Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

period circadian clock 1
Hftm,  m-rigui,  mPer1

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Per1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Per1 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Cystic Angiomatosis Of Bone, Diffuse
Cystic angiomatosis of bone OMIM:123880
Disseminated Sclerosis With Narcolepsy
Narcolepsy OMIM:223300
Attention Deficit-Hyperactivity Disorder
Hyperactivity, Attention deficit hyperactivity disorder OMIM:143465
Invasive Mole
Menometrorrhagia ORPHA:99925
Asherman Syndrome
Infertility, Dysmenorrhea, Metrorrhagia, Oligomenorrhea, Abnormality of the menstrual cycle, Decr... ORPHA:137686
Narcolepsy 3
Narcolepsy OMIM:609039
Intellectual Developmental Disorder, Autosomal Recessive 54
Hyperactivity OMIM:617028
Schizophrenia 15
Hyperactivity OMIM:613950
Endometriosis, Susceptibility To, 1
Endometriosis, Dysmenorrhea, Decreased fertility OMIM:131200
Narcolepsy 7
Narcolepsy OMIM:614250
Premature Ovarian Failure 19
Irregular menstruation, Secondary amenorrhea, Female infertility, Premature ovarian insufficiency OMIM:619245
Narcolepsy 1
Narcolepsy OMIM:161400
Premature Ovarian Failure 15
Oligomenorrhea OMIM:618096
Infertility, Oligomenorrhea, Menorrhagia OMIM:615555
Gordon Holmes Syndrome
Infertility, Oligomenorrhea, Hypogonadotropic hypogonadism OMIM:212840
Placental Site Trophoblastic Tumor
Amenorrhea, Metrorrhagia ORPHA:99928
Premature Ovarian Failure 2A
Secondary amenorrhea, Premature ovarian insufficiency OMIM:300511
Gestational Choriocarcinoma
Metrorrhagia ORPHA:99926
Leptin Deficiency Or Dysfunction
Primary amenorrhea, Abnormal eating behavior, Polyphagia, Hypogonadism, Obesity OMIM:614962
Osteopetrosis, Autosomal Recessive 6
Osteopetrosis OMIM:611497
Dysmenorrhea OMIM:600458
Familial Hyperprolactinemia
Amenorrhea, Infertility, Oligomenorrhea, Menorrhagia, Female hypogonadism ORPHA:397685
Amenorrhea-Galactorrhea Syndrome
Secondary amenorrhea OMIM:104600
Distal Osteosclerosis
Diaphyseal sclerosis, Hyperostosis, Craniofacial osteosclerosis OMIM:126250
Premature Ovarian Failure 1
Irregular menstruation, Premature ovarian insufficiency OMIM:311360
Osteopetrosis, Autosomal Dominant 1
Osteopetrosis, Calvarial osteosclerosis, Thickened cortex of long bones, Generalized osteosclerosis OMIM:607634
Polycystic Ovary Syndrome 1
Amenorrhea, Obesity, Oligomenorrhea OMIM:184700
Paragangliomas 6
Elevated circulating catecholamine level, Paraganglioma OMIM:618464
Cortisone Reductase Deficiency 1
Infertility, Oligomenorrhea, Obesity OMIM:604931
Melorheostosis, Isolated
Increased bone mineral density, Hyperostosis OMIM:155950
Hyperostosis Frontalis Interna
Obesity, Irregular menstruation OMIM:144800
Premature Ovarian Failure 12
Primary amenorrhea OMIM:616947
Premature Ovarian Failure 9
Amenorrhea, Premature ovarian insufficiency OMIM:615724
Premature Ovarian Failure 2B
Primary amenorrhea, Premature ovarian insufficiency OMIM:300604
46,Xy Gonadal Dysgenesis With Minifascicular Neuropathy
Hypergonadotropic hypogonadism, Primary amenorrhea OMIM:607080
Ovarian Dysgenesis 4
Decreased body weight, Primary amenorrhea OMIM:616185
Hypogonadotropic Hypogonadism 7 With Or Without Anosmia
Infertility, Hypogonadotropic hypogonadism, Primary amenorrhea OMIM:146110
Osteopetrosis And Infantile Neuroaxonal Dystrophy
Osteopetrosis OMIM:600329
Peritoneal Cystic Mesothelioma
