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Gene: Per1 MGI:1098283

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
period circadian clock 1
Synonyms:
Hftm,  m-rigui,  mPer1

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Per1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Per1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Cystic Angiomatosis Of Bone, Diffuse
Cystic angiomatosis of bone OMIM:123880
Attention Deficit-Hyperactivity Disorder
Attention deficit hyperactivity disorder, Hyperactivity OMIM:143465
Potocki-Lupski syndrome (17p11.2 duplication syndrome)
Short attention span, Hyperactivity DECIPHER:19
Intellectual Developmental Disorder, Autosomal Recessive 3
Short attention span, Hyperactivity OMIM:608443
Oocyte/Zygote/Embryo Maturation Arrest 9
Abnormality of the menstrual cycle, Oocyte arrest at metaphase I, Female infertility OMIM:619011
Asherman Syndrome
Abnormality of the menstrual cycle, Metrorrhagia, Dysmenorrhea, Decreased fertility in females, O... ORPHA:137686
Schizophrenia 15
Hyperactivity OMIM:613950
Endometriosis, Susceptibility To, 1
Decreased fertility, Endometriosis, Dysmenorrhea OMIM:131200
Premature Ovarian Failure 19
Irregular menstruation, Premature ovarian insufficiency, Female infertility, Secondary amenorrhea OMIM:619245
Oocyte/Zygote/Embryo Maturation Arrest 8
Abnormality of the menstrual cycle, Female infertility OMIM:619009
Invasive Mole
Menometrorrhagia ORPHA:99925
Hyperprolactinemia
Oligomenorrhea, Female infertility, Menorrhagia OMIM:615555
Premature Ovarian Failure 2B
Premature ovarian insufficiency, Female infertility, Primary amenorrhea OMIM:300604
Gestational Choriocarcinoma
Metrorrhagia ORPHA:99926
Placental Site Trophoblastic Tumor
Amenorrhea, Metrorrhagia ORPHA:99928
Osteopetrosis, Autosomal Recessive 6
Osteopetrosis OMIM:611497
Familial Hyperprolactinemia
Female hypogonadism, Amenorrhea, Oligomenorrhea, Infertility, Menorrhagia ORPHA:397685
Leptin Deficiency Or Dysfunction
Hypogonadism, Polyphagia, Obesity, Primary amenorrhea OMIM:614962
Narcolepsy 3
Narcolepsy OMIM:609039
Oocyte/Zygote/Embryo Maturation Arrest 17
Amenorrhea, Female infertility OMIM:620319
Oocyte/Zygote/Embryo Maturation Arrest 20
Amenorrhea, Female infertility OMIM:620383
Premature Ovarian Failure 1
Irregular menstruation, Premature ovarian insufficiency OMIM:311360
Gordon Holmes Syndrome
Hypogonadotropic hypogonadism, Oligomenorrhea, Secondary amenorrhea, Primary amenorrhea OMIM:212840
Cortisone Reductase Deficiency 1
Infertility, Obesity, Oligomenorrhea OMIM:604931
Polycystic Ovary Syndrome 1
Amenorrhea, Obesity, Oligomenorrhea OMIM:184700
Pheochromocytoma/Paraganglioma Syndrome 6
Elevated circulating catecholamine level, Paraganglioma OMIM:618464
Premature Ovarian Failure 12
Primary amenorrhea OMIM:616947
Melorheostosis, Isolated
Increased bone mineral density, Hyperostosis OMIM:155950
46,Xy Gonadal Dysgenesis With Minifascicular Neuropathy
Hypergonadotropic hypogonadism, Primary amenorrhea OMIM:607080
Ovarian Dysgenesis 4
Decreased body weight, Primary amenorrhea OMIM:616185
Narcolepsy 1
Narcolepsy OMIM:161400
Premature Ovarian Failure 15
Irregular menstruation, Oligomenorrhea, Secondary amenorrhea OMIM:618096
Hypothyroidism, Congenital, Nongoitrous, 8
Attention deficit hyperactivity disorder, Secondary amenorrhea OMIM:301033
Peritoneal Cystic Mesothelioma
Weight loss, Dyspareunia, Metrorrhagia, Menorrhagia ORPHA:168816
Narcolepsy 7
Narcolepsy OMIM:614250
Premature Ovarian Failure 22
Premature ovarian insufficiency, Female infertility, Secondary amenorrhea OMIM:620548
