Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Ovary | Section images | heterozygote | 100% (1 of 1) |
Prostate gland | Section images | hemizygote | 100% (1 of 1) |
Testis | Section images | hemizygote | 100% (1 of 1) |
Vas deferens | Section images | hemizygote | 100% (1 of 1) |
Adrenal gland | N/A | hemizygote | 0.0% (0 of 1) |
Adrenal gland | N/A | heterozygote | 0.0% (0 of 1) |
Aorta | N/A | hemizygote | 0.0% (0 of 1) |
Aorta | N/A | heterozygote | 0.0% (0 of 1) |
Blood | N/A | hemizygote | 0.0% (0 of 1) |
Blood | N/A | heterozygote | 0.0% (0 of 1) |
Bone marrow | N/A | hemizygote | 0.0% (0 of 1) |
Bone marrow | N/A | heterozygote | 0.0% (0 of 1) |
Brain | N/A | hemizygote | 0.0% (0 of 1) |
Brain | N/A | heterozygote | 0.0% (0 of 1) |
Brainstem | N/A | hemizygote | Not available |
Brainstem | N/A | heterozygote | Not available |
Brown adipose tissue | N/A | hemizygote | 0.0% (0 of 1) |
Brown adipose tissue | N/A | heterozygote | 0.0% (0 of 1) |
Cartilage tissue | N/A | hemizygote | Not available |
Cartilage tissue | N/A | heterozygote | Not available |
Cecum | N/A | hemizygote | 0.0% (0 of 1) |
Cecum | N/A | heterozygote | Not available |
Cerebellum | N/A | hemizygote | 0.0% (0 of 1) |
Cerebellum | N/A | heterozygote | 0.0% (0 of 1) |
Cerebral cortex | N/A | hemizygote | Not available |
Cerebral cortex | N/A | heterozygote | Not available |
Chest bone | N/A | hemizygote | Not available |
Chest bone | N/A | heterozygote | Not available |
Colon | N/A | hemizygote | 0.0% (0 of 1) |
Colon | N/A | heterozygote | 0.0% (0 of 1) |
Diaphragm | N/A | hemizygote | 0.0% (0 of 1) |
Diaphragm | N/A | heterozygote | 0.0% (0 of 1) |
Duodenum | N/A | hemizygote | 0.0% (0 of 1) |
Duodenum | N/A | heterozygote | 0.0% (0 of 1) |
Epididymis | N/A | hemizygote | Not available |
Epididymis | N/A | heterozygote | Not available |
Esophagus | N/A | hemizygote | 0.0% (0 of 1) |
Esophagus | N/A | heterozygote | 0.0% (0 of 1) |
Eye | N/A | hemizygote | 0.0% (0 of 1) |
Eye | N/A | heterozygote | 0.0% (0 of 1) |
Gall bladder | N/A | hemizygote | Not available |
Gall bladder | N/A | heterozygote | Not available |
Gonadal fat pad | N/A | hemizygote | 0.0% (0 of 1) |
Gonadal fat pad | N/A | heterozygote | 0.0% (0 of 1) |
Harderian gland | N/A | hemizygote | 0.0% (0 of 1) |
Harderian gland | N/A | heterozygote | 0.0% (0 of 1) |
Heart | N/A | hemizygote | Not available |
Heart | N/A | heterozygote | Not available |
Hindlimb | N/A | hemizygote | Not available |
Hindlimb | N/A | heterozygote | Not available |
Hippocampus | N/A | hemizygote | Not available |
Hippocampus | N/A | heterozygote | Not available |
Hypothalamus | N/A | hemizygote | Not available |
Hypothalamus | N/A | heterozygote | Not available |
Ileum | N/A | hemizygote | 0.0% (0 of 1) |
Ileum | N/A | heterozygote | Not available |
Jejunum | N/A | hemizygote | 0.0% (0 of 1) |
Jejunum | N/A | heterozygote | Not available |
Kidney | N/A | hemizygote | 0.0% (0 of 1) |
Kidney | N/A | heterozygote | 0.0% (0 of 1) |
Large intestine | N/A | hemizygote | 0.0% (0 of 1) |
Large intestine | N/A | heterozygote | 0.0% (0 of 1) |
Liver | N/A | hemizygote | 0.0% (0 of 1) |
Liver | N/A | heterozygote | 0.0% (0 of 1) |
Lower urinary tract | N/A | hemizygote | Not available |
Lower urinary tract | N/A | heterozygote | Not available |
Lung | N/A | hemizygote | 0.0% (0 of 1) |
Lung | N/A | heterozygote | 0.0% (0 of 1) |
Lymph node | N/A | hemizygote | Not available |
Lymph node | N/A | heterozygote | Not available |
Mammary gland | N/A | hemizygote | Not available |
Mammary gland | N/A | heterozygote | 0.0% (0 of 1) |
Mesenteric adipose tissue | N/A | hemizygote | 0.0% (0 of 1) |
Mesenteric adipose tissue | N/A | heterozygote | 0.0% (0 of 1) |