Weight loss, Menorrhagia, Dyspareunia, Metrorrhagia ORPHA:168816
Cerebellar Ataxia, Deafness, And Narcolepsy, Autosomal Dominant
Narcolepsy OMIM:604121
Prolactin Deficiency, Isolated
Infertility, Irregular menstruation OMIM:264110
Perrault Syndrome 6
Streak ovary, Irregular menstruation, Primary amenorrhea, Secondary amenorrhea, Premature ovarian... OMIM:617565
Premature Ovarian Failure 5
Hypoplasia of the ovary, Streak ovary, Reduced antral follicle count, Primary amenorrhea, Seconda... OMIM:611548
Gray Platelet Syndrome
Abnormality of the menstrual cycle ORPHA:721
Premature Ovarian Failure 11
Secondary amenorrhea, Oligomenorrhea OMIM:616946
Mitochondrial Dna Depletion Syndrome 16B (Neuroophthalmic Type)
Amenorrhea, Premature ovarian insufficiency OMIM:619425
Ovarian Dysgenesis 7
Primary amenorrhea OMIM:618117
Premature Ovarian Failure 3
Secondary amenorrhea, Premature ovarian insufficiency OMIM:608996
Premature Ovarian Failure 13
Amenorrhea, Oligomenorrhea, Female infertility OMIM:617442
Ovarian Dysgenesis 2
Streak ovary, Hypergonadotropic hypogonadism, Primary amenorrhea, Secondary amenorrhea, Premature... OMIM:300510
Hypersecretion Of Adrenal Androgens, Familial
Amenorrhea OMIM:145295
Ovarian Dysgenesis 1
Primary amenorrhea OMIM:233300
Bardet-Biedl Syndrome 9
Polydipsia, Irregular menstruation, Truncal obesity, Polyphagia, Obesity OMIM:615986
Retinal Dystrophy With Or Without Extraocular Anomalies
Secondary amenorrhea, Premature ovarian insufficiency OMIM:617175
Perrault Syndrome 2
Amenorrhea, Streak ovary OMIM:614926
Glucocorticoid Resistance, Generalized
Infertility, Irregular menstruation OMIM:615962
Hypogonadotropic Hypogonadism 10 With Or Without Anosmia
Hypogonadotropic hypogonadism, Primary amenorrhea OMIM:614839
Ovarian Dysgenesis 5
Primary amenorrhea OMIM:617690
Premature Ovarian Failure 6
Female infertility, Streak ovary, Primary amenorrhea, Secondary amenorrhea, Premature ovarian ins... OMIM:612310
Premature Ovarian Failure 18
Irregular menstruation, Secondary amenorrhea, Hypoplasia of the ovary, Premature ovarian insuffic... OMIM:619203
Hemochromatosis, Type 2A
Amenorrhea, Infertility, Hypogonadotropic hypogonadism, Azoospermia OMIM:602390
Isolated Follicle Stimulating Hormone Deficiency
Testicular atrophy, Delayed menarche, Hypogonadotropic hypogonadism, Primary amenorrhea, Oligomen... ORPHA:52901
Premature Ovarian Failure 20
Secondary amenorrhea, Female infertility OMIM:619938
Ovarian Dysgenesis 8
Primary amenorrhea, Eunuchoid habitus OMIM:618187
Hypogonadotropic Hypogonadism 22 With Or Without Anosmia
Primary amenorrhea, Hypogonadism OMIM:616030
Perrault Syndrome 4
Hypoplasia of the ovary, Oligomenorrhea, Primary amenorrhea, Secondary amenorrhea, Obesity, Prema... OMIM:615300
Hypogonadotropic Hypogonadism 24 With Or Without Anosmia
Infertility, Primary amenorrhea, Azoospermia, Hypogonadism OMIM:229070
Hypogonadotropic Hypogonadism 14 With Or Without Anosmia
Primary amenorrhea OMIM:614858
Premature Ovarian Failure 7
Secondary amenorrhea, Primary amenorrhea, Premature ovarian insufficiency OMIM:612964
Osteopetrosis, Autosomal Dominant 2
Osteopetrosis, Generalized osteosclerosis OMIM:166600
Familial Afibrinogenemia
Menometrorrhagia ORPHA:98880
Double Uterus-Hemivagina-Renal Agenesis Syndrome
Dyspareunia, Dysmenorrhea, Metrorrhagia ORPHA:3411
Plin1-Related Familial Partial Lipodystrophy
Infertility, Oligomenorrhea ORPHA:280356
Craniometaphyseal Dysplasia