Prolactin Deficiency, Isolated
Irregular menstruation, Infertility OMIM:264110
Perrault Syndrome 6
Irregular menstruation, Streak ovary, Primary amenorrhea, Premature ovarian insufficiency, Second... OMIM:617565
Premature Ovarian Failure 11
Oligomenorrhea, Secondary amenorrhea OMIM:616946
Premature Ovarian Failure 5
Reduced antral follicle count, Streak ovary, Hypoplasia of the ovary, Primary amenorrhea, Prematu... OMIM:611548
Mitochondrial Dna Depletion Syndrome 16B (Neuroophthalmic Type)
Amenorrhea, Premature ovarian insufficiency OMIM:619425
Gray Platelet Syndrome
Abnormality of the menstrual cycle ORPHA:721
Osteopetrosis, Autosomal Dominant 1
Thickened cortex of long bones, Generalized osteosclerosis, Osteopetrosis, Calvarial osteosclerosis OMIM:607634
Premature Ovarian Failure 3
Premature ovarian insufficiency, Secondary amenorrhea OMIM:608996
Premature Ovarian Failure 13
Amenorrhea, Oligomenorrhea, Female infertility OMIM:617442
Ovarian Dysgenesis 2
Streak ovary, Primary amenorrhea, Premature ovarian insufficiency, Secondary amenorrhea, Hypergon... OMIM:300510
Ovarian Dysgenesis 1
Primary amenorrhea OMIM:233300
Bardet-Biedl Syndrome 9
Irregular menstruation, Polydipsia, Obesity, Polyphagia, Truncal obesity OMIM:615986
Premature Ovarian Failure 2A
Premature ovarian insufficiency, Secondary amenorrhea OMIM:300511
Perrault Syndrome 2
Amenorrhea, Streak ovary OMIM:614926
Ovarian Dysgenesis 6
Hypergonadotropic hypogonadism, Primary amenorrhea OMIM:618078
Retinal Dystrophy With Or Without Extraocular Anomalies
Premature ovarian insufficiency, Secondary amenorrhea OMIM:617175
Premature Ovarian Failure 6
Female infertility, Streak ovary, Primary amenorrhea, Premature ovarian insufficiency, Secondary ... OMIM:612310
Premature Ovarian Failure 9
Amenorrhea, Hypoplasia of the ovary, Premature ovarian insufficiency OMIM:615724
Premature Ovarian Failure 18
Irregular menstruation, Premature ovarian insufficiency, Hypoplasia of the ovary, Secondary ameno... OMIM:619203
Premature Ovarian Failure 20
Female infertility, Secondary amenorrhea OMIM:619938
Hemochromatosis, Type 2A
Hypogonadotropic hypogonadism, Azoospermia, Infertility, Amenorrhea OMIM:602390
Hypogonadotropic Hypogonadism 14 With Or Without Anosmia
Hypogonadotropic hypogonadism, Primary amenorrhea OMIM:614858
Isolated Follicle Stimulating Hormone Deficiency
Male hypogonadism, Delayed menarche, Azoospermia, Decreased female libido, Hypogonadotropic hypog... ORPHA:52901
Perrault Syndrome 4
Obesity, Hypoplasia of the ovary, Oligomenorrhea, Primary amenorrhea, Premature ovarian insuffici... OMIM:615300
Wilson Disease
Failure to thrive, Abnormality of the menstrual cycle, Increased body weight, Aggressive behavior... ORPHA:905
Premature Ovarian Failure 7
Premature ovarian insufficiency, Secondary amenorrhea, Primary amenorrhea OMIM:612964
Double Uterus-Hemivagina-Renal Agenesis Syndrome
Dyspareunia, Metrorrhagia, Dysmenorrhea ORPHA:3411
Plin1-Related Familial Partial Lipodystrophy
Infertility, Oligomenorrhea ORPHA:280356
Luscan-Lumish Syndrome
Irregular menstruation, Polyphagia, Obesity, Aggressive behavior OMIM:616831
Hypogonadotropic Hypogonadism 24 With Or Without Anosmia
Hypogonadism, Infertility, Azoospermia, Primary amenorrhea OMIM:229070
Ovarian Dysgenesis 8
Eunuchoid habitus, Primary amenorrhea OMIM:618187
Craniometaphyseal Dysplasia
Craniofacial hyperostosis, Osteopetrosis ORPHA:1522
Familial Afibrinogenemia
Menometrorrhagia ORPHA:98880
Ovarian Dysgenesis 10
