Gene: Cyp27b1

Name
cytochrome P450, family 27, subfamily b, polypeptide 1
MGI ID
MGI:1098274
Synonyms
Cyp27b Cyp40 1alpha(OH)ase Cp2b 25(OH)D 1alpha-hydroxylase Cyp1 Pddr Vdd1 Vddr P450c1 VddrI 25-hydroxyvitamin D3 1alpha-hydroxylase P450VD1alpha
Viability
Homozygous - Viable
Other links
View data by physiological system
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal clavicle morphology Cyp27b1tm1b(EUCOMM)Hmgu HOM postnatal 9.26×10-13
decreased lean body mass Cyp27b1tm1b(EUCOMM)Hmgu HOM postnatal 5.57×10-24
abnormal fibula morphology Cyp27b1tm1b(EUCOMM)Hmgu HOM postnatal 9.26×10-13
abnormal behavior Cyp27b1tm1b(EUCOMM)Hmgu HOM postnatal 5.50×10-14
abnormal tibia morphology Cyp27b1tm1b(EUCOMM)Hmgu HOM postnatal 9.26×10-13
abnormal humerus morphology Cyp27b1tm1b(EUCOMM)Hmgu HOM postnatal 9.26×10-13
abnormal rib morphology Cyp27b1tm1b(EUCOMM)Hmgu HOM postnatal 9.26×10-13
decreased grip strength Cyp27b1tm1b(EUCOMM)Hmgu HOM postnatal 1.79×10-09
decreased vertical activity Cyp27b1tm1b(EUCOMM)Hmgu HOM postnatal 2.22×10-07
abnormal joint morphology Cyp27b1tm1b(EUCOMM)Hmgu HOM postnatal 9.26×10-13
decreased startle reflex Cyp27b1tm1b(EUCOMM)Hmgu HOM postnatal 3.96×10-06
abnormal radius morphology Cyp27b1tm1b(EUCOMM)Hmgu HOM postnatal 9.26×10-13
decreased bone mineral density Cyp27b1tm1b(EUCOMM)Hmgu HOM postnatal 0.00
abnormal bone structure Cyp27b1tm1b(EUCOMM)Hmgu HOM postnatal 5.44×10-43
increased circulating alkaline phosphatase level Cyp27b1tm1b(EUCOMM)Hmgu HOM postnatal 2.29×10-11
decreased body length Cyp27b1tm1b(EUCOMM)Hmgu HOM postnatal 6.33×10-43
decreased circulating calcium level Cyp27b1tm1b(EUCOMM)Hmgu HOM postnatal 3.71×10-14
abnormal cranium morphology Cyp27b1tm1b(EUCOMM)Hmgu HOM postnatal 7.41×10-12
hypoactivity Cyp27b1tm1b(EUCOMM)Hmgu HOM postnatal 2.01×10-13
abnormal ulna morphology Cyp27b1tm1b(EUCOMM)Hmgu HOM postnatal 9.26×10-13
abnormal vertebrae morphology Cyp27b1tm1b(EUCOMM)Hmgu HOM postnatal 2.24×10-12
increased circulating bilirubin level Cyp27b1tm1b(EUCOMM)Hmgu HOM postnatal 1.84×10-08
abnormal femur morphology Cyp27b1tm1b(EUCOMM)Hmgu HOM postnatal 9.26×10-13
decreased bone mineral content Cyp27b1tm1b(EUCOMM)Hmgu HOM postnatal 1.68×10-44
abnormal pelvic girdle bone morphology Cyp27b1tm1b(EUCOMM)Hmgu HOM postnatal 2.83×10-08
abnormal scapula morphology Cyp27b1tm1b(EUCOMM)Hmgu HOM postnatal 9.26×10-13
decreased circulating phosphate level Cyp27b1tm1b(EUCOMM)Hmgu HOM postnatal 5.00×10-11
decreased total body fat amount Cyp27b1tm1b(EUCOMM)Hmgu HOM postnatal 2.60×10-11
decreased circulating HDL cholesterol level Cyp27b1tm1b(EUCOMM)Hmgu HOM postnatal 1.26×10-08
short tibia Cyp27b1tm1b(EUCOMM)Hmgu HOM postnatal 0.00
decreased circulating glucose level Cyp27b1tm1b(EUCOMM)Hmgu HOM postnatal 4.01×10-07
decreased circulating cholesterol level Cyp27b1tm1b(EUCOMM)Hmgu HOM postnatal 3.03×10-08

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Filtered by: all phenotypes

 Expression

Expression data not available

 Associated Images

X-ray: XRay Images Skull Dorso Ventral Orientation
14 Images
X-ray: XRay Images Lateral Orientation
14 Images
X-ray: XRay Images Dorso Ventral
14 Images
X-ray: XRay Images Skull Lateral Orientation
14 Images
Gross Pathology and Tissue Collection
4 Images

 Disease Models

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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Cyp27b1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Cyp27b1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Cyp27b1tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice

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