Gene: Fgf10

Name
fibroblast growth factor 10
MGI ID
MGI:1099809
Synonyms
FGF-10 AEY17 Gsfaey17
Viability
Homozygous - Lethal
Other links
View data by physiological system
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
increased circulating cholesterol level Fgf10tm1b(EUCOMM)Wtsi HET postnatal 6.93×10-05
preweaning lethality, complete penetrance Fgf10tm1b(EUCOMM)Wtsi HOM n/a 0.00
decreased spleen weight Fgf10tm1b(EUCOMM)Wtsi HET postnatal 4.83×10-05
decreased lean body mass Fgf10tm1b(EUCOMM)Wtsi HET postnatal 8.09×10-05
decreased kidney weight Fgf10tm1b(EUCOMM)Wtsi HET postnatal 9.14×10-05
increased circulating HDL cholesterol level Fgf10tm1b(EUCOMM)Wtsi HET postnatal 6.29×10-09
decreased grip strength Fgf10tm1b(EUCOMM)Wtsi HET postnatal 4.67×10-08
increased total body fat amount Fgf10tm1b(EUCOMM)Wtsi HET postnatal 5.27×10-06

Download data as:  TSV  XLS

Filtered by: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No  (1/2)  Wholemount images
Bone 2 No N/A
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No  (2/2)  Wholemount images
Gall bladder 2 No N/A
Heart 2 No  (1/2)  Wholemount images
Hippocampus 2 No N/A
Hypothalamus 2 No  (2/2)  Wholemount images
Kidney 2 No  (18/584) N/A
Large intestine 2 No  (10/584)  (2/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No  (1/2) N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No N/A
Oral epithelium 2 No N/A
Ovary 2 No  (1/584) N/A
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (2/2)  Wholemount images
Prostate gland 2 No  (12/584)  (1/2)  Wholemount images
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584)  (2/2)  Wholemount images
Striatum 2 No N/A
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No N/A
Thyroid gland 2 No  (15/584)  (1/2)  Wholemount images
Trachea 2 No  (2/2)  Wholemount images
Uterus 2 No  (1/2)  Wholemount images
Vascular system 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/485)  (2/5) N/A
Ear 2  (1/485)  (1/5) N/A
Embryo 2  (1/485)  (5/5) N/A
Eye 2  (1/485) N/A
Foot 2  (1/485)  (1/5) N/A
Forebrain 2  (1/485)  (2/5) N/A
Forelimb 2  (1/485) N/A
Hand 2  (1/485)  (1/5) N/A
Head 2  (5/485)  (5/5) N/A
Heart 2  (1/485)  (1/5) N/A
Hindbrain 2  (6/485)  (1/5) N/A
Hindlimb 2  (1/485) N/A
Liver 2  (1/485)  (1/5) N/A
Lung 2  (1/485) N/A
Mandibular process 2  (1/485)  (1/5) N/A
Maxillary process 2  (1/485)  (1/5) N/A
Midbrain 2  (1/485) N/A
Oral cavity 2  (1/485) N/A
Skin 2  (1/485) N/A
Tail 2  (1/485) N/A
Tail somite 2  (1/485) N/A

 Associated Images

Embryo LacZ: LacZ images wholemount
8 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
12 Images
X-ray: XRay Images Dorso Ventral
12 Images
X-ray: XRay Images Lateral Orientation
12 Images
Echo: M-Mode Images
31 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images
Adult LacZ: LacZ Images Wholemount
12 Images

 Disease Models

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 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Eye with optic nerve - inflammation Fgf10tm1b(EUCOMM)Wtsi HET postnatal

 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Fgf10tm1c(EUCOMM)Wtsi Wild type floxed exon (post-Flp) Mice
Fgf10tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Fgf10tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Fgf10tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells