Cast | calpastatin

Physiological systems

17 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Homeostasis/metabolism Integument Growth/size/body region Limbs/digits/tail Behavior/neurological Cardiovascular system

11 No significant impact

7 Not tested

Gene metrics:10Significant phenotypes
2Associated diseases
Expression examined in:49Adult tissues
46Embryo tissues

Phenotypes

increased heart weight1 supporting datasetCasttm1.1(KOMP)VlcghomozygoteEarly adult4.14x10-7 
decreased fasting circulating glucose level1 supporting datasetCasttm1.1(KOMP)VlcghomozygoteEarly adult3.43x10-5 
decreased startle reflex1 supporting datasetCasttm1.1(KOMP)VlcghomozygoteEarly adult1.03x10-6 
abnormal digit morphology2 supporting datasetsCasttm1.1(KOMP)VlcghomozygoteEarly adult1.18x10-5 
increased circulating alanine transaminase level1 supporting datasetCasttm1.1(KOMP)VlcghomozygoteEarly adult2.05x10-8 
abnormal nail morphology1 supporting datasetCasttm1.1(KOMP)VlcghomozygoteEarly adult1.18x10-5 
abnormal gait1 supporting datasetCasttm1.1(KOMP)VlcghomozygoteEarly adult3.11x10-8 
increased circulating sodium level1 supporting datasetCasttm1.1(KOMP)VlcghomozygoteEarly adult9.54x10-5 
increased circulating phosphate level1 supporting datasetCasttm1.1(KOMP)VlcghomozygoteEarly adult5.19x10-6 
abnormal limb position1 supporting datasetCasttm1.1(KOMP)VlcghomozygoteEarly adult8.4x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* Does not have a P-value assigned because it was manually marked as significant.
Download data as:  

lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Casttm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)es cell
mouse
Casttm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse
Casttm452444(Ifitm2_intron_L1L2_GT0_LF2A_LacZ_BetactP_neo)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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