Primary amenorrhea, Premature ovarian insufficiency, Streak ovary, Hypoplasia of the ovary OMIM:619834
Osteopetrosis, Autosomal Recessive 9
Increased bone mineral density, Osteopetrosis, Cortical sclerosis OMIM:620366
Glanzmann Thrombasthenia
Menometrorrhagia, Menorrhagia ORPHA:849
Premature Ovarian Failure 21
Streak ovary, Secondary amenorrhea, Primary amenorrhea OMIM:620311
Osteopetrosis, Autosomal Dominant 2
Generalized osteosclerosis, Osteopetrosis OMIM:166600
Hemochromatosis, Type 3
Hypogonadotropic hypogonadism, Impotence, Amenorrhea OMIM:604250
Premature Ovarian Failure 10
Premature ovarian insufficiency, Azoospermia, Hypoplasia of the ovary, Primary amenorrhea OMIM:612885
Premature Ovarian Failure 14
Primary amenorrhea OMIM:618014
Premature Ovarian Failure 8
Premature ovarian insufficiency, Streak ovary, Primary amenorrhea OMIM:615723
Proprotein Convertase 1/3 Deficiency
Hypogonadotropic hypogonadism, Obesity, Primary amenorrhea OMIM:600955
Pituicytoma
Hypogonadotropic hypogonadism, Impotence, Decreased female libido, Amenorrhea ORPHA:251623
Lipodystrophy, Familial Partial, Type 4
Oligomenorrhea OMIM:613877
Lead Poisoning
Decreased male libido, Abnormality of the menstrual cycle, Anorexia, Decreased female libido, Att... ORPHA:330015
Pheochromocytoma/Paraganglioma Syndrome 1
Elevated circulating catecholamine level, Vagal paraganglioma, Chemodectoma, Carotid paragangliom... OMIM:168000
Hydatidiform Mole
Menometrorrhagia ORPHA:99927
Cerebellar Ataxia, Deafness, And Narcolepsy, Autosomal Dominant
Narcolepsy OMIM:604121
Pheochromocytoma/Paraganglioma Syndrome 3
Elevated circulating catecholamine level, Extraadrenal pheochromocytoma, Chemodectoma, Adrenal ph... OMIM:605373
46,Xy Sex Reversal 1
Abnormality of the menstrual cycle, Hypergonadotropic hypogonadism, Primary amenorrhea OMIM:400044
Osteopetrosis, Autosomal Recessive 4
Increased bone mineral density, Osteopetrosis OMIM:611490
Fowler Urethral Sphincter Dysfunction Syndrome
Amenorrhea, Oligomenorrhea, Menorrhagia ORPHA:2795
Osteopetrosis, Autosomal Recessive 8
Osteopetrosis OMIM:615085
Glucocorticoid Resistance, Generalized
Irregular menstruation, Infertility OMIM:615962
Pituitary Dermoid And Epidermoid Cysts
Polydipsia, Hypogonadism, Amenorrhea, Oligomenorrhea, Oligozoospermia ORPHA:91351
Hypogonadotropic Hypogonadism 23 With Or Without Anosmia
Male hypogonadism, Azoospermia, Hypogonadotropic hypogonadism, Oligomenorrhea, Abnormal spermatog... OMIM:228300
Ovarian Dysgenesis 3
Female infertility, Primary amenorrhea OMIM:614324
Prolactinoma
Irregular menstruation, Male hypogonadism, Abnormality of the menstrual cycle, Hypogonadism, Decr... ORPHA:2965
Hypogonadotropic Hypogonadism 10 With Or Without Anosmia
Hypogonadotropic hypogonadism, Primary amenorrhea OMIM:614839
Osteopetrosis, Autosomal Recessive 2
Diaphyseal sclerosis, Osteopetrosis, Cranial hyperostosis, Decreased osteoclast count OMIM:259710
Gangliocytoma
Amenorrhea, Impotence, Decreased female libido, Polyphagia ORPHA:251937
Functioning Gonadotropic Adenoma
Abnormality of the menstrual cycle, Decreased female libido, Amenorrhea, Oligozoospermia, Inferti... ORPHA:91348
Aromatase Deficiency
Hypergonadotropic hypogonadism, Primary amenorrhea OMIM:613546
Lipodystrophy, Familial Partial, Type 5
Irregular menstruation OMIM:615238
Pituitary Adenoma 1, Multiple Types
Irregular menstruation OMIM:102200
Wolfram Syndrome 2
Oligomenorrhea, Primary amenorrhea OMIM:604928
Pure Autonomic Failure
Abnormality of circulating catecholamine level ORPHA:441
Pituitary Adenoma 4, Acth-Secreting