Osteopetrosis, Craniofacial hyperostosis ORPHA:1522
Proprotein Convertase 1/3 Deficiency
Hypogonadotropic hypogonadism, Primary amenorrhea, Obesity OMIM:600955
Ovarian Dysgenesis 10
Hypoplasia of the ovary, Primary amenorrhea, Premature ovarian insufficiency, Streak ovary OMIM:619834
Glanzmann Thrombasthenia
Menorrhagia, Menometrorrhagia ORPHA:849
Premature Ovarian Failure 14
Primary amenorrhea OMIM:618014
Lig4 Syndrome
Amenorrhea, Failure to thrive OMIM:606593
Hemochromatosis, Type 3
Amenorrhea, Hypogonadotropic hypogonadism, Impotence OMIM:604250
Premature Ovarian Failure 10
Azoospermia, Hypoplasia of the ovary, Primary amenorrhea, Premature ovarian insufficiency OMIM:612885
Osteopetrosis, Autosomal Recessive 8
Osteopetrosis OMIM:615085
Premature Ovarian Failure 8
Primary amenorrhea, Premature ovarian insufficiency, Streak ovary OMIM:615723
Lipodystrophy, Familial Partial, Type 4
Oligomenorrhea OMIM:613877
Autosomal Dominant Cerebellar Ataxia-Deafness-Narcolepsy Syndrome
Narcolepsy ORPHA:314404
Hydatidiform Mole
Menometrorrhagia ORPHA:99927
Amenorrhea, Hypogonadotropic hypogonadism, Impotence, Decreased female libido ORPHA:251623
Luscan-Lumish Syndrome
Obesity, Polyphagia, Irregular menstruation OMIM:616831
46,Xy Sex Reversal 1
Primary amenorrhea, Abnormality of the menstrual cycle OMIM:400044
Wilson Disease
Failure to thrive, Increased body weight, Weight loss, Abnormality of the menstrual cycle ORPHA:905
Coloboma, Osteopetrosis, Microphthalmia, Macrocephaly, Albinism, And Deafness
Osteopetrosis OMIM:617306
Paragangliomas 1
Glomus jugular tumor, Extraadrenal pheochromocytoma, Glomus tympanicum paraganglioma, Vagal parag... OMIM:168000
Fowler Urethral Sphincter Dysfunction Syndrome
Amenorrhea, Oligomenorrhea, Menorrhagia ORPHA:2795
Paragangliomas 3
Glomus jugular tumor, Extraadrenal pheochromocytoma, Elevated circulating catecholamine level, Ad... OMIM:605373
Pituitary Dermoid And Epidermoid Cysts
Amenorrhea, Polydipsia, Oligomenorrhea, Oligospermia, Hypogonadism ORPHA:91351
Amenorrhea, Impotence, Dyspareunia, Decreased fertility in males, Hypogonadotropic hypogonadism, ... ORPHA:2965
Ovarian Dysgenesis 3
Female infertility, Primary amenorrhea OMIM:614324
Amenorrhea, Polyphagia, Impotence, Decreased female libido ORPHA:251937
Hypogonadotropic Hypogonadism 23 With Or Without Anosmia
Hypogonadotropic hypogonadism, Oligomenorrhea, Secondary amenorrhea, Abnormal spermatogenesis, Ma... OMIM:228300
Aromatase Deficiency
Hypergonadotropic hypogonadism, Primary amenorrhea OMIM:613546
Interstitial Cystitis
Abnormality of the menstrual cycle, Dyspareunia ORPHA:37202
Functioning Gonadotropic Adenoma
Amenorrhea, Infertility, Impotence, Oligospermia, Abnormality of the menstrual cycle, Decreased f... ORPHA:91348
Lipodystrophy, Familial Partial, Type 5
Irregular menstruation OMIM:615238
Mayer-Rokitansky-Kuster-Hauser Syndrome
Amenorrhea OMIM:277000
Osteopetrosis, Autosomal Recessive 2
Osteopetrosis, Diaphyseal sclerosis, Cranial hyperostosis OMIM:259710
Lead Poisoning
Infertility, Decreased male libido, Reduced sperm motility, Small for gestational age, Oligosperm... ORPHA:330015
Pituitary Adenoma 1, Multiple Types
Irregular menstruation OMIM:102200
Osteopetrosis, Autosomal Recessive 4
Osteopetrosis OMIM:611490
Pure Autonomic Failure
Abnormality of circulating catecholamine level ORPHA:441
Pseudohypoparathyroidism With Albright Hereditary Osteodystrophy
