Gene: Cdk12

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Name
cyclin-dependent kinase 12
MGI ID
MGI:1098802
Synonyms
1810022J16Rik Crk7 D11Ertd752e Crkrs
Viability
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
embryonic lethality prior to organogenesis Cdk12em1(IMPC)Tcp HOM   E9.5 0.00
decreased circulating glucose level Cdk12em1(IMPC)Tcp HET Early adult 2.54×10-05
decreased exploration in new environment Cdk12em1(IMPC)Tcp HET Late adult 3.88×10-05
preweaning lethality, complete penetrance Cdk12em1(IMPC)Tcp HOM   Early adult 0.00
decreased erythrocyte cell number Cdk12em1(IMPC)Tcp HET Early adult 1.06×10-05
decreased circulating serum albumin level Cdk12em1(IMPC)Tcp HET Early adult 6.41×10-05
decreased circulating HDL cholesterol level Cdk12em1(IMPC)Tcp HET Early adult 3.56×10-06
long tibia Cdk12em1(IMPC)Tcp HET Early adult 2.39×10-05
increased heart weight Cdk12em1(IMPC)Tcp HET Early adult 2.34×10-05
increased red blood cell distribution width Cdk12em1(IMPC)Tcp HET Early adult 2.19×10-06
decreased hemoglobin content Cdk12em1(IMPC)Tcp HET Early adult 1.38×10-05
increased neutrophil cell number Cdk12em1(IMPC)Tcp HET Early adult 9.11×10-05
decreased hematocrit Cdk12em1(IMPC)Tcp HET Early adult 4.39×10-08

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Viewing: all phenotypes

 Expression

Expression data not available

 Associated Images

Eye Morphology: Images Ophthalmoscopy
155 Images
X-ray: XRay Images Whole Body Lateral Orientation
10 Images
Eye Morphology: Images Slit Lamp
51 Images
X-ray: XRay Images Whole Body Dorso Ventral
10 Images
X-ray: XRay Images Whole Body Dorso Ventral
10 Images
X-ray: XRay Images Skull Lateral Orientation
10 Images
Eye Morphology: Images Ophthalmoscopy
27 Images
X-ray: XRay Images Whole Body Lateral Orientation
10 Images
X-ray: XRay Images Skull Lateral Orientation
10 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Histopathology

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MGI Allele Allele Type Produced
Cdk12tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Cdk12em1(IMPC)Tcp Exon Deletion Mice, Tissue
Cdk12tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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