Aak1 | AP2 associated kinase 1

GeneMGI:1098687Synonyms: D6Ertd245e, 5530400K14Rik

Physiological systems

19 / 24 physiological systems tested

9 Significantly impacted by the knock-out

 Homeostasis/metabolism Limbs/digits/tail Hearing/vestibular/ear Nervous system Vision/eye Behavior/neurological Skeleton Cardiovascular system Mortality/aging

10 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:18Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal contextual conditioning behavior4 supporting datasetsAak1tm1b(EUCOMM)HmguhomozygoteEarly adult3.39x10-5 
short tibia2 supporting datasetsAak1tm1b(EUCOMM)HmguhomozygoteEarly adult4.7x10-14 
increased circulating alkaline phosphatase level1 supporting datasetAak1tm1b(EUCOMM)HmguhomozygoteEarly adult3.27x10-11 
preweaning lethality, incomplete penetrance1 supporting datasetAak1tm1b(EUCOMM)HmguhomozygoteEarly adultN/A * 
abnormal auditory brainstem response4 supporting datasetsAak1tm1b(EUCOMM)HmguhomozygoteEarly adult4.27x10-16 
decreased circulating total protein level1 supporting datasetAak1tm1b(EUCOMM)HmguhomozygoteEarly adult7.2x10-7 
abnormal bone structure1 supporting datasetAak1tm1b(EUCOMM)HmguhomozygoteEarly adult3.8x10-10 
decreased circulating cholesterol level1 supporting datasetAak1tm1b(EUCOMM)HmguhomozygoteEarly adult5.63x10-5 
impaired glucose tolerance1 supporting datasetAak1tm1b(EUCOMM)HmguhomozygoteEarly adult8.41x10-5 
hyperactivity2 supporting datasetsAak1tm1b(EUCOMM)HmguhomozygoteEarly adult3.54x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Aak1tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Aak1tm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Aak1tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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