Aak1 | AP2 associated kinase 1
Physiological systems
19 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Homeostasis/metabolism Limbs/digits/tail Hearing/vestibular/ear Nervous system Vision/eye Behavior/neurological Skeleton Cardiovascular system Mortality/aging
10 No significant impact
5 Not tested
Data collections
Gene metrics:18Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
abnormal contextual conditioning behavior | 4 supporting datasets | Aak1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.39x10-5 | ||
short tibia | 2 supporting datasets | Aak1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 4.7x10-14 | ||
increased circulating alkaline phosphatase level | 1 supporting dataset | Aak1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.27x10-11 | ||
preweaning lethality, incomplete penetrance | 1 supporting dataset | Aak1tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
abnormal auditory brainstem response | 4 supporting datasets | Aak1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 4.27x10-16 | ||
decreased circulating total protein level | 1 supporting dataset | Aak1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 7.2x10-7 | ||
abnormal bone structure | 1 supporting dataset | Aak1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.8x10-10 | ||
decreased circulating cholesterol level | 1 supporting dataset | Aak1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 5.63x10-5 | ||
impaired glucose tolerance | 1 supporting dataset | Aak1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 8.41x10-5 | ||
hyperactivity | 2 supporting datasets | Aak1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.54x10-5 |
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External links
No external links available for Aak1.
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Aak1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
Aak1tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
Aak1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |