Gene: Cast

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Phenotype System Allele Zyg Sex Life Stage P Value
decreased bone mineral density Casttm1.1(KOMP)Vlcg HOM postnatal 1.75×10-06
decreased bone mineral content Casttm1.1(KOMP)Vlcg HOM postnatal 1.80×10-05
increased circulating phosphate level Casttm1.1(KOMP)Vlcg HOM postnatal 3.34×10-05
abnormal gait Casttm1.1(KOMP)Vlcg HOM postnatal 9.68×10-08
abnormal limb position Casttm1.1(KOMP)Vlcg HOM postnatal 1.83×10-05
increased bone mineral density Casttm1.1(KOMP)Vlcg HOM postnatal 1.75×10-06
abnormal nail morphology Casttm1.1(KOMP)Vlcg HOM postnatal 2.44×10-05
decreased startle reflex Casttm1.1(KOMP)Vlcg HOM postnatal 8.23×10-13
abnormal digit morphology Casttm1.1(KOMP)Vlcg HOM postnatal 7.72×10-07

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No N/A
Bone marrow 2 No  (2/2) N/A
Brain 2 No  (2/2) N/A
Brainstem 2 No  (2/2) N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No  (2/2) N/A
Cerebral cortex 2 No  (2/2) N/A
Epididymis 2 No  (18/134) N/A
Esophagus 2 No  (7/415)  (2/2) N/A
Eye 2 No N/A
Heart 2 No N/A
Hippocampus 2 No  (2/2) N/A
Hypothalamus 2 No  (2/2) N/A
Kidney 2 No  (18/584)  (2/2) N/A
Large intestine 2 No  (10/584)  (2/2) N/A
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No  (2/2) N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Midbrain 2 No  (2/2) N/A
Olfactory lobe 2 No  (2/2) N/A
Ovary 2 No  (1/584)  (1/2) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584) N/A
Peripheral nervous system 2 No  (2/2) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (2/2) N/A
Small intestine 2 No  (9/584)  (2/2) N/A
Spinal cord 2 No  (2/2) N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No N/A
Submandibular gland 2 No  (2/132) N/A
Testis 2 No  (2/584)  (1/2) N/A
Thalamus 2 No  (2/2) N/A
Thymus 2 No  (2/2) N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No N/A
Urinary bladder 2 No N/A
Uterus 2 No N/A
Vascular system 2 No N/A
Vesicular gland 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/485) N/A
Dorsal root ganglion 1  (1/47) N/A
Ear 2  (1/485) N/A
Embryo 2  (1/485) N/A
Eye 2  (1/485) N/A
Foot 2  (1/485) N/A
Forebrain 2  (1/485) N/A
Forelimb 2  (1/485) N/A
Fronto-nasal process 1  (1/48) N/A
Hand 2  (1/485) N/A
Head 2  (5/485) N/A
Heart 2  (1/485) N/A
Hindbrain 2  (6/485) N/A
Hindlimb 2  (1/485) N/A
Liver 2  (1/485) N/A
Lung 2  (1/485) N/A
Mandibular process 2  (1/485) N/A
Maxillary process 2  (1/485) N/A
Midbrain 2  (1/485) N/A
Nose 1  (1/51) N/A
Oral cavity 2  (1/485) N/A
Skin 2  (1/485) N/A
Spinal cord 1  (1/50) N/A
Tail 2  (1/485) N/A
Tail somite 2  (1/485) N/A

 Associated Images

X-ray: XRay Images Forepaw
9 Images
X-ray: XRay Images Dorso Ventral
10 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
9 Images
X-ray: XRay Images Lateral Orientation
10 Images
Combined SHIRPA and Dysmorphology
19 Images
X-ray: XRay Images Skull Lateral Orientation
9 Images

 Disease Models

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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Casttm452444(Ifitm2_intron_L1L2_GT0_LF2A_LacZ_BetactP_neo) Targeting vectors
Casttm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells
Casttm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice

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