Mesenteric lymph node | N/A | hemizygote | 0.0% (0 of 1) |
Mesenteric lymph node | N/A | heterozygote | 0.0% (0 of 1) |
Midbrain | N/A | hemizygote | 0.0% (0 of 1) |
Midbrain | N/A | heterozygote | 0.0% (0 of 1) |
Olfactory lobe | N/A | hemizygote | 0.0% (0 of 1) |
Olfactory lobe | N/A | heterozygote | 0.0% (0 of 1) |
Ovary | N/A | hemizygote | Not available |
Oviduct | N/A | hemizygote | Not available |
Oviduct | N/A | heterozygote | 0.0% (0 of 1) |
Pancreas | N/A | hemizygote | 0.0% (0 of 1) |
Pancreas | N/A | heterozygote | 0.0% (0 of 1) |
Parathyroid gland | N/A | hemizygote | 0.0% (0 of 1) |
Parathyroid gland | N/A | heterozygote | Not available |
Parotid gland | N/A | hemizygote | 0.0% (0 of 1) |
Parotid gland | N/A | heterozygote | Not available |
Penis | N/A | hemizygote | 0.0% (0 of 1) |
Penis | N/A | heterozygote | Not available |
Peripheral nervous system | N/A | hemizygote | Not available |
Peripheral nervous system | N/A | heterozygote | Not available |
Peyer's patch | N/A | hemizygote | Not available |
Peyer's patch | N/A | heterozygote | Not available |
Pituitary gland | N/A | hemizygote | 0.0% (0 of 1) |
Pituitary gland | N/A | heterozygote | 0.0% (0 of 1) |
Prostate gland | N/A | heterozygote | Not available |
Quadriceps | N/A | hemizygote | 0.0% (0 of 1) |
Quadriceps | N/A | heterozygote | 0.0% (0 of 1) |
Sciatic nerve | N/A | hemizygote | 0.0% (0 of 1) |
Sciatic nerve | N/A | heterozygote | 0.0% (0 of 1) |
Skeletal muscle | N/A | hemizygote | Not available |
Skeletal muscle | N/A | heterozygote | Not available |
Skin | N/A | hemizygote | 0.0% (0 of 1) |
Skin | N/A | heterozygote | 0.0% (0 of 1) |
Small intestine | N/A | hemizygote | 0.0% (0 of 1) |
Small intestine | N/A | heterozygote | 0.0% (0 of 1) |
Spinal cord | N/A | hemizygote | 0.0% (0 of 1) |
Spinal cord | N/A | heterozygote | 0.0% (0 of 1) |
Spleen | N/A | hemizygote | 0.0% (0 of 1) |
Spleen | N/A | heterozygote | 0.0% (0 of 1) |
Stomach pyloric region | N/A | hemizygote | Not available |
Stomach pyloric region | N/A | heterozygote | Not available |
Stomach | N/A | hemizygote | 0.0% (0 of 1) |
Stomach | N/A | heterozygote | 0.0% (0 of 1) |
Striatum | N/A | hemizygote | Not available |
Striatum | N/A | heterozygote | Not available |
Sublingual gland | N/A | hemizygote | 0.0% (0 of 1) |
Sublingual gland | N/A | heterozygote | 0.0% (0 of 1) |
Submandibular gland | N/A | hemizygote | 0.0% (0 of 1) |
Submandibular gland | N/A | heterozygote | 0.0% (0 of 1) |
Testis | N/A | heterozygote | Not available |
Thymus | N/A | hemizygote | 0.0% (0 of 1) |
Thymus | N/A | heterozygote | 0.0% (0 of 1) |
Thyroid gland | N/A | hemizygote | 0.0% (0 of 1) |
Thyroid gland | N/A | heterozygote | 0.0% (0 of 1) |
Tongue | N/A | hemizygote | 0.0% (0 of 1) |
Tongue | N/A | heterozygote | 0.0% (0 of 1) |
Trachea | N/A | hemizygote | 0.0% (0 of 1) |
Trachea | N/A | heterozygote | 0.0% (0 of 1) |
Trigeminal V nerve | N/A | hemizygote | 0.0% (0 of 1) |
Trigeminal V nerve | N/A | heterozygote | 0.0% (0 of 1) |
Urinary bladder | N/A | hemizygote | 0.0% (0 of 1) |
Urinary bladder | N/A | heterozygote | Not available |
Uterus | N/A | hemizygote | Not available |
Uterus | N/A | heterozygote | 0.0% (0 of 1) |
Vagina | N/A | hemizygote | Not available |
Vagina | N/A | heterozygote | 0.0% (0 of 1) |
Vas deferens | N/A | heterozygote | Not available |
Vascular system | N/A | hemizygote | Not available |
Vascular system | N/A | heterozygote | Not available |
Vesicular gland | N/A | hemizygote | 0.0% (0 of 1) |
Vesicular gland | N/A | heterozygote | Not available |
White adipose tissue | N/A | hemizygote | Not available |
White adipose tissue | N/A | heterozygote | Not available |
Background staining occurs in wild type mice and embryos at an incidental rate.