Obesity, Irregular menstruation, Abnormality of the menstrual cycle ORPHA:457059
Non-Functioning Pituitary Adenoma
Impotence, Decreased fertility in males, Hypogonadotropic hypogonadism, Irregular menstruation, A... ORPHA:91349
Klippel-Trénaunay Syndrome
Abnormality of the menstrual cycle ORPHA:90308
Hymen, Imperforate
Amenorrhea OMIM:237100
Leukocyte Adhesion Deficiency, Type Iii
Osteopetrosis OMIM:612840
Hermansky-Pudlak Syndrome 5
Menorrhagia, Metrorrhagia OMIM:614074
Osteopetrosis, Autosomal Recessive 3
Osteopetrosis, Diaphyseal sclerosis, Cranial hyperostosis OMIM:259730
Hypopigmentation, Organomegaly, And Delayed Myelination And Development
Osteopetrosis OMIM:618541
Osteopetrosis, Autosomal Recessive 1
Osteopetrosis, Calvarial osteosclerosis, Increased bone mineral density, Craniosynostosis OMIM:259700
Blepharophimosis, Ptosis, And Epicanthus Inversus
Amenorrhea, Irregular menstruation, Female infertility, Premature ovarian insufficiency OMIM:110100
Mullerian Aplasia And Hyperandrogenism
Amenorrhea OMIM:158330
Wolfram Syndrome 2
Oligomenorrhea, Primary amenorrhea OMIM:604928
Osteopathia Striata-Cranial Sclerosis Syndrome
Osteopetrosis, Coarse metaphyseal trabecularization, Increased bone mineral density, Facial hyper... ORPHA:2780
Brain Abnormalities, Neurodegeneration, And Dysosteosclerosis
Osteopetrosis OMIM:618476
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Narcolepsy ORPHA:293987
Tsh-Secreting Pituitary Adenoma
Infertility, Impotence, Decreased fertility in males, Hypogonadotropic hypogonadism, Irregular me... ORPHA:91347
Niemann-Pick Disease Type C
Narcolepsy ORPHA:646
Osteopetrosis, Autosomal Recessive 5
Osteopetrosis, Cranial hyperostosis, Increased bone mineral density, Decreased osteoclast count OMIM:259720
African Trypanosomiasis
Narcolepsy ORPHA:3385
Osteopetrosis, Increased bone mineral density ORPHA:35107
Abnormality of the menstrual cycle, Orchitis ORPHA:556
Osteopetrosis, Autosomal Recessive 7
Osteopetrosis, Abnormal trabecular bone morphology OMIM:612301
Classic Congenital Adrenal Hyperplasia Due To 21-Hydroxylase Deficiency
Failure to thrive, Hypogonadotropic hypogonadism, Oligomenorrhea, Abnormality of the menstrual cy... ORPHA:90794
Lenz-Majewski Hyperostotic Dwarfism
Increased bone mineral density, Osteopetrosis, Abnormal cortical bone morphology, Cranial hyperos... ORPHA:2658
Angioosteohypertrophic Syndrome
Abnormality of the menstrual cycle ORPHA:2346
Von Hippel-Lindau Disease
Paraganglioma, Elevated circulating catecholamine level, Adrenal pheochromocytoma, Pancreatic end... ORPHA:892
Autosomal Recessive Malignant Osteopetrosis
Osteopetrosis, Reduced bone mineral density, Craniosynostosis ORPHA:667
Wiskott-Aldrich Syndrome
Abnormality of the menstrual cycle ORPHA:906
Osteopetrosis With Renal Tubular Acidosis
Osteopetrosis ORPHA:2785
Hypermobile Ehlers-Danlos Syndrome
Abnormality of the menstrual cycle, Decreased fertility ORPHA:285


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Per1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Per1.

No publications found that use IMPC mice or data for Per1.

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MGI Allele Allele Type Produced
Per1tm444593(L1L2_GT1_LF2A_LacZ_BetactP_neo) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Per1tm1(KOMP)Mbp Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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