Obesity, Oligomenorrhea, Abnormal fear-induced behavior, Abdominal obesity OMIM:219090
Akt2-Related Familial Partial Lipodystrophy
Oligomenorrhea ORPHA:79085
Non-Functioning Pituitary Adenoma
Irregular menstruation, Male hypogonadism, Abnormality of the menstrual cycle, Hypogonadism, Decr... ORPHA:91349
Klippel-Trénaunay Syndrome
Abnormality of the menstrual cycle ORPHA:90308
Leukocyte Adhesion Deficiency, Type Iii
Osteopetrosis OMIM:612840
Coloboma, Osteopetrosis, Microphthalmia, Macrocephaly, Albinism, And Deafness
Increased bone mineral density, Osteopetrosis OMIM:617306
Autosomal Dominant Cerebellar Ataxia-Deafness-Narcolepsy Syndrome
Narcolepsy ORPHA:314404
Hermansky-Pudlak Syndrome 5
Metrorrhagia, Menorrhagia OMIM:614074
Hypopigmentation, Organomegaly, And Delayed Myelination And Development
Osteopetrosis OMIM:618541
Osteopetrosis, Autosomal Recessive 3
Diaphyseal sclerosis, Osteopetrosis, Cranial hyperostosis OMIM:259730
Osteopetrosis, Autosomal Recessive 1
Craniosynostosis, Osteopetrosis, Increased bone mineral density, Calvarial osteosclerosis OMIM:259700
Neuroblastoma
Elevated circulating catecholamine level, Antalgic gait, Ataxia ORPHA:635
Osteopathia Striata-Cranial Sclerosis Syndrome
Increased bone mineral density, Osteopetrosis, Coarse metaphyseal trabecularization, Facial hyper... ORPHA:2780
Interstitial Cystitis
Abnormality of the menstrual cycle, Dyspareunia ORPHA:37202
Brain Abnormalities, Neurodegeneration, And Dysosteosclerosis
Osteopetrosis, Craniofacial osteosclerosis, Increased skull ossification, Diaphyseal sclerosis OMIM:618476
Tsh-Secreting Pituitary Adenoma
Irregular menstruation, Male hypogonadism, Abnormality of the menstrual cycle, Hypogonadism, Infe... ORPHA:91347
Osteopetrosis, Autosomal Recessive 5
Increased bone mineral density, Osteopetrosis, Cranial hyperostosis, Decreased osteoclast count OMIM:259720
Malakoplakia
Abnormality of the menstrual cycle, Orchitis ORPHA:556
Desmosterolosis
Increased bone mineral density, Osteopetrosis ORPHA:35107
Osteopetrosis, Autosomal Recessive 7
Abnormal trabecular bone morphology, Osteopetrosis OMIM:612301
Classic Congenital Adrenal Hyperplasia Due To 21-Hydroxylase Deficiency
Failure to thrive, Abnormality of the menstrual cycle, Decreased fertility, Hypogonadotropic hypo... ORPHA:90794
Lenz-Majewski Hyperostotic Dwarfism
Cranial hyperostosis, Facial hyperostosis, Abnormal cortical bone morphology, Osteopetrosis, Incr... ORPHA:2658
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Narcolepsy ORPHA:293987
Niemann-Pick Disease Type C
Narcolepsy ORPHA:646
Von Hippel-Lindau Disease
Elevated circulating catecholamine level, Adrenal pheochromocytoma, Pancreatic islet cell adenoma... ORPHA:892
Autosomal Recessive Malignant Osteopetrosis
Craniosynostosis, Osteopetrosis, Reduced bone mineral density ORPHA:667
African Trypanosomiasis
Abnormality of the menstrual cycle, Aggressive behavior, Weight loss, Infertility, Impotence ORPHA:3385
Wiskott-Aldrich Syndrome
Abnormality of the menstrual cycle ORPHA:906
Osteopetrosis With Renal Tubular Acidosis
Osteopetrosis ORPHA:2785

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Per1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Per1.

No publications found that use IMPC mice or data for Per1.

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MGI Allele Allele Type Produced
Per1tm444593(L1L2_GT1_LF2A_LacZ_BetactP_neo) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Per1tm1(KOMP)Mbp Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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