Anatomy | Background staining in controls (WT) |
---|---|
adrenal gland | 0.0% |
aorta | 0.0% |
blood | |
bone marrow | |
brain | 0.0% |
brainstem | 0.0% |
brown adipose tissue | 0.0% |
cartilage tissue | 0.0% |
cecum | 0.0% |
cerebellum | 0.0% |
cerebral cortex | 0.0% |
chest bone | |
colon | |
diaphragm | 0.0% |
duodenum | 0.0% |
epididymis | Unavailable |
esophagus | 0.0% |
eye | 0.0% |
gall bladder | 0.0% |
gonadal fat pad | 0.0% |
harderian gland | |
heart | 0.0% |
hindlimb | 0.0% |
hippocampus | 0.0% |
hypothalamus | 0.0% |
ileum | 0.0% |
jejunum | |
kidney | 0.0% |
large intestine | 0.0% |
liver | 0.0% |
lower urinary tract | 0.0% |
lung | 0.0% |
lymph node | 0.0% |
mammary gland | 0.0% |
mesenteric adipose tissue | 0.0% |
mesenteric lymph node | |
midbrain | 0.0% |
olfactory lobe | 0.0% |
ovary | 0.0% |
oviduct | 0.0% |
pancreas | 0.0% |
parathyroid gland | 0.0% |
parotid gland | 0.0% |
penis | 0.0% |
peripheral nervous system | 0.0% |
peyers patch | 0.0% |
pituitary gland | 0.0% |
prostate gland | 0.0% |
quadriceps | 0.0% |
sciatic nerve | 0.0% |
skeletal muscle | 0.0% |
skin | 0.0% |
small intestine | 0.0% |
spinal cord | 0.0% |
spleen | 0.0% |
stomach | 0.0% |
stomach pyloric region | 0.0% |
striatum | 0.0% |
sublingual gland | 0.0% |
submandibular gland | 0.0% |
testis | 0.0% |
thymus | 0.0% |
thyroid gland | 0.0% |
tongue | 0.0% |
trachea | 0.0% |
trigeminal v nerve | 0.0% |
urinary bladder | |
uterus | 0.0% |
vagina | 0.0% |
vas deferens | Unavailable |
vascular system | 0.0% |
vesicular gland | Unavailable |
white adipose tissue | 0.0% |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Rbm3 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Fanconi Anemia, Complementation Group E | Prolonged G2 phase of cell cycle | OMIM:600901 | |
Fanconi Anemia, Complementation Group A | Prolonged G2 phase of cell cycle | OMIM:227650 | |
Fanconi Anemia, Complementation Group C | Prolonged G2 phase of cell cycle | OMIM:227645 | |
Fanconi Anemia, Complementation Group D2 | Prolonged G2 phase of cell cycle | OMIM:227646 |
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Rbm3.
There are 5 publications which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. | G3 (Bethesda, Md.) (June 2020) | Rbm33tm1b(EUCOMM)Wtsi | PMC7263671 |
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation. | Nature immunology (December 2019) | Rbm33tm1b(EUCOMM)Wtsi | PMC7338221 |
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. | Nature communications (August 2019) | Rbm33tm1b(EUCOMM)Wtsi | PMC6671969 |
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. | Scientific data (September 2017) | Rbm33tm1b(EUCOMM)Wtsi | PMC5827107 |
The RNA-binding protein Rbm38 is dispensable during pressure overload-induced cardiac remodeling in mice. | PloS one (August 2017) | Rbm38tm1a(KOMP)Mbp | PMC5574583 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Rbm3tm446569(L1L2_GT1_LF2A_LacZ_BetactP_neo) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
Rbm3tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | Mice, Tissue |
Rbm3tm1(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | Targeting vectors, ES Cells |
Rbm3tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | Mice, ES Cells |
Rbm3tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | ES Cells |
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