A
Hand 2  (1/485) N/A
Head 2  (5/485)  (2/3) N/A
Heart 2  (1/485) N/A
Hindbrain 2  (6/485) N/A
Hindlimb 2  (1/485)  (2/3) N/A
Liver 2  (1/485) N/A
Lung 2  (1/485) Image Only N/A
Mandibular process 2  (1/485)  (2/3) N/A
Maxillary process 2  (1/485) N/A
Midbrain 2  (1/485)  (2/3) N/A
Nose 2  (1/51) N/A
Oral cavity 2  (1/485) Image Only N/A
Rib pre-cartilage condensation 1  (1/46)  (1/1) N/A
Skeleton 1  (1/51) Image Only N/A
Skin 2  (1/485) Image Only N/A
Spinal cord 2  (1/50) N/A
Tail 2  (1/485)  (2/3) N/A
Tail somite 2  (1/485) N/A

 Associated Images

X-ray: XRay Images Dorso Ventral
10 Images
Sleep Wake: Wake state (bmp file)
9 Images
Combined SHIRPA and Dysmorphology
28 Images
X-ray: XRay Images Lateral Orientation
10 Images
X-ray: XRay Images Forepaw
10 Images
X-ray: XRay Images Skull Lateral Orientation
10 Images
Embryo LacZ: LacZ images wholemount
12 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images

 Disease Models

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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Pitx3tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells
Pitx3tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice

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