Gene: Cdk12

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Name
cyclin-dependent kinase 12
MGI ID
MGI:1098802
Synonyms
1810022J16Rik Crk7 D11Ertd752e Crkrs
Viability
Embryo viewer
N/A
Other links
Expression & images (0) Disease models (0) Order (3)
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased circulating HDL cholesterol level Cdk12em1(IMPC)Tcp HET Early adult 2.91×10-06
decreased erythrocyte cell number Cdk12em1(IMPC)Tcp HET Early adult 1.09×10-05
embryonic lethality prior to organogenesis Cdk12em1(IMPC)Tcp HOM   E9.5 0.00
abnormal neural tube closure Cdk12em1(IMPC)Tcp HET E9.5 0.00
abnormal hindbrain development Cdk12em1(IMPC)Tcp HET E9.5 0.00
long tibia Cdk12em1(IMPC)Tcp HET Early adult 4.55×10-05
abnormal embryo size Cdk12em1(IMPC)Tcp HET E9.5 0.00
abnormal midbrain development Cdk12em1(IMPC)Tcp HET E9.5 0.00
decreased circulating serum albumin level Cdk12em1(IMPC)Tcp HET Early adult 5.94×10-05
decreased circulating glucose level Cdk12em1(IMPC)Tcp HET Early adult 2.58×10-05
preweaning lethality, complete penetrance Cdk12em1(IMPC)Tcp HOM   Early adult 0.00
increased red blood cell distribution width Cdk12em1(IMPC)Tcp HET Early adult 2.05×10-06
decreased hemoglobin content Cdk12em1(IMPC)Tcp HET Early adult 1.39×10-05
increased heart weight Cdk12em1(IMPC)Tcp HET Early adult 4.61×10-05
decreased hematocrit Cdk12em1(IMPC)Tcp HET Early adult 4.86×10-08

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 Expression

Expression data not available

 Associated Images

Eye Morphology: Images Ophthalmoscopy
27 Images
Eye Morphology: Images Ophthalmoscopy
155 Images
Eye Morphology: Images Slit Lamp
51 Images
X-ray: XRay Images Skull Lateral Orientation
10 Images
Electrocardiogram (ECG): Waveform Image
2 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
X-ray: XRay Images Whole Body Lateral Orientation
10 Images
X-ray: XRay Images Whole Body Dorso Ventral
10 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
X-ray: XRay Images Skull Lateral Orientation
10 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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MGI Allele Allele Type Produced
Cdk12em1(IMPC)Tcp Exon Deletion Mice, Tissue
Cdk12tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Cdk12tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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